AT122298B - Process for the preparation of cholesterol-free or low-cholesterol solutions of the active substance from glands with internal secretion. - Google Patents

Process for the preparation of cholesterol-free or low-cholesterol solutions of the active substance from glands with internal secretion.

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Publication number
AT122298B
AT122298B AT122298DA AT122298B AT 122298 B AT122298 B AT 122298B AT 122298D A AT122298D A AT 122298DA AT 122298 B AT122298 B AT 122298B
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Austria
Prior art keywords
cholesterol
glands
preparation
free
low
Prior art date
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German (de)
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Ig Farbenindustrie Ag
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Publication of AT122298B publication Critical patent/AT122298B/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

   <Desc/Clms Page number 1> 
 



  Verfahren zur Darstellung von cholesterinfreien bzw.-armen Lösungen der wirksamen
Substanz aus Drüsen mit innerer Sekretion. 



   In dem österreichischen Patente Nr. 113810 ist ein Verfahren zur Darstellung von cholesterinfreien bzw. -armen Lösungen der wirksamen Ovarialsubstanz beschrieben, bei dem man als Reinigungs-bzw. Lösungsmittel wasserlösliche Äther und Ester mehrwertiger Alkohole verwendet. 



   Bei weiterer Bearbeitung dieses Arbeitsgebietes wurde nun die Beobachtung gemacht, dass das beschriebene Verfahren nicht auf die Darstellung von wirksamen Substanzen der Ovarialsubstanzen beschränkt ist, sondern dass auch bei Verwendung anderer Organe oder Drüsen mit innerer Sekretion die wasserlöslichen Äther und Ester mehrwertiger Alkohole als Abscheidungsmittel für Cholesterine oder andere Ballaststoffe sowie als Lösungsmittel der wirksamen Substanz mit Erfolg verwendet werden können. 



   Beispiele :
1.   l/ Hpophysenvorderlappen   werden zerkleinert und mit organischen Lösungsmitteln bei niederer Temperatur extrahiert. Die Konzentration des Gesamtextraktes beträgt ungefähr   60-700/0   an organischem Lösungsmittel. Nach Entfernung des Lösungsmittels wird das Rohkonzentrat in Äther aufgenommen. Die   ätherische   Lösung wird eingedampft und der Rückstand in Diäthylin gelöst. Durch Zusatz von Wasser, dessen Menge sich nach dem Cholesteringehalt des Ausgangsmaterials richtet, wird das Cholesterin in kristalliner Form abgeschieden. Das Filtrat enthält die wirksame Substanz und kann ohne weitere Reinigung verwendet werden. 



   2. 1 leg männliche Keimdrüsen werden nach üblicher Methode mit organischen Lösungsmitteln extrahiert und das Rohkonzentrat in Äther aufgenommen. Die Lösung wird hierauf durch Abdampfen von Äther befreit, der Rückstand in Diäthylin gelöst und aus dieser Lösung die vorhandenen Ballaststoffe durch fraktionierte   Fällung   mit Wasser entfernt. Die nach dem Abfiltrieren gewonnenen Flüssigkeiten enthalten die wirksamen Substanzen in gereinigter Form und können beliebig konzentriert werden. 

**WARNUNG** Ende DESC Feld kannt Anfang CLMS uberlappen**.



   <Desc / Clms Page number 1>
 



  Process for the preparation of cholesterol-free or low-cholesterol solutions of the effective
Substance from glands with internal secretion.



   In the Austrian patent no. 113810 a method for the preparation of cholesterol-free or low-cholesterol solutions of the active ovarian substance is described, in which one as a cleaning or. Solvent water-soluble ethers and esters of polyhydric alcohols are used.



   In further processing of this field of work, the observation was made that the method described is not limited to the preparation of active substances of the ovarian substances, but that also when other organs or glands with internal secretion are used, the water-soluble ethers and esters of polyhydric alcohols as separating agents for cholesterol or other dietary fiber can be used with success as well as a solvent of the active ingredient.



   Examples:
1. L / anterior pituitary lobes are crushed and extracted with organic solvents at low temperature. The concentration of the total extract is approximately 60-700 / 0 in organic solvent. After removing the solvent, the raw concentrate is taken up in ether. The ethereal solution is evaporated and the residue is dissolved in diethyline. By adding water, the amount of which depends on the cholesterol content of the starting material, the cholesterol is deposited in crystalline form. The filtrate contains the active substance and can be used without further purification.



   2. 1 leg male gonads are extracted according to the usual method with organic solvents and the raw concentrate is taken up in ether. The solution is then freed from ether by evaporation, the residue is dissolved in diethyline and the dietary fibers present are removed from this solution by fractional precipitation with water. The liquids obtained after filtering off contain the active substances in purified form and can be concentrated as required.

** WARNING ** End of DESC field may overlap beginning of CLMS **.

Claims (1)

PATENT-ANSPRUCH : Verfahren zur Darstellung von cholesterinfreien bzw.-armen Lösungen der wirksamen Substanz aus Drüsen mit innerer Sekretion ausgenommenen Ovarien, dadurch gekennzeichnet, dass man als Reinigungs-bzw. Losungsmittel für die in üblicher Weise aus den Drüsen gewonnenen Rohextrakte wasserlösliche Äther und Ester mehrwertiger Alkohole verwendet. **WARNUNG** Ende CLMS Feld Kannt Anfang DESC uberlappen**. PATENT CLAIM: Process for the preparation of cholesterol-free or low-cholesterol solutions of the active substance from glands with internal secretion gutted ovaries, characterized in that one as cleaning or. Solvent used for the crude extracts obtained in the usual way from the glands, water-soluble ethers and esters of polyhydric alcohols. ** WARNING ** End of CLMS field may overlap beginning of DESC **.
AT122298D 1927-01-11 1927-09-09 Process for the preparation of cholesterol-free or low-cholesterol solutions of the active substance from glands with internal secretion. AT122298B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE122298T 1927-01-11

Publications (1)

Publication Number Publication Date
AT122298B true AT122298B (en) 1931-04-10

Family

ID=29277242

Family Applications (1)

Application Number Title Priority Date Filing Date
AT122298D AT122298B (en) 1927-01-11 1927-09-09 Process for the preparation of cholesterol-free or low-cholesterol solutions of the active substance from glands with internal secretion.

Country Status (1)

Country Link
AT (1) AT122298B (en)

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