DE60037115D1 - Diagnostischer test für menschlisches matrix gla-protein und seine verwendung als biomarker - Google Patents

Diagnostischer test für menschlisches matrix gla-protein und seine verwendung als biomarker

Info

Publication number
DE60037115D1
DE60037115D1 DE60037115T DE60037115T DE60037115D1 DE 60037115 D1 DE60037115 D1 DE 60037115D1 DE 60037115 T DE60037115 T DE 60037115T DE 60037115 T DE60037115 T DE 60037115T DE 60037115 D1 DE60037115 D1 DE 60037115D1
Authority
DE
Germany
Prior art keywords
biomarker
matrix gla
diagnostic test
human matrix
gla protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60037115T
Other languages
English (en)
Other versions
DE60037115T2 (de
Inventor
Cees Vermeer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MGP Diagnostics AS
Original Assignee
CARDIOVASCULAR RES INST MAASTR
Academisch Ziekenhuis Maastricht
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CARDIOVASCULAR RES INST MAASTR, Academisch Ziekenhuis Maastricht filed Critical CARDIOVASCULAR RES INST MAASTR
Application granted granted Critical
Publication of DE60037115D1 publication Critical patent/DE60037115D1/de
Publication of DE60037115T2 publication Critical patent/DE60037115T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/971—Capture of complex after antigen-antibody reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/972—Modified antibody, e.g. hybrid, bifunctional
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE60037115T 1999-07-04 2000-07-02 Diagnostischer test für menschlisches matrix gla-protein und seine verwendung als biomarker Expired - Lifetime DE60037115T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP99202176 1999-07-04
EP99202176 1999-07-04
EP00106409 2000-03-23
EP00106409 2000-03-23
PCT/EP2000/006173 WO2001002863A1 (en) 1999-07-04 2000-07-02 Diagnostic assay for human matrix gla-protein and its use as a biomarker

Publications (2)

Publication Number Publication Date
DE60037115D1 true DE60037115D1 (de) 2007-12-27
DE60037115T2 DE60037115T2 (de) 2008-09-18

Family

ID=26070721

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60037115T Expired - Lifetime DE60037115T2 (de) 1999-07-04 2000-07-02 Diagnostischer test für menschlisches matrix gla-protein und seine verwendung als biomarker

Country Status (7)

Country Link
US (1) US6746847B1 (de)
EP (1) EP1190259B1 (de)
AT (1) ATE378601T1 (de)
AU (1) AU6688700A (de)
DE (1) DE60037115T2 (de)
ES (1) ES2296634T3 (de)
WO (1) WO2001002863A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700296B2 (en) 1999-07-04 2010-04-20 Mgp Diagnostics As Diagnostic assay for human Matrix Gla-protein and its use as a biomarker
WO2004005931A1 (en) * 2002-07-08 2004-01-15 Genova, Ltd. Secreted polypeptide species associated with cardiovascular disorders
EP2671574A1 (de) 2012-06-04 2013-12-11 VitaK B.V. Verwendung von Vitamin K zur Verringerung des Allotransplantatversagens und Patientensterblichkeit nach Organtransplantation
MA41052A (fr) 2014-10-09 2017-08-15 Celgene Corp Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
US20180199610A1 (en) 2015-02-20 2018-07-19 Vitak B.V. Vitamin k and capillary function
EP3881077A1 (de) * 2018-11-15 2021-09-22 Assistance Publique Hôpitaux de Paris Verfahren zur diagnose und behandlung von peripheren neuropathien
EP4132488A1 (de) 2020-04-09 2023-02-15 Emphysema Solutions BV Verwendung von vitamin k zur vorbeugung oder bekämpfung der covid-19-krankheit und diagnostischer test zur schätzung des risikos der entwicklung einer schweren krankheit oder sterblichkeit durch covid-19
NL2030584B1 (en) 2022-01-17 2023-07-27 Emphysema Solutions Bv Use of vitamin K in preventing or counteracting vaccine-related adverse events, symptoms, morbidity and/or mortality after vaccination against COVID-19 or another coronavirus
CN118206648B (zh) * 2024-03-14 2025-01-14 北京赛斯维德生物科技有限公司 一种非羧基化基质Gla蛋白抗体及其应用

Also Published As

Publication number Publication date
ATE378601T1 (de) 2007-11-15
DE60037115T2 (de) 2008-09-18
AU6688700A (en) 2001-01-22
ES2296634T3 (es) 2008-05-01
EP1190259B1 (de) 2007-11-14
WO2001002863A1 (en) 2001-01-11
US6746847B1 (en) 2004-06-08
EP1190259A1 (de) 2002-03-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MGP DIAGNOSTICS AS, MIONDALEN, NO