DE60030281D1 - Methoden zur verbesserung der sensitivität und spezifität von screeningverfahren für krebs und krebs-vorstufen - Google Patents

Methoden zur verbesserung der sensitivität und spezifität von screeningverfahren für krebs und krebs-vorstufen

Info

Publication number
DE60030281D1
DE60030281D1 DE60030281T DE60030281T DE60030281D1 DE 60030281 D1 DE60030281 D1 DE 60030281D1 DE 60030281 T DE60030281 T DE 60030281T DE 60030281 T DE60030281 T DE 60030281T DE 60030281 D1 DE60030281 D1 DE 60030281D1
Authority
DE
Germany
Prior art keywords
cancer
methods
specificity
sensitivity
improving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60030281T
Other languages
English (en)
Other versions
DE60030281T2 (de
Inventor
N Lapidus
P Shuber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Exact Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exact Sciences Corp filed Critical Exact Sciences Corp
Application granted granted Critical
Publication of DE60030281D1 publication Critical patent/DE60030281D1/de
Publication of DE60030281T2 publication Critical patent/DE60030281T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE60030281T 1999-03-26 2000-03-24 Methoden zur verbesserung der sensitivität und spezifität von screeningverfahren für krebs und krebs-vorstufen Expired - Lifetime DE60030281T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/277,016 US6143529A (en) 1996-08-14 1999-03-26 Methods for improving sensitivity and specificity of screening assays
PCT/US2000/007882 WO2000058514A2 (en) 1999-03-26 2000-03-24 Methods for improving sensitivity and specificity of screening assays
US277016 2002-10-21

Publications (2)

Publication Number Publication Date
DE60030281D1 true DE60030281D1 (de) 2006-10-05
DE60030281T2 DE60030281T2 (de) 2007-08-30

Family

ID=23059077

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60030281T Expired - Lifetime DE60030281T2 (de) 1999-03-26 2000-03-24 Methoden zur verbesserung der sensitivität und spezifität von screeningverfahren für krebs und krebs-vorstufen

Country Status (8)

Country Link
US (1) US6143529A (de)
EP (1) EP1185693B1 (de)
JP (3) JP2002539848A (de)
AT (1) ATE337413T1 (de)
AU (1) AU761722B2 (de)
CA (1) CA2369045C (de)
DE (1) DE60030281T2 (de)
WO (1) WO2000058514A2 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6406857B1 (en) 1997-06-16 2002-06-18 Exact Sciences Corporation Methods for stool sample preparation
US6268136B1 (en) * 1997-06-16 2001-07-31 Exact Science Corporation Methods for stool sample preparation
US6818404B2 (en) * 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
JP2002537777A (ja) 1999-02-25 2002-11-12 エグザクト サイエンシーズ コーポレイション Ｄｎａの完全性を保存するための方法
AU767983B2 (en) * 1999-04-09 2003-11-27 Esoterix Genetic Laboratories, Llc Methods for detecting nucleic acids indicative of cancer
US6849403B1 (en) * 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US6586177B1 (en) * 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US6919174B1 (en) * 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
US7368233B2 (en) 1999-12-07 2008-05-06 Exact Sciences Corporation Methods of screening for lung neoplasm based on stool samples containing a nucleic acid marker indicative of a neoplasm
US7250252B2 (en) * 1999-12-30 2007-07-31 David Aaron Katz Amplification based polymorphism detection
US6585646B2 (en) * 2000-11-29 2003-07-01 Hermetic Diagnostics, Inc. Screening test and procedure using skin patches
US6911308B2 (en) * 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
US6428964B1 (en) 2001-03-15 2002-08-06 Exact Sciences Corporation Method for alteration detection
US6727354B2 (en) * 2001-12-12 2004-04-27 Quest Diagnostics Investments, Inc. Compositions and methods for TIGR genotyping assays
US20030180765A1 (en) * 2002-02-01 2003-09-25 The Johns Hopkins University Digital amplification for detection of mismatch repair deficient tumor cells
US7776524B2 (en) 2002-02-15 2010-08-17 Genzyme Corporation Methods for analysis of molecular events
EP1570080A4 (de) * 2002-11-15 2006-03-01 Genomic Health Inc Genexpressionsprofilierung einer egfr-positiven krebserkrankung
US20040231909A1 (en) 2003-01-15 2004-11-25 Tai-Yang Luh Motorized vehicle having forward and backward differential structure
CA2515096A1 (en) * 2003-02-06 2004-08-26 Genomic Health, Inc. Gene expression markers for response to egfr inhibitor drugs
AU2004213871B9 (en) * 2003-02-20 2009-09-03 Genomic Health, Inc. Use of intronic RNA to measure gene expression
ITMI20030434A1 (it) * 2003-03-07 2004-09-08 Istituto Oncologico Romagnolo Coope Rativa Sociale Metodo per l'individuazione di tumori del colon-retto.
US20050164218A1 (en) * 2003-05-30 2005-07-28 David Agus Gene expression markers for response to EGFR inhibitor drugs
EP3470535B1 (de) 2003-06-24 2020-04-01 Genomic Health, Inc. Vorhersage der wahrscheinlichkeit eines wiederauftretens von krebs
US7526387B2 (en) * 2003-07-10 2009-04-28 Genomic Health, Inc. Expression profile algorithm and test for cancer prognosis
WO2005040396A2 (en) * 2003-10-16 2005-05-06 Genomic Health, Inc. qRT-PCR ASSAY SYSTEM FOR GENE EXPRESSION PROFILING
JP4718490B2 (ja) * 2003-12-23 2011-07-06 ジェノミック ヘルス， インコーポレイテッド フラグメント化ｒｎａの全般的増幅
DK2163650T3 (en) * 2004-04-09 2015-11-02 Genomic Health Inc Genekspressionsmarkører for prediction of response to chemotherapy
US20050282196A1 (en) * 2004-04-30 2005-12-22 Jose Costa Methods and compositions for cancer diagnosis
US7981607B2 (en) 2004-08-27 2011-07-19 Esoterix Genetic Laboratories LLC Method for detecting recombinant event
EP1809769A2 (de) 2004-10-22 2007-07-25 Redpath Integrated Pathology, Inc. Erhöhte vervielfältigbarkeit winziger gewebeproben, winzige gefärbte zytologieproben und andere winzige dna-quellen
WO2006047787A2 (en) 2004-10-27 2006-05-04 Exact Sciences Corporation Method for monitoring disease progression or recurrence
HUE051605T2 (hu) * 2004-11-05 2021-03-01 Nsabp Found Inc Kemoterápiára adott válasz elõrejelzése génexpressziós markereket alkalmazva
CA2585561C (en) * 2004-11-05 2018-07-17 Genomic Health, Inc. Esr1, pgr, bcl2 and scube2 group score as indicators of breast cancer prognosis and prediction of treatment response
WO2006094149A2 (en) * 2005-03-01 2006-09-08 Exact Sciences Corporation Methods and compositions for detecting adenoma
WO2007044071A2 (en) 2005-04-21 2007-04-19 Exact Sciences Corporation Analysis of heterogeneous nucleic acid samples
US20070248546A1 (en) * 2005-11-09 2007-10-25 Exact Sciences Corporation Clinical algorithm for excluding patients identified in virtual imaging
US20100124743A1 (en) * 2007-01-23 2010-05-20 Olympus Corporation Method for diagnosis of cancer
CN101952460A (zh) * 2007-11-20 2011-01-19 奥林巴斯株式会社 用于制备粪便样品的方法、制备粪便样品用溶液和采集粪便用试剂盒
US8673555B2 (en) 2008-02-15 2014-03-18 Mayo Foundation For Medical Education And Research Detecting neoplasm
GB201107466D0 (en) 2011-05-05 2011-06-15 Loktionov Alexandre Device and method for non-invasive collection of colorectal mucocellular layer and disease detection
US9341628B2 (en) 2012-11-30 2016-05-17 Interpace Diagnostics Corporation Methods for measuring carcinoembryonic antigen
JP6294614B2 (ja) 2013-05-08 2018-03-14 有限会社マイテック 癌関連物質の定量方法
US10253358B2 (en) 2013-11-04 2019-04-09 Exact Sciences Development Company, Llc Multiple-control calibrators for DNA quantitation
EP3084004A4 (de) 2013-12-19 2017-08-16 Exact Sciences Corporation Synthetische nukleinsäuresteuerungsmoleküle
WO2018017710A1 (en) 2016-07-19 2018-01-25 Exact Sciences Development Company, Llc Nucleic acid control molecules from non-human organisms
EP3488004B1 (de) 2016-07-19 2021-10-06 Exact Sciences Development Company, LLC Methylierte kontroll-dna

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE501439C2 (sv) * 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
EP0871768B1 (de) * 1995-03-17 2004-07-07 John Wayne Cancer Institute Nachweis von melanomenmetastasen unter verwendung eines mehrfachmarker-tests
DE19736691A1 (de) * 1997-08-22 1999-02-25 Michael Prof Dr Med Giesing Verfahren zur Charakterisierung und Identifizierung disseminierter und metastasierter Krebszellen

Also Published As

Publication number Publication date
ATE337413T1 (de) 2006-09-15
WO2000058514A2 (en) 2000-10-05
AU3918900A (en) 2000-10-16
DE60030281T2 (de) 2007-08-30
JP2013116131A (ja) 2013-06-13
EP1185693A2 (de) 2002-03-13
CA2369045A1 (en) 2000-10-05
JP2010172347A (ja) 2010-08-12
US6143529A (en) 2000-11-07
WO2000058514A3 (en) 2001-12-13
CA2369045C (en) 2010-06-01
EP1185693B1 (de) 2006-08-23
JP2002539848A (ja) 2002-11-26
AU761722B2 (en) 2003-06-05

Similar Documents

Publication Publication Date Title
DE60030281D1 (de) Methoden zur verbesserung der sensitivität und spezifität von screeningverfahren für krebs und krebs-vorstufen
ATE515575T1 (de) Verfahren und sonden für den nachweis von krebs
DE60029092D1 (de) Verfahren zur detektion von nukleinsäuren, welche auf krebs hinweisen
DE69930666D1 (de) Krebsnachweisverfahren und reagenzien
DE60231606D1 (de) Zirkuläre sonden amplifizierung (cpa) von zirkularisierten nucleinsäure-molekülen
DE69938662D1 (de) Spurendetektion von analyten mit hilfe artifizieller olfaktometrie
WO2004055519A3 (en) Specific markers for pancreatic cancer
DE60029369D1 (de) Verfahren und Sondenset zur Erkennung von Krebs
HUP0200400A2 (hu) Fehérjék izolálása és elemzése
ATE354588T1 (de) Verfahren und zusammestellungen zum nachweis und behandlung von brustkrebs, beruhend auf brustkrebs-assoziierten polypeptiden
ATE269974T1 (de) Identifizierung und charakterisierung von interagierenden molekülen mittels automatisierter interagierender paarung
ATE454468T1 (de) Nachweis der instabilität von mikrosatelliten und verwendung davon bei der tumordiagnose
ATE382148T1 (de) Antikörper für apoptosemarker und anwendungsverfahren
ATE497164T1 (de) Testverfahren zur messung der phosphorylierung
WO2003033731A3 (en) Methods for detecting ovarian cancer
ATE317451T1 (de) Verfahren zur diagnose, erkennung, und einstufung von dickdarmkrebs
SE8802944L (sv) Material foer lapptestning
DE60027045D1 (de) Oligonukleotide und diese enthaltende komplexe zur detektion der anwesenheit oder abwesenheit einer zielnukleinsäure in einer probe
DE60333876D1 (de) Methoden zum Nachweis Analyten in Proben
WO2003008635A3 (en) η-SECRETASE IN VITRO SCREENING ASSAY
ATE449868T1 (de) Methoden, testsätze und kompositionen zur detektion und quantifizierung von zielsequenzen
DE59814032D1 (de) Nucleinsäuremolekül, kit und verwendung
DE29814996U1 (de) Meßgerät zur amperometrischen Vermessung von Teststreifen
HUP0303890A2 (hu) Differenciációs nukleinsavak és polipeptidek inhibitorának prosztatarák diagnosztizálására és gyógykezelésére alkalmas expressziós analízise
DE60229513D1 (de) Verfahren und mittel zum nachweis von durch gluten induzierten krankheiten

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GENZYME CORP., CAMBRIDGE, MASS., US

R082 Change of representative

Ref document number: 1185693

Country of ref document: EP

Representative=s name: KLUNKER, SCHMITT-NILSON, HIRSCH, 80796 MUENCHEN, D