DE4420501A1 - Neue Hydrazino- und Hydroxyamino-14beta-hydroxyandrostanderivate mit Aktivität für das cardiovaskuläre System, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten - Google Patents
Neue Hydrazino- und Hydroxyamino-14beta-hydroxyandrostanderivate mit Aktivität für das cardiovaskuläre System, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthaltenInfo
- Publication number
- DE4420501A1 DE4420501A1 DE4420501A DE4420501A DE4420501A1 DE 4420501 A1 DE4420501 A1 DE 4420501A1 DE 4420501 A DE4420501 A DE 4420501A DE 4420501 A DE4420501 A DE 4420501A DE 4420501 A1 DE4420501 A1 DE 4420501A1
- Authority
- DE
- Germany
- Prior art keywords
- diol
- androstane
- methyl
- propenyl
- pregnan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4420501A DE4420501A1 (de) | 1994-06-13 | 1994-06-13 | Neue Hydrazino- und Hydroxyamino-14beta-hydroxyandrostanderivate mit Aktivität für das cardiovaskuläre System, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten |
| US08/444,366 US5599806A (en) | 1994-06-13 | 1995-05-18 | Hydrazino and hydroxyamino-14-β-hydroxyandrostane derivatives active on the cardiovascular system processes for their preparation and pharmaceutical compositions containing same |
| TW084105386A TW293823B (enExample) | 1994-06-13 | 1995-05-27 | |
| DE69500517T DE69500517T2 (de) | 1994-06-13 | 1995-05-30 | Neue Hydrazino und Hydroxyamino-14-beta-Hydroxyandrostan-Derivate mit kardiotonischer Aktivität, ein Verfahren zu ihrer Herstellung und pharmaceutische Präparate davon |
| ES95108257T ES2105815T3 (es) | 1994-06-13 | 1995-05-30 | Nuevos derivados de hidrazino- e hidroxiamino-14beta-hidroxiandrostano activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que contienen los mismos. |
| DK95108257.7T DK0688786T3 (da) | 1994-06-13 | 1995-05-30 | Hydrazino- og hydroxyamino-14beta-hydroxyandrostanderivater med aktivitet på det cardiovaskulære system, fremgangsmåder til deres fremstilling og farmaceutiske præparater indeholdende disse. |
| EP95108257A EP0688786B1 (en) | 1994-06-13 | 1995-05-30 | New hydrazino and hydroxyamino-14beta-hydroxyandrostane derivatives active on the cardio-vascular system, processes for their preparation and pharmaceutical compositions containing same |
| AT95108257T ATE156490T1 (de) | 1994-06-13 | 1995-05-30 | Neue hydrazino und hydroxyamino-14-beta- hydroxyandrostan-derivate mit kardiotonischer aktivität, ein verfahren zu ihrer herstellung und pharmaceutische präparate davon |
| KR1019950013868A KR100305739B1 (ko) | 1994-06-13 | 1995-05-30 | 심장혈관계질환에유효한히드라지노및히드록시아미노-14베타-히드록시안드로스탄유도체와이들의제조방법그리고이를함유하는약제조성물 |
| ZA954826A ZA954826B (en) | 1994-06-13 | 1995-06-12 | New hydrazino and hydroxyamino-14beta-hydroxyandrostane derivatives active on the cardiovascular system processes for their preparation and pharmaceutical compositions containing same |
| CA002151561A CA2151561C (en) | 1994-06-13 | 1995-06-12 | Hydrazino and hydroxyamino-14.beta.-hydroxyandrostane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same |
| JP14620395A JP3805406B2 (ja) | 1994-06-13 | 1995-06-13 | 心臓血管系に有効である新規なヒドラジノおよびヒドロキシアミノ−14β−ヒドロキシアンドロスタン誘導体、それらの製造法およびそれらを含む医薬組成物 |
| GR970402710T GR3025064T3 (en) | 1994-06-13 | 1997-10-15 | New hydrazino and hydroxyamino-14beta-hydroxyandrostane derivatives active on the cardio-vascular system, processes for their preparation and pharmaceutical compositions containing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4420501A DE4420501A1 (de) | 1994-06-13 | 1994-06-13 | Neue Hydrazino- und Hydroxyamino-14beta-hydroxyandrostanderivate mit Aktivität für das cardiovaskuläre System, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE4420501A1 true DE4420501A1 (de) | 1995-12-14 |
Family
ID=6520395
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE4420501A Ceased DE4420501A1 (de) | 1994-06-13 | 1994-06-13 | Neue Hydrazino- und Hydroxyamino-14beta-hydroxyandrostanderivate mit Aktivität für das cardiovaskuläre System, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten |
| DE69500517T Expired - Fee Related DE69500517T2 (de) | 1994-06-13 | 1995-05-30 | Neue Hydrazino und Hydroxyamino-14-beta-Hydroxyandrostan-Derivate mit kardiotonischer Aktivität, ein Verfahren zu ihrer Herstellung und pharmaceutische Präparate davon |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69500517T Expired - Fee Related DE69500517T2 (de) | 1994-06-13 | 1995-05-30 | Neue Hydrazino und Hydroxyamino-14-beta-Hydroxyandrostan-Derivate mit kardiotonischer Aktivität, ein Verfahren zu ihrer Herstellung und pharmaceutische Präparate davon |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5599806A (enExample) |
| EP (1) | EP0688786B1 (enExample) |
| JP (1) | JP3805406B2 (enExample) |
| KR (1) | KR100305739B1 (enExample) |
| AT (1) | ATE156490T1 (enExample) |
| CA (1) | CA2151561C (enExample) |
| DE (2) | DE4420501A1 (enExample) |
| DK (1) | DK0688786T3 (enExample) |
| ES (1) | ES2105815T3 (enExample) |
| GR (1) | GR3025064T3 (enExample) |
| TW (1) | TW293823B (enExample) |
| ZA (1) | ZA954826B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4442486A1 (de) * | 1994-11-29 | 1996-05-30 | Sigma Tau Ind Farmaceuti | Neue 17-(3-Imino-2-alkylpropylen)-5ß,14ß-androstan-Derivate, die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
| IT1282289B1 (it) * | 1995-06-23 | 1998-03-16 | Sigma Tau Ind Farmaceuti | 17-idrossiimminoalchil e 17-idrossiimminometilalchenil ciclopentaperidrofenantreni attivi sul sistema cardiovascolare, |
| US20030083231A1 (en) * | 1998-11-24 | 2003-05-01 | Ahlem Clarence N. | Blood cell deficiency treatment method |
| CN105218614B (zh) * | 2015-10-29 | 2017-07-28 | 广西师范学院 | 4‑(4′‑溴)苯基‑2‑雌酮‑17′‑腙噻唑及其制备方法和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD235649C2 (de) | 1985-03-22 | 1987-10-08 | Akad Wissenschaften Ddr | Verfahren zur herstellung von 17beta-amino-5beta, 14beta-androstan-14-olen |
| US5144017A (en) | 1988-07-13 | 1992-09-01 | University Of Manitoba | Compounds that bind to digitalis receptor |
| DE4222404C1 (de) * | 1992-07-08 | 1993-12-02 | Sigma Tau Ind Farmaceuti | Verwendung von Iminoderivaten von Etianaldehyd zur Behandlung von Hypertonie |
| DE4227626C2 (de) * | 1992-08-20 | 1994-11-17 | Sigma Tau Ind Farmaceuti | 17-Hydrazonomethyl-14ß-hydroxy-5ß-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
| DE4227605C2 (de) * | 1992-08-20 | 1995-02-16 | Sigma Tau Ind Farmaceuti | 17-Hydroxyiminomethyl-14beta-hydroxy-5ß-androstan-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die dieselben enthalten |
| DE4344236A1 (de) | 1993-12-23 | 1995-06-29 | Sigma Tau Ind Farmaceuti | Neue 17-Iminomethylalkenyl-5beta,14beta-androstan- und 17-Iminoalkyl-5beta,14beta-androstan-Derivate , die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten |
-
1994
- 1994-06-13 DE DE4420501A patent/DE4420501A1/de not_active Ceased
-
1995
- 1995-05-18 US US08/444,366 patent/US5599806A/en not_active Expired - Lifetime
- 1995-05-27 TW TW084105386A patent/TW293823B/zh active
- 1995-05-30 AT AT95108257T patent/ATE156490T1/de not_active IP Right Cessation
- 1995-05-30 DK DK95108257.7T patent/DK0688786T3/da active
- 1995-05-30 DE DE69500517T patent/DE69500517T2/de not_active Expired - Fee Related
- 1995-05-30 KR KR1019950013868A patent/KR100305739B1/ko not_active Expired - Fee Related
- 1995-05-30 ES ES95108257T patent/ES2105815T3/es not_active Expired - Lifetime
- 1995-05-30 EP EP95108257A patent/EP0688786B1/en not_active Expired - Lifetime
- 1995-06-12 ZA ZA954826A patent/ZA954826B/xx unknown
- 1995-06-12 CA CA002151561A patent/CA2151561C/en not_active Expired - Fee Related
- 1995-06-13 JP JP14620395A patent/JP3805406B2/ja not_active Expired - Fee Related
-
1997
- 1997-10-15 GR GR970402710T patent/GR3025064T3/el unknown
Non-Patent Citations (1)
| Title |
|---|
| Journal of Medicinal Chemisty, 1978, Vol. 21, No. 3, S. 284-288 * |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69500517T2 (de) | 1998-01-08 |
| GR3025064T3 (en) | 1998-01-30 |
| ATE156490T1 (de) | 1997-08-15 |
| JPH07330792A (ja) | 1995-12-19 |
| ZA954826B (en) | 1996-01-30 |
| DK0688786T3 (da) | 1997-09-15 |
| ES2105815T3 (es) | 1997-10-16 |
| KR100305739B1 (ko) | 2001-11-30 |
| JP3805406B2 (ja) | 2006-08-02 |
| CA2151561A1 (en) | 1995-12-14 |
| KR960000916A (ko) | 1996-01-25 |
| CA2151561C (en) | 2006-01-24 |
| US5599806A (en) | 1997-02-04 |
| DE69500517D1 (de) | 1997-09-11 |
| EP0688786A1 (en) | 1995-12-27 |
| EP0688786B1 (en) | 1997-08-06 |
| TW293823B (enExample) | 1996-12-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE4232681A1 (de) | 17-Aryl- und 17-Heterocyclyl-14beta,5alpha-androstan-, androsten-, und androstadien-Derivate, die auf das kardiovaskuläre System wirken, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzung, die diese enthalten | |
| EP1060187B1 (de) | S-substituierte 11beta-benzaldoxim-estra-4,9-dien-kohlensäurethiolester, verfahren zu deren herstellung und diese verbindungen enthaltene pharmazeutische zubereitungen | |
| EP1240157A2 (de) | Substituierte n-benzyl-indol-3-yl- glyoxylsäure-derivate antitumorwirkung | |
| DE69315501T2 (de) | Neue 17-Hydroxyiminomethyl-5beta, 14beta-Androstan-Derivate, kardioaktives Verfahren zu ihrer Herstellung und pharmazeutische Präparate davon | |
| DE69500517T2 (de) | Neue Hydrazino und Hydroxyamino-14-beta-Hydroxyandrostan-Derivate mit kardiotonischer Aktivität, ein Verfahren zu ihrer Herstellung und pharmaceutische Präparate davon | |
| DE69307071T2 (de) | Kardioaktive 17B-aryl und 17B-heterozyklyl-5-beta,14-beta-Androstan-Derivate,ein Verfahren zu ihrer Herstellung und pharmazeutische Phäparate davon | |
| DE69409774T2 (de) | Neue kardioaktive 17-Iminomethylalkenyl-5-beta-14-beta-androstan und 17-Iminoalkyl-5-beta, 14-beta-androstan Derivate, ein Verfahren zu ihrer Herstellung und pharmazeutische Präparate davon | |
| DE4227626C2 (de) | 17-Hydrazonomethyl-14ß-hydroxy-5ß-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen | |
| DE4442486A1 (de) | Neue 17-(3-Imino-2-alkylpropylen)-5ß,14ß-androstan-Derivate, die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen | |
| HK1005878B (en) | 17b-aryl and 17b-heterocyclyl-5-beta, 14-beta-andostane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same | |
| DE69603793T2 (de) | Kardioaktive 17-Hydroxyiminoalkyl- und 17-Hydroxyiminomethylalkenyl-Steroid-Derivate, ein Verfahren zu ihrer Herstellung und pharmazeutische Präparate davon | |
| DE19633376A1 (de) | Neue Seco-D-Steroide, die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten | |
| DE4232656A1 (de) | Neue Cyclopentanperhydrophenanthren-17beta-(hydroxy oder alkoxy)-17alpha-(aryl oder heterocyclyl)-3beta-derivate, die auf das kardiovaskuläre System wirken, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten | |
| DE19805965C1 (de) | Carbonsäureester von seco-D-Steroiden, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten | |
| HK1009334B (en) | New 17-(3-imino -2-alkyl-propenyl)-5beta, 14beta-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same | |
| HK1004919B (en) | New 17-hydroxyiminomethyl-5beta, 14beta-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same | |
| DE1257137B (de) | Verfahren zur Herstellung von Spiro-steroidguanylhydrazonen | |
| DE1270555B (de) | Verfahren zur Herstellung von Steroidguanylhydrazonen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| 8131 | Rejection |