DE3686390D1 - Verfahren zur herstellung vom antihaemophilfaktor (ahf) durch kaeltefaellung und zur verbesserung der loeslichkeit des hergestellten ahf-produktes. - Google Patents
Verfahren zur herstellung vom antihaemophilfaktor (ahf) durch kaeltefaellung und zur verbesserung der loeslichkeit des hergestellten ahf-produktes.Info
- Publication number
- DE3686390D1 DE3686390D1 DE8686115463T DE3686390T DE3686390D1 DE 3686390 D1 DE3686390 D1 DE 3686390D1 DE 8686115463 T DE8686115463 T DE 8686115463T DE 3686390 T DE3686390 T DE 3686390T DE 3686390 D1 DE3686390 D1 DE 3686390D1
- Authority
- DE
- Germany
- Prior art keywords
- ahf
- fibrinogen
- fibronectin
- product
- factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nanotechnology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79655985A | 1985-11-08 | 1985-11-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3686390D1 true DE3686390D1 (de) | 1992-09-17 |
DE3686390T2 DE3686390T2 (de) | 1993-03-04 |
Family
ID=25168481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686115463T Expired - Lifetime DE3686390T2 (de) | 1985-11-08 | 1986-11-07 | Verfahren zur herstellung vom antihaemophilfaktor (ahf) durch kaeltefaellung und zur verbesserung der loeslichkeit des hergestellten ahf-produktes. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4739039A (de) |
EP (1) | EP0221566B1 (de) |
JP (1) | JPH0822879B2 (de) |
AT (1) | ATE79266T1 (de) |
AU (1) | AU6487286A (de) |
CA (1) | CA1293941C (de) |
DE (1) | DE3686390T2 (de) |
ES (1) | ES2051686T3 (de) |
ZA (1) | ZA868516B (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8505882D0 (en) * | 1985-03-07 | 1985-04-11 | Central Blood Lab Authority | Purification of blood coagulation factor viii |
DE3806562A1 (de) * | 1988-03-01 | 1989-09-14 | Alpha Therapeutic Gmbh | Zweikammerspritze mit einer fuellung aus aktivitaetsempfindlichem humanen protein als wirkstoff |
ATE90875T1 (de) * | 1989-05-24 | 1993-07-15 | Miles Inc | Gelfiltration von waermebehandeltem faktor viii. |
DE3926034C3 (de) * | 1989-08-07 | 1996-11-21 | Behringwerke Ag | Verfahren zur Herstellung eines stabilen Faktors VIII |
IT1248723B (it) * | 1990-06-12 | 1995-01-26 | Scalvo S P A | Processo per la purificazione del fattore viii e fattore viii ottenuto con tale processo |
US5259971A (en) * | 1992-03-02 | 1993-11-09 | Cryolife, Inc. | Method of preparing fibrinogen |
US5330974A (en) * | 1993-03-01 | 1994-07-19 | Fibratek, Inc. | Therapeutic fibrinogen compositions |
US5523893A (en) * | 1994-08-24 | 1996-06-04 | Northrop Grumman Corporation | Strain free temperature-compensated optical mounts |
GB9424732D0 (en) * | 1994-12-08 | 1995-02-08 | Common Services Agency | Heat treated blood plasma proteins |
US5659017A (en) * | 1995-11-07 | 1997-08-19 | Alpha Therapeutic Corporation | Anion exchange process for the purification of Factor VIII |
EP1154796B1 (de) * | 1999-02-22 | 2007-06-20 | University of Connecticut | Neue albuminfreie faktor viii formulierungen |
BRPI0921429B1 (pt) | 2008-11-07 | 2022-07-12 | Takeda Pharmaceutical Company Limited | Formulação farmacêutica liofilizada estável, e, método para preparar um fator liofilizado estável |
US10508133B2 (en) | 2013-10-18 | 2019-12-17 | Novasep Process | Purification of proteins |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE713764A (de) * | 1967-05-01 | 1968-09-16 | Baxter Travenol Lab | |
US3652530A (en) * | 1967-08-28 | 1972-03-28 | American Nat Red Cross | Antihemophilic factor prepared from blood plasma using polyethylene glycol |
GB1507198A (en) * | 1974-04-12 | 1978-04-12 | Squibb & Sons Inc | Antihemophilic factor |
US4069216A (en) * | 1975-06-16 | 1978-01-17 | Edward Shanbrom, Inc. | Simplified methods for preparation of very high purity Factor VIII concentrate |
CA1054052A (en) * | 1976-08-14 | 1979-05-08 | Edward Shanbrom | Simplified method for preparation of high yield, high purity factor viii concentrate |
US4104266A (en) * | 1977-04-14 | 1978-08-01 | American National Red Cross | Method for preparation of antihemophilic factor |
FR2460305A2 (fr) * | 1979-06-29 | 1981-01-23 | Merieux Inst | Procede de preparation d'un concentre de facteur viii |
US4289691A (en) * | 1980-01-18 | 1981-09-15 | The Canadian Red Cross Society | Method of obtaining intermediate purity factor VIII |
US4386068A (en) * | 1980-02-26 | 1983-05-31 | Cutter Laboratories, Inc. | Antihemophilic factor concentrate and method for preparation |
US4294826A (en) * | 1980-05-07 | 1981-10-13 | Armour Pharmaceutical Company | Process for the preparation of highly purified antihemophilic factor |
AT369263B (de) * | 1980-08-27 | 1982-12-27 | Immuno Ag | Verfahren zur herstellung eines faktor viii(ahf) -hochkonzentrates |
US4406886A (en) * | 1983-01-14 | 1983-09-27 | University Patents, Inc. | Purification of antihemophilia factor VIII by precipitation with zinc ions |
DE3318521A1 (de) * | 1983-05-20 | 1984-11-22 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Verfahren zur herstellung eines antihaemophiliefaktor-konzentrats |
US4543210A (en) * | 1984-10-04 | 1985-09-24 | Miles Laboratories, Inc. | Process for producing a high purity antihemophilic factor concentrate |
-
1986
- 1986-11-06 AU AU64872/86A patent/AU6487286A/en not_active Abandoned
- 1986-11-06 CA CA000522350A patent/CA1293941C/en not_active Expired - Lifetime
- 1986-11-07 EP EP86115463A patent/EP0221566B1/de not_active Expired - Lifetime
- 1986-11-07 JP JP61266504A patent/JPH0822879B2/ja not_active Expired - Lifetime
- 1986-11-07 DE DE8686115463T patent/DE3686390T2/de not_active Expired - Lifetime
- 1986-11-07 ES ES86115463T patent/ES2051686T3/es not_active Expired - Lifetime
- 1986-11-07 AT AT86115463T patent/ATE79266T1/de not_active IP Right Cessation
- 1986-11-10 ZA ZA868516A patent/ZA868516B/xx unknown
-
1987
- 1987-07-15 US US07/073,380 patent/US4739039A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US4739039A (en) | 1988-04-19 |
JPS62181220A (ja) | 1987-08-08 |
ES2051686T3 (es) | 1994-07-01 |
DE3686390T2 (de) | 1993-03-04 |
JPH0822879B2 (ja) | 1996-03-06 |
EP0221566A3 (en) | 1987-10-07 |
AU6487286A (en) | 1987-05-14 |
CA1293941C (en) | 1992-01-07 |
ZA868516B (en) | 1987-08-26 |
EP0221566A2 (de) | 1987-05-13 |
EP0221566B1 (de) | 1992-08-12 |
ATE79266T1 (de) | 1992-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8365 | Fully valid after opposition proceedings |