DE3886880D1 - Pulverförmige Zubereitungen zur intranasalen Verabreichung von Polypeptiden. - Google Patents

Pulverförmige Zubereitungen zur intranasalen Verabreichung von Polypeptiden.

Info

Publication number
DE3886880D1
DE3886880D1 DE88117029T DE3886880T DE3886880D1 DE 3886880 D1 DE3886880 D1 DE 3886880D1 DE 88117029 T DE88117029 T DE 88117029T DE 3886880 T DE3886880 T DE 3886880T DE 3886880 D1 DE3886880 D1 DE 3886880D1
Authority
DE
Germany
Prior art keywords
polypeptides
intranasal administration
powdery preparations
biologically active
powdery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE88117029T
Other languages
English (en)
Other versions
DE3886880T2 (de
Inventor
Brian H Vickery
Cherng-Chyi Fu
Eric J Benjamin
Lynda M Sanders
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of DE3886880D1 publication Critical patent/DE3886880D1/de
Publication of DE3886880T2 publication Critical patent/DE3886880T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
DE3886880T 1987-10-15 1988-10-13 Pulverförmige Zubereitungen zur intranasalen Verabreichung von Polypeptiden. Expired - Lifetime DE3886880T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10967887A 1987-10-15 1987-10-15

Publications (2)

Publication Number Publication Date
DE3886880D1 true DE3886880D1 (de) 1994-02-17
DE3886880T2 DE3886880T2 (de) 1994-07-14

Family

ID=22328950

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3886880T Expired - Lifetime DE3886880T2 (de) 1987-10-15 1988-10-13 Pulverförmige Zubereitungen zur intranasalen Verabreichung von Polypeptiden.

Country Status (11)

Country Link
US (3) US6521597B1 (de)
EP (1) EP0312052B1 (de)
JP (1) JP2851627B2 (de)
KR (1) KR890006252A (de)
AT (1) ATE99543T1 (de)
AU (1) AU623609B2 (de)
CA (1) CA1336401C (de)
DE (1) DE3886880T2 (de)
ES (1) ES2061591T3 (de)
NZ (1) NZ226557A (de)
ZA (1) ZA887658B (de)

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US6524557B1 (en) 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
NZ298169A (en) 1994-12-22 1999-09-29 Astra Ab Aerosol drug formulation; comprises hydrofluoroalkane propellant, medicament for inhalation and a surfactant
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WO2004073729A1 (ja) 2003-02-21 2004-09-02 Translational Research Ltd. 薬物の経鼻投与用組成物
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US7145125B2 (en) 2003-06-23 2006-12-05 Advanced Optical Technologies, Llc Integrating chamber cone light using LED sources
AU2005211385B2 (en) * 2004-02-02 2008-12-11 Ambrx, Inc. Modified human growth hormone polypeptides and their uses
US8673360B2 (en) 2004-08-10 2014-03-18 Shin Nippon Biomedical Laboratories, Ltd. Compositions that enable rapid-acting and highly absorptive intranasal administration
ES2339790T3 (es) 2004-08-30 2010-05-25 Seo Hong Yoo Efecto neuroprotector de udca solubilizado en modelo isquemico focal.
US7148067B2 (en) * 2004-08-31 2006-12-12 The Board Of Trustees Of The University Of Illinois Thromboplastin reagents
US7115561B2 (en) * 2004-09-22 2006-10-03 Patterson James A Medicament composition and method of administration
CA2584184A1 (en) 2004-10-15 2006-04-27 Seo Hong Yoo Methods and compositions for reducing toxicity of a pharmaceutical compound
KR100834735B1 (ko) * 2004-11-15 2008-06-09 김두만 부신피질 기능 부전증 치료용 부신피질 자극 호르몬의비강 분무 제형
JP2008530208A (ja) * 2005-02-16 2008-08-07 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ 万能前凝固薬
JP2008531692A (ja) * 2005-03-04 2008-08-14 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ 凝固及び線維素溶解カスケードのモジュレーター
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US20070031512A1 (en) * 2005-08-03 2007-02-08 Amcol International Corporation Virus-interacting layered phyllosilicates and methods of inactivating viruses
US20100272769A1 (en) * 2005-08-03 2010-10-28 Amcol International Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use
EP1928484B1 (de) 2005-08-26 2010-02-24 The Board Of Trustees Of The Leland Stanford Junior University Verfahren zur behandlung von kopfschmerzen durch verabreichung von oxytocin
US20080033038A1 (en) * 2006-07-07 2008-02-07 Shytle R D Compositions of polyphenols and methods of use
JP5415769B2 (ja) 2006-12-26 2014-02-12 株式会社新日本科学 経鼻投与用製剤
EP2167069B1 (de) 2007-05-23 2011-10-26 Amcol International Corporation Mit cholesterin interagierende phyllosilikate und verfahren zur reduktion von hypercholesterinämie bei einem säuger
WO2009023125A1 (en) * 2007-08-14 2009-02-19 The Board Of Trustees Of The Leland Stanford Junior University Neuronostatin and its uses
EP2197462A2 (de) * 2007-09-11 2010-06-23 Mondobiotech Laboratories AG Verwendung von il-1-rezeptor-peptid, allein oder in kombination mit d-ala-gln-octadecyl-ester als therapeutisches mittel
WO2009046194A2 (en) * 2007-10-05 2009-04-09 The Board Of Trustees Of The University Of Illinois Fibrin sealant
US20100297257A1 (en) * 2007-11-09 2010-11-25 National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs) Anticoagulant antagonist and hemophillia procoagulant
AU2009219204B2 (en) 2008-02-27 2013-01-17 Amcol International Corporation Methods of treating cardiovascular disorders associated with atherosclerosis
WO2010131486A1 (en) * 2009-05-15 2010-11-18 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
WO2011013003A2 (en) * 2009-07-31 2011-02-03 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
AU2015338717B2 (en) 2014-10-31 2018-12-20 Glaxosmithkline Intellectual Property Development Limited Powder formulation
KR20180023884A (ko) 2015-01-07 2018-03-07 트라이제미나 인코퍼레이티드 마그네슘-함유 옥시토신 제제 및 사용 방법
US20160361253A1 (en) * 2015-06-13 2016-12-15 Noveome Biotherapeutics, Inc. Novel Methods for Delivering Therapeutic Agents to the Eye via Nasal Passages
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
CN110279656B (zh) * 2019-07-11 2021-11-09 温州医科大学 一种用于缓解鼻腔干燥的组合物及其制备方法和使用方法

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FR2465486A1 (fr) * 1979-09-21 1981-03-27 Roussel Uclaf Nouvelle application utilisant la lh-rh ou des agonistes
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EP0094157B1 (de) * 1982-04-30 1987-07-29 Takeda Chemical Industries, Ltd. Pharmazeutische Zusammensetzung und ihre Verwendung
JPS58189118A (ja) * 1982-04-30 1983-11-04 Takeda Chem Ind Ltd 経鼻投与製剤
US4481190A (en) * 1982-12-21 1984-11-06 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US4581169A (en) * 1982-12-21 1986-04-08 Syntex (U.S.A.) Inc. Nona-peptide and deca-peptide analogs of LHRH, useful as LHRH antagonists
US4476116A (en) * 1982-12-10 1984-10-09 Syntex (U.S.A.) Inc. Polypeptides/chelating agent nasal compositions having enhanced peptide absorption
JPS59163313A (ja) * 1983-03-09 1984-09-14 Teijin Ltd 経鼻投与用ペプチドホルモン類組成物
US4548922A (en) * 1983-06-06 1985-10-22 Beth Israel Hospital Drug administration
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Also Published As

Publication number Publication date
ES2061591T3 (es) 1994-12-16
KR890006252A (ko) 1989-06-12
ATE99543T1 (de) 1994-01-15
US6521597B1 (en) 2003-02-18
ZA887658B (en) 1990-06-27
US6815424B2 (en) 2004-11-09
EP0312052A1 (de) 1989-04-19
DE3886880T2 (de) 1994-07-14
US20030181387A1 (en) 2003-09-25
US20050089480A1 (en) 2005-04-28
NZ226557A (en) 1990-07-26
AU2375188A (en) 1989-06-01
JPH01132532A (ja) 1989-05-25
AU623609B2 (en) 1992-05-21
CA1336401C (en) 1995-07-25
JP2851627B2 (ja) 1999-01-27
EP0312052B1 (de) 1994-01-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Free format text: BARZ, P., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 80803 MUENCHEN

8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA CORP., ST. LOUIS, MO., US