AU2001279695A1 - Methods for identifying inhibitors of the anaphase promoting complex - Google Patents
Methods for identifying inhibitors of the anaphase promoting complexInfo
- Publication number
- AU2001279695A1 AU2001279695A1 AU2001279695A AU7969501A AU2001279695A1 AU 2001279695 A1 AU2001279695 A1 AU 2001279695A1 AU 2001279695 A AU2001279695 A AU 2001279695A AU 7969501 A AU7969501 A AU 7969501A AU 2001279695 A1 AU2001279695 A1 AU 2001279695A1
- Authority
- AU
- Australia
- Prior art keywords
- methods
- identifying inhibitors
- promoting complex
- anaphase promoting
- apc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/9015—Ligases (6)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Screening methods for identifying compounds that inhibit the ubiquitination reaction mediated by the APC are based on the ability of the APC subunit APC11 to autoubiquitinate and to be sufficient to ubiquitinate substrate proteins of native APC.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00113832 | 2000-06-29 | ||
EP00113832A EP1167539A1 (en) | 2000-06-29 | 2000-06-29 | Methods for identifying inhibitors of the anaphase promoting complex |
PCT/EP2001/007329 WO2002000923A1 (en) | 2000-06-29 | 2001-06-27 | Methods for identifying inhibitors of the anaphase promoting complex |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001279695A1 true AU2001279695A1 (en) | 2002-01-08 |
Family
ID=8169106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001279695A Abandoned AU2001279695A1 (en) | 2000-06-29 | 2001-06-27 | Methods for identifying inhibitors of the anaphase promoting complex |
Country Status (7)
Country | Link |
---|---|
EP (2) | EP1167539A1 (en) |
JP (1) | JP2004501655A (en) |
AT (1) | ATE265543T1 (en) |
AU (1) | AU2001279695A1 (en) |
DE (1) | DE60103061T2 (en) |
DK (1) | DK1299559T3 (en) |
WO (1) | WO2002000923A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6740495B1 (en) | 2000-04-03 | 2004-05-25 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase assay |
US6979551B2 (en) * | 2000-04-03 | 2005-12-27 | Rigel Pharmaceuticals, Inc. | Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents |
WO2003000726A1 (en) * | 2001-06-22 | 2003-01-03 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Crystal structure of the apc10/doc1 subunit of the human anaphase-promoting complex |
EP1469082A1 (en) * | 2003-04-16 | 2004-10-20 | Boehringer Ingelheim International GmbH | Method of identifying compounds that specifically inhibit the anaphase promoting complex |
CN104877017A (en) * | 2015-05-06 | 2015-09-02 | 东南大学 | Anti-tumor ubiquitinated protein and extraction method and application thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5726025A (en) * | 1995-04-20 | 1998-03-10 | President And Fellows Of Harvard College | Assay and reagents for detecting inhibitors of ubiquitin-dependent degradation of cell cycle regulatory proteins |
NZ332482A (en) * | 1996-04-01 | 2000-05-26 | Rappaport Family Inst For Res | Human and clam cyclin-selective ubiquitin carrier polypeptides (E2) that are involved in the ubiquitination of cyclins A and B, inhibitors of these E2 polypeptides are included |
EP0843008A1 (en) * | 1996-11-14 | 1998-05-20 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Methods for producing the Anaphase Promoting Complex |
-
2000
- 2000-06-29 EP EP00113832A patent/EP1167539A1/en not_active Withdrawn
-
2001
- 2001-06-27 AT AT01957896T patent/ATE265543T1/en not_active IP Right Cessation
- 2001-06-27 DE DE60103061T patent/DE60103061T2/en not_active Expired - Fee Related
- 2001-06-27 WO PCT/EP2001/007329 patent/WO2002000923A1/en active IP Right Grant
- 2001-06-27 AU AU2001279695A patent/AU2001279695A1/en not_active Abandoned
- 2001-06-27 DK DK01957896T patent/DK1299559T3/en active
- 2001-06-27 EP EP01957896A patent/EP1299559B1/en not_active Expired - Lifetime
- 2001-06-27 JP JP2002506237A patent/JP2004501655A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DE60103061T2 (en) | 2004-09-02 |
WO2002000923A1 (en) | 2002-01-03 |
EP1299559B1 (en) | 2004-04-28 |
EP1299559A1 (en) | 2003-04-09 |
DE60103061D1 (en) | 2004-06-03 |
ATE265543T1 (en) | 2004-05-15 |
DK1299559T3 (en) | 2004-07-26 |
JP2004501655A (en) | 2004-01-22 |
EP1167539A1 (en) | 2002-01-02 |
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