DE3842067A1 - Enzym-hemmende aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung - Google Patents

Enzym-hemmende aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung

Info

Publication number
DE3842067A1
DE3842067A1 DE3842067A DE3842067A DE3842067A1 DE 3842067 A1 DE3842067 A1 DE 3842067A1 DE 3842067 A DE3842067 A DE 3842067A DE 3842067 A DE3842067 A DE 3842067A DE 3842067 A1 DE3842067 A1 DE 3842067A1
Authority
DE
Germany
Prior art keywords
alkyl
amino
group
methyl
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE3842067A
Other languages
German (de)
English (en)
Inventor
Wolfgang Dr Rueger
Hansjoerg Dr Urbach
Dieter Dr Ruppert
Bernward Dr Schoelkens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DE3842067A priority Critical patent/DE3842067A1/de
Priority to DE89122794T priority patent/DE58905462D1/de
Priority to ES89122794T priority patent/ES2059688T3/es
Priority to EP89122794A priority patent/EP0373549B1/de
Priority to AT89122794T priority patent/ATE93863T1/de
Priority to US07/448,903 priority patent/US5185324A/en
Priority to FI895921A priority patent/FI895921A0/fi
Priority to IL92660A priority patent/IL92660A0/xx
Priority to KR1019890018354A priority patent/KR900009691A/ko
Priority to ZA899507A priority patent/ZA899507B/xx
Priority to NO89895002A priority patent/NO895002L/no
Priority to CA002005422A priority patent/CA2005422A1/en
Priority to JP1321602A priority patent/JPH02204475A/ja
Priority to PT92558A priority patent/PT92558B/pt
Priority to AU46115/89A priority patent/AU632519B2/en
Priority to DK629889A priority patent/DK629889A/da
Priority to HU896606A priority patent/HU205369B/hu
Publication of DE3842067A1 publication Critical patent/DE3842067A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
DE3842067A 1988-12-14 1988-12-14 Enzym-hemmende aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung Withdrawn DE3842067A1 (de)

Priority Applications (17)

Application Number Priority Date Filing Date Title
DE3842067A DE3842067A1 (de) 1988-12-14 1988-12-14 Enzym-hemmende aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE89122794T DE58905462D1 (de) 1988-12-14 1989-12-11 Enzym-hemmende Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und ihre Verwendung.
ES89122794T ES2059688T3 (es) 1988-12-14 1989-12-11 Derivados de aminoacidos inhibidores de enzimas, procedimiento para su preparacion, agentes que los contienen y su utilizacion.
EP89122794A EP0373549B1 (de) 1988-12-14 1989-12-11 Enzym-hemmende Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und ihre Verwendung
AT89122794T ATE93863T1 (de) 1988-12-14 1989-12-11 Enzym-hemmende aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung.
US07/448,903 US5185324A (en) 1988-12-14 1989-12-12 Enzyme-inhibiting amino acid derivatives, a process for the preparation thereof, agents containing these, and the use thereof
FI895921A FI895921A0 (fi) 1988-12-14 1989-12-12 Enzymhaemmande aminosyraderivat, foerfarande foer deras framstaellning, dessa innehaollande aemnen och deras anvaendning.
IL92660A IL92660A0 (en) 1988-12-14 1989-12-12 Enzyme-inhibiting amino acid derivatives,a process for the preparation thereof,compositions containing these,and the use thereof
KR1019890018354A KR900009691A (ko) 1988-12-14 1989-12-12 효소-억제 아미노산유도체, 이의 제법, 이를 함유하는 약제, 및 이의 용도
ZA899507A ZA899507B (en) 1988-12-14 1989-12-13 Enzyme-inhibiting amino acid derivatives,a process for the preparation thereof,agents containing these,and the use thereof
NO89895002A NO895002L (no) 1988-12-14 1989-12-13 Enzymhemmende aminosyrederivater.
CA002005422A CA2005422A1 (en) 1988-12-14 1989-12-13 Enzyme-inhibiting amino acid derivatives, a process for the preparation thereof, agents containing these, and the use thereof
JP1321602A JPH02204475A (ja) 1988-12-14 1989-12-13 酵素‐阻害アミノ酸誘導体およびその製法
PT92558A PT92558B (pt) 1988-12-14 1989-12-13 Processo para a preparacao de derivados de aminoacidos inibidores de enzimas e de composicoes farmaceuticas que os contem
AU46115/89A AU632519B2 (en) 1988-12-14 1989-12-13 Enzyme-inhibiting amino acid derivatives, a process for the preparation thereof, agents containing these, and the use thereof.
DK629889A DK629889A (da) 1988-12-14 1989-12-13 Aminosyrederivater, deres fremstilling og anvendelse som laegemidler
HU896606A HU205369B (en) 1988-12-14 1989-12-14 Process for producing enzyme inhibiting amino acid and dipeptide derivatives and pharmaceutical compositions comprising such compounds as active ingredient

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3842067A DE3842067A1 (de) 1988-12-14 1988-12-14 Enzym-hemmende aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung

Publications (1)

Publication Number Publication Date
DE3842067A1 true DE3842067A1 (de) 1990-06-21

Family

ID=6369139

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3842067A Withdrawn DE3842067A1 (de) 1988-12-14 1988-12-14 Enzym-hemmende aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE89122794T Expired - Fee Related DE58905462D1 (de) 1988-12-14 1989-12-11 Enzym-hemmende Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und ihre Verwendung.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE89122794T Expired - Fee Related DE58905462D1 (de) 1988-12-14 1989-12-11 Enzym-hemmende Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und ihre Verwendung.

Country Status (16)

Country Link
US (1) US5185324A (ko)
EP (1) EP0373549B1 (ko)
JP (1) JPH02204475A (ko)
KR (1) KR900009691A (ko)
AT (1) ATE93863T1 (ko)
AU (1) AU632519B2 (ko)
CA (1) CA2005422A1 (ko)
DE (2) DE3842067A1 (ko)
DK (1) DK629889A (ko)
ES (1) ES2059688T3 (ko)
FI (1) FI895921A0 (ko)
HU (1) HU205369B (ko)
IL (1) IL92660A0 (ko)
NO (1) NO895002L (ko)
PT (1) PT92558B (ko)
ZA (1) ZA899507B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6313094B1 (en) 1990-12-11 2001-11-06 Japan Energy Corporation β-amino-α-hydroxycarboxylic acid derivatives and HIV protease inhibitors
US5554728A (en) * 1991-07-23 1996-09-10 Nexstar Pharmaceuticals, Inc. Lipid conjugates of therapeutic peptides and protease inhibitors
NZ249789A (en) * 1992-03-11 1997-07-27 Narhex Ltd Hydrazine, carbazate and 1,2-diazacyclic derivatives and pharmaceutical compositions
MXPA93002392A (es) 1992-03-11 2005-02-04 Narhex Ltd Derivados amino de hidrocarburos-oxo e hidroxi-substituidos.
US6071895A (en) * 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
AU725432B2 (en) * 1996-04-17 2000-10-12 Centaur Pharmaceuticals, Inc. Nitrone free radical trap treatment of dementia associated with AIDS virus (HIV-1) infection
FR3012460B1 (fr) 2013-10-25 2015-12-11 Michelin & Cie Composition de caoutchouc comprenant un elastomere dienique portant des fonctions imidazole reparties de facon aleatoire le long de la chaine
FR3012451B1 (fr) * 2013-10-25 2016-11-11 Michelin & Cie Compose 1,3-dipolaire portant une fonction imidazole
FR3012458B1 (fr) 2013-10-25 2015-10-30 Michelin & Cie Composition de caoutchouc comprenant un additif compose 1,3-dipolaire portant une fonction imidazole
WO2021220231A1 (en) 2020-05-01 2021-11-04 Pi Industries Ltd. Composition of propineb and metominostrobin
EP4079748A1 (en) * 2021-04-23 2022-10-26 Insusense ApS Modulators of sortilin activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63503380A (ja) * 1986-01-16 1988-12-08 アボット・ラボラトリーズ ペプチド類似体
DE3626130A1 (de) * 1986-08-01 1988-02-11 Merck Patent Gmbh Aminosaeurederivate

Also Published As

Publication number Publication date
HU896606D0 (en) 1990-02-28
NO895002L (no) 1990-06-15
ATE93863T1 (de) 1993-09-15
DK629889A (da) 1990-06-15
CA2005422A1 (en) 1990-06-14
IL92660A0 (en) 1990-08-31
PT92558B (pt) 1995-08-09
AU632519B2 (en) 1993-01-07
US5185324A (en) 1993-02-09
DE58905462D1 (de) 1993-10-07
FI895921A0 (fi) 1989-12-12
ZA899507B (en) 1990-08-29
ES2059688T3 (es) 1994-11-16
JPH02204475A (ja) 1990-08-14
HU205369B (en) 1992-04-28
EP0373549A3 (de) 1991-08-21
EP0373549B1 (de) 1993-09-01
PT92558A (pt) 1990-06-29
AU4611589A (en) 1990-06-28
DK629889D0 (da) 1989-12-13
EP0373549A2 (de) 1990-06-20
NO895002D0 (no) 1989-12-13
KR900009691A (ko) 1990-07-05
HUT53664A (en) 1990-11-28

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