AU1810492A - Novel microorganisms having a conversion ability to bile acids and method for preparing bile acids - Google Patents

Novel microorganisms having a conversion ability to bile acids and method for preparing bile acids

Info

Publication number
AU1810492A
AU1810492A AU18104/92A AU1810492A AU1810492A AU 1810492 A AU1810492 A AU 1810492A AU 18104/92 A AU18104/92 A AU 18104/92A AU 1810492 A AU1810492 A AU 1810492A AU 1810492 A AU1810492 A AU 1810492A
Authority
AU
Australia
Prior art keywords
alpha
bile acids
hydroxy
beta
cholanic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU18104/92A
Other versions
AU645426B2 (en
Inventor
Hiroshi Kawaide
Hiromi Kimura
Akio Okamura
Takurou Yamaura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tokyo Pharmaceuticals Inc
Original Assignee
Mitsubishi Tokyo Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tokyo Pharmaceuticals Inc filed Critical Mitsubishi Tokyo Pharmaceuticals Inc
Publication of AU1810492A publication Critical patent/AU1810492A/en
Application granted granted Critical
Publication of AU645426B2 publication Critical patent/AU645426B2/en
Assigned to TT PHARMACEUTICALS, INC. reassignment TT PHARMACEUTICALS, INC. Alteration of Name(s) in Register under S187 Assignors: TOKYO TANABE COMPANY LIMITED
Assigned to MITSUBISHI-TOKYO PHARMACEUTICALS, INC. reassignment MITSUBISHI-TOKYO PHARMACEUTICALS, INC. Request to Amend Deed and Register Assignors: TT PHARMACEUTICALS, INC.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention provides a microorganism of the genus Bacillus capable of selectively oxidising a 7 alpha and/or 12 alpha -hydroxy group of a 3 alpha -hydroxy-5 beta -cholanic acid having a 7 alpha - and/or 12 alpha - hydroxy group and a process for selectively oxidising a 7 alpha - and/or 12 alpha - hydroxy group of a 3 alpha -hydroxy-5 beta -cholanic acid having a 7 alpha - and/or 12 alpha -hydroxy group, comprising culturing such a microorganism in a culture medium containing one or more of such 3 alpha -hydroxy-5 beta -cholanic acids to produce a corresponding 7-and/or 12-keto derivative. More particularly, the preparation of 3 alpha -hydroxy-7-keto-5 beta -cholanic acid from chenodeoxycholic acid and of 3 alpha -hydroxy-7-keto-5 beta -cholanic and3 alpha ,12 alpha -dihydroxy-7-keto-5 beta -cholanic acid from cholic acids is described.
AU18104/92A 1991-06-12 1992-06-09 Novel microorganisms having a conversion ability to bile acids and method for preparing bile acids Ceased AU645426B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP23674091 1991-06-12
JP4-11598 1992-01-27
JP1159892 1992-01-27
JP3-236740 1992-01-27

Publications (2)

Publication Number Publication Date
AU1810492A true AU1810492A (en) 1992-12-17
AU645426B2 AU645426B2 (en) 1994-01-13

Family

ID=26347053

Family Applications (1)

Application Number Title Priority Date Filing Date
AU18104/92A Ceased AU645426B2 (en) 1991-06-12 1992-06-09 Novel microorganisms having a conversion ability to bile acids and method for preparing bile acids

Country Status (8)

Country Link
US (1) US5480781A (en)
EP (1) EP0518661B1 (en)
KR (1) KR100225157B1 (en)
AT (1) ATE158023T1 (en)
AU (1) AU645426B2 (en)
CA (1) CA2070720A1 (en)
DE (1) DE69222092T2 (en)
ES (1) ES2106141T3 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU662359B2 (en) * 1991-10-24 1995-08-31 Mitsubishi-Tokyo Pharmaceuticals, Inc. Novel microorganisms and a process for preparing 3alpha, 7alpha-dihydroxy-12-keto-5beta-cholanic acid

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1450610A4 (en) * 2001-11-05 2006-03-29 Ganeden Biotech Inc Probiotic compositions
ITMI20110534A1 (en) * 2011-03-31 2012-10-01 Prodotti Chimici Alimentari "NEW PROCESS FOR SELECTIVE OXIDATION OF BILE ACIDS, THEIR SALTS OR DERIVATIVES"

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3801460A (en) * 1970-12-18 1974-04-02 Merck & Co Inc Simultaneous steroid oxygenation and 1-dehydrogenation with bacillus cereus
GB2057447B (en) * 1979-08-21 1984-01-25 Kuraray Co Microbal process for producing cholanic acid derivatives and microbes used therein
JP3030306B2 (en) * 1991-02-28 2000-04-10 三菱東京製薬株式会社 Method for producing 3-keto 7β-hydroxycholanic acid
JP3082973B2 (en) * 1991-10-24 2000-09-04 三菱東京製薬株式会社 Method for producing 3α, 7α-dihydroxy-12-keto-5β-cholanic acid
JPH05313708A (en) * 1992-05-14 1993-11-26 Fanuc Ltd Sequence program editing system
JP2562093B2 (en) * 1992-05-26 1996-12-11 日本航空電子工業株式会社 Ternary signal transmission method using optical transmission pulse
JPH06225356A (en) * 1993-01-22 1994-08-12 N T T Idou Tsuushinmou Kk Communication system

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU662359B2 (en) * 1991-10-24 1995-08-31 Mitsubishi-Tokyo Pharmaceuticals, Inc. Novel microorganisms and a process for preparing 3alpha, 7alpha-dihydroxy-12-keto-5beta-cholanic acid

Also Published As

Publication number Publication date
DE69222092T2 (en) 1998-02-12
AU645426B2 (en) 1994-01-13
ES2106141T3 (en) 1997-11-01
ATE158023T1 (en) 1997-09-15
EP0518661B1 (en) 1997-09-10
KR930000674A (en) 1993-01-15
US5480781A (en) 1996-01-02
KR100225157B1 (en) 1999-10-15
DE69222092D1 (en) 1997-10-16
EP0518661A1 (en) 1992-12-16
CA2070720A1 (en) 1992-12-13

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Legal Events

Date Code Title Description
HB Alteration of name in register

Free format text: MITSUBISHI-TOKYO PHARMACEUTICALS, INC.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired