DE60010476D1 - Verfahren zur Herstellung eines C-4-Methylcarbonat-Analogons von Paclitaxel - Google Patents

Verfahren zur Herstellung eines C-4-Methylcarbonat-Analogons von Paclitaxel

Info

Publication number
DE60010476D1
DE60010476D1 DE60010476T DE60010476T DE60010476D1 DE 60010476 D1 DE60010476 D1 DE 60010476D1 DE 60010476 T DE60010476 T DE 60010476T DE 60010476 T DE60010476 T DE 60010476T DE 60010476 D1 DE60010476 D1 DE 60010476D1
Authority
DE
Germany
Prior art keywords
methyl carbonate
paclitaxel
preparation
carbonate analogue
analogue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60010476T
Other languages
English (en)
Other versions
DE60010476T2 (de
Inventor
Joydeep Kant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DE60010476D1 publication Critical patent/DE60010476D1/de
Publication of DE60010476T2 publication Critical patent/DE60010476T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
DE60010476T 1999-08-11 2000-08-03 Verfahren zur Herstellung eines C-4-Methylcarbonat-Analogons von Paclitaxel Expired - Fee Related DE60010476T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14839299P 1999-08-11 1999-08-11
US148392P 1999-08-11
PCT/US2000/021260 WO2001010856A1 (en) 1999-08-11 2000-08-03 Process for the preparation of a paclitaxel c-4 methyl carbonate analog

Publications (2)

Publication Number Publication Date
DE60010476D1 true DE60010476D1 (de) 2004-06-09
DE60010476T2 DE60010476T2 (de) 2005-04-14

Family

ID=22525581

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60010476T Expired - Fee Related DE60010476T2 (de) 1999-08-11 2000-08-03 Verfahren zur Herstellung eines C-4-Methylcarbonat-Analogons von Paclitaxel

Country Status (18)

Country Link
US (2) US6248908B1 (de)
EP (1) EP1206461B8 (de)
JP (1) JP2003506446A (de)
KR (1) KR100634249B1 (de)
AT (1) ATE266015T1 (de)
AU (1) AU769858B2 (de)
CA (1) CA2381401A1 (de)
DE (1) DE60010476T2 (de)
DK (1) DK1206461T3 (de)
ES (1) ES2219372T3 (de)
HU (1) HUP0202448A3 (de)
IL (2) IL147851A0 (de)
MX (1) MXPA02001396A (de)
PE (1) PE20010493A1 (de)
PT (1) PT1206461E (de)
TW (1) TWI269792B (de)
UY (1) UY26284A1 (de)
WO (1) WO2001010856A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6916942B2 (en) * 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
US6750246B1 (en) 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
HUP0302599A3 (en) * 2000-09-22 2005-05-30 Bristol Myers Squibb Co Method for reducing toxicity of combined chemotherapic compositions
RU2004119557A (ru) * 2001-12-20 2005-04-20 Бристол-Маерс Сквибб Компани (Us) Фармацевтические композиции перорально активных производных таксана с повышенной биодоступностью
US20070105944A1 (en) * 2002-10-25 2007-05-10 Comezoglu S N Taxane metabolites
WO2005070414A1 (en) * 2004-01-14 2005-08-04 Virginia Tech Intellectual Properties, Inc. Conformationally constrained paclitaxel analogs and their use as anticancer and anti-alzheimers agents
GB0521373D0 (en) 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
PL217731B1 (pl) 2006-06-01 2014-08-29 Tomasz Byrski Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi
UY30639A1 (es) 2006-10-17 2008-05-31 Kudos Pharm Ltd Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
US20080280910A1 (en) * 2007-03-22 2008-11-13 Keith Allan Menear Phthalazinone derivatives
CN102238945B (zh) 2008-10-07 2014-10-29 阿斯利康(英国)有限公司 药物制剂514

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE34277E (en) 1988-04-06 1993-06-08 Centre National De La Recherche Scientifique Process for preparing taxol
US5274124A (en) 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US5990325A (en) * 1993-03-05 1999-11-23 Florida State University Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof
US5399726A (en) * 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
SE470504B (sv) * 1992-10-27 1994-06-06 Ellemtel Utvecklings Ab Sätt att i ett GSM-nät ta emot data för tilläggstjänster i MSC/VLR.
CA2119261C (en) * 1992-12-23 2006-01-31 Michael A. Poss Novel sidechain-bearing taxanes and intermediates thereof
WO1998002426A1 (fr) * 1996-07-15 1998-01-22 Kabushiki Kaisha Yakult Honsha Derives de taxane et medicaments les contenant

Also Published As

Publication number Publication date
UY26284A1 (es) 2001-03-16
PE20010493A1 (es) 2001-07-06
KR20020031405A (ko) 2002-05-01
DE60010476T2 (de) 2005-04-14
EP1206461B8 (de) 2004-07-21
DK1206461T3 (da) 2004-08-16
CA2381401A1 (en) 2001-02-15
EP1206461A4 (de) 2003-03-26
EP1206461B1 (de) 2004-05-06
US6353120B2 (en) 2002-03-05
KR100634249B1 (ko) 2006-10-17
TWI269792B (en) 2007-01-01
JP2003506446A (ja) 2003-02-18
MXPA02001396A (es) 2002-08-12
ES2219372T3 (es) 2004-12-01
HUP0202448A3 (en) 2005-02-28
US6248908B1 (en) 2001-06-19
WO2001010856A1 (en) 2001-02-15
ATE266015T1 (de) 2004-05-15
IL168553A (en) 2007-07-04
EP1206461A1 (de) 2002-05-22
IL147851A0 (en) 2002-08-14
AU6516900A (en) 2001-03-05
HUP0202448A2 (hu) 2002-11-28
US20010044549A1 (en) 2001-11-22
PT1206461E (pt) 2004-09-30
AU769858B2 (en) 2004-02-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee