DE60024480D1 - Thiazol und imidazo[4,5-b]pyridin verbindungen und ihre verwendung als pharmazeutika - Google Patents
Thiazol und imidazo[4,5-b]pyridin verbindungen und ihre verwendung als pharmazeutikaInfo
- Publication number
- DE60024480D1 DE60024480D1 DE60024480T DE60024480T DE60024480D1 DE 60024480 D1 DE60024480 D1 DE 60024480D1 DE 60024480 T DE60024480 T DE 60024480T DE 60024480 T DE60024480 T DE 60024480T DE 60024480 D1 DE60024480 D1 DE 60024480D1
- Authority
- DE
- Germany
- Prior art keywords
- thiazol
- imidazo
- pharmaceuticals
- pyridine compounds
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9925441.9A GB9925441D0 (en) | 1999-10-27 | 1999-10-27 | Organic compounds |
GB9925441 | 1999-10-27 | ||
GBGB9926173.7A GB9926173D0 (en) | 1999-11-04 | 1999-11-04 | Organic compounds |
GB9926173 | 1999-11-04 | ||
PCT/EP2000/010528 WO2001030778A1 (en) | 1999-10-27 | 2000-10-25 | Thiazole and imidazo [4,5-b] pyridine compounds and their pharmaceutical use |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60024480D1 true DE60024480D1 (de) | 2006-01-05 |
DE60024480T2 DE60024480T2 (de) | 2006-07-27 |
Family
ID=26316029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60024480T Expired - Lifetime DE60024480T2 (de) | 1999-10-27 | 2000-10-25 | Thiazol und imidazo[4,5-b]pyridin verbindungen und ihre verwendung als pharmazeutika |
Country Status (11)
Country | Link |
---|---|
US (2) | US6608072B1 (de) |
EP (1) | EP1224185B1 (de) |
JP (1) | JP2003512467A (de) |
AR (1) | AR029011A1 (de) |
AT (1) | ATE311385T1 (de) |
AU (1) | AU7922900A (de) |
CO (1) | CO5251463A1 (de) |
DE (1) | DE60024480T2 (de) |
ES (1) | ES2254238T3 (de) |
PE (1) | PE20011039A1 (de) |
WO (1) | WO2001030778A1 (de) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2274634T3 (es) | 1998-08-29 | 2007-05-16 | Astrazeneca Ab | Compuestos de pirimidina. |
DE69932828T2 (de) | 1998-08-29 | 2007-10-18 | Astrazeneca Ab | Pyrimidine verbindungen |
GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
GB9907658D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Chemical compounds |
GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004886D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004888D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0007371D0 (en) | 2000-03-28 | 2000-05-17 | Astrazeneca Uk Ltd | Chemical compounds |
EP1294718A2 (de) | 2000-06-14 | 2003-03-26 | Warner-Lambert Company Llc | 6,5-kondensierte bizyklische heterozyklen |
GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
GB0021726D0 (en) | 2000-09-05 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
WO2002062792A1 (fr) * | 2001-02-02 | 2002-08-15 | Takeda Chemical Industries, Ltd. | Inhibiteur de jnk |
GB0103926D0 (en) | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
GB0113041D0 (en) | 2001-05-30 | 2001-07-18 | Astrazeneca Ab | Chemical compounds |
KR100922538B1 (ko) | 2001-08-13 | 2009-10-21 | 얀센 파마슈티카 엔.브이. | 2,4,5-삼치환된 티아졸릴 유도체 및 그의 항염증성 활성 |
KR100980163B1 (ko) | 2002-01-07 | 2010-09-03 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 데아자퓨린 및 이의 용도 |
TWI322807B (en) * | 2002-01-07 | 2010-04-01 | Eisai R&D Man Co Ltd | Novel deazapurines and uses thereof |
GB0205690D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
US7442697B2 (en) | 2002-03-09 | 2008-10-28 | Astrazeneca Ab | 4-imidazolyl substituted pyrimidine derivatives with CDK inhibitory activity |
GB0205693D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
GB0205688D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
AU2003247959B2 (en) * | 2002-07-09 | 2010-07-29 | Vertex Pharmaceuticals Incorporated | Imidazoles, oxazoles and thiazoles with protein kinase inhibiting activities |
US20040033222A1 (en) * | 2002-08-14 | 2004-02-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | Anticoagulant and fibrinolytic therapy uning p38 MAP kinase inhibitors |
GB0226583D0 (en) * | 2002-11-14 | 2002-12-18 | Cyclacel Ltd | Compounds |
ATE481402T1 (de) | 2003-02-27 | 2010-10-15 | Palau Pharma Sa | Pyrazolopyridin-derivate |
GB0311274D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
GB0311276D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
TWI334868B (en) * | 2003-06-03 | 2010-12-21 | Nippon Kayaku Kk | [1,2,4] triazoro [1,5-a] pyrimidine-2-ylurea derivative and use thereof |
EP1648887A1 (de) * | 2003-07-30 | 2006-04-26 | Cyclacel Limited | Pyridinylamin-pyrimidin derivate als protein kinase hemmer |
US7632950B2 (en) * | 2003-08-18 | 2009-12-15 | Fujifilm Finechemicals Co., Ltd | Pyridyltetrahydropyridines and pyridylpiperidines and method of manufacturing them |
GB0401336D0 (en) * | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
US7504403B2 (en) * | 2004-01-22 | 2009-03-17 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
TWI332003B (en) * | 2004-01-30 | 2010-10-21 | Lilly Co Eli | Kinase inhibitors |
TW200528101A (en) | 2004-02-03 | 2005-09-01 | Astrazeneca Ab | Chemical compounds |
EP1810972B1 (de) * | 2004-11-10 | 2012-01-25 | Ono Pharmaceutical Co., Ltd. | Stickstoffhaltige heterocyclische verbindung und deren pharmazeutische verwendung |
KR100848205B1 (ko) * | 2005-06-20 | 2008-07-24 | 주식회사 동부하이텍 | 면역 억제 및 염증 억제 활성을 갖는 신규한 치환된1,3-티아졸 유도체 또는 이의 약학적으로 허용가능한 염,중간체 화합물 또는 이의 약학적으로 허용가능한 염, 이의제조방법, 및 이를 포함하는 약학적 조성물 |
WO2007034278A2 (en) * | 2005-09-19 | 2007-03-29 | Pfizer Products Inc. | Fused imidazole derivatives as c3a receptor antagonists |
CN101277956A (zh) | 2005-09-30 | 2008-10-01 | 阿斯利康(瑞典)有限公司 | 具有抗细胞增殖活性的咪唑并【1,2-a】吡啶 |
EP1932840B1 (de) | 2005-10-03 | 2014-04-09 | Ono Pharmaceutical Co., Ltd. | Stickstoffhaltige heterocyclische verbindung und pharmazeutische anwendung davon |
CA2698075C (en) * | 2007-08-27 | 2016-04-12 | Siga Technologies, Inc. | Antiviral drugs for treatment of arenavirus infection |
WO2009076140A1 (en) * | 2007-12-13 | 2009-06-18 | Smithkline Beecham Corporation | Thiazole and oxazole kinase inhibitors |
UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
ES2548135T3 (es) * | 2008-05-13 | 2015-10-14 | Novartis Ag | Heterociclos condensados que contienen nitrógeno y composiciones de los mismos como inhibidores de quinasa |
CN105001196B (zh) * | 2008-12-03 | 2017-05-10 | 斯克里普斯研究所 | 干细胞培养 |
EP2198710A1 (de) | 2008-12-19 | 2010-06-23 | Bayer CropScience AG | Verwendung von 5-Pyridin-4yl-(1,3)Thiazole zur Bekämpfung phytopathogener Pilze |
NZ596123A (en) * | 2009-05-19 | 2014-08-29 | Dow Agrosciences Llc | Compounds and methods for controlling fungi |
WO2012116145A1 (en) * | 2011-02-25 | 2012-08-30 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
CN103145706B (zh) * | 2012-11-16 | 2015-11-25 | 温州医学院 | 一类具有抗炎作用的咪唑并吡啶类化合物及其在制备抗炎药物中的应用 |
TWI623531B (zh) | 2012-11-21 | 2018-05-11 | Ptc治療公司 | 經取代反向嘧啶bmi-1抑制劑 |
WO2014172639A1 (en) * | 2013-04-19 | 2014-10-23 | Ruga Corporation | Raf kinase inhibitors |
KR102232595B1 (ko) | 2013-08-30 | 2021-03-26 | 피티씨 테라퓨틱스, 인크. | 치환된 피리미딘 bmi-1 저해제 |
WO2015076800A1 (en) | 2013-11-21 | 2015-05-28 | Ptc Therapeutics, Inc. | Substituted pyridine and pyrazine bmi-1 inhibitors |
GB201321739D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
RS63190B1 (sr) | 2014-08-04 | 2022-06-30 | Nuevolution As | Opciono fuzionisani derivati pirimidina zamenjeni heterociklilom korisni za lečenje zapaljenskih, metaboličkih, onkoloških i autoimunskih bolesti |
AU2016233289A1 (en) * | 2015-03-18 | 2017-11-09 | Bristol-Myers Squibb Company | Tricyclic heterocyclic compounds useful as inhibitors of TNF |
KR102654709B1 (ko) * | 2015-03-18 | 2024-04-03 | 브리스톨-마이어스 스큅 컴퍼니 | 치환된 트리시클릭 헤테로시클릭 화합물 |
WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
WO2019142128A1 (en) * | 2018-01-18 | 2019-07-25 | Integral Biosciences Private Limited | Dual inhibitors of alk5 and p38α map kinase |
MX2021001870A (es) | 2018-08-17 | 2021-07-15 | Ptc Therapeutics Inc | Metodo para tratar cancer pancreatico. |
HRP20240401T1 (hr) | 2018-10-05 | 2024-06-07 | Annapurna Bio Inc. | Spojevi i pripravci za liječenje patoloških stanja koja su povezana s djelovanjem apj receptora |
EP4076657A1 (de) | 2019-12-20 | 2022-10-26 | Nuevolution A/S | Gegen nukleäre rezeptoren wirksame verbindungen |
EP4126875A1 (de) | 2020-03-31 | 2023-02-08 | Nuevolution A/S | Gegen nukleare rezeptoren aktive verbindungen |
US11780843B2 (en) | 2020-03-31 | 2023-10-10 | Nuevolution A/S | Compounds active towards nuclear receptors |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6058981A (ja) * | 1983-09-09 | 1985-04-05 | Takeda Chem Ind Ltd | 5−ピリジル−1,3−チアゾ−ル誘導体,その製造法およびそれを含んでなる医薬組成物 |
JP3264492B2 (ja) * | 1992-01-13 | 2002-03-11 | スミスクライン・ビーチャム・コーポレイション | ピリジル置換イミダゾール |
WO1995013067A1 (en) * | 1993-11-08 | 1995-05-18 | Smithkline Beecham Corporation | Oxazoles for treating cytokine mediated diseases |
US5658903A (en) * | 1995-06-07 | 1997-08-19 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
US5739143A (en) * | 1995-06-07 | 1998-04-14 | Smithkline Beecham Corporation | Imidazole compounds and compositions |
WO1997005878A1 (en) | 1995-08-10 | 1997-02-20 | Merck & Co., Inc. | 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use |
DE69728688T2 (de) * | 1996-11-19 | 2004-08-19 | Amgen Inc., Thousand Oaks | Aryl und heteroaryl substituierte kondensierte pyrrole als entzündunghemmende mittel |
ZA9711092B (en) * | 1996-12-11 | 1999-07-22 | Smithkline Beecham Corp | Novel compounds. |
AU7132998A (en) * | 1997-04-24 | 1998-11-13 | Ortho-Mcneil Corporation, Inc. | Substituted pyrrolopyridines useful in the treatment of inflammatory diseases |
GB9713726D0 (en) * | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
TR200001079T2 (tr) * | 1997-10-20 | 2000-07-21 | F.Hoffmann-La Roche Ag | Bisiklik kinaz inhibitörleri. |
WO1999021555A2 (en) * | 1997-10-27 | 1999-05-06 | Takeda Chemical Industries, Ltd. | Adenosine a3 receptor antagonists |
JP3990061B2 (ja) * | 1998-01-05 | 2007-10-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | プリン誘導体および糖尿病の予防・治療剤としてのアデノシンa2受容体拮抗剤 |
AU4506399A (en) * | 1998-06-05 | 1999-12-30 | Novartis Ag | Aryl pyridinyl thiazoles |
JP2000119271A (ja) * | 1998-08-12 | 2000-04-25 | Hokuriku Seiyaku Co Ltd | 1h―イミダゾピリジン誘導体 |
CO5170501A1 (es) * | 1999-04-14 | 2002-06-27 | Novartis Ag | AZOLES SUSTITUIDOS UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR TNFa eIL-1 Y ENFERMEDADES DEL METABOLISMO OSEO |
JP3333774B2 (ja) * | 1999-04-23 | 2002-10-15 | 武田薬品工業株式会社 | 5−ピリジル−1,3−アゾール化合物、その製造法及び用途 |
US7101899B1 (en) * | 1999-04-23 | 2006-09-05 | Takeda Pharmaceutical Company Limited | 5-pyridyl-1,3-azole compounds, process for producing the same and use thereof |
US6492516B1 (en) | 1999-05-14 | 2002-12-10 | Merck & Co., Inc. | Compounds having cytokine inhibitory activity |
-
2000
- 2000-10-25 ES ES00969551T patent/ES2254238T3/es not_active Expired - Lifetime
- 2000-10-25 US US10/111,233 patent/US6608072B1/en not_active Expired - Fee Related
- 2000-10-25 DE DE60024480T patent/DE60024480T2/de not_active Expired - Lifetime
- 2000-10-25 JP JP2001533132A patent/JP2003512467A/ja active Pending
- 2000-10-25 AU AU79229/00A patent/AU7922900A/en not_active Abandoned
- 2000-10-25 AT AT00969551T patent/ATE311385T1/de not_active IP Right Cessation
- 2000-10-25 WO PCT/EP2000/010528 patent/WO2001030778A1/en active IP Right Grant
- 2000-10-25 EP EP00969551A patent/EP1224185B1/de not_active Expired - Lifetime
- 2000-10-26 AR ARP000105643A patent/AR029011A1/es unknown
- 2000-10-26 PE PE2000001147A patent/PE20011039A1/es not_active Application Discontinuation
- 2000-10-27 CO CO00082019A patent/CO5251463A1/es not_active Application Discontinuation
-
2003
- 2003-06-23 US US10/601,690 patent/US6891039B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6608072B1 (en) | 2003-08-19 |
ES2254238T3 (es) | 2006-06-16 |
ATE311385T1 (de) | 2005-12-15 |
WO2001030778A1 (en) | 2001-05-03 |
PE20011039A1 (es) | 2001-10-30 |
US6891039B2 (en) | 2005-05-10 |
US20040082604A1 (en) | 2004-04-29 |
DE60024480T2 (de) | 2006-07-27 |
CO5251463A1 (es) | 2003-02-28 |
AR029011A1 (es) | 2003-06-04 |
EP1224185B1 (de) | 2005-11-30 |
EP1224185A1 (de) | 2002-07-24 |
AU7922900A (en) | 2001-05-08 |
JP2003512467A (ja) | 2003-04-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60024480D1 (de) | Thiazol und imidazo[4,5-b]pyridin verbindungen und ihre verwendung als pharmazeutika | |
DE60202200D1 (de) | Imidazo[1,2-a]-pyridinderivate als mglur5 antagonisten | |
EE200200080A (et) | Imidaso[1,2a]püridiini ja pürasolo[2,3a]püridiiniderivaadid | |
DE60014603D1 (de) | Heterocyklischer harnstoff und verwandte verbindungen als entzündungshemmende mittel | |
DK1470124T3 (da) | 2-(Pyridin-2-yl amino)-pyrido[2,3]pyrimidin-7-oner | |
DE60021262D1 (de) | Bizyklische heteroaromatische verbindungen als lh-agonisten | |
DK1147112T3 (da) | Diazabicykliske derivater som nicotiniske acetylcholinreceptorligander | |
ATE375987T1 (de) | Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel | |
DK1163227T3 (da) | Bicykliske heterocykliske forbindelser, farmaceutiske præparater indeholdende disse forbindelser og fremgangsmåder til fremstilling deraf | |
ATE299503T1 (de) | Pyridin-3-carbonsäurederivate und ihre verwendung als zwischenprodukte | |
DE60332396D1 (de) | PYRAZOLOi3,4-B PYRIDINVERBINDUNGEN UND IHRE VERWENDUNG ALS PHOSPHODIESTERASE INHIBITOREN | |
NO20013419L (no) | Substituerte 2-aryl-3-(heteroaryl)-imidazo[1,2a]pyrimidiner, med dertil horende farmasoytiske preparater samt metoder. | |
DE60034683D1 (de) | 3(5)-ureido-pyrazolderivate, deren herstellungsverfahren und verwendung als krebshemmende mittel | |
DE60023012D1 (de) | 3(5)-amino-pyrazolderivate, deren herstellungsverfahren und verwendung als krebshemmende mittel | |
DE50008597D1 (de) | Thiazolylharnstoff-derivate und ihre verwendung als antivirale mittel | |
ATE309247T1 (de) | Heteroaryl substituierte 2-pyridinyl und 2- pyrimidinyl-6,7,8,9-tetrahydropyrimido(1,2- a)pyrimidin-4-onderivate | |
AU2003255323A8 (en) | Imidazo`1,2-a pyridines | |
NO20013384D0 (no) | Imidazo[4,5-c]pyridin-4-on-derivater | |
ATE264315T1 (de) | Aminothiazolderivate und ihre verwendung als crf- rezeptor-liganden | |
ATE260259T1 (de) | Substituierte isochinolinderivate und ihre verwendung als anticonvulsiva | |
EE04372B1 (et) | 5-asendatud-3-oksadiasolüül-1,6-naftüridiin-2(1H)-ooni derivaadid | |
DE60005349D1 (de) | Dithiepino[6,5-b]pyridine und diese verwendete zusamensetzungen und methode | |
NO20031412L (no) | Substituerte 3,4-dihydro-pyrido[1,2-A]pyrimidiner | |
DK1326866T3 (da) | Substituerede 3,4-dihydro-pyrido[1,2-a]pyrimidiner |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN |