DE60022316D1 - 6-substituierte 7-heterochinoxalin-carbonsäure- derivate und ihre additionssalze und verfahren zur herstellung von beiden - Google Patents

6-substituierte 7-heterochinoxalin-carbonsäure- derivate und ihre additionssalze und verfahren zur herstellung von beiden

Info

Publication number
DE60022316D1
DE60022316D1 DE60022316T DE60022316T DE60022316D1 DE 60022316 D1 DE60022316 D1 DE 60022316D1 DE 60022316 T DE60022316 T DE 60022316T DE 60022316 T DE60022316 T DE 60022316T DE 60022316 D1 DE60022316 D1 DE 60022316D1
Authority
DE
Germany
Prior art keywords
denotes
group
substituted
heterochinoxaline
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60022316T
Other languages
English (en)
Other versions
DE60022316T2 (de
Inventor
Yasuo Takano
Futoshi Shiga
Tsuyoshi Anraku
Kazunori Fukuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE60022316D1 publication Critical patent/DE60022316D1/de
Publication of DE60022316T2 publication Critical patent/DE60022316T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60022316T 1999-02-26 2000-02-25 6-substituierte 7-heterochinoxalin-carbonsäure- derivate und ihre additionssalze und verfahren zur herstellung von beiden Expired - Fee Related DE60022316T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP5023899 1999-02-26
JP5023899 1999-02-26
JP2000041813A JP2000309586A (ja) 1999-02-26 2000-02-18 ６−置換−７−ヘテロキノキサリンカルボン酸誘導体とその付加塩及びそれらの製造方法
JP2000041813 2000-02-18
PCT/JP2000/001076 WO2000050420A1 (fr) 1999-02-26 2000-02-25 Derives d'acide 7-heteroquinoxaline carboxilique 6-substitue et leurs sels d'addition, procedes de preparation de ces derives et de leurs sels d'addition

Publications (2)

Publication Number Publication Date
DE60022316D1 true DE60022316D1 (de) 2005-10-06
DE60022316T2 DE60022316T2 (de) 2006-06-29

Family

ID=26390685

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60022316T Expired - Fee Related DE60022316T2 (de) 1999-02-26 2000-02-25 6-substituierte 7-heterochinoxalin-carbonsäure- derivate und ihre additionssalze und verfahren zur herstellung von beiden

Country Status (7)

Country Link
US (1) US6632813B1 (de)
EP (1) EP1156047B1 (de)
JP (1) JP2000309586A (de)
AT (1) ATE303381T1 (de)
CA (1) CA2364749A1 (de)
DE (1) DE60022316T2 (de)
WO (1) WO2000050420A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010053757A1 (en) 2008-10-29 2010-05-14 Gilead Palo Alto, Inc. 2 -oxoquinoxalin blockers of the late sodium channel
WO2010074807A1 (en) 2008-10-30 2010-07-01 Gilead Palo Alto, Inc. 3, 4-dihydroquinolin-2 ( 1h ) -one derivatives as sodium channel modulators

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268380A (en) * 1988-11-29 1993-12-07 Janssen Pharmaceutica N.V. (1H-azol-1-ylmethyl) substituted quinoline derivatives
WO1992011245A1 (en) * 1990-12-20 1992-07-09 Warner-Lambert Company 2-acylamido derivatives of 3,4-dihydro-3-oxo-quinoxaline having pharmaceutical activity
WO1994026737A1 (en) 1993-05-12 1994-11-24 Yamanouchi Pharmaceutical Co., Ltd. Imidazolylquinoxalinedione derivative and pharmaceutical composition thereof
JPH07165756A (ja) 1993-12-14 1995-06-27 Yamanouchi Pharmaceut Co Ltd ヒドロキシキノキサリンジオン誘導体
DE19624808A1 (de) * 1996-06-21 1998-01-02 Basf Ag Pyrrolylchinoxalindione, ihre Herstellung und Verwendung
JPH11130756A (ja) * 1997-09-01 1999-05-18 Kyorin Pharmaceut Co Ltd ７−アリールキノキサリンカルボン酸誘導体とその付加塩及びそれらの製造方法
AU744540B2 (en) 1997-09-01 2002-02-28 Kyorin Pharmaceutical Co. Ltd. 6,7-asymmetrically disubstituted quinoxalinecarboxylic acid derivatives, addition salts thereof, and processes for the preparation of both

Also Published As

Publication number Publication date
US6632813B1 (en) 2003-10-14
ATE303381T1 (de) 2005-09-15
WO2000050420A1 (fr) 2000-08-31
EP1156047A4 (de) 2002-05-15
EP1156047A1 (de) 2001-11-21
DE60022316T2 (de) 2006-06-29
EP1156047B1 (de) 2005-08-31
JP2000309586A (ja) 2000-11-07
CA2364749A1 (en) 2000-08-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee