DE60003006D1 - Mineralisierung und zelluläre strukturierung von biomaterialoberflächen - Google Patents

Mineralisierung und zelluläre strukturierung von biomaterialoberflächen

Info

Publication number
DE60003006D1
DE60003006D1 DE60003006T DE60003006T DE60003006D1 DE 60003006 D1 DE60003006 D1 DE 60003006D1 DE 60003006 T DE60003006 T DE 60003006T DE 60003006 T DE60003006 T DE 60003006T DE 60003006 D1 DE60003006 D1 DE 60003006D1
Authority
DE
Germany
Prior art keywords
mineralization
patterned
mineralized
biomaterial surfaces
tissue engineering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60003006T
Other languages
English (en)
Other versions
DE60003006T2 (de
Inventor
William L Murphy
Martin C Peters
J Mooney
H Kohn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan
Original Assignee
University of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan filed Critical University of Michigan
Publication of DE60003006D1 publication Critical patent/DE60003006D1/de
Application granted granted Critical
Publication of DE60003006T2 publication Critical patent/DE60003006T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Prostheses (AREA)
DE60003006T 1999-03-19 2000-03-17 Mineralisierung und zelluläre strukturierung von biomaterialoberflächen Expired - Lifetime DE60003006T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12511899P 1999-03-19 1999-03-19
US125118P 1999-03-19
US16728999P 1999-11-24 1999-11-24
US167289P 1999-11-24
PCT/US2000/007207 WO2000056375A2 (en) 1999-03-19 2000-03-17 Mineralization and cellular patterning on biomaterial surfaces

Publications (2)

Publication Number Publication Date
DE60003006D1 true DE60003006D1 (de) 2003-07-03
DE60003006T2 DE60003006T2 (de) 2004-04-01

Family

ID=26823278

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60003006T Expired - Lifetime DE60003006T2 (de) 1999-03-19 2000-03-17 Mineralisierung und zelluläre strukturierung von biomaterialoberflächen

Country Status (9)

Country Link
US (2) US6541022B1 (de)
EP (1) EP1163018B1 (de)
AT (1) ATE241397T1 (de)
AU (1) AU4173000A (de)
CA (1) CA2370063C (de)
DE (1) DE60003006T2 (de)
DK (1) DK1163018T3 (de)
ES (1) ES2199815T3 (de)
WO (1) WO2000056375A2 (de)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7427602B1 (en) 1998-05-13 2008-09-23 The Regents Of The University Of Michigan Sustained DNA delivery from structural matrices
US6541022B1 (en) * 1999-03-19 2003-04-01 The Regents Of The University Of Michigan Mineral and cellular patterning on biomaterial surfaces
US6767928B1 (en) * 1999-03-19 2004-07-27 The Regents Of The University Of Michigan Mineralization and biological modification of biomaterial surfaces
AU1622801A (en) * 1999-11-18 2001-05-30 Regents Of The University Of Michigan, The Sustained drug delivery from structural matrices
ATE359053T1 (de) * 2001-02-28 2007-05-15 Ezaki Glico Co Dentalmaterial gegen karies
AU2002251449B2 (en) * 2001-03-29 2008-01-31 Cellect Technologies Corp. Methods devices and systems for sorting and separating particles
US6703235B2 (en) * 2001-06-25 2004-03-09 Board Of Regents, The University Of Texas System Complex multicellular assemblies ex vivo
US7247609B2 (en) * 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
US6884432B2 (en) * 2002-04-25 2005-04-26 Mayo Foundation For Medical Education And Research Blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery
WO2004056321A2 (en) * 2002-12-18 2004-07-08 The Regents Of The University Of California Biocompatible hydrogel bone-like composites
US7309232B2 (en) * 2003-10-10 2007-12-18 Dentigenix Inc. Methods for treating dental conditions using tissue scaffolds
CA2557436A1 (en) * 2004-03-05 2005-09-29 The Trustees Of Columbia University In The City Of New York Polymer-ceramic-hydrogel composite scaffold for osteochondral repair
WO2005086706A2 (en) 2004-03-05 2005-09-22 The Trustees Of Columbia University In The City Of New York Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue to bone
US7473678B2 (en) * 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US8071083B2 (en) * 2004-12-13 2011-12-06 Progentix Orthobiology B.V. Tissue regeneration
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
US8552100B2 (en) * 2005-02-23 2013-10-08 The Regents Of The University Of California Flexible hydrogel-based functional composite materials
DE102005042707A1 (de) * 2005-09-01 2007-03-08 Polymedics Innovations Gmbh Formkörper zur medizinischen Behandlung von Wunden
US8518123B2 (en) * 2005-09-09 2013-08-27 Board Of Trustees Of The University Of Arkansas System and method for tissue generation and bone regeneration
US9763788B2 (en) 2005-09-09 2017-09-19 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
US8936805B2 (en) 2005-09-09 2015-01-20 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
BRPI0618794A2 (pt) 2005-11-17 2011-09-13 Biomimetic Therapeutics Inc uso de uma matriz biocompatìvel, kit e composição para aumento ósseo, especialmente para aumento do osso maxilofacial
ES2804472T3 (es) 2005-12-13 2021-02-08 Harvard College Estructuras para trasplante celular
ES2427993T3 (es) * 2006-02-09 2013-11-05 Biomimetic Therapeutics, Llc Composiciones y métodos para el tratamiento de hueso
KR100829452B1 (ko) * 2006-06-13 2008-05-15 (주)코리아 본 뱅크 생리활성형 단백질-인산칼슘 복합체 및 그 제조 방법
US7767250B2 (en) * 2006-06-15 2010-08-03 National Research Council Of Canada Bioceramic coating of a metal-containing substrate
CN100428964C (zh) * 2006-06-29 2008-10-29 武汉理工大学 RGD多肽接枝聚(羟基乙酸-L-赖氨酸-L-乳酸)/β-磷酸三钙复合材料及其制备方法
WO2008005427A2 (en) 2006-06-30 2008-01-10 Biomimetic Therapeutics, Inc. Pdgf-biomatrix compositions and methods for treating rotator cuff injuries
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
US9439948B2 (en) 2006-10-30 2016-09-13 The Regents Of The University Of Michigan Degradable cage coated with mineral layers for spinal interbody fusion
US10772987B2 (en) 2006-10-30 2020-09-15 Trs Holdings Llc Mineral coated scaffolds
US8275594B2 (en) * 2006-10-30 2012-09-25 The Regents Of The University Of Michigan Engineered scaffolds for intervertebral disc repair and regeneration and for articulating joint repair and regeneration
AU2007333425B2 (en) 2006-11-03 2014-03-27 Biomimetic Therapeutics, Llc Compositions and methods for arthrodetic procedures
US20100047309A1 (en) * 2006-12-06 2010-02-25 Lu Helen H Graft collar and scaffold apparatuses for musculoskeletal tissue engineering and related methods
US20090287309A1 (en) 2007-01-30 2009-11-19 Tornier Sas Intra-articular joint replacement
FR2911773B1 (fr) * 2007-01-30 2009-03-27 Tornier Sas Methode et ensemble d'instrumentation chirurgicale pour poser une prothese totale d'epaule inversee,et prothese correspondante
US20080195476A1 (en) * 2007-02-09 2008-08-14 Marchese Michael A Abandonment remarketing system
US8753391B2 (en) 2007-02-12 2014-06-17 The Trustees Of Columbia University In The City Of New York Fully synthetic implantable multi-phased scaffold
DE602008005987D1 (de) * 2007-02-22 2011-05-19 Corning Inc Substrate für zellkultur und herstellungsverfahren dafür
WO2009002401A2 (en) * 2007-06-21 2008-12-31 President And Fellows Of Harvard College Scaffolds for cell collection or elimination
US8075562B2 (en) * 2007-06-25 2011-12-13 Wisconsin Alumni Research Foundation Controlled release of biopharmaceutical growth factors from hydroxyapatite coating on bioresorbable interference screws used in cruciate ligament reconstruction surgery
US20090286907A1 (en) * 2008-01-23 2009-11-19 Beltz Mark W Fumaric Acid/Diol Polyesters and Their Manufacture and Use
RU2010137106A (ru) * 2008-02-07 2012-03-20 Байомайметик Терапьютикс, Инк. (Us) Композиции и способы для дистракциионного остеогенеза
US9370558B2 (en) 2008-02-13 2016-06-21 President And Fellows Of Harvard College Controlled delivery of TLR agonists in structural polymeric devices
EP2254602B1 (de) 2008-02-13 2018-11-21 President and Fellows of Harvard College Kontinuierliche zellprogrammiervorrichtungen
WO2009146456A1 (en) 2008-05-30 2009-12-03 President And Fellows Of Harvard College Controlled release of growth factors and signaling molecules for promoting angiogenesis
US20100042213A1 (en) 2008-08-13 2010-02-18 Nebosky Paul S Drug delivery implants
US9700431B2 (en) 2008-08-13 2017-07-11 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
US10842645B2 (en) 2008-08-13 2020-11-24 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
US9616205B2 (en) 2008-08-13 2017-04-11 Smed-Ta/Td, Llc Drug delivery implants
CA2734254C (en) 2008-08-13 2018-06-05 Smed-Ta/Td, Llc Orthopaedic screws
WO2010025386A1 (en) 2008-08-29 2010-03-04 Smed-Ta/Td, Llc Orthopaedic implant
CA2735885C (en) 2008-09-09 2018-08-28 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
EP2349212B1 (de) 2008-09-25 2022-01-19 TRS Holdings LLC Mit mineralien beschichtete mikrokügelchen
WO2010102266A1 (en) * 2009-03-05 2010-09-10 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects
US9297005B2 (en) 2009-04-13 2016-03-29 President And Fellows Of Harvard College Harnessing cell dynamics to engineer materials
US8728456B2 (en) 2009-07-31 2014-05-20 President And Fellows Of Harvard College Programming of cells for tolerogenic therapies
US8492339B2 (en) * 2009-10-26 2013-07-23 Empire Technology Development Llc Angiogenesis promoted by caged growth factors
BR112012020566B1 (pt) 2010-02-22 2021-09-21 Biomimetic Therapeutics, Llc Composição de fator de crescimento derivado de plaqueta
WO2011109834A2 (en) 2010-03-05 2011-09-09 President And Fellows Of Harvard College Enhancement of skeletal muscle stem cell engrafment by dual delivery of vegf and igf-1
US9408652B2 (en) 2010-04-27 2016-08-09 Tornier Sas Intra-articular joint replacement and method
WO2011163669A2 (en) 2010-06-25 2011-12-29 President And Fellows Of Harvard College Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones
WO2012027218A2 (en) 2010-08-27 2012-03-01 Corning Incorporated Peptide-modified surfaces for cell culture
US11202759B2 (en) 2010-10-06 2021-12-21 President And Fellows Of Harvard College Injectable, pore-forming hydrogels for materials-based cell therapies
US9603894B2 (en) 2010-11-08 2017-03-28 President And Fellows Of Harvard College Materials presenting notch signaling molecules to control cell behavior
US9200271B2 (en) 2011-02-03 2015-12-01 Empire Technology Development Llc Selective 3D biopatterning
WO2012123028A1 (en) 2011-03-16 2012-09-20 Kuros Biosurgery Ag Pharmaceutical formulation for use in spinal fusion
EP2701753B1 (de) 2011-04-27 2018-12-26 President and Fellows of Harvard College Zellfreundliche inverse und opake hydrogele zur zelleinkapselung, zur arzneimittel- und proteinabgabe sowie für funktionelle nanopartikeleinkapselung
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
EP2701745B1 (de) 2011-04-28 2018-07-11 President and Fellows of Harvard College Injizierbare vorgeformte makroskopische 3d-gerüste für minimal invasive verabreichung
JP6062426B2 (ja) 2011-06-03 2017-01-18 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ インサイチュー抗原生成癌ワクチン
WO2012176023A1 (en) 2011-06-23 2012-12-27 Indian Institute Of Technology Kanpur Hydrogel scaffolds for tissue engineering
US8753309B2 (en) 2011-06-24 2014-06-17 The Invention Science Fund I, Llc Device, system, and method including micro-patterned cell treatment array
ES2773895T3 (es) 2012-04-16 2020-07-15 Harvard College Composiciones de sílice mesoporosa para modular las respuestas inmunitarias
WO2014169249A1 (en) 2013-04-12 2014-10-16 The Trustees Of Columbia University In The City Of New York Methods for host cell homing and dental pulp regeneration
DE102013217085A1 (de) * 2013-08-27 2015-03-05 Gilupi Gmbh Verfahren zur Verbesserung der Biokompatibilität einer Oberfläche
JP7348708B2 (ja) 2014-04-30 2023-09-21 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 組み合わせワクチン装置および癌細胞を殺滅する方法
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
US11786457B2 (en) 2015-01-30 2023-10-17 President And Fellows Of Harvard College Peritumoral and intratumoral materials for cancer therapy
WO2016141242A1 (en) 2015-03-03 2016-09-09 Tissue Regeneration Systems, Inc. Coating scaffolds
JP7094533B2 (ja) 2015-04-10 2022-07-04 プレジデント アンド フェローズ オブ ハーバード カレッジ 免疫細胞捕捉デバイスおよびその製造および使用方法
CN115531609A (zh) 2016-02-06 2022-12-30 哈佛学院校长同事会 重塑造血巢以重建免疫
AU2017295704B2 (en) 2016-07-13 2023-07-13 President And Fellows Of Harvard College Antigen-presenting cell-mimetic scaffolds and methods for making and using the same
EP3630151A4 (de) * 2017-05-30 2021-04-28 Stem Pharm, Incorporated Sichtbare lichtpolymerisation von polyethylenglykol(peg)-hydrogelen
US20230142212A1 (en) 2021-11-09 2023-05-11 Warsaw Orthopedic, Inc. Systems and methods of coating bone material
US11747269B2 (en) 2021-11-09 2023-09-05 Warsaw Orthopedic, Inc. Systems and methods for identifying a coating on an implant

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4636526A (en) 1985-02-19 1987-01-13 The Dow Chemical Company Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics
US5266480A (en) 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US4933185A (en) 1986-09-24 1990-06-12 Massachusetts Institute Of Technology System for controlled release of biologically active compounds
CA1340581C (en) 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
US5041138A (en) 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
US5804178A (en) 1986-11-20 1998-09-08 Massachusetts Institute Of Technology Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
US5079600A (en) 1987-03-06 1992-01-07 Schnur Joel M High resolution patterning on solid substrates
JPS63270061A (ja) 1987-04-28 1988-11-08 Hoya Corp 無機生体材料の表面改質方法
US5011691A (en) 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5965079A (en) * 1995-04-25 1999-10-12 3D Systems, Inc. Method and apparatus for making a three-dimensional object by stereolithography
US4996120A (en) * 1988-12-29 1991-02-26 E. I. Dupont De Nemours And Company Holographic photopolymer compositions and elements containing a ring-opening monomer
DE69013764T2 (de) 1989-06-03 1995-03-30 Kanegafuchi Chemical Ind Kontrolle der Zellanordnung.
US5529914A (en) * 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5558517A (en) 1992-02-24 1996-09-24 Clemson University Polymeric prosthesis having a phosphonylated surface
US5491198A (en) 1992-02-24 1996-02-13 Clemson University Process for phosphonylating the surface of an organic polymeric preform
US5334640A (en) * 1992-04-08 1994-08-02 Clover Consolidated, Ltd. Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
US5330799A (en) * 1992-09-15 1994-07-19 The Phscologram Venture, Inc. Press polymerization of lenticular images
US5514378A (en) * 1993-02-01 1996-05-07 Massachusetts Institute Of Technology Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures
BR9405798A (pt) * 1993-02-22 1995-12-12 Vivorx Pharmaceuticals Inc Métodos para liberação in vivo de material biológico e composições úteis dos mesmos
NZ265818A (en) 1993-04-19 1997-09-22 Medisorb Technologies Internat Compositions of nucleic acids encapsulated with molecules that facilitate uptake and integration into living cells
US5876454A (en) * 1993-05-10 1999-03-02 Universite De Montreal Modified implant with bioactive conjugates on its surface for improved integration
US5512131A (en) 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
US5776748A (en) 1993-10-04 1998-07-07 President And Fellows Of Harvard College Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor
EP0741585A1 (de) * 1994-01-21 1996-11-13 Brown University Research Foundation Bioverträgliche implantate
US5763416A (en) 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US5942496A (en) 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US5962427A (en) 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
CA2147813A1 (en) * 1994-04-28 1995-10-29 Richard Dixon Intravascular prosthesis with anti-thrombogenic coating
US5807406A (en) * 1994-10-07 1998-09-15 Baxter International Inc. Porous microfabricated polymer membrane structures
US5641391A (en) * 1995-05-15 1997-06-24 Hunter; Ian W. Three dimensional microfabrication by localized electrodeposition and etching
US5654381A (en) 1995-06-16 1997-08-05 Massachusetts Institute Of Technology Functionalized polyester graft copolymers
US5965125A (en) * 1995-10-25 1999-10-12 Transkaryotic Therapies, Inc. Hybrid matrix implants and explants
DE69637619D1 (de) 1995-11-06 2008-09-11 Mount Sinai Hospital Corp Rekonstituiertes mineralisiertes knorpelgewebe
US5830539A (en) * 1995-11-17 1998-11-03 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods for functionalizing and coating substrates and devices made according to the methods
US6033719A (en) 1996-04-25 2000-03-07 Medtronic, Inc. Method for covalent attachment of biomolecules to surfaces of medical devices
US5785965A (en) 1996-05-15 1998-07-28 The Board Of Trustees Of The Leland Stanford Junior Univ. VEGF gene transfer into endothelial cells for vascular prosthesis
EP0915967A1 (de) 1996-05-28 1999-05-19 The Board Of Regents Of The University Of Michigan Entwicklung von oralem gewebe
US5855802A (en) * 1996-05-30 1999-01-05 International Business Machines Corporation Method and apparatus for forming a tubular article having a perforated annular wall
US6143037A (en) 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US6210707B1 (en) * 1996-11-12 2001-04-03 The Regents Of The University Of California Methods of forming protein-linked lipidic microparticles, and compositions thereof
US6261493B1 (en) * 1997-03-20 2001-07-17 Therics, Inc. Fabrication of tissue products with additives by casting or molding using a mold formed by solid free-form methods
EP0991705B1 (de) * 1997-03-31 2003-09-10 The Regents Of The University Of Michigan Offenporige bioabbaubare matrize
EP1019492A1 (de) * 1997-07-03 2000-07-19 Massachusetts Institute Of Technology Mittels gewebetechnologie hergestellte gegenstände
EP0891783B1 (de) 1997-07-16 2002-06-12 IsoTis N.V. Vorrichtung zur Knochenbehandlung bestehend aus abbaubarem thermoplastischen Copolyester und kultivierten Zellen
US6077987A (en) * 1997-09-04 2000-06-20 North Shore-Long Island Jewish Research Institute Genetic engineering of cells to enhance healing and tissue regeneration
US6391311B1 (en) 1998-03-17 2002-05-21 Genentech, Inc. Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
US5925069A (en) * 1997-11-07 1999-07-20 Sulzer Intermedics Inc. Method for preparing a high definition window in a conformally coated medical device
US6187329B1 (en) 1997-12-23 2001-02-13 Board Of Regents Of The University Of Texas System Variable permeability bone implants, methods for their preparation and use
AU2565099A (en) 1998-01-27 1999-09-20 Regents Of The University Of California, The Biodegradable polymer/protein based coils for intralumenal implants
US6150459A (en) * 1998-04-13 2000-11-21 Massachusetts Institute Of Technology Comb polymers for regulating cell surface interactions
AU3898699A (en) 1998-05-13 1999-11-29 Regents Of The University Of Michigan, The Sustained dna delivery from structural matrices
US6767928B1 (en) * 1999-03-19 2004-07-27 The Regents Of The University Of Michigan Mineralization and biological modification of biomaterial surfaces
US6541022B1 (en) * 1999-03-19 2003-04-01 The Regents Of The University Of Michigan Mineral and cellular patterning on biomaterial surfaces
US6200646B1 (en) * 1999-08-25 2001-03-13 Spectra Group Limited, Inc. Method for forming polymeric patterns, relief images and colored polymeric bodies using digital light processing technology

Also Published As

Publication number Publication date
WO2000056375A2 (en) 2000-09-28
DE60003006T2 (de) 2004-04-01
ATE241397T1 (de) 2003-06-15
CA2370063C (en) 2012-10-02
US20030203002A1 (en) 2003-10-30
AU4173000A (en) 2000-10-09
CA2370063A1 (en) 2000-09-28
WO2000056375A3 (en) 2001-01-11
EP1163018B1 (de) 2003-05-28
DK1163018T3 (da) 2003-09-29
US6541022B1 (en) 2003-04-01
ES2199815T3 (es) 2004-03-01
EP1163018A2 (de) 2001-12-19

Similar Documents

Publication Publication Date Title
ATE241397T1 (de) Mineralisierung und zelluläre strukturierung von biomaterialoberflächen
DE69926639D1 (de) Knochenmarkszellen als quelle von neuronen zur wiederherstellung von gehirn und knochenmark
DE50005034D1 (de) Resorbierbares knochenersatz- und knochenaufbaumaterial
WO1999026674A3 (de) Verfahren zur immobilisierung von mediatormolekülen auf anorganischen und metallischen implantatmaterialien
DE69727332D1 (de) Zubereitungen enthaltend Kollagen, Vitamin D3 und Kalzium zur Verstärkung des Knochens
DE60137096D1 (de) Zusammensetzung zur Unterbindung von Körpergeruch und Verwendung derselben
IL147974A0 (en) Composite shaped bodies and methods for their production and use
WO2001054746A3 (en) Composite biomaterial including anisometric calcium phosphate reinforcement particles
DE69630389D1 (de) Bioaktives verbundmaterial zum reparieren von hartem und weichem gewebe
ATE360447T1 (de) Osteoinduktion von allogenen kortikalen knochentransplantaten über biopolymere die mit periostalen knochenzellen besiedelt wurden
AR034347A1 (es) Vehiculo para la liberacion de fosfato de calcio para proteinas osteoinductivas
WO2000045867A8 (en) Implant comprising calcium cement and hydrophobic liquid
ATE249849T1 (de) Herstllung von autogenen körperersatzteilen
DE69632829D1 (de) Knochentransplantatmatrix
WO2003011184A8 (en) Adventitial fabric reinforced porous prosthetic graft
ATE412383T1 (de) Faserverstärkte,poröse,biologisch abbaubare implantatvorrichtung
DE69830417D1 (de) Reverse-phase zusamensetzung zur bindegewebsreparatur
NO20011283D0 (no) Anvendelse av integrin-antagonister ved behandling av multippelt myelom og myelom-indusert benresorpsjon
DE59911408D1 (de) Instrument zum applizieren von licht, insbesondere laserlicht, im menschlichen oder tierischen körper
DE602004025145D1 (de) Zusammengesetzte strukturen mit hyaluronsäure und derivaten davon als neue knochensubstitute und transplantate
DE69713350T2 (de) Polgewebe zur erzeugung von langen und kurzen pollängen, gewebe mit langen und kurzen pollängen, und herstellungsverfahren
AR016981A2 (es) Polipeptidos sinteticos
EP1277482A3 (de) Mineralisierung und zelluläre Strukturierung von Biomaterialoberflächen
DE69727240D1 (de) Kombinationen enthaltend vx478, zidovudin und 3tc zur behandlung von hiv
DE60128426D1 (de) Zellenanordnung von Stromquellen, Verfahren zur Auswahl von Stromquellen und Digital-Analog-Wandler des Stromadditionstyps

Legal Events

Date Code Title Description
8364 No opposition during term of opposition