Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
  • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
  • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
  • C07H15/20—Carbocyclic rings
  • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
  • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
  • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P35/00—Antineoplastic agents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
  • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P9/00—Drugs for disorders of the cardiovascular system
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
  • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
  • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms

Definitions

• the present invention relates to new compounds with anticoagulant activity (so-called anticoagulants) and their pharmacologically acceptable salts or solvates and hydrates, pharmaceutical compositions which contain these as an active ingredient, processes for the preparation of such compounds, salts and compositions and their use for prevention and / or treatment of thromboembolytic diseases. These compounds, salts and compositions are very effective factor Xa inhibitors.
• the present invention also relates to pro-drugs, optically active forms, racemates and diastereomers of these compounds and salts.
• Thromboembolytic diseases are based on an increased tendency to clot in people with risk factors, e.g. major operations, prolonged immobilization, broken bones of the lower extremities, obesity, blood lipid metabolism disorders, infections with Gram-negative organisms, cancer and older age.
• risk factors e.g. major operations, prolonged immobilization, broken bones of the lower extremities, obesity, blood lipid metabolism disorders, infections with Gram-negative organisms, cancer and older age.
• Venous thrombosis can cause the tissue removed from the affected vein to develop edema or inflammation.
• Thrombosis of a deep vein can lead to serious complications such as Lead pulmonary embolism.
• Arterial thrombosis can lead to ischemic necrosis of the tissue supplied by the affected artery, e.g. to cardiac infarction in the case of an affected coronary artery.
• Other thromboembolytic diseases are e.g. Arteriosclerosis, apoplexy (stroke), angina pectoris, intermittent claudication.
• the intrinsic blood coagulation pathway is initiated when blood comes into contact with non-physiological surfaces.
• the extrinsic blood coagulation pathway is initiated by the injury to blood vessels.
• Both blood coagulation routes lead to a common path in which the blood coagulation factor X, a serine proteinase, is converted into its active form (factor Xa).
• Factor Xa together with factor Va and Ca 2+ in the so-called prothrombinase complex causes prothrombin to be converted into thrombin, which in turn releases fibrin monomers by cleaving peptides from fibrinogen, which are able to coagulate into fibrin fibers.
• Factor XIII finally leads to cross-linking and thus stabilization of the fibrin fibers.
• Anticoagulants are used both for the prevention and for the treatment of thromboembolytic diseases.
• anticoagulants are differentiated from immediately effective heparin, which directly inhibits certain factors in blood clotting, from vitamin K antagonists (eg coumarin derivatives). The latter inhibit the production of certain coagulation factors in the liver, which is dependent on the presence of vitamin K, and only begin to work slowly.
• Other anticoagulants are fibrinolytics, which cause direct or indirect activation of the fibrinolytic system, and Platelet aggregation inhibitors such as acetylsalicylic acid.
• a less common procedure is the lowering of the fibrinogen level in the blood by the enzyme Ancrod.
• the aim of using anticoagulant agents is to prevent the formation of a vaso-occlusive blood clot or to dissolve it again after it has formed.
• UFH A disadvantage of UFH is the fact that, as a rule, it must be administered intravenously, has a varying anticoagulant effect and therefore requires frequent monitoring of the patient and dose adjustments.
• LMWH can be used subcutaneously in constant, unmonitored doses, its short chain length has a greatly reduced effect compared to UFH.
• the vitamin K antagonists such as Warfarin show - presumably genetically determined - a different effectiveness from patient to patient. In addition to the slow onset of action mentioned above, this has the disadvantage that the patient must be monitored and an individual dose adjustment is required.
• thrombin inhibitors Other known anticoagulants belong to the group of thrombin inhibitors.
• Current overviews of the relevant research activities in this field can be found, for example, in Jules A. Shafer, Current Opinion in Chemical Biology, 1988, 2: 458-485, Joseph P. Vacca, Current Opinion in Chemical Biology, 2000, 4: 394- 400 and Fahad Al-Obeidi and James A. Ostrem, DDT, Vol. 3, No. 5, May 1998: 223-231.
• a decisive disadvantage of thrombin inhibitors is that in order to achieve the desired effect, such a strong suppression of thrombin activity in vivo is required that the tendency to bleed can increase, which makes dosing difficult.
• factor Xa inhibitors suppress the formation of new thrombin from prothrombin, while they do not impair existing thrombin activity, which is required for primary hemostasis.
• An object of the present invention was to provide new compounds with useful properties, in particular anticoagulant activity.
• Suitable pharmaceutical compositions should also be provided. These compounds or compositions should preferably be administrable parenterally or orally, in particular orally.
• Another object of the present invention was to provide a process for the preparation of these new compounds.
• the present invention describes anticoagulant compounds, their pharmacologically acceptable salts or solvates and hydrates and formulations which have high activity and selectivity and which can be administered orally in particular.
• the present invention further relates to pro-drugs, optically active forms, racemates and diastereomers of these compounds and salts.
• the said compounds and salts can themselves be pro-drugs that are only activated by metabolism.
• pharmaceutical compositions which contain the said compounds or salts etc. as active ingredients.
• the present invention relates to a compound of the general formula (I):
• Ar 1 is an aryl, aralkyl, heteroaryl or heteroaralkyl group
• Ar 2 is an aryl, aralkyl, heteroaryl or heteroaralkyl group
• the radicals R 1 independently of one another are a hydrogen atom, a hydroxy, a Ci, C 2 , C 3 or C 4 alkyloxy, an amino, a Ci, C, C 3 or C 4 alkylamino, a Ci, C , C 3 or C 4 dialkylamino group, a cyano group or a halogen atom;
• the radicals R 2 independently of one another are a hydrogen atom, a hydroxy, a Ci, C, C 3 or C 4 alkyloxy, an amino, a Ci, C 2 , C 3 or C 4 alkylamino, a Ci, C , C 3 or C 4 dialkylamino group, a cyano group or a halogen atom;
• R 3 is an alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl,
• heteroalkylcycloalkyl heterocycloalkyl, aralkyl or a heteroaralkyl radical
• G is a glycosyl group
• X is a group of the formula NR 5 , 0, CONR 5 , NR 5 C0, CH 2 NR 5 , S, SO, S0 2 , S0 2 NH, NHS0 2 , P0 2 NH, NHP0 2 , CH 2 , CHMe or CO , wherein R 5 is a hydrogen atom, a Ci, C 2 , C 3 or C 4 alkyl, a Ci, C 2 , C 3 or C heteroalkyl, a C 7 C 8 / C 9 , -C 0 Cu or C 2 aralkyl group or a C 6 , C 7 , C 8 , C 9 , C 0 , Cu or C 2 heteroaralkyl group;
• Y is a group of the formula CONR 6 , COCONR 6 , NR 6 , 0, NR ⁇ CO, S,
• R 6 is a hydrogen atom, a Ci, C 2 , C 3 or C 4 alkyl, is a Ci, C 2 , C 3 or C 4 heteroalkyl, or a C 7 , C 8 , C 9 , Cio, Cu or C ⁇ aralkyl group;
• n 0, 1, 2, 3 or 4 and
• n 0, 1, 2, 3 or 4,
• alkyl refers to a saturated, straight-chain or branched hydrocarbon group which has 1 to 20 carbon atoms, preferably 1 to 12 carbon atoms, particularly preferably 1, 2, 3, 4, 5 or 6 carbon atoms, e.g. the methyl, ethyl, propyl, isopropyl, isobutyl, tert-butyl, n-hexyl, 2, 2-dimethylbutyl or n-octyl group.
• alkenyl refers to straight-chain or branched hydrocarbon groups with at least one double bond which have 2 to 20 carbon atoms, preferably 2 to 12 carbon atoms, particularly preferably 2, 3, 4, 5 or 6 carbon atoms, e.g. B. the ethenyl, allyl, isoprenyl or hex-2-enyl group. They preferably have one or two (particularly preferably one) double bonds.
• alkynyl refers to straight-chain or branched hydrocarbon groups with at least one triple bond which have 2 to 20 carbon atoms, preferably 2 to 12 carbon atoms, particularly preferably 2, 3, 4, 5 or 6 carbon atoms, for example those Acetylenyl or propargyl group. They preferably have one or two (particularly preferably one) triple bonds.
• alkyl, alkenyl and alkynyl refer to groups in which one, two, three or more hydrogen atoms have been replaced by a halogen atom (preferably F or Cl), such as, for. B. the 2, 2, 2-trichloroethyl, or the trifluoromethyl group.
• halogen atom preferably F or Cl
• heteroalkyl refers to an alkyl, a
• carbon atoms are independently replaced by an oxygen, nitrogen, phosphorus, boron, selenium, silicon and / or sulfur atom
• heteroalkyl also refers to one
• acyl such as B. acyl, acylalkyl, alkoxycarbonyl, acyloxy, acyloxyalkyl, carboxyalkylamide or alkoxycarbonyloxy.
• heteroalkyl groups are methoxy,
• heteroalkyl groups are nitrile, isonitrile, cyanate, thiocyanate, isocyanate, isothiocyanate, carbonyl and alkyl
• cycloalkyl refers to a saturated or partially unsaturated (e.g. cycloalkenyl, cycloalkynyl) cyclic group which has one or more rings (preferably 1 or 2, particularly preferably 1) which have a total of 3 to 14 ring carbon atoms, preferably Contain 3 to 10 (especially 3, 4, 5, 6 or 7) ring carbon atoms.
• cyclohexanone 2-cyclohexenone or cyclopentanone.
• cycloalkyl groups are the cyclopropyl, cyclobutyl, cyclopentyl, spiro [4, 5] decanyl, norborny, cyclohexyl, cyclopentenyl, cyclohexadienyl, decalinyl, cubanyl, bicyclo [4.3. O.nonyl, tetralin, cyclopentylcyclohexyl, fluorocyclohexyl or the cyclohex-2-enyl group.
• heterocycloalkyl refers to a cycloalkyl group as defined above (for example saturated or mono- or polyunsaturated cycloalkyl groups such as cycloalkenyl groups) in which one or more (preferably 1, 2 or 3) ring carbon atoms independently of one another by an oxygen, nitrogen or , Silicon, selenium, phosphorus or sulfur atom (preferably oxygen, sulfur or nitrogen) are replaced.
• a heterocycloalkyl group preferably has 1 or 2, (particularly preferably 1) rings with 3 to 10 (in particular 3, 4, 5, 6 or 7) ring atoms.
• alkylcycloalkyl refers to groups which, according to the above definitions, contain both cycloalkyl and also alkyl, alkenyl or alkynyl groups.
• An alkylcycloalkyl group preferably contains one or two (preferably one) cycloalkyl groups, each having 3 to 10 (in particular 3, 4, 5, 6 or 7) ring carbon atoms. thalten, and one or two alkyl, alkenyl or alkynyl groups having 1 or 2 to 6 carbon atoms.
• Alkylcycloalkenyl alkyldicycloalkenyl
• Alkenylcycloalkyl alkenyldicycloalkyl, dialkyldicycloalkyl,
• Alkenylcycloalkenyl alkenyldicycloalkenyl
• Alkynyldicycloalkyl dialkenyldicycloalkyl, alkynylcycloalkenyl, alkynyldicycloalkenyl,
• heteroalkylcycloalkyl refers to alkylcycloalkyl groups, as defined above, in which one or more (preferably 1, 2 or 3) carbon atoms independently of one another by an oxygen, nitrogen,
• a heteroalkylcycloalkyl group preferably has 1 or 2
• Alkenyl, alkynyl or heteroalkyl groups each with 1 or
• Heteroalkyl groups can be substituted
• Heteroalkynylcycloalkenyl heteroalkynyldicycloalkenyl, diheteroalkenyldicycloalkenyl,
• Dialkyldiheterocycloalkyl alkenylheterocycloalkenyl, alkenyldiheterocycloalkenyl, dialkyldiheterocycloalkyl
• Dialkenyl heterocycloalkyl dialkenyl heterocycloalkenyl, alkynyl heterocycloalkyl, alkynyl diheterocycloalkyl,
• aryl or Ar refers to an aromatic group which has one or more rings, preferably a ring which contains 6 to 14 ring carbon atoms, preferably 6 to 10 (in particular 6) ring carbon atoms.
• aryl (or Ar) also refers to corresponding groups in which one or more hydrogen atoms are independently replaced by fluorine, chlorine, bromine or iodine atoms or OH, SH, NH 2 or NO 2 groups. Examples are the phenyl, naphthyl, biphenyl, 2-fluorophenyl, anilinyl, 3-nitrophenyl or 4-hydroxyphenyl group.
• heteroaryl refers to an aromatic group which has one or more rings, preferably a ring, which contain 5 to 14 ring atoms, preferably 5, 6, 7, 8, 9 or 10 (in particular 5 or 6) ring atoms, where a or more (preferably 1, 2, 3 or 4) ring atoms
• heteroaryl also refers to corresponding groups in which one or more hydrogen atoms are independently of one another by fluorine, chlorine, bromine or iodine atoms or OH, SH, NH 2 , or N0 2 groups are replaced. Examples are 4-pyridyl-, 2-imidazolyl-, 3-phenylpyrrolyl-, thiazolyl-, oxazolyl-, triazolyl-, tetrazolyl-, isoxazolyl-, indazolyl-, indolyl- (e.g.
• benzimidazolyl- Pyridazinyl, quinolinyl, purinyl, carbazolyl, acridinyl, pyrimidyl, 2, 3 'bifuryl, 3-pyrazolyl and isoquinolinyl groups.
• aralkyl refers to groups which, in accordance with the above definitions, contain both aryl and alkyl, alkenyl, alkynyl and / or cycloalkyl groups, such as, for example, B. arylalkyl, arylalkenyl, arylalkynyl, arylcycloalkyl, arylcycloalkenyl, arylcycloalkynyl, alkylarylcycloalkyl- alkylarylcycloalkenyl-
• aralkyls are toluene, trityl, xylene, mesitylene, styrene, benzyl chloride, o-fluorotoluene, IH-indene, tetralin, dihydro-naphthalenes, indanone, phenylcyclopentyl, Cu ol, cyclohexylphenyl, fluorene and indane.
• An aralkyl group preferably contains an aromatic ring system (1 or 2 rings) having 6 to 10 carbon atoms (eg phenyl or naphthyl) and one or two alkyl, alkenyl and / or alkynyl groups each having 1 or 2 to 6 carbon atoms and / or a cycloalkyl group with 5 or 6 ring carbon atoms.
• aromatic ring system (1 or 2 rings) having 6 to 10 carbon atoms (eg phenyl or naphthyl) and one or two alkyl, alkenyl and / or alkynyl groups each having 1 or 2 to 6 carbon atoms and / or a cycloalkyl group with 5 or 6 ring carbon atoms.
• heteroaralkyl refers to an aralkyl group as defined above, in which one or more (preferably 1, 2, 3 or 4) carbon atoms independently of one another by an oxygen, nitrogen, silicon, selenium, phosphorus, boron or Sulfur atom (preferably oxygen, sulfur or nitrogen) are replaced, ie on groups which, according to the above definitions, are both aryl or heteroaryl and also alkyl, alkenyl or alkynyl and / or heteroalkyl and / or cycloalkyl or contain cycloalkenyl and / or heterocycloalkyl or heterocycloalkenyl groups.
• a heteroaralkyl group preferably contains one or two aromatic ring systems (each with 1 or 2 rings) each having 5, 6, 7, 8, 9 or 10 ring carbon atoms and one or two alkyl, alkenyl and / or alkynyl groups with 1 or 2 , 3, 4, 5 or 6 carbon atoms and / or a cycloalkyl group with 5 or 6 ring carbon atoms, where 1, 2, 3 or 4 of these carbon atoms and / or ring carbon atoms are independently replaced by oxygen, sulfur or nitrogen atoms.
• Examples are aryl heteroalkyl, aryl heterocycloalkyl, aryl heterocycloalkenyl, aryl alkyl heterocycloalkyl, aryl alkenyl heterocycloalkyl, aryl alkynyl heterocycloalkyl, aryl alkyl heterocycloalkenyl, aryl heteroalkyl heterocyclo , Heteroaryl-alkyl,
• Heteroaryl-heteroalkyl-cycloalkyl, heteroaryl-alkyl-heterocycloalkenyl, heteroaryl-heteroalkyl-cycloalkenyl and heteroaryl-heteroalkyl-heterocycloalkyl groups the cyclic groups being saturated or mono-, di- or trisaturated. Specific examples are the tetrahydroisoquinolinyl, benzoyl, 2- or 3-ethylindolyl, 4-methylpyridino, 2-, 3- or 4-methoxyphenyl, 4-ethoxyphenyl, 2-, 3- or 4-carboxyphenylalkyl group ,
• This expression also refers to groups in which one, two or more hydrogen atoms are independently substituted by unsubstituted C ⁇ -C6 alkyl, CC 6 alkenyl, C 2 -C6 alkynyl, C ⁇ -C 6 heteroalkyl, C 3 -C ⁇ 0 Cycloalkyl, C 2 -C 9 heterocycloalkyl, C ⁇ -Cio aryl, -C-C 9 heteroaryl, C 7 -C ⁇ 2 aralkyl or C 2 -Cn heteroaralkyl groups are replaced.
• glycosyl group or glycosyl radical refers to a saccharide (mono- or oligosaccharide including amino sugar and .beta. Bonded via an ⁇ - or ⁇ -0, S, N or C-glycosidic bond (preferably an O-glycosidic bond) N-acetylamino sugars), in which the OH groups can optionally be protected by acetyl or benzoyl groups, in particular a monosaccharide (e.g. glucose, galactose, fructose, fucose, ribose, glucosamine, N-acetylglucosamine, galactosamine, N-
• a monosaccharide e.g. glucose, galactose, fructose, fucose, ribose, glucosamine, N-acetylglucosamine, galactosamine, N-
• Acetylgalactosamine or mannose preferably ⁇ -D-glucose.
• Y is a group of the formula CONR 6 and R 3 is not a group of the formula -CHR 7 -C0-NR 8 R 9 , where R 7 , R 8 and R 9 independently of one another are a hydrogen atom , an alkyl, alkenylalkynyl, heteroalkyl, heteroaralkyl, heteroaryl, aralkyl, cycloalkyl, heterocycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, or an aryl group, or R 8 and R 9 together form part of a heterocycloalkyl or Heteroarylringsystems are.
• R 3 is not a group of the formula -NR 10 -CHR 7 -CO-NR 8 R 9 , where R 7 , R 8 , R 9 and R 10 independently of one another represent a hydrogen atom, an alkyl, alkenyl, alkynyl, heteroalkyl, heteroaralkyl, heteroaryl, alkylcycloalkyl, heteroalkylcycloalkyl, aralkyl, cycloalkyl, heterocycloalkyl, or an aryl group are or R 8 and R 9 and / or R 7 and R 10 together form part of a heterocycloalkyl or heteroaryl ring system.
• R 8 and R 9 and / or R 7 and R 10 together form part of a heterocycloalkyl or heteroaryl ring system.
• the radical -YR 3 has the following structure:
• Ar 1 is again preferably not a phenyl ring to which A and X are bonded in the para position to one another if A is
• A is furthermore preferably a hydrogen atom.
• R 4 is preferably a hydrogen atom, a hydroxy or a Ci, C 2 , C 3 or C 4 alkyloxy group; R 4 is particularly preferably a hydrogen atom.
• Ar 1 is more preferably a phenyl or a heteroaryl group having 5, 6, 7, 8, 9 or 10 ring atoms and
• Ar 1 is particularly preferably a phenyl group; in particular a phenyl group to which the groups A and X are bonded to one another in the meta position.
• Ar 2 is furthermore preferably a phenyl or a heteroaryl group having 5 or 6 ring atoms and 1, 2 or 3 heteroatoms, selected from 0, S and N;
• Ar 2 is particularly preferably a phenyl group.
• X is preferably a group of the formula NH, NMe, or NAc; X is particularly preferably an NH group.
• n is preferably 0, 1 or 2; particularly preferably 0 or 1.
• R 1 is more preferably a hydroxyl group which, for Ar 1 is phenyl, is bonded, in particular in the para position to A.
• n is preferably 0 or 1, the radicals R 2 and G preferably being in the ortho position to one another; m is particularly preferably 0.
• Y is more preferably a group of the formula CONH.
• R 3 is further preferably a group of the formula -UVW, U being an optionally substituted arylene group having 6-10 of the 12 ring carbon atoms or an optionally substituted heteroarylene group having 5, 6, 7, 8, 9 or 10 ring carbon atoms and 1 , 2, 3 or 4 (preferably 1 or 2) heteroatoms selected from 0, S and N;
• V is a bond, an oxygen atom, a sulfur atom, a group of the formula NR 11 (where R 11 is a hydrogen atom, a C lr C 2 , C 3 or C-alkyl, a Ci, C 2 , C 3 or C 4 heteroalkyl -, a C 7 , C 8 , C 9 , C ⁇ 0 Cu or C ⁇ 2 - aralkyl group or a C 6 C 7 , C 8 , C 9 , C ⁇ 0 , Cu or C ⁇ 2 - heteroaralkyl group), CO, SO, S0 2 or S0 2 NH and W is a hydrogen atom
• U is particularly preferably an optionally substituted phenylene group; especially a para-phenylene group.
• V is particularly preferably a bond or a carbonyl group.
• W is a Ci, C 2 , C 3 or C_ alkyl group, a Ci, C 2 , C 3 or C 4 heteroalkyl group with one or two 0, N or S atoms, an optionally substituted phenyl group, an optionally substituted C 3 C 4 , C 5 , C ⁇ or C 7 cycloalkyl group, an optionally substituted heterocycloalkyl group with 3-7 (preferably 5 or 6) ring carbon atoms and 1, 2 or 3 ring heteroatoms (independently selected from 0, S and N) or an optionally substituted heteroaryl group with 5 or 6 ring carbon atoms and 1, 2, 3 or 4 ring heteroatoms selected from 0, S and N.
• Preferred compounds of the general formula I are those in which Y is a group of the formula CONR 6 and R 3 is not a group of the formula -CHR 7 -CO-NR 8 R 9 in which R 7 , R 8 and R 9 are defined as R 5 , R 6 and R 7 in PCT application PCT / EP 02/01934 (WO 02/068390) from Morphoche AG dated February 22, 2002 or where R 7 , R 8 and R 9 are defined as R 5 , R 6 and R 7 in PCT application PCT / EP 01/09753 (WO 02/16312) from Morphochem AG dated August 23, 2001.
• E is a hydrogen, fluorine, chlorine or bromine atom and the radicals R 1 , R 2 , G, V and W are as defined above, o is 0 or 1, p is 0 or 1 and q is 0 , 1 or 2.
• R 1 is particularly preferably a hydroxyl group
• R 2 is a methoxy or an ethoxy group
• G is a ⁇ -D-glucosyloxy group
• Compounds of formula (I) or (II) may contain one or more centers of chirality due to their substitution.
• the present invention therefore encompasses all pure enantiomers and all pure diastereomers, as well as their mixtures in any mixing ratio.
• the present invention also includes all cis / trans isomers of the compounds of the general formula (I) or (II) and mixtures thereof.
• the present invention further encompasses all tautomeric forms of the compounds of the formula (I) or (II).
• Examples of pharmacologically acceptable salts of the compounds of the formula (I) or (II) are salts of physiologically acceptable mineral acids such as hydrochloric acid, sulfuric acid and phosphoric acid; or salts of organic acids such as methanesulfonic acid, p-toluenesulfonic acid, lactic acid, formic acid, acetic acid, trifluoroacetic acid, citric acid, succinic acid, fumaric acid, maleic acid and salicylic acid.
• Compounds of formula (I) or (II) can be solvated, in particular hydrated. The hydration can e.g. occur during the manufacturing process or as a result of the hygroscopic nature of the initially anhydrous compounds of formula (I) or (II).
• compositions according to the present invention contain at least one compound of the formula (I) or (II) as an active ingredient and optionally excipients and / or adjuvants.
• the pro-drugs e.g. BRB Silverman, Medicinal Chemistry, VCH Weinheim, 1995, Chapter 8, p. 361ff
• the pro-drugs consist of a compound of formula (I) or (II) and at least one pharmacologically acceptable protective group which is split off under physiological conditions, for example a hydroxyl, alkoxy, aralkyloxy, acyl or acyloxy group, such as for example a methoxy, ethoxy, benzyloxy, acetyl or acetyloxy group.
• (II) can e.g. B. by reacting compounds of the formulas (III) (optionally as hydrochloride or similar salt), (IV) and (V) via a multicomponent reaction (A. Dömling, I. Ugi, Angew. Che. 2000, 112, 3300 -3344), where the residues are as defined above.
• a compound of formula (III) with a compound of formula (IV) is preferably dissolved in a suitable solvent (preferably a mixture of acetonitrile and water) and optionally stirred (preferably 30 minutes at room temperature).
• a compound of the formula (V) is then added and, if appropriate, further stirred (preferably 15 h at room temperature).
• the solvent which may be present is then preferably removed in vacuo.
• the compounds produced here can, for. B. cleaned by HPLC and separated into the individual stereoisomers. If appropriate, it may be preferred to carry out the reaction in the presence of a Lewis acid (e.g. indium trichloride, boron trifluoride etherate, trimethylaluminium, lithium chloride, aluminum trichloride, scandiu triflate, zinc chloride, ytterbium triflate, magnesium triflate, magnesium bromide, zirconium chloride or titanium (IV tetrachloride), titanium (IV) chloride chloride ) or a Br0nstedt acid.
• a Lewis acid e.g. indium trichloride, boron trifluoride etherate, trimethylaluminium, lithium chloride, aluminum trichloride, scandiu triflate, zinc chloride, ytterbium triflate, magnesium triflate, magnesium bromide, zirconium chloride or titanium (IV tetrachloride),
• 3-aminobenzamidine is commercially available; 3-Amino-4-hydroxybenzamidine can be obtained from commercially available 4-hydroxy-3-nitrobenzonitrile via a Pinner reaction (A. Pinner, F. Klein, Ber. 10, 1889 (1877); 11, 4, 1475 (1878); 16 , 352, 1643 (1883)) to 4-hydroxy-3-nitro-benzamidine and subsequent reduction with H 2 -Pd / C.
• Pinner reaction A. Pinner, F. Klein, Ber. 10, 1889 (1877); 11, 4, 1475 (1878); 16 , 352, 1643 (1883)
• Other benzamidines (such as 3-amino-4-chloro-benzamidine) can also be prepared analogously.
• Glycosylated aryl compounds e.g. glycosylated benzaldehydes
• B. can e.g. B. according to the in Kleine et al. Carbohydrate Research 1985, 142, 333-337 and Brewster et al. Tetrahedron Letters 1979, 5051-5054 described processes.
• Helicin salicylaldehyde- ⁇ -D-glucoside
• a compound or pharmaceutical composition of the present invention can be used to inhibit factor Xa activity, to prevent and / or treat thromboembolic disorders, arterial restenosis, blood poisoning, cancer, acute inflammation or other diseases caused by factor Xa activity are mediated, and in particular of venous thrombosis, edema or inflammation, of "deep vein thrombosis", pulmonary embolism, thromboembolytic complications after major operations, in vascular surgery, prolonged immobilization, broken bones of the lower extremities etc., of arterial thrombosis, in particular Coronary arteries for myocardial infarction as well as arteriosclerosis, apoplexy, angina pectoris, intermittent claudication can be used to name just a few indications.
• the active compounds according to the invention should have the greatest possible inhibitory effect on factor Xa with the highest possible selectivity.
• the selectivity was determined in the present case by comparing the inhibitory effect on factor Xa and tryptase, trypsin, plasmin, thrombin and other serine proteinases.
• the present / inventive compounds are as
• the present invention also relates to the use of these active substances for the production of medicaments for the prevention and / or treatment of thromboembolytic diseases.
• compounds of formulas (I) or (II) are administered using known and acceptable modes, either individually or in combination with any other therapeutic agent.
• the administration can take place, for example, in one of the following ways: orally, for example as dragées, coated tablets, pills, semi-solids, soft or hard capsules, solutions, emulsions or suspensions; parenterally, for example as an injectable solution; rectally as suppositories; by inhalation, for example as a powder formulation or spray, transdermally or intranasally.
• the therapeutically usable product can be mixed with pharmacologically inert, inorganic or organic drug carrier substances, for example with lactose, sucrose, glucose, gelatin, malt, silica gel, starch or derivatives thereof , Talc, stearic acid or its salts, dry skimmed milk and the like.
• drug carriers such as vegetable oils, petroleum, animal or synthetic oils, wax, fat, polyols can be used.
• drug carriers such as water, alcohols, aqueous salt solution, aqueous dextrose, polyols, glycerin, vegetable oils, petroleum, animal or synthetic oils
• drug carriers such as vegetable oils, petroleum, animal or synthetic oils, wax, fat and polyols
• aerosol Formulations can use compressed gases suitable for this purpose, such as oxygen, nitrogen and carbon dioxide.
• the pharmaceutically usable agents can also contain additives for preservation, stabilization, emulsifiers, sweeteners, flavorings, salts for changing the otic pressure, buffers, coating additives and antioxidants.
• Combinations with other therapeutic agents may include other agents that are commonly used to prevent and / or treat thromboembolytic disorders such as e.g. Warfarin etc.
• the dose of the biologically active compound according to the invention can vary within wide limits and can be adjusted to individual requirements. In general, a dose of 0.1 ⁇ g to 10 mg / kg body weight per day is suitable, with a preferred dose being 0.1 to 4 mg / kg per day. In suitable cases, the dose can also be below or above the values given above.
• the daily dose can be administered in 1, 2, 3 or 4 single doses, for example. It is also possible to dose e.g. to be administered as a single dose for one week.
• EXAMPLE 48 2- ⁇ 2- (3-Carbamimidoyl-phenylamino) -2- [2- (3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy) phenyl] acetylamino ⁇ benzoic acid
• Chromogenic peptide substrates were used to show the inhibitory activity against factor Xa activity.
• the inhibition of the amidolytic activity of factor Xa by the compounds described above was shown as follows. The measurements were taken at room temperature performed in microtiter plates. The compounds were dissolved in dimethyl sulfoxide and 5 ⁇ l of this solution (IM, 100 ⁇ m, 10 ⁇ m, 10 ⁇ m) were converted into 35 ⁇ l of a 2.15 nM solution of human recombinant factor Xa (Enzyme Research Laboratories, South Bend, IN, USA) in a buffer (pH: 8.0 and using 50mM Tris-HCl, 100mM NaCl, 0.1% PEG 6000 and 0.05% Tween 80).
• IC 50 values of the above examples are in the range from 0.1 nM to l ⁇ M.

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• 2003
  • 2003-01-31 BR BR0307266-5A patent/BR0307266A/pt not_active IP Right Cessation
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  • 2003-01-31 MX MXPA04007461A patent/MXPA04007461A/es active IP Right Grant
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  • 2003-01-31 EP EP03734605A patent/EP1470143B1/de not_active Expired - Lifetime
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