DE3703959A1 - Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen - Google Patents

Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen

Info

Publication number
DE3703959A1
DE3703959A1 DE19873703959 DE3703959A DE3703959A1 DE 3703959 A1 DE3703959 A1 DE 3703959A1 DE 19873703959 DE19873703959 DE 19873703959 DE 3703959 A DE3703959 A DE 3703959A DE 3703959 A1 DE3703959 A1 DE 3703959A1
Authority
DE
Germany
Prior art keywords
alkyl
case
phenyl
compounds
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19873703959
Other languages
German (de)
English (en)
Inventor
Martin Dr Bickel
Dietrich Dr Brocks
Harald Dr Burghard
Volkmar Dr Guenzler
Stephan Dr Henke
Hartmut M Dr Hanauske-Abel
Juergen Dr Mohr
Georg Dr Tschank
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DE19873703959 priority Critical patent/DE3703959A1/de
Priority to FI880556A priority patent/FI91525C/fi
Priority to EP88101792A priority patent/EP0278453B1/de
Priority to IL8536288A priority patent/IL85362A/en
Priority to ES88101792T priority patent/ES2067448T3/es
Priority to DE3852554T priority patent/DE3852554D1/de
Priority to AR88310031A priority patent/AR247732A1/es
Priority to AT88101792T priority patent/ATE116299T1/de
Priority to NZ223433A priority patent/NZ223433A/xx
Priority to JP63026723A priority patent/JPH0641450B2/ja
Priority to KR1019880001200A priority patent/KR960011372B1/ko
Priority to DK065988A priority patent/DK167804B1/da
Priority to NO880558A priority patent/NO174420C/no
Priority to IE35288A priority patent/IE65348B1/en
Priority to CA000558496A priority patent/CA1334972C/en
Priority to AU11452/88A priority patent/AU599746B2/en
Priority to PT86736A priority patent/PT86736B/pt
Priority to ZA880896A priority patent/ZA88896B/xx
Priority to HU88609A priority patent/HU205905B/hu
Publication of DE3703959A1 publication Critical patent/DE3703959A1/de
Priority to US07/434,402 priority patent/US5037839A/en
Priority to US07/726,727 priority patent/US5153208A/en
Priority to US08/367,770 priority patent/US5512586A/en
Priority to GR950400026T priority patent/GR3014958T3/el
Priority to US08/482,815 priority patent/US5672614A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
DE19873703959 1987-02-10 1987-02-10 Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen Withdrawn DE3703959A1 (de)

Priority Applications (24)

Application Number Priority Date Filing Date Title
DE19873703959 DE3703959A1 (de) 1987-02-10 1987-02-10 Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
FI880556A FI91525C (fi) 1987-02-10 1988-02-08 Menetelmä terapeuttisesti aktiivisten pyridiini-2,4- ja -2,5-dikarboksyylihappoamidien valmistamiseksi
EP88101792A EP0278453B1 (de) 1987-02-10 1988-02-08 Pyridin-2,4- und 2,5-dicarbonsäureamide, Verfahren zu ihrer Herstellung, Verwendung derselben sowie Arzneimittel auf Basis dieser Verbindungen
IL8536288A IL85362A (en) 1987-02-10 1988-02-08 Amidates of pyridine 2-, 4-, and 5-dicarboxylic acid, processes for their preparation and pharmaceutical preparations containing them
ES88101792T ES2067448T3 (es) 1987-02-10 1988-02-08 Amidas de acidos piridina-2,4- y -2,5-dicarboxilicos, procedimiento para su preparacion, utilizacion de las mismas, asi como medicamentos a base de estos compuestos.
DE3852554T DE3852554D1 (de) 1987-02-10 1988-02-08 Pyridin-2,4- und 2,5-dicarbonsäureamide, Verfahren zu ihrer Herstellung, Verwendung derselben sowie Arzneimittel auf Basis dieser Verbindungen.
AR88310031A AR247732A1 (es) 1987-02-10 1988-02-08 Procedimiento para obtener amidas de acido piridin-2, 4- y -2, 5-dicarboxilico
AT88101792T ATE116299T1 (de) 1987-02-10 1988-02-08 Pyridin-2,4- und 2,5-dicarbonsäureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen.
NZ223433A NZ223433A (en) 1987-02-10 1988-02-08 Pyridine 2,4 or 2,5 dicarboxylic acid derivatives and medicaments
DK065988A DK167804B1 (da) 1987-02-10 1988-02-09 Pyridin-2,4- og -2,5-dicarboxylsyreamider og deres fremstilling
KR1019880001200A KR960011372B1 (ko) 1987-02-10 1988-02-09 피리딘-2,4-및-2,5-디카복실산 아미드, 그의 제조방법 및 용도
JP63026723A JPH0641450B2 (ja) 1987-02-10 1988-02-09 ピリジン−２，４−および−２，５−ジカルボン酸アミド
NO880558A NO174420C (no) 1987-02-10 1988-02-09 Analogifremgangsmåte for fremstilling av terapeutisk aktive pyridin-2,4- og 2,5-dikarboksylsyreamider
IE35288A IE65348B1 (en) 1987-02-10 1988-02-09 Pyridine-2,4- and -2,5-dicarboxylic acid amides processes for their preparation the use thereof and medicaments based on these compounds
CA000558496A CA1334972C (en) 1987-02-10 1988-02-09 Pyridine-2,4- and -2,5-dicarboxylic acid amides, processes for their preparation, the use thereof, and medicaments based on these compounds
AU11452/88A AU599746B2 (en) 1987-02-10 1988-02-09 Pyridine-2,4- and -2,5-dicarboxylic acid amides, processes for their preparation, the use thereof, and medicaments based on these compounds
PT86736A PT86736B (pt) 1987-02-10 1988-02-09 Processo para a preparacao de amidas dos acidos piridino-2,4- e 2,5-dicarboxilicos e de composicoes farmaceuticas que os contem
ZA880896A ZA88896B (en) 1987-02-10 1988-02-09 Pyridine-2,4-and-2,5-dicarboxylic acid amides,processes for their preparation,the use thereof,and medicaments based on these compounds
HU88609A HU205905B (en) 1987-02-10 1988-02-10 Process for producing pyridine-2,4- and -2,5-dicarboxylic acid derivatives and pharmaceutical compositions containing them
US07/434,402 US5037839A (en) 1987-02-10 1989-11-13 Pyridine-2,4-and -2,5-dicarboxylic acid amides and medicaments based on these compounds
US07/726,727 US5153208A (en) 1987-02-10 1991-07-01 Pyridine-2,4- and -2,5-dicarboxylic acid amides and their medicinal compositions and methods of use
US08/367,770 US5512586A (en) 1987-02-10 1995-01-03 Medicaments based on pyridine-2,4- and 2,5-dicarboxylic acid amides
GR950400026T GR3014958T3 (en) 1987-02-10 1995-02-03 2,4- and 2,5-Pyridine-dicarboxylic-acid derivatives, process for their preparation, their use and medicines based on these compounds.
US08/482,815 US5672614A (en) 1987-02-10 1995-06-07 Pharmaceutical use of pyridine-2,4- and -2,5-dicarboxylic acid amides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873703959 DE3703959A1 (de) 1987-02-10 1987-02-10 Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen

Publications (1)

Publication Number Publication Date
DE3703959A1 true DE3703959A1 (de) 1988-08-18

Family

ID=6320590

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19873703959 Withdrawn DE3703959A1 (de) 1987-02-10 1987-02-10 Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3852554T Expired - Fee Related DE3852554D1 (de) 1987-02-10 1988-02-08 Pyridin-2,4- und 2,5-dicarbonsäureamide, Verfahren zu ihrer Herstellung, Verwendung derselben sowie Arzneimittel auf Basis dieser Verbindungen.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE3852554T Expired - Fee Related DE3852554D1 (de) 1987-02-10 1988-02-08 Pyridin-2,4- und 2,5-dicarbonsäureamide, Verfahren zu ihrer Herstellung, Verwendung derselben sowie Arzneimittel auf Basis dieser Verbindungen.

Country Status (20)

Country Link
US (1) US5037839A (pt)
EP (1) EP0278453B1 (pt)
JP (1) JPH0641450B2 (pt)
KR (1) KR960011372B1 (pt)
AR (1) AR247732A1 (pt)
AT (1) ATE116299T1 (pt)
AU (1) AU599746B2 (pt)
CA (1) CA1334972C (pt)
DE (2) DE3703959A1 (pt)
DK (1) DK167804B1 (pt)
ES (1) ES2067448T3 (pt)
FI (1) FI91525C (pt)
GR (1) GR3014958T3 (pt)
HU (1) HU205905B (pt)
IE (1) IE65348B1 (pt)
IL (1) IL85362A (pt)
NO (1) NO174420C (pt)
NZ (1) NZ223433A (pt)
PT (1) PT86736B (pt)
ZA (1) ZA88896B (pt)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004748A (en) * 1987-03-07 1991-04-02 Hoechst Aktiengesellschaft Substituted pyridine-2,4-dicarboxylic acid derivatives and medicaments based on these compounds
LT3798B (en) 1989-07-20 1996-03-25 Hoechst Ag Method for the preparation of n,n'-bis(alkoxyalkyl)-pyrimidine-2,4-dicarboxylic acids diamides and use thereof
LT3918B (en) 1990-06-28 1996-04-25 Hoechst Ag 2,4- and 2,5- substituted pyridin-n-oxides, methods for the production thereof, pharmaceutical compositions and preparation the same
WO1999003844A1 (fr) * 1997-07-17 1999-01-28 Rhone-Poulenc Rorer S.A. Derives de pyrazine, leur preparation et les medicaments les contenant

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5153208A (en) * 1987-02-10 1992-10-06 Hoechst Aktiengesellschaft Pyridine-2,4- and -2,5-dicarboxylic acid amides and their medicinal compositions and methods of use
US5512586A (en) * 1987-02-10 1996-04-30 Hoechst Aktiengesellschaft Medicaments based on pyridine-2,4- and 2,5-dicarboxylic acid amides
ATE113036T1 (de) * 1988-08-04 1994-11-15 Hoechst Ag Verbessertes verfahren zur herstellung von n,n- bis(alkoxyalkyl)-pyridin -2,4- dicarbonsäurediamiden.
US5425289A (en) * 1993-10-21 1995-06-20 Snap-On Incorporated Bung tool
DE3928144A1 (de) * 1989-08-25 1991-02-28 Hoechst Ag Zyklische pyridin-2,4- und -2,5-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung
DE3931432A1 (de) * 1989-09-21 1991-04-04 Hoechst Ag Pyrimidin-4,6-dicarbonsaeurediamide, verfahren zu deren herstellung sowie verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3938805A1 (de) * 1989-11-23 1991-05-29 Hoechst Ag Pyridin-2,4- und 2,5-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung
ZA91291B (en) * 1990-01-16 1991-09-25 Hoechst Ag Di(nitroxyalkyl)amides of pyridine-2,4-and-2,5-dicarboxylic acids,a process for the preparation thereof,and the use thereof
US5260323A (en) * 1990-06-28 1993-11-09 Hoechst Aktiengesellschaft 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use
DE4031000A1 (de) * 1990-10-01 1992-04-09 Hoechst Ag 4- oder 5-substituierte pyridin-2-carbonsaeuren, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
YU9492A (sh) * 1991-02-05 1995-03-27 Hoechst Ag. 2,4- i 2,5-bis-tetrazolilni piridini i postupak za njihovo dobijanje
TW199147B (pt) * 1991-03-18 1993-02-01 Hoechst Ag
EP0541042A1 (de) * 1991-11-05 1993-05-12 Hoechst Aktiengesellschaft Pyridin-2,4- und 2,5-dicarbonsäureamide und deren Derivate, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
CA2085954A1 (en) * 1991-12-24 1993-06-25 Klaus Weidmann Substituted pyridine n-oxides, processes for their preparation, and their use
TW352384B (en) * 1992-03-24 1999-02-11 Hoechst Ag Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
EP0567997A1 (de) * 1992-04-30 1993-11-03 Hoechst Aktiengesellschaft 4- oder 5-(Sulf)imido- und (Sulfon)amidopyridine, sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE4233124A1 (de) * 1992-10-02 1994-04-07 Hoechst Ag Acylsulfonamido- und Sulfonamidopyridin-2-carbonsäureester sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US5789426A (en) * 1995-01-20 1998-08-04 Cornell Research Foundation, Inc. Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation
US6046219A (en) * 1995-01-20 2000-04-04 Cornell Research Foundation, Inc. Method for the treatment of conditions mediated by collagen formation together with cell proliferation by application of inhibitors of protein hydroxylation
ATE255581T1 (de) * 1997-10-24 2003-12-15 Fibrogen Inc Phenanthrolin-derivate
EP1932834B1 (en) * 2006-12-11 2011-04-27 The Genetics Company, Inc. Aromatic 1,4-DI-Carboxylamides and their use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2852519A (en) * 1954-12-27 1958-09-16 Phillips Petroleum Co Method for producing esters of heterocyclic nitrogen carboxylic acids
JPS49277A (pt) * 1972-04-18 1974-01-05
DE2803592A1 (de) * 1978-01-27 1979-08-02 Scott Eugene J Van Therapeutisches mittel
DE3174885D1 (en) * 1981-02-03 1986-07-31 Ici Plc Process for the extraction of metal values and novel metal extractants
DE3432094A1 (de) * 1984-08-31 1986-03-06 Hoechst Ag, 6230 Frankfurt Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase
EP0198202B1 (en) * 1985-03-09 1991-07-17 Mitsubishi Corporation Novel n-cyclohexyl-polycarboxamide compound and derivatives thereof, processes for preparing them, and use of them in preparation of host-guest complexes
GB8702890D0 (en) * 1987-02-10 1987-03-18 Zyma Sa Heterocyclic compounds
ATE113036T1 (de) * 1988-08-04 1994-11-15 Hoechst Ag Verbessertes verfahren zur herstellung von n,n- bis(alkoxyalkyl)-pyridin -2,4- dicarbonsäurediamiden.

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004748A (en) * 1987-03-07 1991-04-02 Hoechst Aktiengesellschaft Substituted pyridine-2,4-dicarboxylic acid derivatives and medicaments based on these compounds
US5356909A (en) * 1987-03-07 1994-10-18 Hoechst Aktiengesellschaft Substituted pyridine-2,4-dicarboxylic acid compounds and the use thereof and medicaments
LT3798B (en) 1989-07-20 1996-03-25 Hoechst Ag Method for the preparation of n,n'-bis(alkoxyalkyl)-pyrimidine-2,4-dicarboxylic acids diamides and use thereof
LT3918B (en) 1990-06-28 1996-04-25 Hoechst Ag 2,4- and 2,5- substituted pyridin-n-oxides, methods for the production thereof, pharmaceutical compositions and preparation the same
WO1999003844A1 (fr) * 1997-07-17 1999-01-28 Rhone-Poulenc Rorer S.A. Derives de pyrazine, leur preparation et les medicaments les contenant
US6399613B1 (en) 1997-07-17 2002-06-04 Aventis Pharma S.A. Pyrazine derivatives, their preparation and medicaments containing them

Also Published As

Publication number Publication date
ES2067448T3 (es) 1995-04-01
CA1334972C (en) 1995-03-28
FI91525C (fi) 1994-07-11
ZA88896B (en) 1988-08-08
IE880352L (en) 1988-08-10
NZ223433A (en) 1990-07-26
NO174420C (no) 1994-05-04
GR3014958T3 (en) 1995-05-31
FI880556A0 (fi) 1988-02-08
AU599746B2 (en) 1990-07-26
IL85362A0 (en) 1988-07-31
ATE116299T1 (de) 1995-01-15
DK167804B1 (da) 1993-12-20
AR247732A1 (es) 1995-03-31
DK65988D0 (da) 1988-02-09
EP0278453A2 (de) 1988-08-17
HU205905B (en) 1992-07-28
FI880556A (fi) 1988-08-11
PT86736A (pt) 1988-03-01
NO174420B (no) 1994-01-24
FI91525B (fi) 1994-03-31
NO880558L (no) 1988-08-11
HUT47250A (en) 1989-02-28
JPS63216873A (ja) 1988-09-09
JPH0641450B2 (ja) 1994-06-01
EP0278453A3 (en) 1989-10-25
PT86736B (pt) 1992-05-29
EP0278453B1 (de) 1994-12-28
US5037839A (en) 1991-08-06
IL85362A (en) 1994-01-25
KR960011372B1 (ko) 1996-08-22
DE3852554D1 (de) 1995-02-09
KR880009936A (ko) 1988-10-06
IE65348B1 (en) 1995-10-18
DK65988A (da) 1988-08-11
NO880558D0 (no) 1988-02-09
AU1145288A (en) 1988-08-11

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