DE552820C - Process for the preparation of cholesterol-free or low-cholesterol solutions of the active substance from the anterior pituitary gland and male germ glands - Google Patents

Process for the preparation of cholesterol-free or low-cholesterol solutions of the active substance from the anterior pituitary gland and male germ glands

Info

Publication number
DE552820C
DE552820C DEI29995D DEI0029995D DE552820C DE 552820 C DE552820 C DE 552820C DE I29995 D DEI29995 D DE I29995D DE I0029995 D DEI0029995 D DE I0029995D DE 552820 C DE552820 C DE 552820C
Authority
DE
Germany
Prior art keywords
cholesterol
free
anterior pituitary
low
active substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEI29995D
Other languages
German (de)
Inventor
Dr Willi Ludwig
Dr Otto Schaumann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IG Farbenindustrie AG
Original Assignee
IG Farbenindustrie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IG Farbenindustrie AG filed Critical IG Farbenindustrie AG
Priority to DEI29995D priority Critical patent/DE552820C/en
Application granted granted Critical
Publication of DE552820C publication Critical patent/DE552820C/en
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/52—Sperm; Prostate; Seminal fluid; Leydig cells of testes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Description

Verfahren zur Darstellung von cholesterinfreien bzw. -armen Lösungen der wirksamen Substanz aus Hypophysenvorderlappen und männlichen Keimdrüsen Im Patent 527 153 ist ein Verfahren zur Darstellung von cholesterinfreien bzw. -armen Lösungen der wirksamen Ovarialsubstanz beschrieben, bei dem man als Reinigungs- bzw. Lösungsmittel wasserlösliche Äther und Ester mehrwertiger Alkohole verwendet.Method for the preparation of cholesterol-free or low-cholesterol solutions of the active substance from the anterior pituitary gland and male gonads In patent 527 153 a method for the preparation of cholesterol-free or low-cholesterol solutions of the active ovarian substance is described in which one uses water-soluble ethers as a cleaning agent or solvent and esters of polyhydric alcohols are used.

Bei weiterer Bearbeitung dieses Arbeitsge-j bietes wurde nun die Beobachtung gemacht,' daB das beschriebene Verfahren nicht auf die Darstellung von wirksamen Substanzen der Ovarialsubstanzen =beschränkt ist, sondern daß auch bei Verwendung anderer Organe oder Drüsen mit innerer Sekretion die wasserlöslichen Äther und Ester mehrwertiger Alkohole als Abscheidungsmittel-für Cholesterine oder andere Ballaststoffe sowie als Lösungsmittel der wirksamen Substanz mit Erfolg verwendet werden können.With further processing of this work area, the observation made 'that the procedure described does not affect the representation of effective Substances of the ovarian substances = is limited, but that also when using other organs or glands with internal secretion the water-soluble ethers and esters polyhydric alcohols as a separator for cholesterol or other dietary fiber as well as the active substance solvent can be used with success.

Beispiel i kg Hypophysenvorderlappen oder männliche Keimdrüsen werden nach üblicher Methode mit organischen Lösungsmitteln extrahiert und das Rohkonzentrat in Äther aufgenommen. Die Lösung wird hierauf durch Abdampfen von Äther befreit, der Rückstand in Diäthylin gelöst und aus dieser Lösung die vorhandenen Ballaststoffe durch fraktionierte Fällung mit Wasser entfernt. Die nach dem Abfiltrieren gewonnenen Flüssigkeiten enthalten die wirksamen Substanzen in gereinigter Form und können beliebig konzentriert werden.Example i kg anterior pituitary gland or male gonads extracted according to the usual method with organic solvents and the raw concentrate absorbed into ether. The solution is then freed from ether by evaporation, the residue is dissolved in diethyline and the existing dietary fiber from this solution removed by fractional precipitation with water. Those obtained after filtering off Liquids contain the active substances in purified form and can can be concentrated at will.

Claims (1)

PATENTANSPRUCH: Weitere Ausbildung der durch Patent 527 153 geschützten Erfindung, darin bestehend, daß man zwecks Darstellung von cholesterinfreien bzw. -armen Lösungen der wirksamen Substanz aus Hypophysenvorderlappen und aus männlichen Keimdrüsen an Stelle der Rohextrakte aus Ovarialsubstanz hier solche aus Hypophysenvorderlappen oder aus männlichen Keimdrüsen der Behandlung mit wasserlöslichen Äthern oder Estern mehrwertiger Alkohole unterwirft. PATENT CLAIM: Further development of the invention protected by patent 527 153, consisting in that, for the purpose of preparing cholesterol-free or low-cholesterol solutions of the active substance from the anterior pituitary glands and from male gonads, instead of the crude extracts from ovarian substance, here those from the anterior pituitary glands or from male gonads Subjects to treatment with water-soluble ethers or esters of polyhydric alcohols.
DEI29995D 1927-01-12 1927-01-12 Process for the preparation of cholesterol-free or low-cholesterol solutions of the active substance from the anterior pituitary gland and male germ glands Expired DE552820C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEI29995D DE552820C (en) 1927-01-12 1927-01-12 Process for the preparation of cholesterol-free or low-cholesterol solutions of the active substance from the anterior pituitary gland and male germ glands

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEI29995D DE552820C (en) 1927-01-12 1927-01-12 Process for the preparation of cholesterol-free or low-cholesterol solutions of the active substance from the anterior pituitary gland and male germ glands

Publications (1)

Publication Number Publication Date
DE552820C true DE552820C (en) 1932-06-17

Family

ID=7187490

Family Applications (1)

Application Number Title Priority Date Filing Date
DEI29995D Expired DE552820C (en) 1927-01-12 1927-01-12 Process for the preparation of cholesterol-free or low-cholesterol solutions of the active substance from the anterior pituitary gland and male germ glands

Country Status (1)

Country Link
DE (1) DE552820C (en)

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