DE60007841D1 - Neue azabicyclo derivate und ihre verwendung - Google Patents

Neue azabicyclo derivate und ihre verwendung

Info

Publication number
DE60007841D1
DE60007841D1 DE60007841T DE60007841T DE60007841D1 DE 60007841 D1 DE60007841 D1 DE 60007841D1 DE 60007841 T DE60007841 T DE 60007841T DE 60007841 T DE60007841 T DE 60007841T DE 60007841 D1 DE60007841 D1 DE 60007841D1
Authority
DE
Germany
Prior art keywords
derivatives
azabicyclo derivatives
new
new azabicyclo
labelled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60007841T
Other languages
English (en)
Other versions
DE60007841T2 (de
Inventor
Dan Peters
Joergen Scheel-Krueger
Elsebet Oestergaard Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Application granted granted Critical
Publication of DE60007841D1 publication Critical patent/DE60007841D1/de
Publication of DE60007841T2 publication Critical patent/DE60007841T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60007841T 1999-01-28 2000-01-28 Neue azabicyclo derivate und ihre verwendung Expired - Lifetime DE60007841T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DK99106 1999-01-28
DKPA199900106 1999-01-28
DK99950 1999-07-01
DKPA199900950 1999-07-01
PCT/DK2000/000038 WO2000044746A1 (en) 1999-01-28 2000-01-28 Novel azabicyclo derivatives and their use

Publications (2)

Publication Number Publication Date
DE60007841D1 true DE60007841D1 (de) 2004-02-26
DE60007841T2 DE60007841T2 (de) 2004-07-08

Family

ID=26063317

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60007841T Expired - Lifetime DE60007841T2 (de) 1999-01-28 2000-01-28 Neue azabicyclo derivate und ihre verwendung

Country Status (6)

Country Link
US (1) US6617459B2 (de)
EP (1) EP1149095B1 (de)
AT (1) ATE258176T1 (de)
AU (1) AU2278700A (de)
DE (1) DE60007841T2 (de)
WO (1) WO2000044746A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7307087B2 (en) * 2000-10-13 2007-12-11 Neurosearch A/S Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance
WO2005121796A2 (en) * 2004-05-07 2005-12-22 The Regents Of The University Of California Method for detecting alzheimer’s disease and other forms of dementia, and measuring their progression
CA2577084A1 (en) 2004-08-25 2006-03-02 Olivier Bezencon Bicyclononene derivatives as renin inhibitors
BRPI0519382A2 (pt) * 2004-12-22 2009-01-20 Neurosearch As composto, composiÇço farmacÊutica, uso do composto, e, mÉtodo para o tratamento, a prevenÇço ou o alÍvio de uma doenÇa ou de um distérbio ou de uma condiÇço de um corpo de animal vivo
AU2006233884A1 (en) * 2005-04-08 2006-10-19 Neurosearch A/S (+) - and (-) -8-alkyl-3-(trifluoralkylsulfonyloxy)-8-azabicycl (3.2.1.)oct-2-ene
EP1728520A1 (de) * 2005-05-04 2006-12-06 Charité - Universitätsmedizin Berlin Verwendung von spezifisch an das Serotonin-Transport-Protein (SERT) bindenden Radiopharmaka zur Herstellung eines Diagnostikums zur Untersuchung von Kopfschmerzerkrankungen
WO2006117218A2 (en) * 2005-05-04 2006-11-09 Charite Universitätsmedizin - Berlin Serotonin-transport-protein binding radiopharmaceutical for the production of a diagnostic medicament for the diagnosis of headache
US8114382B2 (en) * 2006-12-11 2012-02-14 General Electric Company Myelin detection using benzofuran derivatives
AU2010286595A1 (en) * 2009-08-28 2012-02-23 NEBA Health, LLC. Systems and methods to identify a subgroup of ADHD at higher risk for complicating conditions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3509161A (en) * 1967-07-10 1970-04-28 Boehringer & Soehne Gmbh 3-phenyl-granatene-(2)-derivatives
GB9507203D0 (en) * 1995-04-07 1995-05-31 Smithkline Beecham Plc Novel compounds
DK0859777T3 (da) * 1995-10-13 2007-09-03 Neurosearch As 8-azabicyclo[3.2.1]oct-2-en-derivater, deres fremstilling og anvendelse
GB9706222D0 (en) * 1997-03-26 1997-05-14 Zeneca Ltd Bicyclic amine derivatives
ATE231861T1 (de) * 1997-05-30 2003-02-15 Neurosearch As 9-azabicyclo(3.3.1)non-2-ene und nonanderivate als liganden der nicotinergen rezeptoren
DK0984965T3 (da) * 1997-05-30 2004-09-27 Neurosearch As 8-azabicyclo[3.2.1]oct-2-enderivater som cholinerge ligander ved nikotin-ACh-receptorer
WO1999038866A1 (en) * 1998-01-28 1999-08-05 Neurosearch A/S 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled form and use of 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled and unlabelled form

Also Published As

Publication number Publication date
EP1149095A1 (de) 2001-10-31
ATE258176T1 (de) 2004-02-15
US6617459B2 (en) 2003-09-09
US20010047028A1 (en) 2001-11-29
AU2278700A (en) 2000-08-18
DE60007841T2 (de) 2004-07-08
EP1149095B1 (de) 2004-01-21
WO2000044746A1 (en) 2000-08-03

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Legal Events

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