DE3853811D1 - ACV-Synthetase kodierende DNS. - Google Patents

ACV-Synthetase kodierende DNS.

Info

Publication number
DE3853811D1
DE3853811D1 DE3853811T DE3853811T DE3853811D1 DE 3853811 D1 DE3853811 D1 DE 3853811D1 DE 3853811 T DE3853811 T DE 3853811T DE 3853811 T DE3853811 T DE 3853811T DE 3853811 D1 DE3853811 D1 DE 3853811D1
Authority
DE
Germany
Prior art keywords
penicillin
gene
acv
synthetase
dna encoding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3853811T
Other languages
English (en)
Other versions
DE3853811T2 (de
Inventor
Martin Karl Russell Burnham
Alison Jane Earl
John Henry University Of Bull
David John University Of Smith
Geoffrey University Of Turner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of DE3853811D1 publication Critical patent/DE3853811D1/de
Publication of DE3853811T2 publication Critical patent/DE3853811T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
DE3853811T 1987-12-09 1988-12-09 ACV-Synthetase kodierende DNS. Expired - Lifetime DE3853811T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878728811A GB8728811D0 (en) 1987-12-09 1987-12-09 Novel substance

Publications (2)

Publication Number Publication Date
DE3853811D1 true DE3853811D1 (de) 1995-06-22
DE3853811T2 DE3853811T2 (de) 1995-10-12

Family

ID=10628254

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3853811T Expired - Lifetime DE3853811T2 (de) 1987-12-09 1988-12-09 ACV-Synthetase kodierende DNS.

Country Status (8)

Country Link
EP (1) EP0320272B1 (de)
JP (1) JP2970918B2 (de)
AT (1) ATE122718T1 (de)
DE (1) DE3853811T2 (de)
ES (1) ES2073409T3 (de)
GB (1) GB8728811D0 (de)
GR (1) GR3017073T3 (de)
WO (1) WO1989005350A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5108918A (en) * 1988-08-11 1992-04-28 Gist-Brocades Method for identifying and using biosynthetic genes for enhanced production of secondary metabolites
FI104264B1 (fi) * 1988-08-11 1999-12-15 Dsm Nv Menetelmä sekundääristen metaboliittien tuoton parantamiseksi käyttämällä rykelmöityjä biosynteettisiä geenejä
US5882879A (en) * 1990-02-28 1999-03-16 Gist-Brocades, N.V. Method for influencing β-lactam antibiotic production and for isolation of large quantities of ACV synthetase
ATE169059T1 (de) * 1990-02-28 1998-08-15 Gist Brocades Nv Verfahren zur beeinflussung der produktion von beta-lactam antibiotika und zur isolierung grosser mengen von acv-synthetase
US6322998B1 (en) 1990-06-01 2001-11-27 Eli Lilly And Company Recombinant DNA compounds that encode ACV synthetase activity of Cephalosporium acremonium
US5589571A (en) * 1994-10-28 1996-12-31 Cor Therapeutics, Inc. Process for production of inhibited forms of activated blood factors
MX2007006780A (es) * 2004-12-10 2007-08-06 Dsm Ip Assets Bv Produccion de beta-lactamas en celulas individuales.
DK2029750T3 (da) * 2006-06-22 2011-10-17 Dsm Ip Assets Bv Fremstilling af pravastatin

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59111699A (ja) * 1982-12-17 1984-06-27 富士通株式会社 話者認識方式
IL78531A0 (en) * 1985-04-22 1986-08-31 Lilly Co Eli Recombinant dna expression vectors and dna compounds which encode isopenicillin n synthetase
US4892819A (en) * 1985-11-25 1990-01-09 Eli Lilly And Company Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from penicillium chrysogenum
DE3789880T2 (de) * 1986-01-31 1994-09-08 Beecham Group Plc Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen.
IL85535A (en) * 1987-03-04 1994-02-27 Lilly Co Eli AND Recombinant expression vectors encoding datastoxysplosporin C synthetase and datacetylsephalosporin C synthetase
GB2208077A (en) * 1987-04-24 1989-02-22 Antibioticos Sa Isopenicillin n synthetase gene derived from aspergillus nidulans

Also Published As

Publication number Publication date
ES2073409T3 (es) 1995-08-16
DE3853811T2 (de) 1995-10-12
GB8728811D0 (en) 1988-01-27
JP2970918B2 (ja) 1999-11-02
GR3017073T3 (en) 1995-11-30
ATE122718T1 (de) 1995-06-15
JPH02502606A (ja) 1990-08-23
WO1989005350A1 (en) 1989-06-15
EP0320272A1 (de) 1989-06-14
EP0320272B1 (de) 1995-05-17

Similar Documents

Publication Publication Date Title
Smith et al. Cloning and heterologous expression of the penicillin biosynthetic gene cluster from Penicillium chrysogenum
Alvarez et al. Purification to homogeneity and characterization of acyl coenzyme A: 6-aminopenicillanic acid acyltransferase of Penicillium chrysogenum
RU2002130702A (ru) Новый биологический способ получения 7-ацк и 7-адац
Queener Molecular biology of penicillin and cephalosporin biosynthesis
TW270149B (de)
Martin et al. Molecular genetics of penicillin and cephalosporin antibiotic biosynthesis
ATE122718T1 (de) Acv-synthetase kodierende dns.
FI104264B1 (fi) Menetelmä sekundääristen metaboliittien tuoton parantamiseksi käyttämällä rykelmöityjä biosynteettisiä geenejä
ES2086386T3 (es) Procedimiento para producir compuestos de 7-aminocefem o sus sales.
GR3031739T3 (en) Improved process for preparing cephalosporins.
HUT52156A (en) Genes and gene products for producing beta-lactam compounds
ATE142698T1 (de) Verfahren zur herstellung von ascorbinsäure-2- phosphat
AU589550B2 (en) Biosynthesis of unnatural cephalosporins
WO1998016648A3 (en) Isopenicillin n synthetase and deacetoxycephalosporin c synthetase enzymes and methods
GB1399349A (en) Process for acylation of dephalosporin esters
Ghosh Strategies for manipulation of genes in microbes for production of β-lactam antibiotics
PT96912A (pt) Processo para influenciar a producao de antibioticos de beta-lactama e para o isolamento de grandes quantidades de sintetase de acv
Liras Padín et al. Biochemistry and genetics of Cephamycin C production by Nocardia lactamdurans

Legal Events

Date Code Title Description
8364 No opposition during term of opposition