DE50012021D1 - Nucleinsauremoleküle mit spezifischer erkennung von nativem prpsc, herstellung und verwendung - Google Patents

Nucleinsauremoleküle mit spezifischer erkennung von nativem prpsc, herstellung und verwendung

Info

Publication number
DE50012021D1
DE50012021D1 DE50012021T DE50012021T DE50012021D1 DE 50012021 D1 DE50012021 D1 DE 50012021D1 DE 50012021 T DE50012021 T DE 50012021T DE 50012021 T DE50012021 T DE 50012021T DE 50012021 D1 DE50012021 D1 DE 50012021D1
Authority
DE
Germany
Prior art keywords
sup
molecules
nucleic acid
nuclein
sea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE50012021T
Other languages
English (en)
Inventor
Stefan Weiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LASMEZAS CORINNE IDA
Original Assignee
LASMEZAS CORINNE IDA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LASMEZAS CORINNE IDA filed Critical LASMEZAS CORINNE IDA
Priority to DE50012021T priority Critical patent/DE50012021D1/de
Application granted granted Critical
Publication of DE50012021D1 publication Critical patent/DE50012021D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
    • A61K41/13—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultrasonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases
DE50012021T 1999-06-01 2000-05-31 Nucleinsauremoleküle mit spezifischer erkennung von nativem prpsc, herstellung und verwendung Expired - Fee Related DE50012021D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE50012021T DE50012021D1 (de) 1999-06-01 2000-05-31 Nucleinsauremoleküle mit spezifischer erkennung von nativem prpsc, herstellung und verwendung

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19925073A DE19925073C2 (de) 1999-06-01 1999-06-01 Nucleinsäuremoleküle mit spezifischer Erkennung von nativem PrP·S··c·, Herstellung und Verwendung
PCT/EP2000/005020 WO2000073501A2 (de) 1999-06-01 2000-05-31 Nucleinsäuremoleküle mit spezifischer erkennung von nativem prpsc, herstellung und verwendung
DE50012021T DE50012021D1 (de) 1999-06-01 2000-05-31 Nucleinsauremoleküle mit spezifischer erkennung von nativem prpsc, herstellung und verwendung

Publications (1)

Publication Number Publication Date
DE50012021D1 true DE50012021D1 (de) 2006-03-30

Family

ID=7909872

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19925073A Expired - Fee Related DE19925073C2 (de) 1999-06-01 1999-06-01 Nucleinsäuremoleküle mit spezifischer Erkennung von nativem PrP·S··c·, Herstellung und Verwendung
DE50012021T Expired - Fee Related DE50012021D1 (de) 1999-06-01 2000-05-31 Nucleinsauremoleküle mit spezifischer erkennung von nativem prpsc, herstellung und verwendung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19925073A Expired - Fee Related DE19925073C2 (de) 1999-06-01 1999-06-01 Nucleinsäuremoleküle mit spezifischer Erkennung von nativem PrP·S··c·, Herstellung und Verwendung

Country Status (8)

Country Link
US (1) US7371833B1 (de)
EP (1) EP1100958B1 (de)
JP (1) JP2003501050A (de)
AT (1) ATE315105T1 (de)
AU (1) AU5527700A (de)
CA (1) CA2339131A1 (de)
DE (2) DE19925073C2 (de)
WO (1) WO2000073501A2 (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000713A1 (en) * 2000-06-26 2002-01-03 Universität Zürich Prion-binding activity in serum and plasma determined as plasminogen and fibrinogen
GB0012054D0 (en) * 2000-05-18 2000-07-12 Isis Innovation Ligands
EP1333090A1 (de) * 2002-02-01 2003-08-06 NascaCell GmbH Prionprotein-spezifische Aptamere
CN101123993A (zh) * 2002-08-07 2008-02-13 特拉华大学 治疗表现出蛋白质错误组装和聚集的疾病的组合物和方法
US7480382B2 (en) * 2003-09-30 2009-01-20 Microsoft Corporation Image file container
CN103301475B (zh) 2005-12-28 2016-08-03 斯克里普斯研究所 药物组合物和表达载体以及调节基因表达的方法和核酸分子的应用
CA2739464C (en) * 2008-10-03 2020-03-31 Opko Curna, Llc Treatment of apolipoprotein-a1 related diseases by inhibition of natural antisense transcript to apolipoprotein-a1
MX2011005910A (es) 2008-12-04 2011-06-17 Opko Curna Llc Tratamiento de enfermedades relacionadas con eritropoyetina (epo) mediante inhibicion del transcrito antisentido natural a eritropoyetina.
US20110294870A1 (en) 2008-12-04 2011-12-01 Opko Curna, Llc Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene
CA2746003C (en) 2008-12-04 2020-03-31 Opko Curna, Llc Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf
KR101682735B1 (ko) 2009-02-12 2016-12-06 큐알엔에이, 인크. 뇌 유래된 신경영양성 인자 (ｂｄｎｆ)에 대한 자연 안티센스 전사체의 저해에 의한 뇌 유래된 신경영양성 인자 (ｂｄｎｆ) 관련된 질환의 치료
WO2010107733A2 (en) 2009-03-16 2010-09-23 Curna, Inc. Treatment of nuclear factor (erythroid-derived 2)-like 2 (nrf2) related diseases by inhibition of natural antisense transcript to nrf2
CN102549159B (zh) 2009-03-17 2016-08-10 库尔纳公司 通过抑制针对δ样1同源物(DLK1)的天然反义转录物来治疗DLK1相关的疾病
KR101835889B1 (ko) 2009-05-06 2018-03-08 큐알엔에이, 인크. 지질 수송 및 대사 유전자에 대한 천연 안티센스 전사체의 억제에 의해 지질 수송 및 대사 유전자 관련된 질환의 치료
CA2761142C (en) 2009-05-06 2021-06-08 Opko Curna, Llc Treatment of tristetraproline (ttp) related diseases by inhibition of natural antisense transcript to ttp
US9012139B2 (en) 2009-05-08 2015-04-21 Curna, Inc. Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to DMD family
DK2432881T3 (en) 2009-05-18 2018-02-26 Curna Inc TREATMENT OF REPROGRAMMING FACTOR-RELATED DISEASES BY INHIBITING NATURAL ANTISENSE TRANSCRIPTS TO A REPROGRAMMING FACTOR
WO2010135695A2 (en) 2009-05-22 2010-11-25 Curna, Inc. TREATMENT OF TRANSCRIPTION FACTOR E3 (TFE3) and INSULIN RECEPTOR SUBSTRATE 2 (IRS2) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO TFE3
CN103221541B (zh) 2009-05-28 2017-03-01 库尔纳公司 通过抑制抗病毒基因的天然反义转录物来治疗抗病毒基因相关疾病
ES2629339T3 (es) 2009-06-16 2017-08-08 Curna, Inc. Tratamiento de enfermedades relacionadas con la paraoxonasa 1 (pon1) por inhibición de transcrito antisentido natural a pon1
JP5944311B2 (ja) 2009-06-16 2016-07-05 クルナ・インコーポレーテッド コラーゲン遺伝子に対する天然アンチセンス転写物の抑制によるコラーゲン遺伝子関連疾患の治療
CA2765889A1 (en) 2009-06-24 2010-12-29 Opko Curna, Llc Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2
KR101807324B1 (ko) 2009-06-26 2017-12-08 큐알엔에이, 인크. 다운 증후군 유전자에 대한 천연 안티센스 전사체의 억제에 의한 다운 증후군 유전자 관련된 질환의 치료
CA2768947C (en) 2009-07-24 2018-06-19 Opko Curna, Llc Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
WO2011017516A2 (en) 2009-08-05 2011-02-10 Curna, Inc. Treatment of insulin gene (ins) related diseases by inhibition of natural antisense transcript to an insulin gene (ins)
EP2464731B1 (de) 2009-08-11 2016-10-05 CuRNA, Inc. Behandlung von adiponectin (adipoq)-bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen ein adiponectin (adipoq)
EP2982755B1 (de) 2009-08-21 2020-10-07 CuRNA, Inc. Behandlung von erkrankungen im zusammenhang mit c-terminus des hsp70-interagierenden proteins (chip) durch hemmung des natürlichen antisense-transkripts gegen chip
EP2470657B1 (de) 2009-08-25 2019-10-23 CuRNA, Inc. Behandlung von iqgap ('iq-motiv-haltiges gtpase-aktivierendes protein')-bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen iqgap
DK2480669T3 (en) 2009-09-25 2018-02-12 Curna Inc TREATMENT OF FILAGGRIN- (FLG) RELATED DISEASES BY MODULATING FLG EXPRESSION AND ACTIVITY
CA2782366A1 (en) 2009-12-16 2011-07-14 Opko Curna, Llc Treatment of membrane bound transcription factor peptidase, site 1 (mbtps1) related diseases by inhibition of natural antisense transcript to mbtps1
US9068183B2 (en) 2009-12-23 2015-06-30 Curna, Inc. Treatment of uncoupling protein 2 (UCP2) related diseases by inhibition of natural antisense transcript to UCP2
WO2011079261A2 (en) 2009-12-23 2011-06-30 Curna, Inc. Treatment of hepatocyte growth factor (hgf) related diseases by inhibition of natural antisense transcript to hgf
RU2611186C2 (ru) 2009-12-29 2017-02-21 Курна, Инк. ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С ОПУХОЛЕВЫМ БЕЛКОМ 63 (р63), ПУТЕМ ИНГИБИРОВАНИЯ ПРИРОДНОГО АНТИСМЫСЛОВОГО ТРАНСКРИПТА К р63
EP2519633B1 (de) 2009-12-29 2017-10-25 CuRNA, Inc. Behandlung von erkrankungen im zusammenhang mit dem nuclear-respirator-faktor 1 (nrf1) mittels hemmung des natürlichen antisense-transkripts gegen nrf1
RU2016115782A (ru) 2009-12-31 2018-11-28 Курна, Инк. Лечение заболеваний, связанных с субстратом рецептора инсулина 2 (irs2), путем ингибирования природного антисмыслового транскрипта к irs2 и транскрипционному фактору е3 (tfe3)
US8946181B2 (en) 2010-01-04 2015-02-03 Curna, Inc. Treatment of interferon regulatory factor 8 (IRF8) related diseases by inhibition of natural antisense transcript to IRF8
WO2011085066A2 (en) 2010-01-06 2011-07-14 Curna, Inc. Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene
EP2524039B1 (de) 2010-01-11 2017-11-29 CuRNA, Inc. Behandlung von krankheiten im zusammenhang mit dem sexualhormonbindenden globulin (shgb) mittels hemmung des natürlichen antisense-transkripts gegen shbg
RU2611192C2 (ru) 2010-01-25 2017-02-21 Курна, Инк. ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С РНКазой Н1, ПУТЕМ ИНГИБИРОВАНИЯ ПРИРОДНОГО АНТИСМЫСЛОВОГО ТРАНСКРИПТА К РНКазе Н1
KR101838308B1 (ko) 2010-02-22 2018-03-13 큐알엔에이, 인크. 피롤린-5-카르복실레이트 환원효소 1(ｐｙｃｒ1)에 대한 천연 안티센스 전사체의 억제에 의한 ｐｙｃｒ1과 관련된 질환의 치료
US8980856B2 (en) 2010-04-02 2015-03-17 Curna, Inc. Treatment of colony-stimulating factor 3 (CSF3) related diseases by inhibition of natural antisense transcript to CSF3
RU2610661C2 (ru) 2010-04-09 2017-02-14 Курна, Инк. Лечение заболеваний, связанных с фактором роста фибробластов 21 (fgf21), путем ингибирования природного антисмыслового транскрипта к fgf21
RU2693462C2 (ru) 2010-05-03 2019-07-03 Курна, Инк. Лечение заболеваний, связанных с сиртуином (sirt), путем ингибирования природного антисмыслового транскрипта к сиртуину (sirt)
TWI586356B (zh) 2010-05-14 2017-06-11 可娜公司 藉由抑制ｐａｒ４天然反股轉錄本治療ｐａｒ４相關疾病
EP2576783B1 (de) 2010-05-26 2017-11-29 CuRNA, Inc. Behandlung von durch atonal homolog 1 (atoh1) vermittelten erkrankungen durch hemmung des natürlichen antisense-transkripts für atoh1
JP5917497B2 (ja) 2010-05-26 2016-05-18 カッパーアールエヌエー，インコーポレイテッド メチオニンスルホキシドレダクターゼａ（ｍｓｒａ）に対する天然アンチセンス転写物の阻害によるｍｓｒａ関連疾患の治療
JP6023705B2 (ja) 2010-06-23 2016-11-09 カッパーアールエヌエー，インコーポレイテッド ナトリウムチャネル、電位依存性、αサブユニット（ＳＣＮＡ）に対する天然アンチセンス転写物の阻害によるＳＣＮＡ関連疾患の治療
JP5998131B2 (ja) 2010-07-14 2016-09-28 カッパーアールエヌエー，インコーポレイテッド Ｄｉｓｃｓｌａｒｇｅｈｏｍｏｌｏｇ（ｄｌｇ）ｄｌｇ１への天然アンチセンス転写物の阻害によるｄｌｇ関連疾患の治療
ES2640755T3 (es) 2010-10-06 2017-11-06 Curna, Inc. Tratamiento de enfermedades relacionadas con la Sialidasa 4 (neu4) mediante inhibición del transcrito antisentido natural al gen neu4
EP2630241B1 (de) 2010-10-22 2018-10-17 CuRNA, Inc. Behandlung von alpha-l-iduronidase (idua)-bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen idua
US8987225B2 (en) 2010-11-23 2015-03-24 Curna, Inc. Treatment of NANOG related diseases by inhibition of natural antisense transcript to NANOG
ES2653247T3 (es) 2011-06-09 2018-02-06 Curna, Inc. Tratamiento de enfermedades relacionadas con la frataxina (FXN) mediante inhibición del transcrito antisentido natural al gen FXN
CN108272782B (zh) 2011-09-06 2021-04-23 库尔纳公司 小分子在制备治疗Dravet综合征或全面性癫痫伴热性惊厥附加症的药物中的用途
US20150031750A1 (en) 2012-03-15 2015-01-29 The Scripps Research Institute Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
EP3056901B1 (de) 2015-02-13 2018-08-29 Technische Universität Berlin Verfahren zum Nachweis von Proteinen mit Hilfe von Aptameren

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543507A (en) * 1992-03-05 1996-08-06 Isis Pharmaceuticals, Inc. Covalently cross-linked oligonucleotides
ATE171210T1 (de) * 1992-07-02 1998-10-15 Hybridon Inc Selbststabilisierte oligonukleotide als therapeutika
DE852011T1 (de) 1995-09-14 2001-10-11 Univ California Für natives prp-sc spezifische antikörper
DE69618614T2 (de) * 1995-10-26 2002-09-12 Winnacker Ernst Ludwig NUKLEINSÄUREMOLEKÜLE MIT DER FÄHIGKEIT ZUR UNTERSCHEIDUNG VON PrPc UND PrPSc-PRIONPROTEIN-ISOFORMEN UND VERFAHREN ZU DEREN HERSTELLUNG
EP0959877A4 (de) * 1996-04-10 2000-08-23 Univ California Korrektur der genetischen fehler mittels chemische begleiter
ATE221663T1 (de) * 1996-05-29 2002-08-15 Univ Mcgill Prionbindende proteine und deren verwendungen
ES2209108T3 (es) * 1997-02-06 2004-06-16 Enfer Technology Limited Ensayo inmunologico para encefalopatias espongiformes.
JP2002501385A (ja) * 1997-05-30 2002-01-15 ヴァイス ステファン 可溶性ラミニン受容体前駆体及びその相互作用を阻止するための方法

Also Published As

Publication number Publication date
WO2000073501A3 (de) 2001-03-08
DE19925073C2 (de) 2001-07-19
JP2003501050A (ja) 2003-01-14
AU5527700A (en) 2000-12-18
EP1100958A2 (de) 2001-05-23
CA2339131A1 (en) 2000-12-07
DE19925073A1 (de) 2001-03-15
ATE315105T1 (de) 2006-02-15
EP1100958B1 (de) 2006-01-04
WO2000073501A2 (de) 2000-12-07
US7371833B1 (en) 2008-05-13

Similar Documents

Publication Publication Date Title
DE50012021D1 (de) Nucleinsauremoleküle mit spezifischer erkennung von nativem prpsc, herstellung und verwendung
Bessen et al. Non-genetic propagation of strain-specific properties of scrapie prion protein
Liang et al. Chemical synthesis of diubiquitin‐based photoaffinity probes for selectively profiling ubiquitin‐binding proteins
Solomon et al. Light chain-associated amyloid deposits comprised of a novel κ constant domain
NO20001052L (no) 1C, 15N, 2H merkede proteiner for NMR-strukturbestemmelser og deres fremstilling
DE60111247D1 (de) Verfahren für die produktion von peptiden unter verwendung eines in vitro transkription/translation system
Sevilla et al. Development of Monoclonal Antibodies to the Malondialdehyde− Deoxyguanosine Adduct, Pyrimidopurinone1
DE60231651D1 (de) Proteinreinigungsverfahren
DE69714654D1 (de) Verwendung von einem Metalloporphyrinkonjugat für den Nachweis biologischer Verbindungen
SE9803838D0 (sv) A chromatography method and a column material useful in said method
DE69942459D1 (de) Isolierte nukleinsäuremoleküle die t-zellen induzierbare faktoren kodieren (tif), kodierte proteine und ihre anwendung
DE69821376D1 (de) Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht
ATE212065T1 (de) Nukleinsäuremoleküle mit der fähigkeit zur unterscheidung von prpc und prpsc-prionprotein- isoformen und verfahren zu deren herstellung
Rosen et al. Capture and Recycling of Sortase A through Site‐Specific Labeling with Lithocholic Acid
Lakemeyer et al. Tailored peptide phenyl esters block ClpXP proteolysis by an unusual breakdown into a heptamer–hexamer assembly
Ramanathan et al. Modular synthesis of cyclic peptidomimetics inspired by γ-turns
Rao et al. Identification by mass spectrometry of a new α-tubulin isotype expressed in human breast and lung carcinoma cell lines
Rae et al. Lactoperoxidase heme structure characterized by paramagnetic proton NMR spectroscopy
Heinnickel et al. Resolution and reconstitution of a bound Fe− S protein from the photosynthetic reaction center of Heliobacterium modesticaldum
Crofton Site of alkaline phosphatase attachment in alkaline phosphatase-immunoglobulin G complexes
ATE369442T1 (de) In vitro evolution von nukleinsäuren und kodierten polypeptiden
DK1540304T3 (da) Depletering af plasmaproteiner
Itakura et al. Evidence that malondialdehyde-derived aminoenimine is not a fluorescent age pigment
Parker et al. Control of the yeast cell cycle with a photocleavable α-factor analogue
Bi et al. Affinity‐Based Labeling of Cytohesins with a Bifunctional SecinH3 Photoaffinity Probe

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee