DE3874056D1 - Chinolinderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten. - Google Patents
Chinolinderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.Info
- Publication number
- DE3874056D1 DE3874056D1 DE8888306583T DE3874056T DE3874056D1 DE 3874056 D1 DE3874056 D1 DE 3874056D1 DE 8888306583 T DE8888306583 T DE 8888306583T DE 3874056 T DE3874056 T DE 3874056T DE 3874056 D1 DE3874056 D1 DE 3874056D1
- Authority
- DE
- Germany
- Prior art keywords
- 6alkylthio
- 6alkoxy
- amino
- production
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- -1 cyano, amino, hydroxy, carbamoyl Chemical group 0.000 abstract 1
- 230000027119 gastric acid secretion Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB878717644A GB8717644D0 (en) | 1987-07-24 | 1987-07-24 | Compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3874056D1 true DE3874056D1 (de) | 1992-10-01 |
DE3874056T2 DE3874056T2 (de) | 1993-01-07 |
Family
ID=10621289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8888306583T Expired - Fee Related DE3874056T2 (de) | 1987-07-24 | 1988-07-19 | Chinolinderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5051508A (de) |
EP (1) | EP0307078B1 (de) |
JP (1) | JPS6440482A (de) |
AT (1) | ATE79880T1 (de) |
AU (1) | AU1920088A (de) |
DE (1) | DE3874056T2 (de) |
DK (1) | DK414488A (de) |
GB (1) | GB8717644D0 (de) |
PT (1) | PT88033B (de) |
ZA (1) | ZA885311B (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8901430D0 (en) * | 1989-01-23 | 1989-03-15 | Smithkline Beckman Intercredit | Compounds |
CA2011086A1 (en) * | 1989-03-17 | 1990-09-17 | Karl-Heinz Geiss | 2-alkyl-4-arylmethylaminoquinolines, the use thereof and drugs prepared therefrom |
GB8928281D0 (en) * | 1989-12-14 | 1990-02-21 | Smith Kline French Lab | Compounds |
IS4164A (is) * | 1993-06-11 | 1994-12-12 | Ab Astra | Efnasambönd sem hindra flæði magasýru |
US5556863A (en) * | 1993-06-11 | 1996-09-17 | Astra Aktiebolag | Compound for gastric acid secretion inhibition |
KR100187475B1 (ko) * | 1996-05-17 | 1999-05-01 | 이서봉 | 1-아릴-4-옥소 피롤로(3,2-c)퀴놀린 유도체의 제조방법 |
KR100251522B1 (ko) * | 1997-08-13 | 2000-08-01 | 김충섭 | 할로알콕시기를 함유하는 피롤[3,2-c]퀴놀린 유도체 및 약학적으로 허용되는 그의 염 |
CA2301510A1 (en) * | 1998-07-02 | 2000-01-13 | Korea Research Institute Of Chemical Technology | 3-alkylpyrrolo[3,2-c]quinoline derivatives |
UA80393C2 (uk) | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
GB0211649D0 (en) | 2002-05-21 | 2002-07-03 | Novartis Ag | Organic compounds |
CN100471840C (zh) | 2003-03-10 | 2009-03-25 | 尼科梅德有限责任公司 | 制备罗氟司特的方法 |
EP1682133A1 (de) | 2003-11-03 | 2006-07-26 | AstraZeneca AB | Imidazo-1,2-a-pyridin-derivate zur behandlung von beschwerdefreiem gastroösophagealem reflux |
AU2006224619B2 (en) * | 2005-03-16 | 2012-06-07 | Takeda Gmbh | Taste masked dosage form containing roflumilast |
GB0522715D0 (en) | 2005-11-08 | 2005-12-14 | Helperby Therapeutics Ltd | New use |
GB0709513D0 (en) * | 2007-05-17 | 2007-06-27 | Helperby Therapeutics Ltd | Topical formulations |
WO2023003497A1 (ru) * | 2021-07-23 | 2023-01-26 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Соединения с лизосомотропной и противовирусной активностью |
US11939328B2 (en) | 2021-10-14 | 2024-03-26 | Incyte Corporation | Quinoline compounds as inhibitors of KRAS |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB725745A (en) * | 1952-05-26 | 1955-03-09 | Bayer Ag | Pyrrolinoquinolines and processes for making same |
US2691023A (en) * | 1952-05-26 | 1954-10-05 | Schenley Ind Inc | Dihydropyrrolo-(3.2-c) quinoline derivatives |
GB1492029A (en) * | 1974-01-30 | 1977-11-16 | Bellon R Lab | 4-oxo-1,4-dihydro-1,6-benzo-(h)-naphthyridine-3-carboxylic acid derivatives useful as anti-bacterial agents and their preparation |
-
1987
- 1987-07-24 GB GB878717644A patent/GB8717644D0/en active Pending
-
1988
- 1988-07-19 AT AT88306583T patent/ATE79880T1/de not_active IP Right Cessation
- 1988-07-19 DE DE8888306583T patent/DE3874056T2/de not_active Expired - Fee Related
- 1988-07-19 PT PT88033A patent/PT88033B/pt not_active IP Right Cessation
- 1988-07-19 EP EP88306583A patent/EP0307078B1/de not_active Expired - Lifetime
- 1988-07-20 AU AU19200/88A patent/AU1920088A/en not_active Abandoned
- 1988-07-21 JP JP63184463A patent/JPS6440482A/ja active Pending
- 1988-07-21 ZA ZA885311A patent/ZA885311B/xx unknown
- 1988-07-22 DK DK414488A patent/DK414488A/da not_active Application Discontinuation
-
1990
- 1990-06-19 US US07/540,394 patent/US5051508A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK414488D0 (da) | 1988-07-22 |
JPS6440482A (en) | 1989-02-10 |
US5051508A (en) | 1991-09-24 |
PT88033B (pt) | 1995-03-31 |
DK414488A (da) | 1989-01-25 |
AU1920088A (en) | 1989-01-27 |
EP0307078B1 (de) | 1992-08-26 |
EP0307078A1 (de) | 1989-03-15 |
PT88033A (pt) | 1989-06-30 |
GB8717644D0 (en) | 1987-09-03 |
ZA885311B (en) | 1989-07-26 |
DE3874056T2 (de) | 1993-01-07 |
ATE79880T1 (de) | 1992-09-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3874056D1 (de) | Chinolinderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten. | |
EG18408A (en) | Process for preparing novel substituted quinoline derivatives | |
NL950022I2 (nl) | Analoga van mevalolacton en derivaten daarvan, werkwijzen voor hun bereiding, farmaceutische prepar aten die ze bevatten en hun toepassing als farmaceutica. | |
IL88507A (en) | 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them | |
MY105158A (en) | Substituted 4-aminoquinoline derivatives as gastric acid secretion inhibutors. | |
GB8804443D0 (en) | Compounds | |
ES8705858A1 (es) | Procedimiento para preparar diselenobis-(amidas de acidos benzoicos) | |
GR860679B (en) | Novel 3-pyridylmethylnaphthyl derivatives method for their preparation and their use as medicine | |
DE3660764D1 (en) | Triazole derivatives, process for their preparation and pharmaceutical compositions containing them | |
ZA878658B (en) | Substituted thienoimidazole-toluidine derivatives,a process for their preparation,pharmaceutical compositions containing them,and their use as inhibitors of gastric acid secretion | |
AU6174586A (en) | Substituted toluidines, a process for their preparation pharmaceutical formulations containing them, and their use as inhibitors of gastric acid secretion |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |