DE60011241D1 - Neue diazol-derivate und ihre verwendung als serotonergische wirkstoffe - Google Patents

Neue diazol-derivate und ihre verwendung als serotonergische wirkstoffe

Info

Publication number
DE60011241D1
DE60011241D1 DE60011241T DE60011241T DE60011241D1 DE 60011241 D1 DE60011241 D1 DE 60011241D1 DE 60011241 T DE60011241 T DE 60011241T DE 60011241 T DE60011241 T DE 60011241T DE 60011241 D1 DE60011241 D1 DE 60011241D1
Authority
DE
Germany
Prior art keywords
alkyl
optionally substituted
new
active substances
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60011241T
Other languages
English (en)
Other versions
DE60011241T2 (de
Inventor
Louise Sabb
Lewis Vogel
Gerard Kelly
Latko Palmer
Everett Childers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of DE60011241D1 publication Critical patent/DE60011241D1/de
Application granted granted Critical
Publication of DE60011241T2 publication Critical patent/DE60011241T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
DE60011241T 1999-03-03 2000-03-01 Neue diazol-derivate und ihre verwendung als serotonergische wirkstoffe Expired - Fee Related DE60011241T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26134399A 1999-03-03 1999-03-03
US261343 1999-03-03
PCT/US2000/005240 WO2000051999A1 (en) 1999-03-03 2000-03-01 New diazole derivatives as serotonergic agents

Publications (2)

Publication Number Publication Date
DE60011241D1 true DE60011241D1 (de) 2004-07-08
DE60011241T2 DE60011241T2 (de) 2005-06-30

Family

ID=22992878

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60011241T Expired - Fee Related DE60011241T2 (de) 1999-03-03 2000-03-01 Neue diazol-derivate und ihre verwendung als serotonergische wirkstoffe

Country Status (11)

Country Link
EP (1) EP1161424B1 (de)
JP (1) JP2002538152A (de)
CN (1) CN1164580C (de)
AT (1) ATE268328T1 (de)
AU (1) AU3247800A (de)
CA (1) CA2361179A1 (de)
DE (1) DE60011241T2 (de)
DK (1) DK1161424T3 (de)
ES (1) ES2220422T3 (de)
PT (1) PT1161424E (de)
WO (1) WO2000051999A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003517468A (ja) * 1999-11-12 2003-05-27 ワイス セロトニン５−ｈｔ１ａ活性を有する分枝アダマンチルおよびノルアダマチルアリール−およびアラルキルピペラジン
US6974818B2 (en) * 2002-03-01 2005-12-13 Euro-Celtique S.A. 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain
US7067518B2 (en) 2002-09-05 2006-06-27 Wyeth Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents
WO2004083235A2 (en) * 2003-03-19 2004-09-30 Exelixis Inc. Tie-2 modulators and methods of use
KR100997549B1 (ko) 2005-08-15 2010-11-30 에프. 호프만-라 로슈 아게 Ｐ2ｘ3 길항제로서의 피페리딘 및 피페라진 유도체
AU2012280420B2 (en) * 2011-07-01 2017-01-05 Remynd Nv 1, 2, 4 -thiadiazol- 5 -ylpiperazine derivatives useful in the treatment neurodegenerative diseases
US8822527B2 (en) 2011-10-17 2014-09-02 Biotheryx, Inc. Substituted biaryl alkyl amides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4539318A (en) * 1984-06-04 1985-09-03 Merck & Co., Inc. Tertiary aminohydroxypropoxy substituted thiadiazoles, pharmaceutical compositions and use
IE911774A1 (en) * 1990-06-11 1991-12-18 Akzo Nv Pyridinylpiperazine derivatives
DK60493D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
EP0888355A1 (de) * 1996-03-19 1999-01-07 Novo Nordisk A/S Heterocyclische verbindungen und ihre herstelung und verwendung

Also Published As

Publication number Publication date
PT1161424E (pt) 2004-08-31
DK1161424T3 (da) 2004-09-13
EP1161424B1 (de) 2004-06-02
EP1161424A1 (de) 2001-12-12
WO2000051999A1 (en) 2000-09-08
AU3247800A (en) 2000-09-21
CN1349520A (zh) 2002-05-15
JP2002538152A (ja) 2002-11-12
ATE268328T1 (de) 2004-06-15
CN1164580C (zh) 2004-09-01
ES2220422T3 (es) 2004-12-16
CA2361179A1 (en) 2000-09-08
DE60011241T2 (de) 2005-06-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee