DE3687369D1 - Tripeptidverbindungen mit hypotensiver wirksamkeit. - Google Patents

Tripeptidverbindungen mit hypotensiver wirksamkeit.

Info

Publication number
DE3687369D1
DE3687369D1 DE8686200946T DE3687369T DE3687369D1 DE 3687369 D1 DE3687369 D1 DE 3687369D1 DE 8686200946 T DE8686200946 T DE 8686200946T DE 3687369 T DE3687369 T DE 3687369T DE 3687369 D1 DE3687369 D1 DE 3687369D1
Authority
DE
Germany
Prior art keywords
tripeptide compounds
hypotensive
effectiveness
hypotensive effectiveness
tripeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686200946T
Other languages
English (en)
Other versions
DE3687369T2 (de
Inventor
Alessandro Sisto
Antonio Silvio Verdini
Antonino Virdia
Luca Giovanna De
Stazio Giovanni Di
Vincenzo Politi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polifarma SpA
Original Assignee
Polifarma SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polifarma SpA filed Critical Polifarma SpA
Application granted granted Critical
Publication of DE3687369D1 publication Critical patent/DE3687369D1/de
Publication of DE3687369T2 publication Critical patent/DE3687369T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/80—Antihypertensive peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE8686200946T 1985-06-05 1986-05-30 Tripeptidverbindungen mit hypotensiver wirksamkeit. Expired - Fee Related DE3687369T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21042/85A IT1186733B (it) 1985-06-05 1985-06-05 Composti tripeptidici ad azione ipotensiva

Publications (2)

Publication Number Publication Date
DE3687369D1 true DE3687369D1 (de) 1993-02-11
DE3687369T2 DE3687369T2 (de) 1993-05-27

Family

ID=11175835

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686200946T Expired - Fee Related DE3687369T2 (de) 1985-06-05 1986-05-30 Tripeptidverbindungen mit hypotensiver wirksamkeit.

Country Status (5)

Country Link
US (1) US5051404A (de)
EP (1) EP0204374B1 (de)
JP (1) JPS61293995A (de)
DE (1) DE3687369T2 (de)
IT (1) IT1186733B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1237474B (it) * 1989-10-05 1993-06-07 Polifarma Spa Composti tripeptidici e loro uso farmaceutico come immuno-modulatori
US5115098A (en) * 1990-02-28 1992-05-19 President And Fellows Of Harvard College End-blocked peptides inhibiting binding capacity of gp120
IT1242002B (it) * 1990-10-03 1994-02-02 Polifarma Spa Composti con attivita' farmacologica antiipertensiva, analgesica, immunomodulante e antiinfiammatoria, che presentano nella molecola una sequenza di tre radicali, essendo alfa-amminoacido quello centrale
US5504071A (en) * 1990-10-03 1996-04-02 Polifarma S.P.A. Compounds with a sequence of three radicals, the central one being α-a
KR101566036B1 (ko) * 2007-03-23 2015-11-04 닛신 파마 가부시키가이샤 간질환의 예방 또는 치료용 조성물
JP5337809B2 (ja) * 2008-09-22 2013-11-06 日清ファルマ株式会社 抗炎症性ペプチド

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2563743A (en) * 1947-11-07 1951-08-07 Ralph L Evans 1-prolyl-1-cysteinyl-1-tyrosine
US3821188A (en) * 1972-06-14 1974-06-28 American Home Prod Proline and pyroglutamic acid containing tripeptides
ZA735680B (en) * 1972-09-21 1974-07-31 Hoffmann La Roche Polypeptides
DE2343037A1 (de) * 1973-08-25 1975-03-06 Hoechst Ag Arzneimittel mit antidepressiver wirkung
US3917578A (en) * 1973-12-10 1975-11-04 Ayerst Mckenna & Harrison Process for producing somatostatin and intermediates
GB1533129A (en) * 1975-10-23 1978-11-22 Sagami Chem Res Process for producing a peptide in the presence of an enzyme
DE2625539C2 (de) * 1976-06-05 1982-11-04 Basf Ag, 6700 Ludwigshafen Cyclische Ester des 3,4-Dihydroxy-2,5-diphenyl-thiophen-1,1-dioxids und des 3,4-Dihydroxy-2,5-diphenyl-cyclopentadienons und deren Verwendung
SE428332B (sv) * 1979-03-08 1983-06-20 Wallac Oy Forfarande for fluorescensspektroskopisk bestemning av biologiskt aktivt emne, sasom hapten, antikropp eller antigen
US4216209A (en) * 1979-03-19 1980-08-05 American Home Products Corporation Tripeptide angiotensin converting enzyme inhibitors
HU180925B (en) * 1979-06-28 1983-05-30 Richter Gedeon Vegyeszet Process for producing tripeptide-amides trh-analogues,effectives on the central nerve systhem
DE3161915D1 (en) * 1980-03-05 1984-02-23 Univ Miami Angiotensin converting enzyme inhibitors
JPS5781447A (en) * 1980-11-11 1982-05-21 Toyo Jozo Co Ltd Human chorionic gonadotropic hormone c-terminal fragment
SE425439B (sv) * 1981-04-30 1982-09-27 Wallac Oy Immunologisk analys med lantanidkelatkomplex som markor
IT1172391B (it) * 1983-12-23 1987-06-18 Polifarma Spa Composti tirpeptidici contenenti acido piroglutaminico e triptofano,procedimentio di produzione ed applicazioni terapeutiche
DE3418491A1 (de) * 1984-05-18 1985-11-21 Merck Patent Gmbh, 6100 Darmstadt Diaminosaeurederivate
IT1190383B (it) * 1985-08-01 1988-02-16 Eniricerche Spa Sostanze peptidominetiche ad azione ipotensiva

Also Published As

Publication number Publication date
DE3687369T2 (de) 1993-05-27
EP0204374A3 (en) 1988-07-13
IT1186733B (it) 1987-12-16
JPS61293995A (ja) 1986-12-24
EP0204374B1 (de) 1992-12-30
US5051404A (en) 1991-09-24
EP0204374A2 (de) 1986-12-10
IT8521042A0 (it) 1985-06-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee