DE60008508D1 - Agglomerate durch kristallisation - Google Patents
Agglomerate durch kristallisationInfo
- Publication number
- DE60008508D1 DE60008508D1 DE60008508T DE60008508T DE60008508D1 DE 60008508 D1 DE60008508 D1 DE 60008508D1 DE 60008508 T DE60008508 T DE 60008508T DE 60008508 T DE60008508 T DE 60008508T DE 60008508 D1 DE60008508 D1 DE 60008508D1
- Authority
- DE
- Germany
- Prior art keywords
- crystalization
- agglomerate
- lactum
- agglomerates
- solvents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99201034 | 1999-04-01 | ||
EP99201034 | 1999-04-01 | ||
EP00917035A EP1165049B2 (de) | 1999-04-01 | 2000-04-03 | Agglomerate durch kristallisation |
PCT/EP2000/002917 WO2000041478A2 (en) | 1999-04-01 | 2000-04-03 | Agglomerates by crystallisation |
Publications (4)
Publication Number | Publication Date |
---|---|
DE60008508D1 true DE60008508D1 (de) | 2004-04-01 |
DE60008508T2 DE60008508T2 (de) | 2004-12-23 |
DE60008508T3 DE60008508T3 (de) | 2012-01-19 |
DE60008508T9 DE60008508T9 (de) | 2012-06-14 |
Family
ID=8240058
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60008508T Active DE60008508T9 (de) | 1999-04-01 | 2000-04-03 | Agglomerate durch kristallisation |
Country Status (12)
Country | Link |
---|---|
US (3) | US6979735B1 (de) |
EP (1) | EP1165049B2 (de) |
CN (1) | CN1209099C (de) |
AT (1) | ATE260096T1 (de) |
AU (1) | AU3817300A (de) |
CA (1) | CA2364342C (de) |
DE (1) | DE60008508T9 (de) |
ES (1) | ES2215628T5 (de) |
MX (1) | MXPA01009808A (de) |
SI (1) | SI1165049T2 (de) |
TR (1) | TR200102771T2 (de) |
WO (1) | WO2000041478A2 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7250176B1 (en) * | 1999-04-13 | 2007-07-31 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection |
US6878386B1 (en) | 1999-04-13 | 2005-04-12 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate |
US6294199B1 (en) | 1999-04-13 | 2001-09-25 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection comprising administering amoxycillin |
DE60108154T2 (de) * | 2000-10-20 | 2005-12-22 | Sandoz Ag | Pharmazeutische Zubereitungen enthaltend Clavulansäure |
GB0031267D0 (en) * | 2000-12-21 | 2001-01-31 | Smithkline Beecham Plc | Novel compositions |
US20040132712A1 (en) * | 2001-04-12 | 2004-07-08 | Otto Damon | Pharmaceutical compositions comprising clavulanic acid |
AT500131A1 (de) * | 2002-02-01 | 2005-11-15 | Sandoz Ag | Organische verbindungen |
AT500132A1 (de) * | 2002-02-06 | 2005-11-15 | Sandoz Ag | Organische verbindungen |
AT500134A1 (de) * | 2002-02-01 | 2005-11-15 | Sandoz Ag | Verfahren zur herstellung eines entmischungsstabilen granulats |
AT500133A1 (de) * | 2002-02-06 | 2005-11-15 | Sandoz Ag | Verfahren zur herstellung eines entmischungsstabilen granulats |
US7534781B2 (en) | 2003-03-21 | 2009-05-19 | Dsm Ip Assets B.V. | Crystalline amoxicillin trihydrate powder |
CN1761457B (zh) * | 2003-03-21 | 2010-05-12 | 帝斯曼知识产权资产管理有限公司 | 三水羟氨苄青霉素 |
CA2552632A1 (en) * | 2004-01-06 | 2005-07-21 | Panacea Biotec Ltd. | Controlled release pharmaceutical composition comprising an acid-insoluble polymer and a bioadhesive polymer |
US10130678B2 (en) | 2014-12-29 | 2018-11-20 | Bioventus, LLC. | Systems and methods for improved delivery of osteoinductive molecules in bone repair |
CN108905264A (zh) * | 2018-07-17 | 2018-11-30 | 凯莱英医药集团(天津)股份有限公司 | 连续化结晶方法在β-内酰胺类抗生素合成中的应用及连续化结晶系统 |
US11905286B2 (en) | 2018-08-09 | 2024-02-20 | Antabio Sas | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3697506A (en) * | 1970-08-07 | 1972-10-10 | Pfizer | Crystalline alkali metal salts of {60 -carboxybenzylpenicillin and process therefor |
US3692781A (en) * | 1971-02-26 | 1972-09-19 | Glaxo Lab Ltd | Recovery of pure cephalexin from acidic reaction mixtures |
US4138555A (en) * | 1971-05-14 | 1979-02-06 | Glaxo Laboratories, Limited | (6R,7R)-7-[2-aryl-2-(etherified oximino)acetamido]-3-carbamoyloxymethylceph-3-em-4-carboxylic acid 1-oxides |
AR206201A1 (es) * | 1972-06-29 | 1976-07-07 | Ciba Geigy Ag | Procedimiento para la obtencion de compuestos de acido 7beta-amino-3-cefem-3-01-4-carboxilico0-substituidos |
US3932386A (en) * | 1973-06-18 | 1976-01-13 | American Home Products Corporation | Sodium 6-(L-aminocyclohexane carboxamido)penicillanic acid |
GB1563103A (en) * | 1975-10-13 | 1980-03-19 | Beecham Group Ltd | Process for the preparation of clavulanic acid |
NZ189022A (en) * | 1977-12-08 | 1981-11-19 | Beecham Group Ltd | Pharmaceutically acceptable particles of clavulanates dispersed in a polymeric binder |
US4454069A (en) * | 1979-08-24 | 1984-06-12 | Beecham Group Limited | Clavulanic acid salts and their preparation from the tertiary butyl amine salt |
NZ199061A (en) * | 1980-12-09 | 1984-10-19 | Beecham Group Ltd | 9-(n-tetrazolyl)-deoxyclavulanic acids,salts,esters,and pharmaceutical compositions |
US4522701A (en) * | 1982-02-11 | 1985-06-11 | E. I. Du Pont De Nemours And Company | Process for preparing an anisotropic aromatic pitch |
US4456753A (en) * | 1983-02-07 | 1984-06-26 | Pfizer Inc. | Process for the manufacture of highly crystalline sodium cefoperazone |
DE3314725A1 (de) * | 1983-04-22 | 1984-10-25 | Siemens AG, 1000 Berlin und 8000 München | Oberflaechenwellen-resonatorfilter |
US4659812A (en) * | 1985-08-20 | 1987-04-21 | Bristol-Myers Company | Cephalosporin intermediates |
GB8608962D0 (en) * | 1986-04-12 | 1986-05-14 | Beecham Group Plc | Beta-lactam antibiotics |
US5288861A (en) * | 1987-01-29 | 1994-02-22 | Beecham Group Plc | Potassium clavulanate in rosette form |
CA1326486C (en) * | 1987-01-29 | 1994-01-25 | Dennis Edward Clark | Potassium clavulanate |
WO1991000865A1 (en) | 1989-07-10 | 1991-01-24 | Gema S.A. | A novel stable form of cephradine, process for its production and intermediates used therein |
GB9009473D0 (en) | 1990-04-27 | 1990-06-20 | Beecham Group Plc | Pharmaceutical formulation |
RU2043988C1 (ru) * | 1991-02-12 | 1995-09-20 | Плива Хандельс ГмбХ | 4-оксоазетидин-2-сульфоновые кислоты или их соли в качестве промежуточных продуктов в синтезе бета-лактамовых антибиотиков и способ их получения |
GB9109862D0 (en) | 1991-05-08 | 1991-07-03 | Beecham Lab Sa | Pharmaceutical formulations |
AT400033B (de) * | 1992-03-10 | 1995-09-25 | Biochemie Gmbh | Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben |
AT401871B (de) † | 1994-01-28 | 1996-12-27 | Gebro Broschek Gmbh | Verfahren zur herstellung von s(+)-ibuprofen- partikeln mit verbesserten fliesseigenschaften und deren verwendung zur arzneimittelherstellung |
SI9400107A (en) * | 1994-03-02 | 1995-10-31 | Lek Tovarna Farmacevtskih | New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. |
GB9408117D0 (en) | 1994-04-23 | 1994-06-15 | Smithkline Beecham Corp | Pharmaceutical formulations |
DE4426973C1 (de) * | 1994-07-29 | 1996-03-28 | Degussa | Verfahren zur Herstellung eines als Brennstoffzellenelektrode einsetzbaren Plattinlegierungskatalysators |
TWI225402B (en) * | 1996-03-13 | 2004-12-21 | Biochemie Gmbh | Auxiliary-free agglomerates |
ZA975198B (en) * | 1996-06-13 | 1997-12-15 | Smithkline Beecham Corp | Improved process for preparing potassium clavulanate. |
US6242006B1 (en) | 1996-07-16 | 2001-06-05 | Gist-Brocades B.V. | β-lactam granules free of organic solvents |
GB9616536D0 (en) | 1996-08-06 | 1996-09-25 | Quadrant Holdings Cambridge | Co-amoxiclav dosage form |
EP0937084A1 (de) * | 1996-11-11 | 1999-08-25 | Gist-Brocades B.V. | Verfahren zur herstellung von clavulansäure-salzen und estern |
ATE187498T1 (de) * | 1997-03-24 | 1999-12-15 | Cipan Comp Ind Prod | Verfahren zur isolierung eines pharmazeutisch verträglichen alkalimetallsalzes der clavulansäure |
EP1023065A1 (de) | 1997-08-29 | 2000-08-02 | Dsm N.V. | Zusatzfreie granulate |
-
2000
- 2000-04-03 TR TR2001/02771T patent/TR200102771T2/xx unknown
- 2000-04-03 MX MXPA01009808A patent/MXPA01009808A/es active IP Right Grant
- 2000-04-03 EP EP00917035A patent/EP1165049B2/de not_active Expired - Lifetime
- 2000-04-03 US US09/937,834 patent/US6979735B1/en not_active Expired - Fee Related
- 2000-04-03 ES ES00917035T patent/ES2215628T5/es not_active Expired - Lifetime
- 2000-04-03 AT AT00917035T patent/ATE260096T1/de active
- 2000-04-03 AU AU38173/00A patent/AU3817300A/en not_active Abandoned
- 2000-04-03 WO PCT/EP2000/002917 patent/WO2000041478A2/en active IP Right Grant
- 2000-04-03 SI SI200030366T patent/SI1165049T2/sl unknown
- 2000-04-03 CA CA2364342A patent/CA2364342C/en not_active Expired - Fee Related
- 2000-04-03 CN CNB008057117A patent/CN1209099C/zh not_active Expired - Fee Related
- 2000-04-03 DE DE60008508T patent/DE60008508T9/de active Active
-
2005
- 2005-11-30 US US11/290,185 patent/US20060079496A1/en not_active Abandoned
-
2010
- 2010-03-26 US US12/748,167 patent/US20110045082A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE60008508T9 (de) | 2012-06-14 |
SI1165049T2 (sl) | 2011-11-30 |
ES2215628T3 (es) | 2004-10-16 |
CN1345231A (zh) | 2002-04-17 |
MXPA01009808A (es) | 2002-04-24 |
EP1165049A2 (de) | 2002-01-02 |
EP1165049B2 (de) | 2011-07-06 |
SI1165049T1 (en) | 2004-12-31 |
US20110045082A1 (en) | 2011-02-24 |
TR200102771T2 (tr) | 2002-04-22 |
US20060079496A1 (en) | 2006-04-13 |
US6979735B1 (en) | 2005-12-27 |
DE60008508T3 (de) | 2012-01-19 |
AU3817300A (en) | 2000-08-01 |
CA2364342A1 (en) | 2000-07-20 |
EP1165049B1 (de) | 2004-02-25 |
CN1209099C (zh) | 2005-07-06 |
ES2215628T5 (es) | 2011-11-28 |
CA2364342C (en) | 2011-02-01 |
ATE260096T1 (de) | 2004-03-15 |
DE60008508T2 (de) | 2004-12-23 |
WO2000041478A3 (en) | 2000-11-02 |
WO2000041478A2 (en) | 2000-07-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
R102 | Epo decision maintaining patent in amended form now final |
Ref document number: 1165049 Country of ref document: EP Effective date: 20110706 |
|
R082 | Change of representative |
Ref document number: 1165049 Country of ref document: EP Representative=s name: DIEHL & PARTNER GBR, 80333 MUENCHEN, DE |
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R081 | Change of applicant/patentee |
Ref document number: 1165049 Country of ref document: EP Owner name: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V., NL Free format text: FORMER OWNER: DSM IP ASSETS B.V., HEERLEN, NL Effective date: 20120515 |
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R082 | Change of representative |
Ref document number: 1165049 Country of ref document: EP Representative=s name: DIEHL & PARTNER GBR, DE Effective date: 20120515 |