DE60004768D1 - Komplexe von paroxetin mit cyclodextrin oder cyclodextrin derivaten - Google Patents

Komplexe von paroxetin mit cyclodextrin oder cyclodextrin derivaten

Info

Publication number
DE60004768D1
DE60004768D1 DE60004768T DE60004768T DE60004768D1 DE 60004768 D1 DE60004768 D1 DE 60004768D1 DE 60004768 T DE60004768 T DE 60004768T DE 60004768 T DE60004768 T DE 60004768T DE 60004768 D1 DE60004768 D1 DE 60004768D1
Authority
DE
Germany
Prior art keywords
cyclodextrin
paroxetine
complexes
derivatives
oral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60004768T
Other languages
English (en)
Other versions
DE60004768T2 (de
Inventor
Paolo Mascagni
Giuseppe Bottoni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Italfarmaco SpA
Original Assignee
Italfarmaco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT1999MI001459A external-priority patent/ITMI991459A1/it
Priority claimed from IT99MI002406 external-priority patent/IT1314232B1/it
Application filed by Italfarmaco SpA filed Critical Italfarmaco SpA
Publication of DE60004768D1 publication Critical patent/DE60004768D1/de
Application granted granted Critical
Publication of DE60004768T2 publication Critical patent/DE60004768T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Materials Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE60004768T 1999-07-01 2000-06-30 Komplexe von paroxetin mit cyclodextrin oder cyclodextrin derivaten Expired - Lifetime DE60004768T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IT1999MI001459A ITMI991459A1 (it) 1999-07-01 1999-07-01 Complessi di sali di paroxetina con ciclodestrine
ITMI991459 1999-07-01
IT99MI002406 IT1314232B1 (it) 1999-11-17 1999-11-17 Complessi di paroxetina base con ciclodestrine o derivati delleciclodestrine.
ITMI992406 1999-11-17
PCT/EP2000/006121 WO2001002393A1 (en) 1999-07-01 2000-06-30 Complexes of paroxetine, with cyclodextrins or cyclodextrin derivatives

Publications (2)

Publication Number Publication Date
DE60004768D1 true DE60004768D1 (de) 2003-10-02
DE60004768T2 DE60004768T2 (de) 2004-07-08

Family

ID=26331667

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60004768T Expired - Lifetime DE60004768T2 (de) 1999-07-01 2000-06-30 Komplexe von paroxetin mit cyclodextrin oder cyclodextrin derivaten

Country Status (13)

Country Link
US (1) US6984632B1 (de)
EP (1) EP1109806B8 (de)
JP (1) JP2003503493A (de)
KR (1) KR100759159B1 (de)
AT (1) ATE248165T1 (de)
AU (1) AU5535900A (de)
BR (1) BR0006838A (de)
CA (1) CA2341984A1 (de)
DE (1) DE60004768T2 (de)
DK (1) DK1109806T3 (de)
ES (1) ES2206254T3 (de)
PT (1) PT1109806E (de)
WO (1) WO2001002393A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6699882B2 (en) 1998-03-24 2004-03-02 Smithkline Beecham P.L.C. Paroxetine compositions
AU2003903597A0 (en) * 2003-07-11 2003-07-24 Jakov Vaisman Treatment of premature ejaculation
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
US7658913B2 (en) * 2005-11-28 2010-02-09 Verrow Pharmaceuticals, Inc. Compositions useful for reducing nephrotoxicity and methods of use thereof
ES2743043T3 (es) * 2007-01-23 2020-02-18 Pharmagra Labs Inc Sulforafano estabilizado

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
DE3688827T2 (de) 1985-10-25 1994-03-31 Beecham Group Plc Piperidinderivat, seine Herstellung und seine Verwendung als Arzneimittel.
IL111184A (en) * 1993-10-08 2000-08-13 Farmarc Nederland B V Of Cito Crystalline inclusion complex of diclofenac with unsubstituted beta-cyclodextrin
CA2206592A1 (en) 1996-05-30 1997-11-30 Shu-Zhong Wang Method of producing amorphous paroxetine hydrochloride
US5672612A (en) 1996-09-09 1997-09-30 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
US6638948B1 (en) * 1996-09-09 2003-10-28 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
WO1998018827A1 (en) * 1996-10-28 1998-05-07 Farmarc Nederland B.V. Inclusion complexes of beta-2-andrenergics for oral mucosal delivery
JPH10167958A (ja) * 1996-12-09 1998-06-23 Sankyo Co Ltd ロキソプロフェンナトリウム類を含有する口腔内速溶性製剤及びその製造方法
JPH10194996A (ja) * 1996-12-25 1998-07-28 Janssen Pharmaceut Nv アシル化シクロデキストリン含有製薬組成物
WO1998031365A1 (en) 1997-01-15 1998-07-23 Smithkline Beecham Plc Paroxetine compositions
JP2001515473A (ja) * 1997-02-27 2001-09-18 ノボ ノルディスク アクティーゼルスカブ 包接複合体水溶液
HUP9700632A3 (en) * 1997-03-24 1999-10-28 Cyclolab Ciklodextrin Kutato F Pharmaceutical compositions containing propylamine derivative and cyclodextrine and process for producing the same
GB9711643D0 (en) * 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
ES2155995T3 (es) * 1997-06-10 2001-06-01 Synthon Bv Compuestos de 4-fenilpiperidina.
GB9724544D0 (en) 1997-11-21 1998-01-21 Smithkline Beecham Plc Novel Formulation
WO2000008016A1 (en) * 1998-08-08 2000-02-17 Smithkline Beecham Plc Paroxetine salts

Also Published As

Publication number Publication date
AU5535900A (en) 2001-01-22
BR0006838A (pt) 2001-08-07
CA2341984A1 (en) 2001-01-11
JP2003503493A (ja) 2003-01-28
KR20010072880A (ko) 2001-07-31
DE60004768T2 (de) 2004-07-08
ES2206254T3 (es) 2004-05-16
EP1109806A1 (de) 2001-06-27
KR100759159B1 (ko) 2007-09-14
DK1109806T3 (da) 2003-12-22
EP1109806B1 (de) 2003-08-27
PT1109806E (pt) 2004-02-27
US6984632B1 (en) 2006-01-10
EP1109806B8 (de) 2003-10-29
WO2001002393A1 (en) 2001-01-11
ATE248165T1 (de) 2003-09-15

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