KR100305739B1 - 심장혈관계질환에유효한히드라지노및히드록시아미노-14베타-히드록시안드로스탄유도체와이들의제조방법그리고이를함유하는약제조성물 - Google Patents

심장혈관계질환에유효한히드라지노및히드록시아미노-14베타-히드록시안드로스탄유도체와이들의제조방법그리고이를함유하는약제조성물 Download PDF

Info

Publication number
KR100305739B1
KR100305739B1 KR1019950013868A KR19950013868A KR100305739B1 KR 100305739 B1 KR100305739 B1 KR 100305739B1 KR 1019950013868 A KR1019950013868 A KR 1019950013868A KR 19950013868 A KR19950013868 A KR 19950013868A KR 100305739 B1 KR100305739 B1 KR 100305739B1
Authority
KR
South Korea
Prior art keywords
diol
androstan
methyl
propenyl
pregnan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019950013868A
Other languages
English (en)
Korean (ko)
Other versions
KR960000916A (ko
Inventor
알베르토세르리
기우세페비안치
파트리지아페르라리
엘레나폴피니
피에로멜로니
Original Assignee
알도 파시
시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 알도 파시, 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. filed Critical 알도 파시
Publication of KR960000916A publication Critical patent/KR960000916A/ko
Application granted granted Critical
Publication of KR100305739B1 publication Critical patent/KR100305739B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1019950013868A 1994-06-13 1995-05-30 심장혈관계질환에유효한히드라지노및히드록시아미노-14베타-히드록시안드로스탄유도체와이들의제조방법그리고이를함유하는약제조성물 Expired - Fee Related KR100305739B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4420501A DE4420501A1 (de) 1994-06-13 1994-06-13 Neue Hydrazino- und Hydroxyamino-14beta-hydroxyandrostanderivate mit Aktivität für das cardiovaskuläre System, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten
DEP4420501.5 1994-06-13

Publications (2)

Publication Number Publication Date
KR960000916A KR960000916A (ko) 1996-01-25
KR100305739B1 true KR100305739B1 (ko) 2001-11-30

Family

ID=6520395

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950013868A Expired - Fee Related KR100305739B1 (ko) 1994-06-13 1995-05-30 심장혈관계질환에유효한히드라지노및히드록시아미노-14베타-히드록시안드로스탄유도체와이들의제조방법그리고이를함유하는약제조성물

Country Status (12)

Country Link
US (1) US5599806A (enExample)
EP (1) EP0688786B1 (enExample)
JP (1) JP3805406B2 (enExample)
KR (1) KR100305739B1 (enExample)
AT (1) ATE156490T1 (enExample)
CA (1) CA2151561C (enExample)
DE (2) DE4420501A1 (enExample)
DK (1) DK0688786T3 (enExample)
ES (1) ES2105815T3 (enExample)
GR (1) GR3025064T3 (enExample)
TW (1) TW293823B (enExample)
ZA (1) ZA954826B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4442486A1 (de) * 1994-11-29 1996-05-30 Sigma Tau Ind Farmaceuti Neue 17-(3-Imino-2-alkylpropylen)-5ß,14ß-androstan-Derivate, die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
IT1282289B1 (it) * 1995-06-23 1998-03-16 Sigma Tau Ind Farmaceuti 17-idrossiimminoalchil e 17-idrossiimminometilalchenil ciclopentaperidrofenantreni attivi sul sistema cardiovascolare,
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
CN105218614B (zh) * 2015-10-29 2017-07-28 广西师范学院 4‑(4′‑溴)苯基‑2‑雌酮‑17′‑腙噻唑及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD235649C2 (de) 1985-03-22 1987-10-08 Akad Wissenschaften Ddr Verfahren zur herstellung von 17beta-amino-5beta, 14beta-androstan-14-olen
US5144017A (en) 1988-07-13 1992-09-01 University Of Manitoba Compounds that bind to digitalis receptor
DE4222404C1 (de) * 1992-07-08 1993-12-02 Sigma Tau Ind Farmaceuti Verwendung von Iminoderivaten von Etianaldehyd zur Behandlung von Hypertonie
DE4227626C2 (de) * 1992-08-20 1994-11-17 Sigma Tau Ind Farmaceuti 17-Hydrazonomethyl-14ß-hydroxy-5ß-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE4227605C2 (de) * 1992-08-20 1995-02-16 Sigma Tau Ind Farmaceuti 17-Hydroxyiminomethyl-14beta-hydroxy-5ß-androstan-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die dieselben enthalten
DE4344236A1 (de) 1993-12-23 1995-06-29 Sigma Tau Ind Farmaceuti Neue 17-Iminomethylalkenyl-5beta,14beta-androstan- und 17-Iminoalkyl-5beta,14beta-androstan-Derivate , die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten

Also Published As

Publication number Publication date
DE4420501A1 (de) 1995-12-14
DE69500517T2 (de) 1998-01-08
GR3025064T3 (en) 1998-01-30
ATE156490T1 (de) 1997-08-15
JPH07330792A (ja) 1995-12-19
ZA954826B (en) 1996-01-30
DK0688786T3 (da) 1997-09-15
ES2105815T3 (es) 1997-10-16
JP3805406B2 (ja) 2006-08-02
CA2151561A1 (en) 1995-12-14
KR960000916A (ko) 1996-01-25
CA2151561C (en) 2006-01-24
US5599806A (en) 1997-02-04
DE69500517D1 (de) 1997-09-11
EP0688786A1 (en) 1995-12-27
EP0688786B1 (en) 1997-08-06
TW293823B (enExample) 1996-12-21

Similar Documents

Publication Publication Date Title
EP0590271B1 (en) 17-Aryl and 17-heterocyclyl-14beta-5alpha-androstane, androstene and androstadiene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same
KR100305739B1 (ko) 심장혈관계질환에유효한히드라지노및히드록시아미노-14베타-히드록시안드로스탄유도체와이들의제조방법그리고이를함유하는약제조성물
KR100276527B1 (ko) 심장혈관계 질환에 유효한 신규 17-하이드록시이미노메틸-14베타-하이드록시-5베타-안드로스탄 유도체와 이들의 제조방법 및 약제학적조성물
HK1005877B (en) Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders
HK1005877A1 (en) Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders
EP0590272B1 (en) 17B-Aryl and 17B-heterocyclyl-5-beta,14-beta-andostane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same
JP3545477B2 (ja) 心臓血管系に活性な新しい１７−イミノメチルアルケニル−５β，１４β−アンドロスタンおよび１７−イミノアルキル−５β，１４β−アンドロスタン誘導体、それらの製造方法およびそれらを含有する薬学的組成物
EP0714908B1 (en) New 17-(3-imino-2-alkyl-propenyl)-5beta,14beta-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same
HK1005878B (en) 17b-aryl and 17b-heterocyclyl-5-beta, 14-beta-andostane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same
HK1009334B (en) New 17-(3-imino -2-alkyl-propenyl)-5beta, 14beta-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same
JPH06184187A (ja) 心血管系に有効な新規ヒドラゾノ−５β、１４β−アンドロスタン誘導体、その製造法およびその化合物を含む医薬組成物
HK1004919B (en) New 17-hydroxyiminomethyl-5beta, 14beta-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same
HK1009333B (en) New-17-iminomethylalkenyl-5beta-14beta-androstane and 17-iminoalkyl-5beta-14beta-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same
JPH1077256A (ja) 心臓血管系に活性のある新規のｓｅｃｏ−ステロイドおよびそれらの調製方法およびそれらを含有する製薬用組成物
HK1005880B (en) 17-aryl and 17-heterocyclyl-14beta-5alpha-androstane, androstene and androstadiene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

FPAY Annual fee payment

Payment date: 20080730

Year of fee payment: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20090802

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20090802

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000