PL369772A1 - Compounds that inhibit factor xa activity - Google Patents

Compounds that inhibit factor xa activity

Info

Publication number
PL369772A1
PL369772A1 PL03369772A PL36977203A PL369772A1 PL 369772 A1 PL369772 A1 PL 369772A1 PL 03369772 A PL03369772 A PL 03369772A PL 36977203 A PL36977203 A PL 36977203A PL 369772 A1 PL369772 A1 PL 369772A1
Authority
PL
Poland
Prior art keywords
compounds
activity
inhibit factor
pharmaceutically acceptable
factor
Prior art date
Application number
PL03369772A
Other languages
English (en)
Polish (pl)
Inventor
Robert Eckl
Silke Schabbert
Thilo Fuchs
Lutz Weber
Christian Oefner
Original Assignee
Morphochem Aktiengesellschaft Für Kombinatorischechemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10204072A external-priority patent/DE10204072A1/de
Priority claimed from DE10300049A external-priority patent/DE10300049A1/de
Application filed by Morphochem Aktiengesellschaft Für Kombinatorischechemie filed Critical Morphochem Aktiengesellschaft Für Kombinatorischechemie
Publication of PL369772A1 publication Critical patent/PL369772A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL03369772A 2002-01-31 2003-01-31 Compounds that inhibit factor xa activity PL369772A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10204072A DE10204072A1 (de) 2002-01-31 2002-01-31 Neue Verbindungen, die Faktor Xa-Aktivität inhibieren
DE10300049A DE10300049A1 (de) 2003-01-03 2003-01-03 Neue Verbindungen, die Faktor VIIa inhibieren

Publications (1)

Publication Number Publication Date
PL369772A1 true PL369772A1 (en) 2005-05-02

Family

ID=27664555

Family Applications (1)

Application Number Title Priority Date Filing Date
PL03369772A PL369772A1 (en) 2002-01-31 2003-01-31 Compounds that inhibit factor xa activity

Country Status (13)

Country Link
US (1) US20050049283A1 (enExample)
EP (1) EP1470143B1 (enExample)
JP (1) JP2005525325A (enExample)
KR (1) KR20040096541A (enExample)
CN (1) CN1322001C (enExample)
AT (1) ATE377017T1 (enExample)
BR (1) BR0307266A (enExample)
CA (1) CA2473169A1 (enExample)
DE (1) DE50308492D1 (enExample)
MX (1) MXPA04007461A (enExample)
NZ (1) NZ534238A (enExample)
PL (1) PL369772A1 (enExample)
WO (1) WO2003064440A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2283833A3 (en) * 2004-02-25 2013-07-10 La Jolla Pharmaceutical Co. Amines and amides for the treatment of diseases
CN101341129B (zh) * 2005-12-14 2011-12-14 布里斯托尔-迈尔斯斯奎布公司 作为因子xia抑制剂的芳基丙酰胺，芳基丙烯酰胺，芳基丙炔酰胺，或芳基甲基脲类似物
AR058379A1 (es) * 2005-12-14 2008-01-30 Bristol Myers Squibb Co Derivados de arilpropionamida arilacrilamida arilpropinamida o arilmetilurea como inhibidores del factor xia. proceso de obtencion y composiciones farmaceuticas.
WO2017156071A1 (en) 2016-03-09 2017-09-14 Blade Therapeutics, Inc. Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof
AU2017292646A1 (en) 2016-07-05 2019-02-07 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
WO2018064119A1 (en) 2016-09-28 2018-04-05 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2614893B1 (fr) * 1987-05-04 1989-12-22 Fournier Innovation Synergie Nouveaux b-d-phenyl-thioxylosides, leur procede de preparation et leur application en therapeutique
EP0560568A3 (en) * 1992-03-13 1994-06-29 Takeda Chemical Industries Ltd Hydroquinone derivatives and intermediates for production thereof
SI0921116T1 (en) * 1997-12-04 2003-10-31 F. Hoffmann - La Roche Ag N-(4-carbamimido-phenyl)-glycine amide derivatives
KR20010082515A (ko) * 1998-02-17 2001-08-30 우에노 도시오 아미디노 유도체 및 그 유도체를 유효 성분으로서함유하는 약제
SK286755B6 (sk) * 1998-06-17 2009-05-07 Universiteit Leiden Antitrombotické zlúčeniny, farmaceutický prostriedok s ich obsahom a ich použitie
DE10041402A1 (de) * 2000-08-23 2002-03-14 Morphochem Ag Neue Verbindungen, die Faktor Xa-Aktivität inhibieren
EP1336605B1 (en) * 2000-11-22 2006-04-12 Astellas Pharma Inc. Substituted phenol derivatives or salts thereof as inhibitors of coagulation factor x

Also Published As

Publication number Publication date
NZ534238A (en) 2006-09-29
WO2003064440A1 (de) 2003-08-07
KR20040096541A (ko) 2004-11-16
US20050049283A1 (en) 2005-03-03
EP1470143A1 (de) 2004-10-27
MXPA04007461A (es) 2005-07-13
CA2473169A1 (en) 2003-08-07
ATE377017T1 (de) 2007-11-15
BR0307266A (pt) 2004-12-07
EP1470143B1 (de) 2007-10-31
DE50308492D1 (de) 2007-12-13
CN1625559A (zh) 2005-06-08
CN1322001C (zh) 2007-06-20
JP2005525325A (ja) 2005-08-25

Similar Documents

Publication Publication Date Title
MY141661A (en) 17b-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
IL164511A0 (en) Heterocyclic compounds
GB0114286D0 (en) Nucleoside Derivatives
JO2311B1 (en) Alkyl inhibitors Ariel phosphodiesterase-4
NZ544009A (en) Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain
MY147780A (en) Carboxamide compounds and their use as calpain inhibitors
MXPA04005790A (es) Compuestos y usos de los mismos para reducir la actividad de la lipasa sensible a la hormona.
MXPA05011411A (es) 1,4-diazepinas sustituidas y usos de las mismas.
UA84141C2 (ru) Применение ингибитора пктжк для лечения или профилактики запора
IL164613A0 (en) Thienyl compounds
IL164509A0 (en) Furyl compounds
ZA200306419B (en) Phenyl derivatives.
TW200509949A (en) Pharmaceutical compositions and methods relating to inhibiting fibrous adhesions using various agents
DE602004011394D1 (en) Thiazolderivate
HK1052170A1 (zh) 新型化合物抑制因子xa活度
MXPA05010000A (es) Derivados de p-diaminobenceno substituidos.
DE60205899D1 (en) 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
SE9802208D0 (sv) Novel compounds
MXPA05009282A (es) Derivados de anilina sustituidos.
MXPA04003611A (es) Piperidina- y piperazinacetaminas como inhibidores de la 17 beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades androgeno-dependientes.
MY130792A (en) 17ß-HYDROXYSTEROID DEHYDROGENASE TYPE 3 INHIBITORS FOR THE TREATMENT OF ANDROGEN DEPENDENT DISEASES
SE9902267D0 (sv) New compounds
DK1206444T3 (da) Forbindelser der hæmmer tryptaseaktivitet
PL369772A1 (en) Compounds that inhibit factor xa activity
GB0212410D0 (en) Organic compounds

Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)