DE60032631D1 - Vorrichtung und verfahren zur herstellung von mikropartikeln - Google Patents

Vorrichtung und verfahren zur herstellung von mikropartikeln

Info

Publication number
DE60032631D1
DE60032631D1 DE60032631T DE60032631T DE60032631D1 DE 60032631 D1 DE60032631 D1 DE 60032631D1 DE 60032631 T DE60032631 T DE 60032631T DE 60032631 T DE60032631 T DE 60032631T DE 60032631 D1 DE60032631 D1 DE 60032631D1
Authority
DE
Germany
Prior art keywords
emulsion
mixing assembly
static mixing
microparticles
static
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60032631T
Other languages
English (en)
Other versions
DE60032631T2 (de
Inventor
L Lyons
G Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Inc
Original Assignee
Alkermes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc filed Critical Alkermes Inc
Application granted granted Critical
Publication of DE60032631D1 publication Critical patent/DE60032631D1/de
Publication of DE60032631T2 publication Critical patent/DE60032631T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60032631T 1999-11-12 2000-11-03 Vorrichtung und verfahren zur herstellung von mikropartikeln Expired - Lifetime DE60032631T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/438,659 US6331317B1 (en) 1999-11-12 1999-11-12 Apparatus and method for preparing microparticles
US438659 1999-11-12
PCT/US2000/041842 WO2001034113A2 (en) 1999-11-12 2000-11-03 Apparatus and method for preparing microparticles

Publications (2)

Publication Number Publication Date
DE60032631D1 true DE60032631D1 (de) 2007-02-08
DE60032631T2 DE60032631T2 (de) 2007-10-04

Family

ID=23741495

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60032631T Expired - Lifetime DE60032631T2 (de) 1999-11-12 2000-11-03 Vorrichtung und verfahren zur herstellung von mikropartikeln

Country Status (12)

Country Link
US (7) US6331317B1 (de)
EP (1) EP1231898B1 (de)
JP (1) JP4146639B2 (de)
AT (1) ATE349201T1 (de)
AU (1) AU771497B2 (de)
CA (1) CA2390284C (de)
CY (1) CY1106372T1 (de)
DE (1) DE60032631T2 (de)
DK (1) DK1231898T3 (de)
ES (1) ES2277867T3 (de)
PT (1) PT1231898E (de)
WO (1) WO2001034113A2 (de)

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US20040224030A1 (en) * 2003-05-06 2004-11-11 Shastri Venkatram R. Microsphere delivery systems
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US20090022805A1 (en) * 2007-06-28 2009-01-22 Joram Slager Polypeptide microparticles having sustained release characteristics, methods and uses
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EP2306991B1 (de) * 2008-06-27 2019-12-25 Tepha, Inc. Verbesserte injektionsabgabe von mikroteilchen und zusammensetzungen dafür
JP5107220B2 (ja) * 2008-12-11 2012-12-26 三菱重工業株式会社 燃料供給装置及びガスタービン
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JP2012515790A (ja) * 2009-01-23 2012-07-12 サーモディクス ファーマシューティカルズ， インコーポレイテッド 微粒子製造のための連続二重エマルジョン工程
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WO2011119262A1 (en) 2010-03-26 2011-09-29 Cerulean Pharma Inc. Methods and systems for generating nanoparticles
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WO2012103182A1 (en) 2011-01-28 2012-08-02 Cerulean Pharma Inc. Method for fabricating nanoparticles
US20140099380A1 (en) 2012-06-28 2014-04-10 Ansun Biopharma, Inc. Microparticle Formulations for Delivery to the Lower and Central Respiratory Tract and Methods of Manufacture
JP5314794B2 (ja) * 2012-08-27 2013-10-16 三菱重工業株式会社 燃料供給装置及びガスタービン
HRP20171402T4 (hr) 2013-06-20 2023-07-21 Pharmathen S.A. Priprava polilaktidno-poliglikolidnih mikročestica sa sigmoidnim profilom oslobađanja
US10449150B2 (en) * 2014-05-20 2019-10-22 Texas State University Fluidic system for high throughput preparation of microparticles and nanoparticles
US10783678B2 (en) * 2016-08-24 2020-09-22 Bj Services, Llc System and method for blending of bulk dry materials in oil well cementing
EP3870263A4 (de) 2018-10-23 2022-08-03 ABK Biomedical Incorporated Abgabevorrichtung
AU2020214626A1 (en) 2019-01-31 2021-09-16 Elektrofi, Inc. Particle formation and morphology
JP2022547546A (ja) 2019-09-13 2022-11-14 エレクトロフィ，インコーポレイテッド 疾患の処置のための治療用生物学的作用剤の送達のための組成物及び方法
EP4135667A1 (de) * 2020-04-17 2023-02-22 Elektrofi, Inc. Verfahren zur herstellung von partikeln durch kontinuierliche tröpfchenbildung und dehydrierung
EP4163006B8 (de) * 2021-10-11 2024-03-20 leon-nanodrugs GmbH Verfahren zur validierung einer vorrichtung zur herstellung von nanopartikeln

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Also Published As

Publication number Publication date
JP2003513710A (ja) 2003-04-15
CA2390284C (en) 2008-10-21
AU3437901A (en) 2001-06-06
EP1231898A2 (de) 2002-08-21
US6537586B2 (en) 2003-03-25
EP1231898B1 (de) 2006-12-27
US20020146461A1 (en) 2002-10-10
US6713090B2 (en) 2004-03-30
DK1231898T3 (da) 2007-04-10
ATE349201T1 (de) 2007-01-15
US6861016B2 (en) 2005-03-01
US20010031801A1 (en) 2001-10-18
US6331317B1 (en) 2001-12-18
CA2390284A1 (en) 2001-05-17
CY1106372T1 (el) 2011-10-12
DE60032631T2 (de) 2007-10-04
JP4146639B2 (ja) 2008-09-10
US6540393B1 (en) 2003-04-01
ES2277867T3 (es) 2007-08-01
PT1231898E (pt) 2007-03-30
WO2001034113A3 (en) 2002-03-14
AU771497B2 (en) 2004-03-25
US20050196457A1 (en) 2005-09-08
US20040197469A1 (en) 2004-10-07
US6395304B2 (en) 2002-05-28
US20030147967A1 (en) 2003-08-07
WO2001034113A2 (en) 2001-05-17

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