DE60013939D1 - Stereoselektive Transaminase, deren kodierende Gen und deren Verwendungen - Google Patents

Stereoselektive Transaminase, deren kodierende Gen und deren Verwendungen

Info

Publication number
DE60013939D1
DE60013939D1 DE60013939T DE60013939T DE60013939D1 DE 60013939 D1 DE60013939 D1 DE 60013939D1 DE 60013939 T DE60013939 T DE 60013939T DE 60013939 T DE60013939 T DE 60013939T DE 60013939 D1 DE60013939 D1 DE 60013939D1
Authority
DE
Germany
Prior art keywords
coding gene
stereoselective transaminase
stereoselective
transaminase
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60013939T
Other languages
English (en)
Other versions
DE60013939T2 (de
Inventor
Yoshiki Takashima
Satoshi Mitsuda
Marco Wieser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Application granted granted Critical
Publication of DE60013939D1 publication Critical patent/DE60013939D1/de
Publication of DE60013939T2 publication Critical patent/DE60013939T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/009—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving hydantoins or carbamoylamino compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DE60013939T 1999-03-19 2000-03-14 Stereoselektive Transaminase, deren kodierende Gen und deren Verwendungen Expired - Lifetime DE60013939T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP7551199 1999-03-19
JP7551199 1999-03-19
JP8863499 1999-03-30
JP8863499 1999-03-30

Publications (2)

Publication Number Publication Date
DE60013939D1 true DE60013939D1 (de) 2004-10-28
DE60013939T2 DE60013939T2 (de) 2005-10-06

Family

ID=26416636

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60013939T Expired - Lifetime DE60013939T2 (de) 1999-03-19 2000-03-14 Stereoselektive Transaminase, deren kodierende Gen und deren Verwendungen

Country Status (4)

Country Link
US (2) US6413752B1 (de)
EP (1) EP1038953B1 (de)
AT (1) ATE277170T1 (de)
DE (1) DE60013939T2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7202070B2 (en) * 2000-10-31 2007-04-10 Biocatalytics, Inc. Method for reductive amination of a ketone using a mutated enzyme
US20050009151A1 (en) * 2003-07-10 2005-01-13 Pharmacia Corporation Methods for the stereospecific and enantiomeric enrichment of beta-amino acids
DE202004014986U1 (de) * 2004-09-25 2006-02-02 A & M Electric Tools Gmbh Umlaufrädergetriebe
US7172885B2 (en) * 2004-12-10 2007-02-06 Cambrex North Brunswick, Inc. Thermostable omega-transaminases
US8586398B2 (en) * 2008-01-18 2013-11-19 Miasole Sodium-incorporation in solar cell substrates and contacts
CN102341494B (zh) 2009-01-08 2014-10-15 科德克希思公司 转氨酶多肽
JP5707344B2 (ja) * 2009-02-26 2015-04-30 コデクシス， インコーポレイテッド トランスアミナーゼ生体触媒
SG177329A1 (en) 2009-06-22 2012-02-28 Codexis Inc Transaminase reactions
MX2012002561A (es) 2009-09-02 2012-04-10 Lonza Ag Un proceso para la identificacion y preparacion de una omega-transaminasa (r)-especifica.
US8852900B2 (en) 2010-06-17 2014-10-07 Codexis, Inc. Biocatalysts and methods for the synthesis of (S)-3-(1-aminoethyl)-phenol
CN103189519B (zh) 2010-07-14 2018-01-26 DPx控股有限公司 (r)‑选择性胺化
WO2014037376A1 (en) 2012-09-04 2014-03-13 C5 Ligno Technologies In Lund Ab Stereoselective biosynthesis in microbial host cells
CN109234327A (zh) * 2017-07-11 2019-01-18 上海弈柯莱生物医药科技有限公司 一种立体选择性的转氨酶在不对称合成手性胺中的应用
EP4050100A4 (de) * 2019-10-25 2022-11-09 Asymchem Laboratories (Fuxin) Co., Ltd. Transaminase-mutant und verwendung davon
CN113881720B (zh) * 2020-12-31 2023-08-25 上海合全药物研发有限公司 一种转氨酶及使用其进行催化制备的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522630A (en) * 1978-08-07 1980-02-18 Mitsui Toatsu Chem Inc Preparation of alpha-phenylethylamine
JPS60248647A (ja) * 1984-05-25 1985-12-09 Yamakawa Yakuhin Kogyo Kk α−フエニルエチルアミンの製造法
JPS61187786A (ja) 1985-02-14 1986-08-21 Daicel Chem Ind Ltd 耐熱性ｄ−アミノ酸トランスアミナ−ゼ
US4950606A (en) * 1989-06-22 1990-08-21 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
EP0857790B1 (de) 1995-10-23 2005-08-17 Kaneka Corporation Verfahren zur herstellung optisch aktiver aminoverbindungen
JPH10165194A (ja) 1996-12-12 1998-06-23 Sumitomo Chem Co Ltd 光学純度の向上方法
DE69841075D1 (de) 1997-04-23 2009-10-01 Kaneka Corp Deoxynukleinsäure welche ein Polypeptid mit stereoselektiver Transaminase Aktivität kodiert, sowie die Deoxynukleinsäure enthaltende Transformanden
CA2322605A1 (en) * 1998-03-11 1999-09-16 Celgro Improvements in the enzymatic synthesis of chiral amines
US6346402B1 (en) * 1998-10-30 2002-02-12 Kaneka Corporation (S)-α-phenethylamine: pyruvate transaminase

Also Published As

Publication number Publication date
ATE277170T1 (de) 2004-10-15
US6413752B1 (en) 2002-07-02
US6727083B2 (en) 2004-04-27
DE60013939T2 (de) 2005-10-06
EP1038953A1 (de) 2000-09-27
EP1038953B1 (de) 2004-09-22
US20020127664A1 (en) 2002-09-12

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: SUMITOMO CHEMICAL CO. LTD., TOKIO/TOKYO, JP

8364 No opposition during term of opposition