DE3883387D1 - Bis(methylendioxy)biphenyl-verbindungen. - Google Patents

Bis(methylendioxy)biphenyl-verbindungen.

Info

Publication number
DE3883387D1
DE3883387D1 DE8888307199T DE3883387T DE3883387D1 DE 3883387 D1 DE3883387 D1 DE 3883387D1 DE 8888307199 T DE8888307199 T DE 8888307199T DE 3883387 T DE3883387 T DE 3883387T DE 3883387 D1 DE3883387 D1 DE 3883387D1
Authority
DE
Germany
Prior art keywords
methylene dioxy
biphenyl compounds
biphenyl
alkyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888307199T
Other languages
English (en)
Other versions
DE3883387T2 (de
Inventor
Shi-Jie Gu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST OF MATERIA MEDICA OF CHIN
Taisho Pharmaceutical Co Ltd
Original Assignee
INST OF MATERIA MEDICA OF CHIN
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INST OF MATERIA MEDICA OF CHIN, Taisho Pharmaceutical Co Ltd filed Critical INST OF MATERIA MEDICA OF CHIN
Publication of DE3883387D1 publication Critical patent/DE3883387D1/de
Application granted granted Critical
Publication of DE3883387T2 publication Critical patent/DE3883387T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE88307199T 1988-07-28 1988-08-04 Bis(methylendioxy)biphenyl-Verbindungen. Expired - Fee Related DE3883387T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/225,365 US4868207A (en) 1988-07-28 1988-07-28 Bis (methylenedioxy) biphenyl compounds useful for the treatment of liver diseases

Publications (2)

Publication Number Publication Date
DE3883387D1 true DE3883387D1 (de) 1993-09-23
DE3883387T2 DE3883387T2 (de) 1993-12-09

Family

ID=22844582

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88307199T Expired - Fee Related DE3883387T2 (de) 1988-07-28 1988-08-04 Bis(methylendioxy)biphenyl-Verbindungen.

Country Status (5)

Country Link
US (1) US4868207A (de)
EP (1) EP0353358B1 (de)
AT (1) ATE93232T1 (de)
DE (1) DE3883387T2 (de)
ES (1) ES2043830T3 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5211953A (en) * 1989-07-21 1993-05-18 Suntory, Limited Liver function improver
ATE208195T1 (de) * 1989-07-21 2001-11-15 Suntory Ltd Mittel zur verbesserung der leberfunktion
US5612341A (en) * 1995-06-07 1997-03-18 Biotech Research Laboratories Brominated hexahydroxybiphenyl derivatives
US6383515B2 (en) * 1999-05-28 2002-05-07 Sawyer Maryjean Solvent system for enhancing solubility
CN1173968C (zh) * 2002-10-11 2004-11-03 常俊标 卤代六羟基联苯衍生物的制法及药物用途
CN100542528C (zh) * 2003-10-23 2009-09-23 中国医学科学院药物研究所 双环醇微粉化及口服控释制剂
CN100435791C (zh) * 2003-10-23 2008-11-26 中国医学科学院药物研究所 双环醇固体分散体
WO2005123711A1 (fr) * 2004-06-21 2005-12-29 Jiangsu Hengrui Medicine Co., Ltd. Glycosides de bicyclol, leurs procedes de preparation et leurs utilisations
CN100364526C (zh) * 2004-08-11 2008-01-30 中国医学科学院药物研究所 双环醇在制备预防和/或治疗急性酒精中毒和急慢性酒精性肝损伤药物中的应用
KR100697056B1 (ko) * 2006-01-09 2007-03-20 재단법인서울대학교산학협력재단 리퀴리티게닌을 유효성분으로 포함하는 간질환의 예방 및치료용 조성물
CN100556913C (zh) * 2007-07-23 2009-11-04 中国海洋大学 一种双环醇糖苷化合物及其制备方法和应用
CN101550127B (zh) * 2008-03-31 2013-12-04 中国医学科学院药物研究所 双环醇的两种晶型物质、其制法和其药物组合物与用途
CN101654401B (zh) * 2008-08-18 2013-06-05 中国人民解放军军事医学科学院毒物药物研究所 不对称联苯类化合物、含有它的药物组合物及其用途
CN103242286A (zh) * 2013-01-24 2013-08-14 辽宁亿灵科创生物医药科技有限公司 一种双环醇药物组合物及其制备方法
EA030485B1 (ru) 2013-04-29 2018-08-31 Харша Чигурупати Спиртные напитки с пониженной гепатотоксичностью
CN104341383A (zh) * 2014-09-24 2015-02-11 中国医学科学院医药生物技术研究所 新型2′-胺甲酰基联苯类化合物及其在抗肝纤维化中的应用
CN104402856B (zh) * 2014-12-08 2017-05-03 浙江东亚药业有限公司 一种二（亚甲二氧基）联苯衍生化合物的制备方法
CN107141278B (zh) * 2017-06-06 2019-05-07 北京元延医药科技股份有限公司 利用联苯双酯制备双环醇的方法
CN112250658B (zh) * 2020-12-21 2021-05-07 北京鑫开元医药科技有限公司 一种甲酰化双环醇及其制备方法
CN114652692B (zh) * 2022-04-28 2023-09-01 长春钻智制药有限公司 一种治疗肝病的药物缓释片及其制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60209582A (ja) * 1984-04-04 1985-10-22 Isukura Sangyo Kk Ｄｄｂの合成方法
DE3620324A1 (de) * 1985-07-04 1987-01-22 Karl Prof Dr Cammann Verfahren und vorrichtung zur analyse von atomspektreten

Also Published As

Publication number Publication date
ATE93232T1 (de) 1993-09-15
EP0353358B1 (de) 1993-08-18
US4868207A (en) 1989-09-19
EP0353358A1 (de) 1990-02-07
ES2043830T3 (es) 1994-01-01
DE3883387T2 (de) 1993-12-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee