DE60038966D1 - Transgenes tiermodel für neurodegenerative erkrankungen - Google Patents

Transgenes tiermodel für neurodegenerative erkrankungen

Info

Publication number
DE60038966D1
DE60038966D1 DE60038966T DE60038966T DE60038966D1 DE 60038966 D1 DE60038966 D1 DE 60038966D1 DE 60038966 T DE60038966 T DE 60038966T DE 60038966 T DE60038966 T DE 60038966T DE 60038966 D1 DE60038966 D1 DE 60038966D1
Authority
DE
Germany
Prior art keywords
neurodegenerative diseases
transgenic animal
human
animal model
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60038966T
Other languages
English (en)
Inventor
Hermann Luebbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biofrontera Bioscience GmbH
Original Assignee
Biofrontera Pharmaceuticals GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biofrontera Pharmaceuticals GmbH filed Critical Biofrontera Pharmaceuticals GmbH
Application granted granted Critical
Publication of DE60038966D1 publication Critical patent/DE60038966D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60038966T 1999-08-30 2000-08-18 Transgenes tiermodel für neurodegenerative erkrankungen Expired - Fee Related DE60038966D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99116766A EP1081225A1 (de) 1999-08-30 1999-08-30 Transgenes Tiermodel für neurodegenerative Erkrankungen
PCT/EP2000/008071 WO2001016176A2 (en) 1999-08-30 2000-08-18 Transgenic animal model for neurodegenerative diseases

Publications (1)

Publication Number Publication Date
DE60038966D1 true DE60038966D1 (de) 2008-07-03

Family

ID=8238860

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60038966T Expired - Fee Related DE60038966D1 (de) 1999-08-30 2000-08-18 Transgenes tiermodel für neurodegenerative erkrankungen

Country Status (7)

Country Link
EP (2) EP1081225A1 (de)
JP (1) JP2003512026A (de)
AT (1) ATE396263T1 (de)
CA (1) CA2383564A1 (de)
DE (1) DE60038966D1 (de)
ES (1) ES2304973T3 (de)
WO (1) WO2001016176A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2845245A1 (fr) * 2002-10-07 2004-04-09 Aventis Pharma Sa Modele animal de la maladie de parkinson
US6943278B2 (en) * 2002-10-15 2005-09-13 Genexel, Inc. Transgenic Drosophila having a disrupted Parkin gene and exhibits reduced climbing ability
JP7068973B2 (ja) * 2018-08-31 2022-05-17 株式会社 大昌電子 変位検出センサ組み込みプリント配線板装置およびその製造方法
CN113373150B (zh) * 2021-06-18 2022-11-22 南方科技大学 一种靶向dat基因的sgRNA及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8163798A (en) * 1997-06-25 1999-01-04 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Cloning of a gene mutation for parkinson's disease
ATE315645T1 (de) * 1998-02-09 2006-02-15 Boehringer Ingelheim Int Dns oder gene, die an der parkinsonschen krankheit beteiligt sind
PT1131424E (pt) * 1998-11-19 2009-10-23 Aventis Pharma Sa Mutações do gene da parkina, composições, métodos e utilizações

Also Published As

Publication number Publication date
EP1208200A2 (de) 2002-05-29
CA2383564A1 (en) 2001-03-08
ES2304973T3 (es) 2008-11-01
EP1081225A1 (de) 2001-03-07
WO2001016176A2 (en) 2001-03-08
JP2003512026A (ja) 2003-04-02
ATE396263T1 (de) 2008-06-15
WO2001016176A3 (en) 2001-09-27
EP1208200B1 (de) 2008-05-21

Similar Documents

Publication Publication Date Title
IL154794A0 (en) Remedies for heart failure
EA200600525A1 (ru) Еро-имитирующие миметичекие антитела человека с центральной шарнирной областью, композиции, способы и применения
WO2002047466A3 (en) Beta-secretase transgenic organisms, anti-beta-secretase antibodies, and methods of use thereof
DE60115883D1 (de) Infusion von flüssigkeiten in den menschlichen oder tierischen körper
AU1280799A (en) Non-transgenic animal model of alzheimer's disease
AU6090799A (en) Transgenic c. elegans as a model organism for research into alzheimer's disease
DE60038966D1 (de) Transgenes tiermodel für neurodegenerative erkrankungen
EP0981602A4 (de) Transgenes tier exprimierend nicht-natives wildtyp und familiäre alzheimer krankheit mutiertes presenilin-1 protein ohne ein hintergrundsniveau von nativen presenilin 1
HUP0003116A2 (hu) Béta-amiloid-peptid-kötő fehérjék és az őket kódoló polinukleotidok
WO1998001549A3 (en) Genetic sequences and proteins related to alzheimer's disease, and uses therefor
DE60327094D1 (de) Transgenes säugetier, das in dieses eingebrachte ganp-gene trägt, sowie seine verwendung
DE69224327T2 (de) Nucleotidsequenzen
Glicksman Referral of the periodontal patient to the periodontist.
IL174726A (en) Non-human animals with transgenic nucleic acid encoded by a mutant perinylin 1 protein
WO2001002552A3 (en) Double transgenic animals as models for neurodegenerative disease
ATE394481T1 (de) Transgentier-modell für die krankheit von alzheimer
DE60143608D1 (de) Neueskollagen-ähnliches protein clac, dessen vorläufer und dafür kodierende gene
WO1998003643A3 (en) Transgenic animals with mutant human APP or A4CT sequences
EP1063298A3 (de) Transgenes Tiermodell für die Krankheit von Alzheimer
WO2002000878A3 (fr) Dynamine mitochondriale humaine msp1, ses isoformes msp1-x, et leur utilisation en therapeutique
ATE336888T1 (de) Caspase 1 transgenes tier
CY1110304T1 (el) Διαγονιδιακο ζωο που εκφραζει μια πολυ-μεταλλαγμενη μορφη της πρεσενιλινης 1
DE60121324D1 (de) Tiermodel für neurodegenerative erkrankungen
WO2001029231A3 (en) Genetic switch
FR2795739B1 (fr) Gene synthetique cryic et plantes transgeniques exprimant ledit gene

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee