WO1998055510A3 - Human ubiquitin carrier protein e2-like protein and cyclin b-like protein - Google Patents

Human ubiquitin carrier protein e2-like protein and cyclin b-like protein Download PDF

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Publication number
WO1998055510A3
WO1998055510A3 PCT/US1998/011735 US9811735W WO9855510A3 WO 1998055510 A3 WO1998055510 A3 WO 1998055510A3 US 9811735 W US9811735 W US 9811735W WO 9855510 A3 WO9855510 A3 WO 9855510A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
cyclin
human ubiquitin
ubiquitin carrier
hcrp
Prior art date
Application number
PCT/US1998/011735
Other languages
French (fr)
Other versions
WO1998055510A2 (en
Inventor
Jennifer L Hillman
Neil C Corley
Karn J Guegler
Benjamin Graeme Cocks
Purvi Shah
Original Assignee
Incyte Pharma Inc
Jennifer L Hillman
Neil C Corley
Karn J Guegler
Benjamin Graeme Cocks
Purvi Shah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharma Inc, Jennifer L Hillman, Neil C Corley, Karn J Guegler, Benjamin Graeme Cocks, Purvi Shah filed Critical Incyte Pharma Inc
Priority to EP98930079A priority Critical patent/EP1003880A2/en
Priority to AU79549/98A priority patent/AU7954998A/en
Priority to JP50298899A priority patent/JP2002502264A/en
Priority to CA002292643A priority patent/CA2292643A1/en
Publication of WO1998055510A2 publication Critical patent/WO1998055510A2/en
Publication of WO1998055510A3 publication Critical patent/WO1998055510A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides two human proteins, involved in the cyclin-mediated regulatory pathway; a cyclin B-like protein, designated HCRP-2, and a ubiquitin conjugating enzyme E2-like protein, allegedly specifically involved in the degradation of mitotic cyclins, designated HCRP-1.
PCT/US1998/011735 1997-06-05 1998-06-05 Human ubiquitin carrier protein e2-like protein and cyclin b-like protein WO1998055510A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP98930079A EP1003880A2 (en) 1997-06-05 1998-06-05 Human ubiquitin carrier protein e2-like protein and cyclin b-like protein
AU79549/98A AU7954998A (en) 1997-06-05 1998-06-05 Cyclin related proteins
JP50298899A JP2002502264A (en) 1997-06-05 1998-06-05 Cyclin-related proteins
CA002292643A CA2292643A1 (en) 1997-06-05 1998-06-05 Human ubiquitin carrier protein e2-like protein and cyclin b-like protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87014397A 1997-06-05 1997-06-05
US08/870,143 1997-06-05

Publications (2)

Publication Number Publication Date
WO1998055510A2 WO1998055510A2 (en) 1998-12-10
WO1998055510A3 true WO1998055510A3 (en) 1999-03-18

Family

ID=25354862

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/011735 WO1998055510A2 (en) 1997-06-05 1998-06-05 Human ubiquitin carrier protein e2-like protein and cyclin b-like protein

Country Status (5)

Country Link
EP (1) EP1003880A2 (en)
JP (1) JP2002502264A (en)
AU (1) AU7954998A (en)
CA (1) CA2292643A1 (en)
WO (1) WO1998055510A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262249B1 (en) 1998-06-23 2001-07-17 Chiron Corporation Pancreatic cancer genes
CN1328059A (en) * 2000-06-14 2001-12-26 上海博德基因开发有限公司 Polypeptide-human cell cyclin G29.13 and polynucleotide for coding it
US20040142325A1 (en) 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
WO2004063355A2 (en) * 2003-01-10 2004-07-29 Protein Design Labs, Inc. Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of matastatic cancer
US20050186600A1 (en) * 2004-01-13 2005-08-25 Osnat Sella-Tavor Polynucleotides encoding novel UbcH10 polypeptides and kits and methods using same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037027A1 (en) * 1996-04-01 1997-10-09 President And Fellows Of Harvard College Novel cyclin-selective ubiquitin carrier polypeptides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037027A1 (en) * 1996-04-01 1997-10-09 President And Fellows Of Harvard College Novel cyclin-selective ubiquitin carrier polypeptides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TOWNSLEY F M ET AL: "DOMINANT-NEGATIVE CYCLIN-SELECTIVE UBIQUITIN CARRIER PROTEIN E2-C/UBCH10 BLOCKS CELLS IN METAPHASE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 94, no. 6, 18 March 1997 (1997-03-18), pages 2362 - 2367, XP002039885 *

Also Published As

Publication number Publication date
WO1998055510A2 (en) 1998-12-10
EP1003880A2 (en) 2000-05-31
CA2292643A1 (en) 1998-12-10
AU7954998A (en) 1998-12-21
JP2002502264A (en) 2002-01-22

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