DE473846C - Process for the preparation of tubercle bacilli and toxin-free tubercle waxes - Google Patents

Process for the preparation of tubercle bacilli and toxin-free tubercle waxes

Info

Publication number
DE473846C
DE473846C DEI30802D DEI0030802D DE473846C DE 473846 C DE473846 C DE 473846C DE I30802 D DEI30802 D DE I30802D DE I0030802 D DEI0030802 D DE I0030802D DE 473846 C DE473846 C DE 473846C
Authority
DE
Germany
Prior art keywords
tubercle
waxes
toxin
free
bacilli
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEI30802D
Other languages
German (de)
Inventor
Dr Carl Ludwig Lautenschlaeger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IG Farbenindustrie AG
Original Assignee
IG Farbenindustrie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IG Farbenindustrie AG filed Critical IG Farbenindustrie AG
Priority to DEI30802D priority Critical patent/DE473846C/en
Application granted granted Critical
Publication of DE473846C publication Critical patent/DE473846C/en
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Description

Verfahren zur Darstellung von tuberkelbazillen- und toxinfreien Tuberkelwachsen Die aus Tuberkelbaz'allen gewonnenem Tuberkelwachse vermögen eine sehr günstige therapeutische Wirkung auf die verschiedenen Formen der Lepra, auszuüben, wenn man die diesen Wachsen stets noch anhaftenden Reste von Tuberkelbazillen und Toxinen. entfernt, die nach bekannten Methoden nicht mehr zu entfernen sind. Durch die noch beigemengten Tuberkelbazillen werden infolge autolytischer Prozesse häufig Herd- und Allgem:einreaktianen ausgelöst, welche die Verwendung der Wachse zu therapeutischen Zwecken naturgemäß sehr beeinträchtigen.Process for the preparation of tubercle bacilli and toxin-free tubercle waxes The tubercle waxes obtained from tubercle bacals have a very favorable effect therapeutic effect on the various forms of leprosy, exert when one the remains of tubercle bacilli and toxins still adhering to these waxes. removed that can no longer be removed using known methods. Through the still added tubercle bacilli are often focal points as a result of autolytic processes and general: a reaction that triggered the use of the waxes to be therapeutic Purposes naturally very impairing.

Es wurde nun gefunden, daß es auf einfache Weise gelingt, von Tuberkelbazillen und -toxinen befreite Tuberkelwachse dadurch darzustellen, daß man die nach den üblichen Methoden entfetteten und von der Hauptmenge der Tuberkelbazillen befreiten Wachse mit verdünnten Säuren digerlert. Die so behandelten Wachsee lassen sich dann durch wiederholtes Lösen in Äther und Ausfällen mit geeigneten organischen Lösungsmitteln einem weiteren Reinigungsprozeß unterwerfen. Beispiel Das aus i oo g abgetöteter Tuherkelbazi1len beliebiger Herkunft gewonnene Tub:erkel.-wach.s wird bei: Wasserbadrempe Tatur längere Zeit mit verdünnter Säure (ungefähr 5prozentig) digeaiert. Nach dem Erkalten wird das Wachs von der wäßrig@en Flüssigkeit abgetrennt und mehrmals mit warmem Wasser digeriert. Das Wachs wird darauf in Äther gelöst und nach dem Trocknen mit Natriftunsulfat aus der Lösung das reine Wachs mit einem geeigneten organischen Lösungsmittel (Aceton oder Alkohol) gefällt.It has now been found that it is possible to remove tubercle bacilli in a simple manner and tubercle waxes freed from toxins to be represented by the fact that the after the the usual methods of degreasing and removing most of the tubercle bacilli Waxes digested with dilute acids. The wax lakes treated in this way can then be used by repeated dissolving in ether and precipitation with suitable organic solvents subject to another purification process. Example that from i oo g killed Tub obtained from Tuherkelbazi1len of any origin: erkel.-wach.s at: Wasserbadrempe Tatur digested with dilute acid (about 5 percent) for a long time. After this When it cools, the wax is separated from the aqueous liquid and mixed with it several times digested in warm water. The wax is then dissolved in ether and after drying with sodium sulfate from the solution the pure wax with a suitable organic Solvent (acetone or alcohol) precipitated.

Claims (1)

PATENTANSPRUCH. Verfahren zur Darstellung von tuberkelbazillen- und toxinfreien Tuberkelwachsen, dadurch gekennzeichnet, daß man die nach den üblichen Methoden von der Hauptmenge der TuberkeUeiber befreiten und entfetteten Wachsee mit verdünntenSäuren, zweckmäßig -in der Wänn.e, digeriert.PATENT CLAIM. Procedure for the representation of tubercle bacilli and toxin-free tubercle waxes, characterized in that the customary Methods from the bulk of the tubercle eggs freed and degreased wax lake digested with dilute acids, expediently -in der Wänn.e.
DEI30802D 1927-03-31 1927-03-31 Process for the preparation of tubercle bacilli and toxin-free tubercle waxes Expired DE473846C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEI30802D DE473846C (en) 1927-03-31 1927-03-31 Process for the preparation of tubercle bacilli and toxin-free tubercle waxes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEI30802D DE473846C (en) 1927-03-31 1927-03-31 Process for the preparation of tubercle bacilli and toxin-free tubercle waxes

Publications (1)

Publication Number Publication Date
DE473846C true DE473846C (en) 1934-01-20

Family

ID=7187712

Family Applications (1)

Application Number Title Priority Date Filing Date
DEI30802D Expired DE473846C (en) 1927-03-31 1927-03-31 Process for the preparation of tubercle bacilli and toxin-free tubercle waxes

Country Status (1)

Country Link
DE (1) DE473846C (en)

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