DE60028393D1 - Schichtvorrichtung mit einfangbereichen zur zellulären analyse - Google Patents

Schichtvorrichtung mit einfangbereichen zur zellulären analyse

Info

Publication number
DE60028393D1
DE60028393D1 DE60028393T DE60028393T DE60028393D1 DE 60028393 D1 DE60028393 D1 DE 60028393D1 DE 60028393 T DE60028393 T DE 60028393T DE 60028393 T DE60028393 T DE 60028393T DE 60028393 D1 DE60028393 D1 DE 60028393D1
Authority
DE
Germany
Prior art keywords
biomolecules
sample
layer device
intended range
cellular analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60028393T
Other languages
English (en)
Other versions
DE60028393T2 (de
Inventor
R Emmert-Buck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Department of Health and Human Services
Original Assignee
United States Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United States Department of Health and Human Services filed Critical United States Department of Health and Human Services
Publication of DE60028393D1 publication Critical patent/DE60028393D1/de
Application granted granted Critical
Publication of DE60028393T2 publication Critical patent/DE60028393T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57555—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4742—Keratin; Cytokeratin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/7051—T-cell receptor (TcR)-CD3 complex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96455—Kallikrein (3.4.21.34; 3.4.21.35)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
DE60028393T 1999-07-26 2000-07-26 Schichtvorrichtung mit einfangbereichen zur zellulären analyse Expired - Lifetime DE60028393T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14561399P 1999-07-26 1999-07-26
US145613P 1999-07-26
PCT/US2000/020354 WO2001007915A2 (en) 1999-07-26 2000-07-26 Layered device with capture regions for cellular analysis

Publications (2)

Publication Number Publication Date
DE60028393D1 true DE60028393D1 (de) 2006-07-06
DE60028393T2 DE60028393T2 (de) 2007-06-14

Family

ID=22513857

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60028393T Expired - Lifetime DE60028393T2 (de) 1999-07-26 2000-07-26 Schichtvorrichtung mit einfangbereichen zur zellulären analyse

Country Status (9)

Country Link
US (2) US6602661B1 (de)
EP (1) EP1218743B1 (de)
JP (1) JP4137444B2 (de)
AT (1) ATE328277T1 (de)
AU (1) AU771499B2 (de)
CA (1) CA2375034C (de)
DE (1) DE60028393T2 (de)
ES (1) ES2269171T3 (de)
WO (1) WO2001007915A2 (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6969614B1 (en) * 1999-02-16 2005-11-29 The United States Of America As Represented By The Department Of Health And Human Services Methods for the isolation and analysis of cellular protein content
US7214477B1 (en) * 1999-07-26 2007-05-08 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Layered device with capture regions for cellular analysis
US7838222B2 (en) * 1999-07-26 2010-11-23 United States of America/ NIH Methods, devices and kits for multiplex blotting of biological samples from multi-well plates
US6969615B2 (en) * 1999-07-26 2005-11-29 20/20 Genesystems, Inc. Methods, devices, arrays and kits for detecting and analyzing biomolecules
WO2002010751A2 (en) * 2000-07-26 2002-02-07 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Transfer microdissection
US20060275851A1 (en) * 2000-07-26 2006-12-07 Emmert-Buck Michael R Layered peptide/antigen arrays - for high-throughput antibody screening of clinical samples
US20040053326A1 (en) * 2001-03-14 2004-03-18 Emmert-Buck Michael R. Transfer microdessection
DE10137864B4 (de) * 2001-08-02 2005-05-19 Picorapid Technologie Gmbh Substanzträger mit Markierung
US20040072274A1 (en) * 2002-05-09 2004-04-15 Lebrun Stewart J. System and method for visualization and digital analysis of protein and other macromolecule microarrays
SE0202346D0 (sv) * 2002-07-30 2002-07-30 Astrazeneca Ab Profiling process
WO2004048928A2 (en) * 2002-11-25 2004-06-10 The United States Of America As Represented By The Secretary Of Health And Human Services, Nih Method and apparatus for performing multiple simultaneous manipulations of biomolecules in a two-dimensional array
US20040171167A1 (en) * 2002-12-13 2004-09-02 Affymetrix, Inc. Chip-in-a-well scanning
WO2004065543A2 (en) * 2003-01-16 2004-08-05 Exact Sciences Corporation Devices and method for recovery of a target molecule from a sample
EP1646725A2 (de) * 2003-07-07 2006-04-19 Syngenta Participations AG Reagentien, verfahren und kits zum nachweis von futterenzymen
US20050121325A1 (en) * 2003-09-19 2005-06-09 Timothy Updyke Composite compositions for electrophoresis
AU2005211907A1 (en) * 2004-02-11 2005-08-25 Pamgene B.V. A device for analysing an interaction between target and probe molecules
EP1853696B1 (de) 2005-02-24 2019-04-17 Life Technologies (Israel) Ltd. Vorrichtungen, systeme und kits zum elektroblotting sowie verfahren zu ihrer verwendung
EP1963480A2 (de) * 2005-12-08 2008-09-03 Protein Discovery, Inc. Verfahren und vorrichtungen zur konzentration und fraktionierung von analyten für die chemische analyse
JP4915527B2 (ja) * 2007-09-27 2012-04-11 凸版印刷株式会社 電気泳動兼転写用積層体、電気泳動兼転写用チップ、電気泳動兼転写装置、電気泳動兼転写方法、電気泳動兼転写用積層体の製造方法
CN102150045A (zh) * 2008-07-11 2011-08-10 生命技术公司 增强型电泳检测固相支持物上的分析物
WO2010126897A1 (en) * 2009-04-27 2010-11-04 Protein Discovery, Inc. Programmable electrophoretic notch filter systems and methods
US8524507B2 (en) * 2009-08-19 2013-09-03 The Cleveland Clinic Foundation Method for detecting a target molecule in a biological sample
US9714937B2 (en) 2009-10-13 2017-07-25 Nanostring Technologies, Inc. Protein detection via nanoreporters
CN102639716A (zh) * 2009-12-04 2012-08-15 株式会社日立制作所 使用二维cDNA文库的基因表达解析方法
KR101866401B1 (ko) 2010-04-05 2018-06-11 프로그노시스 바이오사이언스, 인코포레이티드 공간적으로 엔코딩된 생물학적 검정
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
GB201106254D0 (en) * 2011-04-13 2011-05-25 Frisen Jonas Method and product
JP2013178140A (ja) * 2012-02-28 2013-09-09 Sharp Corp 核酸−タンパク質複合体の単離装置
EP3901280B1 (de) * 2012-10-17 2025-03-12 10x Genomics Sweden AB Verfahren und produkt zur optimierung einer lokalisierten oder räumlichen detektion einer genexpression in einer gewebeprobe
US9291596B2 (en) 2013-02-12 2016-03-22 Pierce Biotechnology, Inc. Electroblot transfer buffer
USD738527S1 (en) 2013-05-28 2015-09-08 Life Technologies Corporation Electroblotting apparatus
CN111500680B (zh) 2013-06-25 2024-04-16 普罗格诺西斯生物科学公司 检测样品中生物靶标的空间分布的方法和系统
WO2015178249A1 (ja) * 2014-05-19 2015-11-26 国立大学法人名古屋大学 サンプル中の成分の分析方法、サンプル中の成分の特異的分離方法及び質量分析用サンプル
EP4321627A3 (de) 2015-04-10 2024-04-17 10x Genomics Sweden AB Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben
US10501777B2 (en) 2015-07-17 2019-12-10 Nanostring Technologies, Inc. Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue
CN114350752B (zh) 2015-07-17 2025-02-25 布鲁克空间生物学公司 在横切面组织的用户定义区域中的基因表达的同时定量
WO2017202962A1 (en) 2016-05-24 2017-11-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd)
WO2018046736A1 (en) 2016-09-12 2018-03-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from cancer
EP3515453A1 (de) 2016-09-22 2019-07-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren und pharmazeutische zusammensetzungen zur neuprogrammierung der immunumgebung bei einer darauf angewiesenen person
WO2018122249A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer
WO2018122245A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting the survival time of patients suffering from cms3 colorectal cancer
US20200150109A1 (en) 2017-05-05 2020-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Microtubule-targeting drugs as immune checkpoint inhibitors and methods of screening novel immune checkpoint inhibitors for the treatment of cancers and infectious diseases
JP7372927B6 (ja) 2018-02-12 2023-11-27 ナノストリング テクノロジーズ，インコーポレイティド 遺伝子およびタンパク質の発現を検出する生体分子プローブおよびその検出方法
CN109254346B (zh) * 2018-07-16 2020-09-11 哈尔滨工程大学 一种基于波分复用技术的单光纤光镊
CN109556939B (zh) * 2018-12-03 2021-05-11 中国科学院青藏高原研究所 样品裂变径迹原位蚀刻观测方法及设备
EP3894585A2 (de) 2018-12-10 2021-10-20 10X Genomics, Inc. Erzeugung von erfassungssonden zur räumlichen analyse
MX2021008121A (es) 2019-01-03 2021-12-10 Inst Nat Sante Rech Med Metodos y composiciones farmaceuticas para mejorar las respuestas inmunitarias dependientes de celulas t cd8+ en sujetos que sufren de cancer.
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
WO2020201362A2 (en) 2019-04-02 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
US20220160692A1 (en) 2019-04-09 2022-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of sk2 inhibitors in combination with immune checkpoint blockade therapy for the treatment of cancer
CN114072676B (zh) 2019-06-03 2024-07-12 法国国家卫生及研究医学协会 调节治疗方案的方法
EP4045686A1 (de) 2019-10-17 2022-08-24 Institut National de la Santé et de la Recherche Médicale (INSERM) Verfahren zur diagnose von nasalen adenokarzinomen vom intestinalen typ
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US12399123B1 (en) 2020-02-14 2025-08-26 10X Genomics, Inc. Spatial targeting of analytes
US12281357B1 (en) 2020-02-14 2025-04-22 10X Genomics, Inc. In situ spatial barcoding
WO2021170777A1 (en) 2020-02-28 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing, prognosing and managing treatment of breast cancer
EP4421186B1 (de) 2020-06-08 2025-08-13 10X Genomics, Inc. Verfahren zur bestimmung eines chirurgischen randes und verfahren zur verwendung davon
JP7741831B2 (ja) 2020-06-30 2025-09-18 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 術前補助療法及び根治手術後の固形がんを患っている患者の再発及び／又は死亡のリスクを予測するための方法
EP4172621A1 (de) 2020-06-30 2023-05-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur vorhersage des risikos des wiederauftretens und/oder tods von patienten mit solidem krebs nach präoperativen adjuvanten therapien
JP7475999B2 (ja) * 2020-07-03 2024-04-30 旭化成株式会社 イムノクロマト展開膜及びその製造方法並びに迅速検査キット
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
KR20240012352A (ko) 2021-03-23 2024-01-29 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) T 세포 림프종의 진단 및 치료 방법
ES3030033T3 (en) 2021-06-03 2025-06-26 10X Genomics Inc Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis
WO2023144303A1 (en) 2022-01-31 2023-08-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Cd38 as a biomarker and biotarget in t-cell lymphomas
US20250035635A1 (en) 2022-03-17 2025-01-30 Institut National De La Sante Et De La Recherche Medicale Methods for predicting response to an immunotherapeutic treatment in a patient with a cancer
WO2023198648A1 (en) 2022-04-11 2023-10-19 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of t-cell malignancies
WO2023198874A1 (en) 2022-04-15 2023-10-19 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of t cell-lymphomas
WO2024003310A1 (en) 2022-06-30 2024-01-04 Institut National de la Santé et de la Recherche Médicale Methods for the diagnosis and treatment of acute lymphoblastic leukemia
US20260029402A1 (en) 2022-07-22 2026-01-29 Institut National de la Santé et de la Recherche Médicale Garp as a biomarker and biotarget in t-cell malignancies
WO2024023283A1 (en) 2022-07-29 2024-02-01 Institut National de la Santé et de la Recherche Médicale Lrrc33 as a biomarker and biotarget in cutaneous t-cell lymphomas
WO2024079192A1 (en) 2022-10-12 2024-04-18 Institut National de la Santé et de la Recherche Médicale Cd81 as a biomarker and biotarget in t-cell malignancies
WO2026101896A1 (en) 2024-11-05 2026-05-15 Compass Therapeutics Llc Novel prognostic biomarkers in patients with cancer

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3620947A (en) 1969-04-10 1971-11-16 Ortec Inc Electrophoretic system
DE2622684B2 (de) * 1976-05-21 1979-03-15 Licentia Patent-Verwaltungs-Gmbh, 6000 Frankfurt Membranaustauscher
US4337131A (en) 1978-11-13 1982-06-29 C. Desaga Gmbh Nachf. Erich Fecht Process for electrophoresis
US4668619A (en) * 1980-10-30 1987-05-26 Miles Laboratories, Inc. Multilayer homogeneous specific binding assay device
US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
EP0063810B1 (de) * 1981-04-29 1986-03-05 Ciba-Geigy Ag Prüfmittel und Ausrüstung für immunologische Analysen
JPS5818167A (ja) * 1981-07-24 1983-02-02 Fuji Photo Film Co Ltd 分析フイルム及びこれを用いる分析方法
JPS5934154A (ja) * 1982-08-19 1984-02-24 Konishiroku Photo Ind Co Ltd 免疫分析素子測定法
US4539294A (en) * 1982-09-30 1985-09-03 Akzona Incorporated Immobilization of proteins on polymeric supports
EP0139373A1 (de) * 1983-08-26 1985-05-02 The Regents Of The University Of California System für vielfache Immunoassays
DE3516579A1 (de) * 1984-11-19 1986-05-22 Boehringer Mannheim Gmbh, 6800 Mannheim Gerinnungstest auf teststreifen
US4716101A (en) 1984-12-18 1987-12-29 Calgene, Inc. Rapid enzyme assay by product selective blot
US4795562A (en) 1985-09-13 1989-01-03 Walsh James W Membrane batch-processing apparatus
US4959305A (en) * 1986-06-18 1990-09-25 Miles Inc. Reversible immobilization of assay reagents in a multizone test device
US5057438A (en) * 1986-09-24 1991-10-15 Agency Of Industrial Science And Technology Electrophoretic antigen-antibody determination with laminate of multiple membranes
DE3638654A1 (de) * 1986-11-12 1988-05-26 Boehringer Mannheim Gmbh Testtraeger zur analytischen bestimmung eines bestandteils einer koerperfluessigkeit
US4840714A (en) 1987-05-13 1989-06-20 American Bionetics, Inc. Electroblotting technique for transferring specimens from a polyacrylamide electrophoresis or like gel onto a membrane
US4874691A (en) * 1987-10-16 1989-10-17 Quadra Logic Technologies Inc. Membrane-supported immunoassays
EP0334615B1 (de) 1988-03-22 1994-11-17 Erik Nieman Elektroforesegerät
US5173159A (en) 1988-09-06 1992-12-22 Bertin & Cie Multiple electrophoresis method for the controlled migration of macromolecules through rectangular gel plates
GB8905001D0 (en) * 1989-03-04 1989-04-19 Univ Leicester Screening for natural products of microbial metabolism
US5155049A (en) 1989-08-22 1992-10-13 Terrapin Technologies, Inc. Blotting technique for membrane assay
US5238651A (en) 1990-07-23 1993-08-24 New York University Gel plates, equipment and kits for combined electrophoretic-immunoelectrophoretic analysis
CS257291A3 (en) 1990-12-13 1992-06-17 Jan J Prof Mudr Opplt Multi-layered, non-sequential discontinuous polyacrylamide gels, forming equilibrium molecular sieves for biomolecules separation
US5078853A (en) 1991-03-22 1992-01-07 Assay Technology, Inc. Segmented electrophoretic separation system useful for lipid profiling
CA2107905A1 (en) * 1991-04-08 1992-10-09 Kenneth Allen Blake Multilayer test device matrix structure
US5877028A (en) * 1991-05-29 1999-03-02 Smithkline Diagnostics, Inc. Immunochromatographic assay device
CA2074752A1 (en) * 1991-07-29 1993-01-30 Tadakazu Yamauchi Process and device for specific binding assay
DE4132743A1 (de) * 1991-10-02 1993-04-08 Boehringer Mannheim Gmbh Testtraeger fuer die analyse von fluessigkeiten
US5438128A (en) * 1992-02-07 1995-08-01 Millipore Corporation Method for rapid purifiction of nucleic acids using layered ion-exchange membranes
DE69427690T2 (de) 1993-04-07 2002-05-02 Gradipore Ltd., Frenchs Forest Verbesserungen im auftrennen von proteinen
US5384255A (en) * 1993-06-21 1995-01-24 Rappaport Family Institute For Research In The Medical Sciences Ubiquitin carrier enzyme E2-F1, purification, production, and use
US5427664A (en) 1993-07-22 1995-06-27 Stoev; Stoyan V. Free solution electrophoresis-membrane filters trapping assay apparatus and method
US5332484A (en) 1993-08-02 1994-07-26 Hi-Tech Bio-Tech, Inc. Apparatus and process for the large scale separation and retrieval of proteins from cellular extracts
US5716508A (en) 1993-09-09 1998-02-10 Glyko Incorporated Utilization of additives and defined storage systems to increase the stability and performance of electrophoresis media
US5843657A (en) 1994-03-01 1998-12-01 The United States Of America As Represented By The Department Of Health And Human Services Isolation of cellular material under microscopic visualization
DE69422604T2 (de) 1994-03-08 2000-06-08 Zeptosens Ag, Witterwil Vorrichtung und Verfahren, die Bioaffinitätsassay und elektrophoretische Auftrennung kombinieren
US5679310A (en) * 1995-07-11 1997-10-21 Polyfiltronics, Inc. High surface area multiwell test plate
US5665596A (en) * 1995-07-31 1997-09-09 Becton, Dickinson And Company Device for cell co-culture and method for its use in culturing cells
AU5427398A (en) 1996-11-01 1998-05-29 Grace Bio-Labs, Inc. Cytoperfusion of tissue specimens
GB9624927D0 (en) 1996-11-29 1997-01-15 Oxford Glycosciences Uk Ltd Gels and their use
US5804384A (en) * 1996-12-06 1998-09-08 Vysis, Inc. Devices and methods for detecting multiple analytes in samples
US6087134A (en) 1997-01-14 2000-07-11 Applied Imaging Corporation Method for analyzing DNA from a rare cell in a cell population
US6168929B1 (en) * 1997-01-27 2001-01-02 University Of Pittsburgh Method of identifying agents that disrupt the interaction of SV40 T antigen with Dnak homologues
WO1998041863A1 (en) * 1997-03-14 1998-09-24 Compucyte Corp. Multiple simultaneous testing media
US5993627A (en) 1997-06-24 1999-11-30 Large Scale Biology Corporation Automated system for two-dimensional electrophoresis
US6013165A (en) 1998-05-22 2000-01-11 Lynx Therapeutics, Inc. Electrophoresis apparatus and method
WO1999067647A1 (en) * 1998-06-24 1999-12-29 Chen & Chen, Llc Multi-layer testing column
US6232067B1 (en) * 1998-08-17 2001-05-15 The Perkin-Elmer Corporation Adapter directed expression analysis
US6135942A (en) 1998-11-30 2000-10-24 Leptin; Maria Nucleic acids proteins of a D. melanogaster insulin-like gene and uses thereof
ATE268903T1 (de) 1999-01-28 2004-06-15 Univ Geneve Verfahren und vorrichtung zur identifikation oder karakterisierung von polypeptiden
US20020012920A1 (en) * 2000-11-20 2002-01-31 Kevin Gardner Method and kit for proteomic identification
US6969615B2 (en) * 1999-07-26 2005-11-29 20/20 Genesystems, Inc. Methods, devices, arrays and kits for detecting and analyzing biomolecules

Also Published As

Publication number Publication date
WO2001007915A2 (en) 2001-02-01
JP4137444B2 (ja) 2008-08-20
EP1218743B1 (de) 2006-05-31
EP1218743A2 (de) 2002-07-03
WO2001007915A3 (en) 2001-04-05
JP2003505694A (ja) 2003-02-12
WO2001007915A8 (en) 2002-03-07
CA2375034A1 (en) 2001-02-01
AU771499B2 (en) 2004-03-25
US20040081987A1 (en) 2004-04-29
DE60028393T2 (de) 2007-06-14
ATE328277T1 (de) 2006-06-15
AU6609100A (en) 2001-02-13
CA2375034C (en) 2012-01-03
US6602661B1 (en) 2003-08-05
ES2269171T3 (es) 2007-04-01

Similar Documents

Publication Publication Date Title
ATE328277T1 (de) Schichtvorrichtung mit einfangbereichen zur zellulären analyse
WO2002048674A3 (en) Methods, devices, arrays and kits for detecting and analyzing biomolecules
WO2004074310A3 (en) Mycobacterial diagnostics
JPH11248708A5 (de)
WO2004005477A3 (en) Protein microarrays on mirrored surfaces for performing proteomic analyses
TR200000565T2 (tr) Biyolojik örneklerdeki analiz bileşenlerinin hızlı analizi için yöntem
DE50113911D1 (de) Biochip zur archivierung und labormedizinischen analyse von biologischem probenmaterial
WO2007001436A3 (en) Surface modification for non-specific adsorption of biological material
EP1151300A4 (de) Versuchsanordnung zum nachweis von bindungspartnern
JP2004528574A5 (de)
DE69724249D1 (de) Verbesserungen in oder in bezug auf spezifische bindungsassays
WO2002097398A3 (en) Closed substrate platforms suitable for analysis of biomolecules
IL129022A (en) Multi-array, multi specific electrochemiluminescence testing
ATE254285T1 (de) Geräte und verfahren, die strukturfelder zum binden von analyten verwenden
ATE461450T1 (de) Verwendung von kontrollflächen zur detektion von störproben in einem nachweisverfahren
DE69928507D1 (de) Festphasenverfahren und testsatz zur antigen- und antikörperprüfung in der blutgruppen-serologie
CA2285219A1 (en) Detection of low level analytes in samples
WO2003102541A3 (en) Universal biosensor and methods of use
DE59712595D1 (de) Homogene Nachweisverfahren zur Bestimmung von Subpopulationen eines Analyten
DE50105263D1 (de) Verfahren zur analyse von proteinen
SG164389A1 (en) Detection of a therapeutic antibody in an experimental animal
CA2499355A1 (en) Compositions, methods and kits for detection of an antigen on a cell and in a biological mixture
DE69818706D1 (de) Analytisches verfahren mit teilchen und testkit um das verfahren durchzuführen
WO2004039963A8 (en) Antibodies specific for phosphorylated insulin receptor substrate-1/2 (ser 1101/ser1149) and uses thereof
ATE418073T1 (de) Elementaranalytik von markierten biologisch aktiven substanzen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition