ATE520656T1 - Verfahren zur herstellung von 2-oxo-1- pyrrolidinderivaten - Google Patents
Verfahren zur herstellung von 2-oxo-1- pyrrolidinderivatenInfo
- Publication number
- ATE520656T1 ATE520656T1 AT06026414T AT06026414T ATE520656T1 AT E520656 T1 ATE520656 T1 AT E520656T1 AT 06026414 T AT06026414 T AT 06026414T AT 06026414 T AT06026414 T AT 06026414T AT E520656 T1 ATE520656 T1 AT E520656T1
- Authority
- AT
- Austria
- Prior art keywords
- oxo
- producing
- pyrrolidine derivatives
- relates
- present
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229960002161 brivaracetam Drugs 0.000 abstract 1
- MSYKRHVOOPPJKU-BDAKNGLRSA-N brivaracetam Chemical compound CCC[C@H]1CN([C@@H](CC)C(N)=O)C(=O)C1 MSYKRHVOOPPJKU-BDAKNGLRSA-N 0.000 abstract 1
- 229960004002 levetiracetam Drugs 0.000 abstract 1
- HPHUVLMMVZITSG-ZCFIWIBFSA-N levetiracetam Chemical compound CC[C@H](C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-ZCFIWIBFSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- ANWPENAPCIFDSZ-BQBZGAKWSA-N seletracetam Chemical compound CC[C@@H](C(N)=O)N1C[C@@H](C=C(F)F)CC1=O ANWPENAPCIFDSZ-BQBZGAKWSA-N 0.000 abstract 1
- 229950000852 seletracetam Drugs 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75407005P | 2005-12-21 | 2005-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE520656T1 true ATE520656T1 (de) | 2011-09-15 |
Family
ID=37963913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06026414T ATE520656T1 (de) | 2005-12-21 | 2006-12-20 | Verfahren zur herstellung von 2-oxo-1- pyrrolidinderivaten |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8338621B2 (de) |
| EP (1) | EP1806339B1 (de) |
| AT (1) | ATE520656T1 (de) |
| ES (1) | ES2371351T3 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5100298B2 (ja) * | 2007-10-11 | 2012-12-19 | 株式会社トクヤマ | 光学活性α−スルホニルオキシカルボン酸アミド誘導体及びその製造方法 |
| PL2285357T3 (pl) * | 2008-05-30 | 2014-08-29 | Ucb Pharma Sa | Kompozycja farmaceutyczna zawierająca brivaracetam |
| EP2341777B1 (de) * | 2008-11-07 | 2015-01-21 | NovaBay Pharmaceuticals, Inc. | Antimikrobielle oxazolidinon-, hydantoin- und imidazolidinon-zusammensetzungen |
| TW201124078A (en) | 2009-12-22 | 2011-07-16 | Du Pont | Fungicidal 2-(bicyclic aryloxy) carboxamides |
| US8697879B2 (en) | 2010-07-01 | 2014-04-15 | Northwestern University | Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors |
| WO2012087372A1 (en) | 2010-12-22 | 2012-06-28 | E. I. Du Pont De Nemours And Company | Fungicidal 2-(bicyclic aryloxy)carboxamides |
| WO2013167986A2 (en) * | 2012-05-08 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of epilepsy |
| CN106146379B (zh) * | 2013-06-19 | 2018-03-20 | 成都百途医药科技有限公司 | 一种奥拉西坦的合成方法 |
| PT3096790T (pt) | 2014-01-21 | 2019-10-15 | Janssen Pharmaceutica Nv | Combinações compreendendo moduladores alostéricos positivos ou agonistas ortostéricos do recetor glutamatérgico metabotrópico do subtipo 2 e seu uso |
| EA202192105A3 (ru) | 2014-02-04 | 2022-02-28 | Янссен Фармацевтика Нв | Комбинации, содержащие положительные аллостерические модуляторы или ортостерические агонисты метаботропного глутаматергического рецептора 2 подтипа, и их применение |
| WO2016075082A1 (en) | 2014-11-10 | 2016-05-19 | Sandoz Ag | Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam |
| CN104892483B (zh) * | 2015-04-16 | 2017-05-24 | 广东赛烽医药科技有限公司 | 2‑氧代‑1‑吡咯烷手性衍生物的制备方法 |
| CN106279074B (zh) * | 2015-05-25 | 2018-06-26 | 苏州鹏旭医药科技有限公司 | 一种化合物及其制备方法和在合成布瓦西坦中的用途 |
| MX380263B (es) * | 2015-05-25 | 2025-03-12 | Suzhou Pengxu Pharmatech Co Ltd | Procesos para producir brivaracetam. |
| CN108101823A (zh) | 2018-02-13 | 2018-06-01 | 扬州奥锐特药业有限公司 | 一种高手性纯度内酰胺中间体及布瓦西坦的制备方法 |
| WO2020051796A1 (zh) * | 2018-09-12 | 2020-03-19 | 上海宣泰医药科技有限公司 | 布瓦西坦的制备方法及其中间体 |
| CN111333563B (zh) | 2018-12-19 | 2023-11-07 | 上海科胜药物研发有限公司 | 一种布瓦西坦中间体的制备方法 |
| US10781170B1 (en) | 2019-10-21 | 2020-09-22 | Divi's Laboratories Ltd. | Process for preparing Brivaracetam |
| CN111675643B (zh) * | 2020-06-15 | 2021-10-26 | 浙江天宇药业股份有限公司 | 一种布瓦西坦的制备方法 |
| EP4166540A1 (de) * | 2020-06-15 | 2023-04-19 | Zhejiang Tianyu Pharmaceutical Co., Ltd | Herstellungsverfahren für brivaracetam |
| US11400074B1 (en) | 2021-02-01 | 2022-08-02 | Divi's Laboratories Ltd. | Enzymatic process for the preparation of (2S)-2-[(4R)-2-oxo-4-propyl-pyrrolidin-1-yl]butyric acid and its conversion into brivaracetam |
| CN115784959B (zh) * | 2021-09-09 | 2025-05-27 | 凯特立斯（深圳）科技有限公司 | 一种布瓦西坦的制备方法 |
| WO2023100110A1 (en) * | 2021-12-02 | 2023-06-08 | Macfarlan Smith Limited | Process for preparing brivaracetam |
| CN114409586A (zh) * | 2021-12-23 | 2022-04-29 | 山东诚汇双达药业有限公司 | 一种左乙拉西坦的制备方法 |
| US11884623B2 (en) | 2022-05-23 | 2024-01-30 | Divi's Laboratories Ltd. | Process for the preparation of (R)-4-propyl pyrrolidine-2-one, a key intermediate for synthesis of brivaracetam |
| CN118993973B (zh) * | 2024-10-22 | 2024-12-24 | 山东玉满坤生物科技有限公司 | 一种吡拉西坦的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8412357D0 (en) | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| GB8827389D0 (en) | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
| GB0004297D0 (en) | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| EP1419144B1 (de) * | 2001-08-10 | 2008-10-08 | UCB Pharma S.A. | Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen |
| EP1758855B1 (de) | 2004-06-11 | 2007-11-21 | UCB Pharma, S.A. | Verfahren zur herstellung von 2-oxo-1-pyrrolidinderivaten durch intramolekulare allylierung |
-
2006
- 2006-12-19 US US11/612,654 patent/US8338621B2/en not_active Expired - Fee Related
- 2006-12-20 AT AT06026414T patent/ATE520656T1/de not_active IP Right Cessation
- 2006-12-20 EP EP06026414A patent/EP1806339B1/de active Active
- 2006-12-20 ES ES06026414T patent/ES2371351T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1806339B1 (de) | 2011-08-17 |
| EP1806339A1 (de) | 2007-07-11 |
| ES2371351T3 (es) | 2011-12-30 |
| US20080009638A1 (en) | 2008-01-10 |
| US8338621B2 (en) | 2012-12-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |