DE50308492D1 - Verbindungen, die faktor xa-aktiv t inhibieren - Google Patents

Verbindungen, die faktor xa-aktiv t inhibieren

Info

Publication number
DE50308492D1
DE50308492D1 DE50308492T DE50308492T DE50308492D1 DE 50308492 D1 DE50308492 D1 DE 50308492D1 DE 50308492 T DE50308492 T DE 50308492T DE 50308492 T DE50308492 T DE 50308492T DE 50308492 D1 DE50308492 D1 DE 50308492D1
Authority
DE
Germany
Prior art keywords
inhibiting factor
connections
active
pharmaceutically acceptable
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE50308492T
Other languages
German (de)
English (en)
Inventor
Robert Eckl
Silke Schabbert
Thilo Fuchs
Lutz Weber
Christian Oefner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morphochem GmbH
Original Assignee
Morphochem AG fuer Kombinatorische Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10204072A external-priority patent/DE10204072A1/de
Priority claimed from DE10300049A external-priority patent/DE10300049A1/de
Application filed by Morphochem AG fuer Kombinatorische Chemie filed Critical Morphochem AG fuer Kombinatorische Chemie
Priority to DE50308492T priority Critical patent/DE50308492D1/de
Application granted granted Critical
Publication of DE50308492D1 publication Critical patent/DE50308492D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE50308492T 2002-01-31 2003-01-31 Verbindungen, die faktor xa-aktiv t inhibieren Expired - Fee Related DE50308492D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE50308492T DE50308492D1 (de) 2002-01-31 2003-01-31 Verbindungen, die faktor xa-aktiv t inhibieren

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10204072A DE10204072A1 (de) 2002-01-31 2002-01-31 Neue Verbindungen, die Faktor Xa-Aktivität inhibieren
DE10300049A DE10300049A1 (de) 2003-01-03 2003-01-03 Neue Verbindungen, die Faktor VIIa inhibieren
DE50308492T DE50308492D1 (de) 2002-01-31 2003-01-31 Verbindungen, die faktor xa-aktiv t inhibieren
PCT/EP2003/001011 WO2003064440A1 (de) 2002-01-31 2003-01-31 Verbindungen, die faktor xa-aktivät inhibieren

Publications (1)

Publication Number Publication Date
DE50308492D1 true DE50308492D1 (de) 2007-12-13

Family

ID=27664555

Family Applications (1)

Application Number Title Priority Date Filing Date
DE50308492T Expired - Fee Related DE50308492D1 (de) 2002-01-31 2003-01-31 Verbindungen, die faktor xa-aktiv t inhibieren

Country Status (13)

Country Link
US (1) US20050049283A1 (enExample)
EP (1) EP1470143B1 (enExample)
JP (1) JP2005525325A (enExample)
KR (1) KR20040096541A (enExample)
CN (1) CN1322001C (enExample)
AT (1) ATE377017T1 (enExample)
BR (1) BR0307266A (enExample)
CA (1) CA2473169A1 (enExample)
DE (1) DE50308492D1 (enExample)
MX (1) MXPA04007461A (enExample)
NZ (1) NZ534238A (enExample)
PL (1) PL369772A1 (enExample)
WO (1) WO2003064440A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2283833A3 (en) * 2004-02-25 2013-07-10 La Jolla Pharmaceutical Co. Amines and amides for the treatment of diseases
CN101341129B (zh) * 2005-12-14 2011-12-14 布里斯托尔-迈尔斯斯奎布公司 作为因子xia抑制剂的芳基丙酰胺，芳基丙烯酰胺，芳基丙炔酰胺，或芳基甲基脲类似物
AR058379A1 (es) * 2005-12-14 2008-01-30 Bristol Myers Squibb Co Derivados de arilpropionamida arilacrilamida arilpropinamida o arilmetilurea como inhibidores del factor xia. proceso de obtencion y composiciones farmaceuticas.
WO2017156071A1 (en) 2016-03-09 2017-09-14 Blade Therapeutics, Inc. Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
AU2017292646A1 (en) 2016-07-05 2019-02-07 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
WO2018064119A1 (en) 2016-09-28 2018-04-05 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2614893B1 (fr) * 1987-05-04 1989-12-22 Fournier Innovation Synergie Nouveaux b-d-phenyl-thioxylosides, leur procede de preparation et leur application en therapeutique
EP0560568A3 (en) * 1992-03-13 1994-06-29 Takeda Chemical Industries Ltd Hydroquinone derivatives and intermediates for production thereof
SI0921116T1 (en) * 1997-12-04 2003-10-31 F. Hoffmann - La Roche Ag N-(4-carbamimido-phenyl)-glycine amide derivatives
KR20010082515A (ko) * 1998-02-17 2001-08-30 우에노 도시오 아미디노 유도체 및 그 유도체를 유효 성분으로서함유하는 약제
SK286755B6 (sk) * 1998-06-17 2009-05-07 Universiteit Leiden Antitrombotické zlúčeniny, farmaceutický prostriedok s ich obsahom a ich použitie
DE10041402A1 (de) * 2000-08-23 2002-03-14 Morphochem Ag Neue Verbindungen, die Faktor Xa-Aktivität inhibieren
EP1336605B1 (en) * 2000-11-22 2006-04-12 Astellas Pharma Inc. Substituted phenol derivatives or salts thereof as inhibitors of coagulation factor x

Also Published As

Publication number Publication date
NZ534238A (en) 2006-09-29
PL369772A1 (en) 2005-05-02
WO2003064440A1 (de) 2003-08-07
KR20040096541A (ko) 2004-11-16
US20050049283A1 (en) 2005-03-03
EP1470143A1 (de) 2004-10-27
MXPA04007461A (es) 2005-07-13
CA2473169A1 (en) 2003-08-07
ATE377017T1 (de) 2007-11-15
BR0307266A (pt) 2004-12-07
EP1470143B1 (de) 2007-10-31
CN1625559A (zh) 2005-06-08
CN1322001C (zh) 2007-06-20
JP2005525325A (ja) 2005-08-25

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee