DE60023633T2 - Vorrichtung und Verfahren zur Trennung von Bestandteilen einer flüssigen Probe - Google Patents
Vorrichtung und Verfahren zur Trennung von Bestandteilen einer flüssigen Probe Download PDFInfo
- Publication number
- DE60023633T2 DE60023633T2 DE60023633T DE60023633T DE60023633T2 DE 60023633 T2 DE60023633 T2 DE 60023633T2 DE 60023633 T DE60023633 T DE 60023633T DE 60023633 T DE60023633 T DE 60023633T DE 60023633 T2 DE60023633 T2 DE 60023633T2
- Authority
- DE
- Germany
- Prior art keywords
- separator
- tube
- seal
- ring
- density
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007788 liquid Substances 0.000 title claims description 10
- 238000000034 method Methods 0.000 title description 4
- 238000007789 sealing Methods 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 17
- 229920002725 thermoplastic elastomer Polymers 0.000 claims description 5
- 239000006260 foam Substances 0.000 claims description 3
- 239000004620 low density foam Substances 0.000 claims description 3
- 239000007769 metal material Substances 0.000 claims 2
- 239000000523 sample Substances 0.000 description 30
- 239000012071 phase Substances 0.000 description 26
- 239000012530 fluid Substances 0.000 description 21
- 210000004369 blood Anatomy 0.000 description 18
- 239000008280 blood Substances 0.000 description 18
- 239000000499 gel Substances 0.000 description 14
- 238000000926 separation method Methods 0.000 description 9
- 230000005484 gravity Effects 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- 238000005119 centrifugation Methods 0.000 description 5
- 239000000306 component Substances 0.000 description 5
- 239000002184 metal Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 230000009974 thixotropic effect Effects 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000000565 sealant Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5021—Test tubes specially adapted for centrifugation purposes
- B01L3/50215—Test tubes specially adapted for centrifugation purposes using a float to separate phases
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Centrifugal Separators (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16917299P | 1999-12-06 | 1999-12-06 | |
| US169172P | 1999-12-06 | ||
| US694996 | 2000-10-24 | ||
| US09/694,996 US6793892B1 (en) | 1999-12-06 | 2000-10-24 | Device and method for separating components of a fluid sample |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60023633D1 DE60023633D1 (de) | 2005-12-08 |
| DE60023633T2 true DE60023633T2 (de) | 2006-07-06 |
Family
ID=26864836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60023633T Expired - Lifetime DE60023633T2 (de) | 1999-12-06 | 2000-11-24 | Vorrichtung und Verfahren zur Trennung von Bestandteilen einer flüssigen Probe |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US6793892B1 (https=) |
| EP (1) | EP1106251B1 (https=) |
| JP (1) | JP4741068B2 (https=) |
| DE (1) | DE60023633T2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6406671B1 (en) * | 1998-12-05 | 2002-06-18 | Becton, Dickinson And Company | Device and method for separating components of a fluid sample |
| US7947236B2 (en) | 1999-12-03 | 2011-05-24 | Becton, Dickinson And Company | Device for separating components of a fluid sample |
| AT500247B1 (de) | 2001-03-30 | 2007-06-15 | Greiner Bio One Gmbh | Aufnahmeeinrichtung, insbesondere für körperflüssigkeiten, mit einer trennvorrichtung sowie trennvorrichtung hierzu |
| JP4472634B2 (ja) * | 2003-07-10 | 2010-06-02 | ユニヴェルシテ リブル ドゥ ブリュッセル | 生物学的試料を試剤でパルスし、こうしてパルスされた試料を安定化するための装置、キット及び方法 |
| US7947450B2 (en) | 2003-07-10 | 2011-05-24 | Universite Libre De Bruxelles | Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed |
| AT500459B1 (de) | 2004-01-23 | 2010-08-15 | Greiner Bio One Gmbh | Verfahren zum zusammenbau einer kappe mit einem aufnahmebehälter |
| US20060116270A1 (en) * | 2004-07-16 | 2006-06-01 | Mehdi Hatamian | Centrifuge system |
| US7993610B2 (en) * | 2005-10-05 | 2011-08-09 | Idexx Laboratories, Incorporated | Blood centrifuge rotor with fill indicator |
| US8021630B2 (en) * | 2007-10-29 | 2011-09-20 | Idexx Laboratories, Inc. | Anticoagulant-coated dipstick for use with a blood centrifuge rotor |
| JP5364102B2 (ja) * | 2007-12-07 | 2013-12-11 | ハーベスト・テクノロジーズ・コーポレイション | 血液成分を分離するための浮動ディスク |
| CA2717894C (en) | 2008-03-05 | 2014-05-27 | Becton, Dickinson And Company | Capillary action collection device and container assembly |
| CA2731156C (en) | 2008-07-21 | 2013-09-24 | Becton, Dickinson And Company | Density phase separation device |
| CN102149472B (zh) | 2008-07-21 | 2014-08-13 | 贝克顿·迪金森公司 | 密度相分离装置 |
| CN104588140B (zh) | 2008-07-21 | 2016-06-29 | 贝克顿·迪金森公司 | 密度相分离装置 |
| PL3006109T3 (pl) | 2009-05-15 | 2019-12-31 | Becton, Dickinson And Company | Urządzenie do rozdzielania faz gęstości |
| US20130225387A1 (en) * | 2010-11-09 | 2013-08-29 | Jms Co., Ltd. | Separation container and separation method |
| US9694359B2 (en) | 2014-11-13 | 2017-07-04 | Becton, Dickinson And Company | Mechanical separator for a biological fluid |
| US20160136639A1 (en) * | 2014-11-13 | 2016-05-19 | Becton, Dickinson And Company | Mechanical Separator for a Biological Fluid |
| KR102424605B1 (ko) * | 2015-06-10 | 2022-07-25 | 세키스이 메디칼 가부시키가이샤 | 혈청 또는 혈장 분리용 조성물, 혈액 검사용 용기, 그리고 혈청 또는 혈장 분리용 조성물의 안정화 방법 |
| AU2016359598B2 (en) | 2015-11-24 | 2021-10-07 | Royal Biologics | Methods and apparatus for separating fluid components |
| DE102017108940A1 (de) | 2017-04-26 | 2018-10-31 | Sarstedt Aktiengesellschaft & Co.Kg | Trennkörper |
| CN110075942B (zh) * | 2019-05-09 | 2024-03-26 | 北京粒基生物科技有限公司 | 可实现离心后固液相隔离的生物体液采样分离装置及方法 |
| CN110496659B (zh) * | 2019-09-19 | 2024-06-11 | 成都瑞琦医疗科技有限责任公司 | 一种血液采集分离管及分离方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3779383A (en) * | 1972-04-25 | 1973-12-18 | Becton Dickinson Co | Sealed assembly for separation of blood components and method |
| US3852194A (en) * | 1972-12-11 | 1974-12-03 | Corning Glass Works | Apparatus and method for fluid collection and partitioning |
| US3897343A (en) * | 1974-02-27 | 1975-07-29 | Becton Dickinson Co | Plasma separator-hydrostatic pressure type |
| US3931018A (en) * | 1974-08-09 | 1976-01-06 | Becton, Dickinson And Company | Assembly for collection, separation and filtration of blood |
| US4012325A (en) * | 1975-01-08 | 1977-03-15 | Eastman Kodak Company | Biological fluid dispenser and separator |
| US3976579A (en) * | 1975-07-10 | 1976-08-24 | Becton, Dickinson And Company | Novel assembly |
| US4180465A (en) * | 1975-12-19 | 1979-12-25 | Sherwood Medical Industries Inc. | Fluid collection device with phase separation means |
| JPS5555259A (en) * | 1978-10-17 | 1980-04-23 | Eritsukuson Kuruto | Method and device for treating blood sample |
| JPS5917386B2 (ja) * | 1979-03-23 | 1984-04-20 | テルモ株式会社 | 血液分離方法および装置 |
| US4308232A (en) * | 1979-07-09 | 1981-12-29 | Sherwood Medical Industries Inc. | Anticoagulant stopper coating |
| JPS56118669A (en) * | 1980-02-25 | 1981-09-17 | Sekisui Chem Co Ltd | Blood serum separator |
| US4295974A (en) * | 1980-05-05 | 1981-10-20 | Sherwood Medical Industries Inc. | Blood sample collection and phase separation device |
| US4315892A (en) * | 1980-07-18 | 1982-02-16 | Sherwood Medical Industries, Inc. | Fluid collection device having phase partitioning means |
| US4443345A (en) * | 1982-06-28 | 1984-04-17 | Wells John R | Serum preparator |
| US4492634A (en) * | 1982-09-28 | 1985-01-08 | Emde Medical Research | Pre-evacuated blood collection tube with anti-hemolysis baffle system and centrifugation propelled filtration disc and efficient serum-from cells separator |
| US4917801A (en) * | 1984-12-04 | 1990-04-17 | Becton Dickinson And Company | Lymphocyte collection tube |
| SE448323B (sv) * | 1985-08-27 | 1987-02-09 | Ersson Nils Olof | Forfarande och anordnig att separera serum eller plasma fran blod |
| US5030341A (en) * | 1987-04-03 | 1991-07-09 | Andronic Technologies, Inc. | Apparatus for separating phases of blood |
| US5019243A (en) * | 1987-04-03 | 1991-05-28 | Mcewen James A | Apparatus for collecting blood |
| US4828716A (en) * | 1987-04-03 | 1989-05-09 | Andronic Devices, Ltd. | Apparatus and method for separating phases of blood |
| US4877520A (en) * | 1987-10-08 | 1989-10-31 | Becton, Dickinson And Company | Device for separating the components of a liquid sample having higher and lower specific gravities |
| US4946601A (en) * | 1988-08-22 | 1990-08-07 | Sherwood Medical Company | Blood serum separator tube |
| US5266199A (en) * | 1990-11-20 | 1993-11-30 | Nigata Chemicals And Plastics Co., Ltd. | Serum separating apparatus |
| US5236604A (en) * | 1991-05-29 | 1993-08-17 | Sherwood Medical Company | Serum separation blood collection tube and the method of using thereof |
| JPH07103969A (ja) * | 1993-08-13 | 1995-04-21 | Niigata Kako Kk | 血液分離部材及び血液分離用採血管 |
| US5560830A (en) * | 1994-12-13 | 1996-10-01 | Coleman; Charles M. | Separator float and tubular body for blood collection and separation and method of use thereof |
| AT404317B (de) * | 1996-08-02 | 1998-10-27 | Greiner & Soehne C A | Verschlussvorrichtung, trennvorrichtung sowie aufnahmebehälter für eine aufnahmeeinrichtung |
| AT409725B (de) * | 1997-05-12 | 2002-10-25 | Greiner & Soehne C A | Trennvorrichtung |
| US5901402A (en) * | 1997-07-16 | 1999-05-11 | Williams; Stephen R. | Mop handle connector |
| US6406671B1 (en) * | 1998-12-05 | 2002-06-18 | Becton, Dickinson And Company | Device and method for separating components of a fluid sample |
| ES2260881T3 (es) * | 1998-12-05 | 2006-11-01 | Becton Dickinson And Company | Dispositivo y metodo para separar componentes de una muestra de fluido. |
| US6479298B1 (en) | 1998-12-05 | 2002-11-12 | Becton, Dickinson And Company | Device and method for separating components of a fluid sample |
-
2000
- 2000-10-24 US US09/694,996 patent/US6793892B1/en not_active Expired - Lifetime
- 2000-11-24 DE DE60023633T patent/DE60023633T2/de not_active Expired - Lifetime
- 2000-11-24 EP EP00125760A patent/EP1106251B1/en not_active Expired - Lifetime
- 2000-12-06 JP JP2000371795A patent/JP4741068B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1106251A2 (en) | 2001-06-13 |
| JP2001232243A (ja) | 2001-08-28 |
| US6793892B1 (en) | 2004-09-21 |
| EP1106251B1 (en) | 2005-11-02 |
| DE60023633D1 (de) | 2005-12-08 |
| EP1106251A3 (en) | 2002-09-18 |
| JP4741068B2 (ja) | 2011-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |