DE3888357D1 - Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen. - Google Patents

Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen.

Info

Publication number
DE3888357D1
DE3888357D1 DE88202845T DE3888357T DE3888357D1 DE 3888357 D1 DE3888357 D1 DE 3888357D1 DE 88202845 T DE88202845 T DE 88202845T DE 3888357 T DE3888357 T DE 3888357T DE 3888357 D1 DE3888357 D1 DE 3888357D1
Authority
DE
Germany
Prior art keywords
carry
amino acid
modified amino
cyclosporin derivatives
cyclosporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88202845T
Other languages
English (en)
Other versions
DE3888357T2 (de
Inventor
Arthur A Patchett
Raymond F White
Robert T Goegelman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3888357D1 publication Critical patent/DE3888357D1/de
Publication of DE3888357T2 publication Critical patent/DE3888357T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE3888357T 1987-06-22 1988-12-12 Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen. Expired - Fee Related DE3888357T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6467487A 1987-06-22 1987-06-22
EP88202845A EP0373260B1 (de) 1987-06-22 1988-12-12 Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen
US31126789A 1989-02-16 1989-02-16
US63078690A 1990-12-21 1990-12-21
US80921391A 1991-12-16 1991-12-16

Publications (2)

Publication Number Publication Date
DE3888357D1 true DE3888357D1 (de) 1994-04-14
DE3888357T2 DE3888357T2 (de) 1994-09-15

Family

ID=39710817

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3888357T Expired - Fee Related DE3888357T2 (de) 1987-06-22 1988-12-12 Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen.

Country Status (3)

Country Link
US (1) US5318901A (de)
EP (1) EP0373260B1 (de)
DE (1) DE3888357T2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0484281T4 (da) * 1990-11-02 2001-02-05 Novartis Ag Cyclosporiner
DE69133095T2 (de) * 1990-11-20 2003-03-27 Dade Behring Marburg Gmbh Cyclosporin-Immunoassay
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
CN1087725C (zh) * 1994-03-25 2002-07-17 同位素技术有限公司 用氘代方法增强药物效果
KR0126610B1 (ko) * 1994-10-18 1997-12-29 김충환 고생산 세포융합변이균주에 의한 사이클로스포린 a의 제조방법
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
WO1999018120A1 (en) * 1997-10-08 1999-04-15 Isotechnika Inc. Deuterated cyclosporine analogs and their use as immunomodulating agents
AU2002331509B2 (en) 2001-10-19 2007-12-06 Aurinia Pharmaceuticals Inc. Synthesis of cyclosporin analogs
KR100512019B1 (ko) * 2002-07-25 2005-09-02 신득용 사이클로스포린 ａ 또는 이의 유도체를 이용한 세포의노화를 억제하는 방법 및 배양배지
KR100641295B1 (ko) * 2002-11-11 2006-10-31 김성수 사이클로필린의 항산화제로서의 용도 및 사이클로필린의과발현에 의해 세포이식에서 사이클로스포린 ａ에 의해유발되는 세포독성의 방지
EP1603512A2 (de) * 2003-03-17 2005-12-14 Albany Molecular Research, Inc. Neue cyclosporine
JP2008514701A (ja) * 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキン類似体およびそれらの薬学的使用
US7511013B2 (en) * 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
EP1812037A4 (de) * 2004-10-06 2009-11-11 Amr Technology Inc Neue cyclosporin-alkyne und ihre nutzung als pharmazeutishe mittel
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
MY192981A (en) 2010-12-15 2022-09-20 Contravir Pharmaceuticals Inc Cyclosporine analogue molecules modified at amino acid 1 and 3
EP2705856A1 (de) 2012-09-07 2014-03-12 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. Verbindungen zur Behandlung von neurodegenerativen Erkrankungen

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210581A (en) * 1975-11-04 1980-07-01 Sandoz Ltd. Organic compounds
CH614931A5 (de) * 1975-11-04 1979-12-28 Sandoz Ag
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4102877A (en) * 1976-07-28 1978-07-25 Merck & Co., Inc. Cyclization of peptides
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
SE448386B (sv) * 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4396542A (en) * 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
EP0056782B1 (de) * 1981-01-09 1984-08-01 Sandoz Ag Cyclosporine
CH667274A5 (de) * 1984-03-23 1988-09-30 Sandoz Ag Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
GB8422253D0 (en) * 1984-09-04 1984-10-10 Sandoz Ltd Organic compounds
DE3685885D1 (de) * 1985-01-16 1992-08-13 Ciba Geigy Ag Oligopeptide sowie zwischenprodukte und verfahren zu ihrer herstellung.
EP0194972B1 (de) * 1985-03-11 1992-07-29 Sandoz Ag Cyclosporine
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
GB2206119B (en) * 1987-06-22 1990-10-31 Merck & Co Inc A new cyclosporin derivative with modified "8-amino acid"

Also Published As

Publication number Publication date
EP0373260A1 (de) 1990-06-20
US5318901A (en) 1994-06-07
EP0373260B1 (de) 1994-03-09
DE3888357T2 (de) 1994-09-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee