DE3779563T2 - Reduzierte derivate von avermectin. - Google Patents

Reduzierte derivate von avermectin.

Info

Publication number
DE3779563T2
DE3779563T2 DE8787309347T DE3779563T DE3779563T2 DE 3779563 T2 DE3779563 T2 DE 3779563T2 DE 8787309347 T DE8787309347 T DE 8787309347T DE 3779563 T DE3779563 T DE 3779563T DE 3779563 T2 DE3779563 T2 DE 3779563T2
Authority
DE
Germany
Prior art keywords
avermectin
reduced derivatives
derivatives
reduced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787309347T
Other languages
English (en)
Other versions
DE3779563D1 (de
Inventor
Helmut Mrozik
Thomas L Shih
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE3779563D1 publication Critical patent/DE3779563D1/de
Application granted granted Critical
Publication of DE3779563T2 publication Critical patent/DE3779563T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Environmental Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Animal Husbandry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fodder In General (AREA)
DE8787309347T 1986-10-31 1987-10-22 Reduzierte derivate von avermectin. Expired - Fee Related DE3779563T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/925,772 US4831016A (en) 1986-10-31 1986-10-31 Reduced avermectin derivatives

Publications (2)

Publication Number Publication Date
DE3779563D1 DE3779563D1 (de) 1992-07-09
DE3779563T2 true DE3779563T2 (de) 1993-01-07

Family

ID=25452211

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787309347T Expired - Fee Related DE3779563T2 (de) 1986-10-31 1987-10-22 Reduzierte derivate von avermectin.

Country Status (7)

Country Link
US (1) US4831016A (de)
EP (1) EP0266131B1 (de)
JP (1) JP2530344B2 (de)
AU (1) AU598045B2 (de)
DE (1) DE3779563T2 (de)
NZ (1) NZ222251A (de)
ZA (1) ZA878159B (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
IE62125B1 (en) * 1986-03-12 1994-12-14 American Cyanamid Co Macrolide compounds
DK168866B1 (da) * 1986-03-12 1994-06-27 American Cyanamid Co 5-Keto-S541-macrolidforbindelse; krystallinsk produkt indeholdende over 90 % af forbindelsen; præparater indeholdende forbindelsen til anvendelse inden for human- og veterinærmedicin; skadedyrsbekæmpelsespræparat indeholdende forbindelsen; ikke-terapeutisk fremgangsmåde til bekæmpelse af skadedyr under anvendelse af forbindelsen; fremgangsmåde til fremstilling af et fermentationsmedium indeholdend
US5840704A (en) * 1986-07-16 1998-11-24 Pfizer Inc. Antiparasitic agents and process for their preparation
US5234831A (en) * 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5525506A (en) * 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5077278A (en) * 1987-01-23 1991-12-31 Pfizer Inc. Non-natural demethylavermectins compositions and method of use
US5238848A (en) * 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US4874749A (en) * 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb
US5240850A (en) * 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
ES2045146T3 (es) * 1987-11-09 1994-01-16 Pfizer Avermectinas etiladas.
GB8726730D0 (en) * 1987-11-14 1987-12-16 Pfizer Ltd Antiparasitic agents
US4918097A (en) * 1988-03-11 1990-04-17 Ciba-Geigy Corporation Insecticides and parasiticides
NZ228866A (en) * 1988-05-02 1991-10-25 Merck & Co Inc Fluoro-substituted milbemycins and avermectins for combatting parasites and insects
KR960013442B1 (ko) * 1988-05-10 1996-10-05 아메리칸 사이아나미드 캄파니 마크롤리드 화합물
US5015662A (en) * 1988-10-18 1991-05-14 Merck & Co., Inc. Anthelmintic bioconversion products
PE5591A1 (es) * 1988-12-19 1991-02-15 Lilly Co Eli Un nuevo grupo de compuestos de macrolida
NZ231773A (en) * 1988-12-23 1992-09-25 Merck & Co Inc Avermectin derivatives, preparation and parasiticidal pharmaceutical compositions thereof
US5322692A (en) * 1989-02-28 1994-06-21 American Cyanamid Company Sustained release bolus effective for the prolonged prevention, treatment or control of nematode, acarid and endo- and ectoparasitic infestations of ruminants
NZ233680A (en) * 1989-05-17 1995-02-24 Beecham Group Plc Avermectins and milbemycins and compositions thereof
US5030622A (en) * 1989-06-02 1991-07-09 Merck & Co., Inc. Avermectin derivatives
US5057499A (en) * 1989-06-02 1991-10-15 Merck & Co. Inc. Avermectin derivatives
NZ233792A (en) * 1989-06-02 1992-06-25 Merck & Co Inc Avermectin 3,4-epoxide derivatives; pesticidal compositions
US5023241A (en) * 1989-07-31 1991-06-11 Merck & Co., Inc. Avermectin derivatives
ATE130006T1 (de) * 1989-09-11 1995-11-15 American Cyanamid Co 13-alkyl-23-imino und 13-halo-23-imino-derivate von ll-f28249-verbindungen und ihre verwendung als endo- und ectoparasitizide, insektizide, akarizide und nematozide mittel.
IL98599A (en) * 1990-06-28 1995-06-29 Merck & Co Inc Stable salts of "4-deoxy-" 4-epi-methylamino abramectin and insecticides containing them
US5539089A (en) * 1991-11-08 1996-07-23 Dowelanco A83543 aglycones and pseudoglycones
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
CA2105251C (en) * 1992-09-01 2004-12-07 Mitsugi Shibano Novel processes for the production of 13-ether derivatives of milbemycins, and novel intermediates therefor
US5591606A (en) * 1992-11-06 1997-01-07 Dowelanco Process for the production of A83543 compounds with Saccharopolyspora spinosa
DK0688332T3 (da) * 1993-03-12 1997-10-13 Dowelanco Nye A83543-forbindelser og fremgangsmåder til fremstilling heraf.
DE19507018A1 (de) * 1995-03-01 1996-09-05 Bayer Ag Verfahren zur Herstellung von Ivermectin
US6001981A (en) * 1996-06-13 1999-12-14 Dow Agrosciences Llc Synthetic modification of Spinosyn compounds
EG23124A (en) * 2001-02-27 2004-04-28 Syngenta Participations Ag Avermectins substituted in the 4-position having pesticidal properties
CR6574A (es) * 2001-02-27 2004-10-28 Syngenta Participations Ag Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas
AR036486A1 (es) * 2001-08-28 2004-09-15 Syngenta Participations Ag Derivados 4"-desoxi-4"-(s)-amino avermectina, composicion plaguicida, procedimiento para la preparacion de esa composicion, metodo para controlar plagas, y uso de estos derivados para preparar una composicion
HUP0401677A2 (hu) * 2001-10-25 2004-12-28 Sankyo Lifetech Company, Limited Parazitaellenes készítmény és alkalmazása
TW200407330A (en) * 2002-05-07 2004-05-16 Syngenta Participations Ag 4"-Deoxy-4"-(S)-amido avermectin derivatives
WO2004058786A1 (en) * 2002-12-31 2004-07-15 Council Of Scientific And Industrial Research Process for the synthesis of 2-deoxy-d-glucose
GB0302308D0 (en) * 2003-01-31 2003-03-05 Syngenta Participations Ag Avermectin and avermectin monosaccharide derivatives substituted in the 4"- or 4'-position having pesticidal properties
GB0302309D0 (en) * 2003-01-31 2003-03-05 Syngenta Participations Ag Avermectin monosaccharide derivatives substituted in the 4 -position having pesticidal properties
GB0302310D0 (en) * 2003-01-31 2003-03-05 Syngenta Participations Ag Avermectin- and avermectin monosaccharide derivatives substituted in the 4"- or 4' - positionhaving pesticidal properties
GB0302547D0 (en) * 2003-02-04 2003-03-12 Syngenta Participations Ag Avermectins and avermectin monosaccharide substituted in the 4'- and 4" position having pesticidal properties
GB0320176D0 (en) * 2003-08-28 2003-10-01 Syngenta Participations Ag Avermectins and avermectin monosaccharides substitued in the 4'-and 4"-positionhaving pesticidal properties
WO2010065852A1 (en) 2008-12-04 2010-06-10 Merial Limited Dimeric avermectin and milbemycin derivatives
WO2011075592A1 (en) 2009-12-17 2011-06-23 Merial Limited Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
BR112014013371B1 (pt) 2011-12-02 2020-04-07 Merial Ltd formulações de moxidectina injetável de ação prolongada e novas formas de cristal de moxidectina
CN111269281B (zh) * 2020-02-27 2021-06-01 中国农业大学 阿维菌素B2a衍生物及其制备方法与应用
CN114478667B (zh) * 2021-12-27 2023-11-17 河北威远生物化工有限公司 4”,23-氧醚基取代的阿维菌素B2a/B2b衍生物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4914624A (de) * 1972-06-08 1974-02-08
PH15982A (en) * 1977-10-03 1983-05-18 Merck & Co Inc Selective hydrogenation producta of c-076 compounds and derivatives thereof
US4530921A (en) * 1983-10-03 1985-07-23 Merck & Co., Inc. Avermectin epoxide derivatives and method of use
PT80577B (pt) * 1984-06-05 1987-09-18 American Cyanamid Co Processo para a producao de novos agentes macrolidos ll-f28249 uteis no tratamento de infeccoes helminticas por ectoparasitas artropodes e por acarideos
US4579864A (en) * 1984-06-11 1986-04-01 Merck & Co., Inc. Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives

Also Published As

Publication number Publication date
JPS63122688A (ja) 1988-05-26
JP2530344B2 (ja) 1996-09-04
AU8003287A (en) 1988-05-05
EP0266131B1 (de) 1992-06-03
DE3779563D1 (de) 1992-07-09
EP0266131A1 (de) 1988-05-04
US4831016A (en) 1989-05-16
AU598045B2 (en) 1990-06-14
NZ222251A (en) 1990-10-26
ZA878159B (en) 1988-04-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee