DE3781973D1 - 2-(acylthio)methyl-dihydropyridine, ein verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents

2-(acylthio)methyl-dihydropyridine, ein verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Info

Publication number
DE3781973D1
DE3781973D1 DE8787110821T DE3781973T DE3781973D1 DE 3781973 D1 DE3781973 D1 DE 3781973D1 DE 8787110821 T DE8787110821 T DE 8787110821T DE 3781973 T DE3781973 T DE 3781973T DE 3781973 D1 DE3781973 D1 DE 3781973D1
Authority
DE
Germany
Prior art keywords
dihydropyridine
acylthio
methyl
production
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787110821T
Other languages
German (de)
English (en)
Inventor
Marco Frigerio
Carlo Riva
Andrea Zaliani
Carmelo A Gandolfi
Odoardo Tofanetti
Sergio Tognella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics SpA
Original Assignee
Roche Diagnostics SpA
Boehringer Mannheim Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics SpA, Boehringer Mannheim Italia SpA filed Critical Roche Diagnostics SpA
Application granted granted Critical
Publication of DE3781973D1 publication Critical patent/DE3781973D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
DE8787110821T 1986-07-29 1987-07-25 2-(acylthio)methyl-dihydropyridine, ein verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. Expired - Lifetime DE3781973D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21290/86A IT1197012B (it) 1986-07-29 1986-07-29 2-(aciltio) metil diidropiridine, un processo per la loro preparazione e composizioni farmaceutiche che le contengono

Publications (1)

Publication Number Publication Date
DE3781973D1 true DE3781973D1 (de) 1992-11-05

Family

ID=11179618

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787110821T Expired - Lifetime DE3781973D1 (de) 1986-07-29 1987-07-25 2-(acylthio)methyl-dihydropyridine, ein verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Country Status (6)

Country Link
US (1) US4935433A (it)
EP (1) EP0255075B1 (it)
JP (1) JPS6366169A (it)
AT (1) ATE81119T1 (it)
DE (1) DE3781973D1 (it)
IT (1) IT1197012B (it)

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284634A (en) * 1975-07-02 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 1,4-Dihydropyridine derivatives, and pharmaceutical method of the same
DE2658183A1 (de) * 1976-12-22 1978-07-06 Bayer Ag In 2-position substituierte 1,4- dihydropyridin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS57175166A (en) * 1981-04-23 1982-10-28 Banyu Pharmaceut Co Ltd Carbamoyloxyalkyl-1,4-dihydropyridine derivative and its preparation
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
IL68604A0 (en) * 1982-05-21 1983-09-30 Haessle Ab Processes for preparing therapeutically active dihydropyridines and intermediates for the processes
HU192166B (en) * 1982-08-06 1987-05-28 Banyu Pharma Co Ltd Process for producing 2-carbamoyl-oxy-alkyl-1,4-dihydro-pyridine derivatives
PH19166A (en) * 1982-09-04 1986-01-16 Pfizer Dihydropyridined,pharmaceutical compositions and method of use
EP0107293A3 (en) * 1982-09-04 1984-06-06 Pfizer Limited Dihydropyridines
JPS59152373A (ja) * 1983-02-16 1984-08-31 Banyu Pharmaceut Co Ltd １，４―ジヒドロピリジン誘導体
GB8306666D0 (en) * 1983-03-10 1983-04-13 Pfizer Ltd Therapeutic agents
US4568677A (en) * 1983-07-23 1986-02-04 Pfizer Inc. 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents
GB8401288D0 (en) * 1984-01-18 1984-02-22 Pfizer Ltd Therapeutic agents
DE3412947A1 (de) * 1984-04-06 1985-10-17 Bayer Ag, 5090 Leverkusen Tetrahydothienopyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
FI862343A (fi) * 1985-06-17 1986-12-18 Warner Lambert Co Foerfarande foer framstaellning av terapeutiskt verkande 1,4-dihydropyridinfoereningar.
WO1987000836A1 (en) * 1985-08-06 1987-02-12 Boehringer Biochemia Robin S.P.A. Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines

Also Published As

Publication number Publication date
IT1197012B (it) 1988-11-25
JPS6366169A (ja) 1988-03-24
IT8621290A1 (it) 1988-01-29
EP0255075A1 (en) 1988-02-03
EP0255075B1 (en) 1992-09-30
ATE81119T1 (de) 1992-10-15
US4935433A (en) 1990-06-19

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Legal Events

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8332 No legal effect for de