NZ332482A - Human and clam cyclin-selective ubiquitin carrier polypeptides (E2) that are involved in the ubiquitination of cyclins A and B, inhibitors of these E2 polypeptides are included - Google Patents

Human and clam cyclin-selective ubiquitin carrier polypeptides (E2) that are involved in the ubiquitination of cyclins A and B, inhibitors of these E2 polypeptides are included

Info

Publication number
NZ332482A
NZ332482A NZ332482A NZ33248297A NZ332482A NZ 332482 A NZ332482 A NZ 332482A NZ 332482 A NZ332482 A NZ 332482A NZ 33248297 A NZ33248297 A NZ 33248297A NZ 332482 A NZ332482 A NZ 332482A
Authority
NZ
New Zealand
Prior art keywords
polypeptides
ubiquitination
involved
inhibitors
human
Prior art date
Application number
NZ332482A
Inventor
Joan V Rudderman
Avram Hershko
Marc W Kirschner
Fiona Townsley
Alexander Aristarkov
Esther Eytan
Hongtao Yu
Original Assignee
Rappaport Family Inst For Res
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rappaport Family Inst For Res, Harvard College filed Critical Rappaport Family Inst For Res
Publication of NZ332482A publication Critical patent/NZ332482A/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Isolated and purified human and clam ubiquitin carrier peptide (Ubc) which is involved in the ubiquitination of cyclin A and/or B. Also disclosed are dominant negative selective inhibitors of Ubc, nucleic acids encoding such polypeptides, antibodies specific for such polypeptides, and methods of their use.
NZ332482A 1996-04-01 1997-03-31 Human and clam cyclin-selective ubiquitin carrier polypeptides (E2) that are involved in the ubiquitination of cyclins A and B, inhibitors of these E2 polypeptides are included NZ332482A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1449296P 1996-04-01 1996-04-01
US82063997A 1997-03-18 1997-03-18
PCT/US1997/005296 WO1997037027A1 (en) 1996-04-01 1997-03-31 Novel cyclin-selective ubiquitin carrier polypeptides

Publications (1)

Publication Number Publication Date
NZ332482A true NZ332482A (en) 2000-05-26

Family

ID=26686162

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ332482A NZ332482A (en) 1996-04-01 1997-03-31 Human and clam cyclin-selective ubiquitin carrier polypeptides (E2) that are involved in the ubiquitination of cyclins A and B, inhibitors of these E2 polypeptides are included

Country Status (7)

Country Link
EP (1) EP0900276A1 (en)
KR (1) KR20000005413A (en)
AU (1) AU732547B2 (en)
BR (1) BR9710415A (en)
CA (1) CA2250849A1 (en)
NZ (1) NZ332482A (en)
WO (1) WO1997037027A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9626603D0 (en) * 1996-12-20 1997-02-05 Zeneca Ltd Protein assay
CA2292643A1 (en) * 1997-06-05 1998-12-10 Incyte Pharmaceuticals, Inc. Human ubiquitin carrier protein e2-like protein and cyclin b-like protein
EP1167539A1 (en) * 2000-06-29 2002-01-02 Boehringer Ingelheim International GmbH Methods for identifying inhibitors of the anaphase promoting complex
WO2023200263A1 (en) * 2022-04-14 2023-10-19 아주대학교산학협력단 U-box variant of e3 ligase with enhanced ubiquitin ligase activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5384255A (en) * 1993-06-21 1995-01-24 Rappaport Family Institute For Research In The Medical Sciences Ubiquitin carrier enzyme E2-F1, purification, production, and use
WO1995018974A2 (en) * 1994-01-04 1995-07-13 Mitotix, Inc. Ubiquitin conjugating enzymes
US5726025A (en) * 1995-04-20 1998-03-10 President And Fellows Of Harvard College Assay and reagents for detecting inhibitors of ubiquitin-dependent degradation of cell cycle regulatory proteins

Also Published As

Publication number Publication date
KR20000005413A (en) 2000-01-25
WO1997037027A1 (en) 1997-10-09
AU2600697A (en) 1997-10-22
EP0900276A1 (en) 1999-03-10
CA2250849A1 (en) 1997-10-09
BR9710415A (en) 1999-08-17
AU732547B2 (en) 2001-04-26

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