ATE122718T1 - Acv-synthetase kodierende dns. - Google Patents

Acv-synthetase kodierende dns.

Info

Publication number
ATE122718T1
ATE122718T1 AT88311655T AT88311655T ATE122718T1 AT E122718 T1 ATE122718 T1 AT E122718T1 AT 88311655 T AT88311655 T AT 88311655T AT 88311655 T AT88311655 T AT 88311655T AT E122718 T1 ATE122718 T1 AT E122718T1
Authority
AT
Austria
Prior art keywords
penicillin
gene
acv
synthetase
dna encoding
Prior art date
Application number
AT88311655T
Other languages
English (en)
Inventor
Martin Karl Russell Burnham
Alison Jane Earl
John Henry University Of Bull
The Medical Schoo Microbiology
David John University Of Smith
Geoffrey University Of Turner
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Application granted granted Critical
Publication of ATE122718T1 publication Critical patent/ATE122718T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
AT88311655T 1987-12-09 1988-12-09 Acv-synthetase kodierende dns. ATE122718T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878728811A GB8728811D0 (en) 1987-12-09 1987-12-09 Novel substance

Publications (1)

Publication Number Publication Date
ATE122718T1 true ATE122718T1 (de) 1995-06-15

Family

ID=10628254

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88311655T ATE122718T1 (de) 1987-12-09 1988-12-09 Acv-synthetase kodierende dns.

Country Status (8)

Country Link
EP (1) EP0320272B1 (de)
JP (1) JP2970918B2 (de)
AT (1) ATE122718T1 (de)
DE (1) DE3853811T2 (de)
ES (1) ES2073409T3 (de)
GB (1) GB8728811D0 (de)
GR (1) GR3017073T3 (de)
WO (1) WO1989005350A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5108918A (en) * 1988-08-11 1992-04-28 Gist-Brocades Method for identifying and using biosynthetic genes for enhanced production of secondary metabolites
FI104264B1 (fi) * 1988-08-11 1999-12-15 Dsm Nv Menetelmä sekundääristen metaboliittien tuoton parantamiseksi käyttämällä rykelmöityjä biosynteettisiä geenejä
EP0444758A1 (de) * 1990-02-28 1991-09-04 Gist-Brocades N.V. Verfahren zur Modifikation der ACV-Synthetase und Verwendung des modifizierten Enzyms zur Herstellung von beta-Laktam-Antibiotika
US5882879A (en) * 1990-02-28 1999-03-16 Gist-Brocades, N.V. Method for influencing β-lactam antibiotic production and for isolation of large quantities of ACV synthetase
US6322998B1 (en) 1990-06-01 2001-11-27 Eli Lilly And Company Recombinant DNA compounds that encode ACV synthetase activity of Cephalosporium acremonium
US5589571A (en) * 1994-10-28 1996-12-31 Cor Therapeutics, Inc. Process for production of inhibited forms of activated blood factors
MX2007006780A (es) * 2004-12-10 2007-08-06 Dsm Ip Assets Bv Produccion de beta-lactamas en celulas individuales.
SI2029750T1 (sl) * 2006-06-22 2011-11-30 Dsm Ip Assets Bv Proizvajanje pravastatina

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59111699A (ja) * 1982-12-17 1984-06-27 富士通株式会社 話者認識方式
DE3683080D1 (de) * 1985-04-22 1992-02-06 Lilly Co Eli Rekombinante dns-expressionsvektoren und dns-verbindungen.
US4892819A (en) * 1985-11-25 1990-01-09 Eli Lilly And Company Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from penicillium chrysogenum
EP0233715B1 (de) * 1986-01-31 1994-05-25 BEECHAM GROUP plc Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen
CA1327170C (en) * 1987-03-04 1994-02-22 Stephen Wyatt Queener Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase and deacetylcephalosporin c synthetase
GB2208077A (en) * 1987-04-24 1989-02-22 Antibioticos Sa Isopenicillin n synthetase gene derived from aspergillus nidulans

Also Published As

Publication number Publication date
GR3017073T3 (en) 1995-11-30
ES2073409T3 (es) 1995-08-16
DE3853811T2 (de) 1995-10-12
GB8728811D0 (en) 1988-01-27
JP2970918B2 (ja) 1999-11-02
EP0320272B1 (de) 1995-05-17
EP0320272A1 (de) 1989-06-14
WO1989005350A1 (en) 1989-06-15
DE3853811D1 (de) 1995-06-22
JPH02502606A (ja) 1990-08-23

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Publication Publication Date Title
Smith et al. Cloning and heterologous expression of the penicillin biosynthetic gene cluster from Penicillium chrysogenum
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NO940848L (no) Biologisk fremgangsmåte for fremstilling av 7-ADCA
DE3853811D1 (de) ACV-Synthetase kodierende DNS.
FI104264B1 (fi) Menetelmä sekundääristen metaboliittien tuoton parantamiseksi käyttämällä rykelmöityjä biosynteettisiä geenejä
ES2086386T3 (es) Procedimiento para producir compuestos de 7-aminocefem o sus sales.
AU3712593A (en) Improved process for preparing cephalosporins
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WO1998016648A3 (en) Isopenicillin n synthetase and deacetoxycephalosporin c synthetase enzymes and methods
GB1399349A (en) Process for acylation of dephalosporin esters
Ghosh Strategies for manipulation of genes in microbes for production of β-lactam antibiotics
PT96912A (pt) Processo para influenciar a producao de antibioticos de beta-lactama e para o isolamento de grandes quantidades de sintetase de acv
Liras Padín et al. Biochemistry and genetics of Cephamycin C production by Nocardia lactamdurans

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time