DE3873200T2 - Neue androst-4-en-3,17-dion-derivate und verfahren zur herstellung. - Google Patents
Neue androst-4-en-3,17-dion-derivate und verfahren zur herstellung.Info
- Publication number
- DE3873200T2 DE3873200T2 DE8888901462T DE3873200T DE3873200T2 DE 3873200 T2 DE3873200 T2 DE 3873200T2 DE 8888901462 T DE8888901462 T DE 8888901462T DE 3873200 T DE3873200 T DE 3873200T DE 3873200 T2 DE3873200 T2 DE 3873200T2
- Authority
- DE
- Germany
- Prior art keywords
- ene
- dione
- 14alpha
- 6beta
- androst
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- AEMFNILZOJDQLW-QAGGRKNESA-N androst-4-ene-3,17-dione Chemical class O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 AEMFNILZOJDQLW-QAGGRKNESA-N 0.000 title abstract 4
- BTTWKVFKBPAFDK-UHFFFAOYSA-N (9beta,10alpha)-Androst-4-ene-3,17-dione Natural products OC1CCC2(C)C3CCC(C)(C(CC4)O)C4C3CCC2=C1 BTTWKVFKBPAFDK-UHFFFAOYSA-N 0.000 abstract 2
- AEMFNILZOJDQLW-UHFFFAOYSA-N androstenedione Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 AEMFNILZOJDQLW-UHFFFAOYSA-N 0.000 abstract 2
- OSVMTWJCGUFAOD-KZQROQTASA-N formestane Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1O OSVMTWJCGUFAOD-KZQROQTASA-N 0.000 abstract 2
- UDHAKZRCGHAPAZ-NFBMXZEVSA-N (6r,8r,9s,10r,13s,14r)-6,14-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,15,16-decahydrocyclopenta[a]phenanthrene-3,17-dione Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@]4(O)[C@@H]3C[C@@H](O)C2=C1 UDHAKZRCGHAPAZ-NFBMXZEVSA-N 0.000 abstract 1
- UKVVNEHFNYKGMX-KIVPVIKRSA-N (8r,9s,10r,13s,14r)-14-hydroxy-10,13-dimethyl-2,7,8,9,11,12,15,16-octahydro-1h-cyclopenta[a]phenanthrene-3,6,17-trione Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@]4(O)[C@@H]3CC(=O)C2=C1 UKVVNEHFNYKGMX-KIVPVIKRSA-N 0.000 abstract 1
- YQTCQNIPQMJNTI-UHFFFAOYSA-N 2,2-dimethylpropan-1-one Chemical group CC(C)(C)[C]=O YQTCQNIPQMJNTI-UHFFFAOYSA-N 0.000 abstract 1
- 241001019659 Acremonium <Plectosphaerellaceae> Species 0.000 abstract 1
- MESHAHUSFQBSNL-BPRDAKSVSA-N O[C@@]12CCC([C@@]1(C)CC[C@@H]1[C@]3(CCC(C=C3[C@@H](C[C@@H]21)OC(C(C)(C)C)=O)=O)C)=O Chemical compound O[C@@]12CCC([C@@]1(C)CC[C@@H]1[C@]3(CCC(C=C3[C@@H](C[C@@H]21)OC(C(C)(C)C)=O)=O)C)=O MESHAHUSFQBSNL-BPRDAKSVSA-N 0.000 abstract 1
- 241000228417 Sarocladium strictum Species 0.000 abstract 1
- IQFUOVVYVZVYPA-YNGAPGBGSA-N [(6r,8r,9s,10r,13s,14r)-14-hydroxy-10,13-dimethyl-3,17-dioxo-1,2,6,7,8,9,11,12,15,16-decahydrocyclopenta[a]phenanthren-6-yl] acetate Chemical compound C1CC(=O)C=C2[C@H](OC(=O)C)C[C@H]3[C@]4(O)CCC(=O)[C@@]4(C)CC[C@@H]3[C@]21C IQFUOVVYVZVYPA-YNGAPGBGSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 150000008065 acid anhydrides Chemical class 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- -1 isobutyryl Chemical group 0.000 abstract 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/06—Hydroxylating
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62024599A JPS63192797A (ja) | 1987-02-06 | 1987-02-06 | ６β，１４α−ジヒドロキシ−△↑４−アンドロステン−３，１７−ジオン誘導体 |
| JP62024595A JPS63192795A (ja) | 1987-02-06 | 1987-02-06 | ６β，１１α−ジヒドロキシ−４−アンドロステン−３，１７−ジオン |
| JP62024598A JPS63192796A (ja) | 1987-02-06 | 1987-02-06 | ６β，１４α−ジヒドロキシ−４−アンドロステン−３，１７−ジオン |
| JP62024594A JPS63192794A (ja) | 1987-02-06 | 1987-02-06 | １４α−ヒドロキシ−４−アンドロステン−３，６，１７−トリオン |
| PCT/JP1988/000114 WO1988005781A1 (en) | 1987-02-06 | 1988-02-05 | Novel androst-4-ene-3,17-dione derivatives and process for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3873200D1 DE3873200D1 (de) | 1992-09-03 |
| DE3873200T2 true DE3873200T2 (de) | 1993-02-25 |
Family
ID=27458173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8888901462T Expired - Fee Related DE3873200T2 (de) | 1987-02-06 | 1988-02-05 | Neue androst-4-en-3,17-dion-derivate und verfahren zur herstellung. |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US4975368A (de) |
| EP (1) | EP0300062B1 (de) |
| AT (1) | ATE78825T1 (de) |
| DE (1) | DE3873200T2 (de) |
| WO (1) | WO1988005781A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0643439B2 (ja) * | 1989-02-07 | 1994-06-08 | 雪印乳業株式会社 | 光による６β，１４α‐ジヒドロキシ‐４‐アンドロステン‐３，１７‐ジオンの６β位水酸基の酸化方法 |
| JP2602456B2 (ja) * | 1990-04-12 | 1997-04-23 | 雪印乳業株式会社 | 子宮内膜症治療剤 |
| DE4129005A1 (de) * | 1991-08-28 | 1993-03-04 | Schering Ag | Verfahren zur herstellung von 14(alpha)-hydroxy-4-androsten-3,17-dion |
| JPH06225793A (ja) * | 1992-11-27 | 1994-08-16 | Nippon Kayaku Co Ltd | ６β，１４α−ジヒドロキシ−４−アンドロステン−３，１７−ジオンの新規製造法 |
| EP0626388A3 (en) * | 1993-05-28 | 1996-06-19 | Nippon Kayaku Kk | 14alpha-hydroxy-4-androstene-3,6,17-trione hydrate crystal and process for producing same. |
| US8084446B2 (en) | 2005-04-26 | 2011-12-27 | Eric Marchewitz | Use of DHEA derivatives for enhancing physical performance |
| EP2556082B1 (de) * | 2010-04-08 | 2017-02-22 | Emory University | Substituierte androst-4-en-dione |
| CN106990186B (zh) * | 2017-05-22 | 2019-05-21 | 成都欣捷高新技术开发股份有限公司 | 衍生检测甾体化合物a环双键异构体的高效液相色谱方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2786855A (en) * | 1953-01-31 | 1957-03-26 | Syntex Sa | Oxidation of delta4-3, 6-dihydroxy steroids to delta4-3-keto-6-hydroxy steroids |
| JPS58179498A (ja) * | 1982-04-13 | 1983-10-20 | Dainippon Ink & Chem Inc | 微生物による１１α−ヒドロキシル化アンドロスタン系化合物の製造方法 |
-
1988
- 1988-02-05 WO PCT/JP1988/000114 patent/WO1988005781A1/ja active IP Right Grant
- 1988-02-05 DE DE8888901462T patent/DE3873200T2/de not_active Expired - Fee Related
- 1988-02-05 EP EP88901462A patent/EP0300062B1/de not_active Expired
- 1988-02-05 AT AT88901462T patent/ATE78825T1/de not_active IP Right Cessation
- 1988-09-26 US US07/279,596 patent/US4975368A/en not_active Expired - Fee Related
-
1990
- 1990-07-23 US US07/555,691 patent/US5079377A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE78825T1 (de) | 1992-08-15 |
| EP0300062B1 (de) | 1992-07-29 |
| US5079377A (en) | 1992-01-07 |
| US4975368A (en) | 1990-12-04 |
| EP0300062A4 (de) | 1989-03-21 |
| DE3873200D1 (de) | 1992-09-03 |
| WO1988005781A1 (en) | 1988-08-11 |
| EP0300062A1 (de) | 1989-01-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3873200T2 (de) | Neue androst-4-en-3,17-dion-derivate und verfahren zur herstellung. | |
| DE3888789D1 (de) | Mikroorganismus mit geringer Fähigkeit zur Acetat-Bildung und Verfahren zur Herstellung nützlicher Substrate unter Verwendung dieses Mikroorganismus. | |
| DE3774987D1 (de) | Verfahren zur kontrolle der epimerischen verteilung in der herstellung von pregnane-16,17-acetal oder ketal derivaten. | |
| ATE26279T1 (de) | Verfahren zur isolierung und reinigung von antibiotika. | |
| NO20023276L (no) | Fremgangsmåter fremstilling av betulinsyre | |
| JPS578794A (en) | Preparation of androstane-type steroid | |
| ATE44532T1 (de) | Verfahren zur herstellung von pregnan-derivaten. | |
| ATE107656T1 (de) | Verfahren zur herstellung von 14-alpha-hydroxy-4- androsten-3,6,17, trion. | |
| DE69500643D1 (de) | Neues Verfahren zur Herstellung von einem 16-beta-steroid und neue Zwischenprodukte davon | |
| DE69112716T2 (de) | Verfahren zur biologischen Herstellung einer Hydroxyvitamin-D-Verbindung. | |
| DE3866047D1 (de) | Neue 7-g(b)-hydroxy-4-pregnen-3,20-dion-derivate und verfahren zur herstellung. | |
| DE68912236T2 (de) | Verfahren zur Herstellung von hochgradig ungesättigten Fettsäuren. | |
| DE69612871T2 (de) | Verfahren zur herstellung von (11beta,16beta)-21-(acetyloxy)-11-hydroxy-2'-methyl-5'h-pregna-1,4-dieno(17,16-d)oxazole-3,20-dione | |
| ATE30728T1 (de) | Verfahren zur herstellung von 3-(delta43ketosteroid-17alpha-yl)-propion-saeurelactonen. | |
| ATE71106T1 (de) | Verfahren zur herstellung von 1-methyl-androsta- 1,4-dien-3,17-dion und die neuen zwischenprodukte fuer dieses verfahren. | |
| ATE60785T1 (de) | Verfahren zur herstellung von estran-derivaten. | |
| DE59304635D1 (de) | Verfahren zur fermentativen herstellung von 2-hydroxyphenylessigsäure | |
| AU1810492A (en) | Novel microorganisms having a conversion ability to bile acids and method for preparing bile acids | |
| ATE147438T1 (de) | Verfahren zur herstellung von 4-pregnen-3,20-dion und seinen derivaten | |
| ATE192454T1 (de) | Verfahren zur herstellung von (11beta,16beta)-21- (3-carboxy-3-oxopropoxy)-11-hydroxy-2'-methyl-5 h-pregna-1,4-dieno(17,16-d)oxazole-3,20-dione | |
| KR950700422A (ko) | (D)-2-히드록시카르복실산을 2-케토 카르복실산으로 효소 산화시키는 방법(Process for the Enzymatic Oxidation of (D)-2-Hydroxycarboxylic Acids to 2-Ketonic Carboxylic Acids) | |
| JPS5585396A (en) | Microbiological preparation of androstane compound | |
| JPS5459395A (en) | Microbial preparation of androstane compounds | |
| JPS5270082A (en) | Microbial oxidation of steroids | |
| JPS5467098A (en) | Preparation of androstane compound |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |