DE570830C - Process for obtaining the hormone of the male gonads - Google Patents

Process for obtaining the hormone of the male gonads

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Publication number
DE570830C
DE570830C DE1930570830D DE570830DD DE570830C DE 570830 C DE570830 C DE 570830C DE 1930570830 D DE1930570830 D DE 1930570830D DE 570830D D DE570830D D DE 570830DD DE 570830 C DE570830 C DE 570830C
Authority
DE
Germany
Prior art keywords
hormone
obtaining
urine
male gonads
male
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1930570830D
Other languages
German (de)
Inventor
Dr Max Gehrke
Dr Walter Schoeller
Dr Erwin Schwenk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schering Kahlbaum AG
Original Assignee
Schering Kahlbaum AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Kahlbaum AG filed Critical Schering Kahlbaum AG
Application granted granted Critical
Publication of DE570830C publication Critical patent/DE570830C/en
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Description

Verfahren zur Gewinnung des Hormons der männlichen Keimdrüsen Es ist bekannt, daß man aus dein Harn gravider Frauen das ovarielle Hormon durch E xtraiction mit Olivenöl in einer Form gewinnen kann, die sich zur weiteren keinigtniggut eignet und zur Darstellung des Hormons in kristallisierter Forni geführt hat (The Journal of Biological Chemistrv, Band C(, Seite 499).Method of obtaining the hormone of the male gonads It is known that the urine of pregnant women can be extracted from the ovarian hormone by e xtraiction can win with olive oil in a form that is suitable for further no good and led to the presentation of the hormone in crystallized form (The Journal of Biological Chemistrv, Volume C (, page 499).

Es wurde nun gefunden, daß man auf ähnliche Weise auch das Hormon der männlichen Keimdrüse gewinnen kann, wenn man den Harn von Männern. besonders solcher im Alter von 2o bis 30 Jahren, mit fetten Ölen. wie Olivenöl oder Sesamöl, extrahiert und aus der öligen Lösung das Hormon mit flüssigen, flüchtigen, mit Ölen nicht mischbaren Alkoholen ausschüttelt. Als solche können verwendet werden: Methylalkohol, Äthylalkohol. Isopropylalkohol und ähnliche Alkohole aliphatischer Natur.It has now been found that the hormone of the male gonad can also be obtained in a similar manner if the urine of men is obtained. especially those between the ages of 20 and 30 , with fatty oils. such as olive oil or sesame oil, and the hormone is extracted from the oily solution with liquid, volatile alcohol that is immiscible with oils. As such can be used: methyl alcohol, ethyl alcohol. Isopropyl alcohol and similar alcohols of an aliphatic nature.

Beispiel i i 1 Männerharn wird mit Salzsäure kongosauer gemacht und nach Stehen über Nacht vom Sediment getrennt. Dann wird er etwa 3o Minuten lang mit so ccm Olivenöl gut durchgerührt, die Ölschicht abgetrennt und diese Extraktion noch mehrfach wiederholt. Die erhaltene ölige Lösung wird mehrfach mit heißem, etwa 9j°(oigetn Methylalkohol ausgeschüttelt. An Stelle von Methylalkohol kann man hier auch Äthylalkohol, Isopropylalkohol usw. verwenden. Verdampft man danach die wäßrig-alkoholische Lösung, gegebenenfalls unter vermindertem Druck, so erhält man einen öligen Rückstand, der in Öl gelöst, an Kapaunen subkutan appliziert, Wachstum des Kammes bewirkt.Example i i 1 Men's urine is made Congo acidic with hydrochloric acid and separated from the sediment after standing overnight. Then it becomes about 30 minutes long Stirred well with so ccm of olive oil, separated the oil layer and this extraction repeated several times. The oily solution obtained is several times with hot, about 9 ° (oigetn methyl alcohol shaken out. Instead of methyl alcohol one can use here also use ethyl alcohol, isopropyl alcohol, etc. If you then evaporate the aqueous-alcoholic Solution, optionally under reduced pressure, an oily residue is obtained, dissolved in oil, applied subcutaneously to capons, causes the comb to grow.

Statt vom Harn als solchen auszugehen. kann man den Harn auch vorher konzentrieren oder zur Trockne bringen, was eine Ersparnis an Lösungsmitteln mit sich bringt. Gegebenenfalls kann der nach dem Abdampfen des flüchtigen Lösungsmittels verbleibende ölige Rückstand noch weiter gereinigt werden.Instead of starting from the urine as such. you can also urine beforehand concentrate or bring to dryness, which means a saving in solvents brings itself. If necessary, this can be done after the volatile solvent has evaporated remaining oily residue can be further purified.

Beispiel Behandelt man den nach Beispiel i erhaltenen öligen Auszug, mit Diacetonalkohol und dampft die erhaltene alkoholische Lösung im Vakuum der Wasserstrahlpurripe ein, so erhält man als Rückstand ein braunes Öl. Es ist löslich in den gebräuchlichen organischen Lösungsmitteln, kaum löslich in Wasser. Eine Lösung dieses Rückstandes in Olivenöl ruft bei subkutaner Verabreichung am Kapaun Kammwachstum, beim kastrierten männlichen Nager Samenblasenwachstum hervor.Example If the oily extract obtained according to Example i is treated, with diacetone alcohol and the alcoholic solution obtained is evaporated in the vacuum of the water jet pipe a brown oil is obtained as residue. It is soluble in common organic solvents, hardly soluble in water. A solution of this residue In olive oil, when administered subcutaneously, the capon causes crest growth, in the castrated male rodent seminal vesicle growth.

Claims (1)

PATENTANSPRUCH: Verfahren zur Gewinnung des Hormons der männlichen Keimdrüsen, dadurch gekennzeichnet, daß man Harn von Männern, gegebenenfalls nach Konzentration, mit fetten Ölen extrahiert und aus der öligen Lösung das Hormon mit flüssigen, flüchtigen, mit 01 nicht mischbaren aliphatischen Alkoholen ausschüttelt und das Lösunzsmittel entfernt.PATENT CLAIM: A method for obtaining the hormone of the male gonads, characterized in that urine from men, optionally after concentration, is extracted with fatty oils and the hormone is shaken out of the oily solution with liquid, volatile, aliphatic alcohols which are immiscible with 01, and the solvent removed.
DE1930570830D 1930-05-03 1930-05-03 Process for obtaining the hormone of the male gonads Expired DE570830C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE570830T 1930-05-03

Publications (1)

Publication Number Publication Date
DE570830C true DE570830C (en) 1933-02-22

Family

ID=6568681

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1930570830D Expired DE570830C (en) 1930-05-03 1930-05-03 Process for obtaining the hormone of the male gonads

Country Status (1)

Country Link
DE (1) DE570830C (en)

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