DK65988A - Pyridin-2,4- og -2,5-dicarboxylsyreamider, deres fremstilling og anvendelse - Google Patents

Pyridin-2,4- og -2,5-dicarboxylsyreamider, deres fremstilling og anvendelse

Info

Publication number
DK65988A
DK65988A DK065988A DK65988A DK65988A DK 65988 A DK65988 A DK 65988A DK 065988 A DK065988 A DK 065988A DK 65988 A DK65988 A DK 65988A DK 65988 A DK65988 A DK 65988A
Authority
DK
Denmark
Prior art keywords
pyridine
preparation
dicarboxylic acid
acid amides
amides
Prior art date
Application number
DK065988A
Other languages
English (en)
Other versions
DK167804B1 (da
DK65988D0 (da
Inventor
Martin Bickel
Dietrich Brocks
Harald Burghard
Volkmar Guenzler
Stephan Henke
Hartmut Hanauske-Abel
Juergen Mohr
Georg Tschank
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK65988D0 publication Critical patent/DK65988D0/da
Publication of DK65988A publication Critical patent/DK65988A/da
Application granted granted Critical
Publication of DK167804B1 publication Critical patent/DK167804B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
DK065988A 1987-02-10 1988-02-09 Pyridin-2,4- og -2,5-dicarboxylsyreamider og deres fremstilling DK167804B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3703959 1987-02-10
DE19873703959 DE3703959A1 (de) 1987-02-10 1987-02-10 Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen

Publications (3)

Publication Number Publication Date
DK65988D0 DK65988D0 (da) 1988-02-09
DK65988A true DK65988A (da) 1988-08-11
DK167804B1 DK167804B1 (da) 1993-12-20

Family

ID=6320590

Family Applications (1)

Application Number Title Priority Date Filing Date
DK065988A DK167804B1 (da) 1987-02-10 1988-02-09 Pyridin-2,4- og -2,5-dicarboxylsyreamider og deres fremstilling

Country Status (20)

Country Link
US (1) US5037839A (da)
EP (1) EP0278453B1 (da)
JP (1) JPH0641450B2 (da)
KR (1) KR960011372B1 (da)
AR (1) AR247732A1 (da)
AT (1) ATE116299T1 (da)
AU (1) AU599746B2 (da)
CA (1) CA1334972C (da)
DE (2) DE3703959A1 (da)
DK (1) DK167804B1 (da)
ES (1) ES2067448T3 (da)
FI (1) FI91525C (da)
GR (1) GR3014958T3 (da)
HU (1) HU205905B (da)
IE (1) IE65348B1 (da)
IL (1) IL85362A (da)
NO (1) NO174420C (da)
NZ (1) NZ223433A (da)
PT (1) PT86736B (da)
ZA (1) ZA88896B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5153208A (en) * 1987-02-10 1992-10-06 Hoechst Aktiengesellschaft Pyridine-2,4- and -2,5-dicarboxylic acid amides and their medicinal compositions and methods of use
US5512586A (en) * 1987-02-10 1996-04-30 Hoechst Aktiengesellschaft Medicaments based on pyridine-2,4- and 2,5-dicarboxylic acid amides
DE3707429A1 (de) * 1987-03-07 1988-09-15 Hoechst Ag Substituierte pyridin-2,4-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
ATE113036T1 (de) * 1988-08-04 1994-11-15 Hoechst Ag Verbessertes verfahren zur herstellung von n,n- bis(alkoxyalkyl)-pyridin -2,4- dicarbonsäurediamiden.
DE3924093A1 (de) 1989-07-20 1991-02-07 Hoechst Ag N,n'-bis(alkoxy-alkyl)-pyridin-2,4-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung
US5425289A (en) * 1993-10-21 1995-06-20 Snap-On Incorporated Bung tool
DE3928144A1 (de) * 1989-08-25 1991-02-28 Hoechst Ag Zyklische pyridin-2,4- und -2,5-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung
DE3931432A1 (de) * 1989-09-21 1991-04-04 Hoechst Ag Pyrimidin-4,6-dicarbonsaeurediamide, verfahren zu deren herstellung sowie verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3938805A1 (de) * 1989-11-23 1991-05-29 Hoechst Ag Pyridin-2,4- und 2,5-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung
ZA91291B (en) * 1990-01-16 1991-09-25 Hoechst Ag Di(nitroxyalkyl)amides of pyridine-2,4-and-2,5-dicarboxylic acids,a process for the preparation thereof,and the use thereof
DE4020570A1 (de) 1990-06-28 1992-01-02 Hoechst Ag 2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung
US5260323A (en) * 1990-06-28 1993-11-09 Hoechst Aktiengesellschaft 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use
DE4031000A1 (de) * 1990-10-01 1992-04-09 Hoechst Ag 4- oder 5-substituierte pyridin-2-carbonsaeuren, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
YU9492A (sh) * 1991-02-05 1995-03-27 Hoechst Ag. 2,4- i 2,5-bis-tetrazolilni piridini i postupak za njihovo dobijanje
TW199147B (da) * 1991-03-18 1993-02-01 Hoechst Ag
EP0541042A1 (de) * 1991-11-05 1993-05-12 Hoechst Aktiengesellschaft Pyridin-2,4- und 2,5-dicarbonsäureamide und deren Derivate, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
CA2085954A1 (en) * 1991-12-24 1993-06-25 Klaus Weidmann Substituted pyridine n-oxides, processes for their preparation, and their use
TW352384B (en) * 1992-03-24 1999-02-11 Hoechst Ag Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
EP0567997A1 (de) * 1992-04-30 1993-11-03 Hoechst Aktiengesellschaft 4- oder 5-(Sulf)imido- und (Sulfon)amidopyridine, sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE4233124A1 (de) * 1992-10-02 1994-04-07 Hoechst Ag Acylsulfonamido- und Sulfonamidopyridin-2-carbonsäureester sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US5789426A (en) * 1995-01-20 1998-08-04 Cornell Research Foundation, Inc. Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation
US6046219A (en) * 1995-01-20 2000-04-04 Cornell Research Foundation, Inc. Method for the treatment of conditions mediated by collagen formation together with cell proliferation by application of inhibitors of protein hydroxylation
FR2766187B1 (fr) 1997-07-17 2000-06-02 Rhone Poulenc Rorer Sa Derives de pyrazine, leur preparation et les medicaments les contenant
ATE255581T1 (de) * 1997-10-24 2003-12-15 Fibrogen Inc Phenanthrolin-derivate
EP1932834B1 (en) * 2006-12-11 2011-04-27 The Genetics Company, Inc. Aromatic 1,4-DI-Carboxylamides and their use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2852519A (en) * 1954-12-27 1958-09-16 Phillips Petroleum Co Method for producing esters of heterocyclic nitrogen carboxylic acids
JPS49277A (da) * 1972-04-18 1974-01-05
DE2803592A1 (de) * 1978-01-27 1979-08-02 Scott Eugene J Van Therapeutisches mittel
DE3174885D1 (en) * 1981-02-03 1986-07-31 Ici Plc Process for the extraction of metal values and novel metal extractants
DE3432094A1 (de) * 1984-08-31 1986-03-06 Hoechst Ag, 6230 Frankfurt Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase
EP0198202B1 (en) * 1985-03-09 1991-07-17 Mitsubishi Corporation Novel n-cyclohexyl-polycarboxamide compound and derivatives thereof, processes for preparing them, and use of them in preparation of host-guest complexes
GB8702890D0 (en) * 1987-02-10 1987-03-18 Zyma Sa Heterocyclic compounds
ATE113036T1 (de) * 1988-08-04 1994-11-15 Hoechst Ag Verbessertes verfahren zur herstellung von n,n- bis(alkoxyalkyl)-pyridin -2,4- dicarbonsäurediamiden.

Also Published As

Publication number Publication date
ES2067448T3 (es) 1995-04-01
CA1334972C (en) 1995-03-28
FI91525C (fi) 1994-07-11
ZA88896B (en) 1988-08-08
IE880352L (en) 1988-08-10
NZ223433A (en) 1990-07-26
NO174420C (no) 1994-05-04
GR3014958T3 (en) 1995-05-31
FI880556A0 (fi) 1988-02-08
AU599746B2 (en) 1990-07-26
IL85362A0 (en) 1988-07-31
ATE116299T1 (de) 1995-01-15
DK167804B1 (da) 1993-12-20
AR247732A1 (es) 1995-03-31
DK65988D0 (da) 1988-02-09
EP0278453A2 (de) 1988-08-17
HU205905B (en) 1992-07-28
FI880556A (fi) 1988-08-11
PT86736A (pt) 1988-03-01
NO174420B (no) 1994-01-24
FI91525B (fi) 1994-03-31
NO880558L (no) 1988-08-11
HUT47250A (en) 1989-02-28
JPS63216873A (ja) 1988-09-09
JPH0641450B2 (ja) 1994-06-01
EP0278453A3 (en) 1989-10-25
PT86736B (pt) 1992-05-29
EP0278453B1 (de) 1994-12-28
US5037839A (en) 1991-08-06
IL85362A (en) 1994-01-25
DE3703959A1 (de) 1988-08-18
KR960011372B1 (ko) 1996-08-22
DE3852554D1 (de) 1995-02-09
KR880009936A (ko) 1988-10-06
IE65348B1 (en) 1995-10-18
NO880558D0 (no) 1988-02-09
AU1145288A (en) 1988-08-11

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed