DE60037115D1 - Diagnostischer test für menschlisches matrix gla-protein und seine verwendung als biomarker - Google Patents

Diagnostischer test für menschlisches matrix gla-protein und seine verwendung als biomarker

Info

Publication number
DE60037115D1
DE60037115D1 DE60037115T DE60037115T DE60037115D1 DE 60037115 D1 DE60037115 D1 DE 60037115D1 DE 60037115 T DE60037115 T DE 60037115T DE 60037115 T DE60037115 T DE 60037115T DE 60037115 D1 DE60037115 D1 DE 60037115D1
Authority
DE
Germany
Prior art keywords
biomarker
matrix gla
diagnostic test
human matrix
gla protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60037115T
Other languages
English (en)
Other versions
DE60037115T2 (de
Inventor
Cees Vermeer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MGP Diagnostics AS
Original Assignee
CARDIOVASCULAR RES INST MAASTR
Cardiovascular Research Institute of Maastrich CARIM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CARDIOVASCULAR RES INST MAASTR, Cardiovascular Research Institute of Maastrich CARIM filed Critical CARDIOVASCULAR RES INST MAASTR
Application granted granted Critical
Publication of DE60037115D1 publication Critical patent/DE60037115D1/de
Publication of DE60037115T2 publication Critical patent/DE60037115T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/971—Capture of complex after antigen-antibody reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/972—Modified antibody, e.g. hybrid, bifunctional
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE60037115T 1999-07-04 2000-07-02 Diagnostischer test für menschlisches matrix gla-protein und seine verwendung als biomarker Expired - Lifetime DE60037115T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP99202176 1999-07-04
EP99202176 1999-07-04
EP00106409 2000-03-23
EP00106409 2000-03-23
PCT/EP2000/006173 WO2001002863A1 (en) 1999-07-04 2000-07-02 Diagnostic assay for human matrix gla-protein and its use as a biomarker

Publications (2)

Publication Number Publication Date
DE60037115D1 true DE60037115D1 (de) 2007-12-27
DE60037115T2 DE60037115T2 (de) 2008-09-18

Family

ID=26070721

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60037115T Expired - Lifetime DE60037115T2 (de) 1999-07-04 2000-07-02 Diagnostischer test für menschlisches matrix gla-protein und seine verwendung als biomarker

Country Status (7)

Country Link
US (1) US6746847B1 (de)
EP (1) EP1190259B1 (de)
AT (1) ATE378601T1 (de)
AU (1) AU6688700A (de)
DE (1) DE60037115T2 (de)
ES (1) ES2296634T3 (de)
WO (1) WO2001002863A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700296B2 (en) 1999-07-04 2010-04-20 Mgp Diagnostics As Diagnostic assay for human Matrix Gla-protein and its use as a biomarker
US20070009955A1 (en) * 2002-07-08 2007-01-11 Lydie Bougueleret Secreted polypeptide species associated with cardiovascular disorders
EP2671574A1 (de) 2012-06-04 2013-12-11 VitaK B.V. Verwendung von Vitamin K zur Verringerung des Allotransplantatversagens und Patientensterblichkeit nach Organtransplantation
MA41052A (fr) 2014-10-09 2017-08-15 Celgene Corp Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
EP3258924A2 (de) 2015-02-20 2017-12-27 VitaK B.V. Vitamin k und kapillarfunktion
US20230233484A1 (en) 2020-04-09 2023-07-27 Emphysema Solutions Bv Use of vitamin k in preventing or counteracting covid-19 disease and diagnostic test to estimate the risk of developing severe disease or mortality by covid-19
NL2030584B1 (en) 2022-01-17 2023-07-27 Emphysema Solutions Bv Use of vitamin K in preventing or counteracting vaccine-related adverse events, symptoms, morbidity and/or mortality after vaccination against COVID-19 or another coronavirus

Also Published As

Publication number Publication date
WO2001002863A1 (en) 2001-01-11
AU6688700A (en) 2001-01-22
US6746847B1 (en) 2004-06-08
DE60037115T2 (de) 2008-09-18
EP1190259A1 (de) 2002-03-27
ES2296634T3 (es) 2008-05-01
ATE378601T1 (de) 2007-11-15
EP1190259B1 (de) 2007-11-14

Similar Documents

Publication Publication Date Title
Žigon et al. Detection of antiphosphatidylserine/prothrombin antibodies and their potential diagnostic value
HK1120865A1 (en) Prognostic allergy test
PT838680E (pt) Determinacao de antigenios complexados especificos da prostata
DE602005025559D1 (de) Diagnostischer Test für menschliches matrix Gla-Protein und seine Verwendung als Biomarker
JP3055789B2 (ja) 骨由来アルカリホスファターゼの検定法
Hidayat et al. Enzyme linked immunosorbent assay (ELISA) technique guideline
US20040023309A1 (en) Immunoassay and kit for an early and simultaneous detection of biochemical markers in a patient's sample
US20040214254A1 (en) Methods and device for detecting prostate specific antigen (PSA)
KR20130081952A (ko) 암 진단용 바이오마커 및 이를 이용한 암세포 분리 방법
DE60037115D1 (de) Diagnostischer test für menschlisches matrix gla-protein und seine verwendung als biomarker
DE50210021D1 (de) Antikörper zum spezifischen Nachweis von pathogenen Prionen humanen Ursprungs und damit durchgeführte Nachweisverfahren
JP2021529948A (ja) 自己抗体の直接イムノアッセイ測定法
ES2141348T3 (es) Metodo de deteccion de la presencia de una especie de mycobacterium, kit y anticuerpos utilizados en este metodo.
EP1802972A2 (de) Auf immunreaktion gegen boris basierendes verfahren für den nachweis von krebs
CN208537565U (zh) C-反应蛋白、血清淀粉样蛋白a免疫层析定量联合检测试纸条
JPH05113443A (ja) 酵素免疫測定方法
AU2004258830A1 (en) Methods and compositions for use in diagnosing and characterizing diseases involving abnormal apoptosis
DE69811157D1 (de) Immunoassay zur Bestimmung von PSA-ACT
ATE249043T1 (de) Immunoassay und kit für iga antikörper, spezifisch für acetaldehyd-addukte
SE9900875D0 (sv) Antinuclear antibody assay utilizing stress-treated cells or cell extracts
JP5257788B2 (ja) クラスリン重鎖とその自己抗体との複合体の免疫測定方法、それに用いるキット及びそれを用いた癌判定方法
JP3470936B2 (ja) 免疫測定方法及びその測定試薬
Arseneault ENZYME IMMUNOASSAY IN THE CLINICAL LABORATORY.
CN111971305A (zh) 用于鉴定可能受益于治疗剂治疗的受试者的夹心酶联免疫吸附测定
CN117561445A (zh) Ⅰ型胶原c末端肽的免疫学分析方法

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MGP DIAGNOSTICS AS, MIONDALEN, NO