DE3673047D1 - (imidazolyl-4)-piperidine, ihre herstellung und anwendung als heilmittel. - Google Patents

(imidazolyl-4)-piperidine, ihre herstellung und anwendung als heilmittel.

Info

Publication number
DE3673047D1
DE3673047D1 DE8686400639T DE3673047T DE3673047D1 DE 3673047 D1 DE3673047 D1 DE 3673047D1 DE 8686400639 T DE8686400639 T DE 8686400639T DE 3673047 T DE3673047 T DE 3673047T DE 3673047 D1 DE3673047 D1 DE 3673047D1
Authority
DE
Germany
Prior art keywords
imidazolyl
piperidine
production
medicinal product
medicinal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686400639T
Other languages
English (en)
Inventor
Jean-Michel Bat -Res Arrang
Monique Garbarg
Jean-Charles Maurice Lancelot
Jeanne-Marie Lecomte
Max-Fernand Robba
Jean-Charles Schwartz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioprojet SC
Universite de Caen Normandie
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Bioprojet SC
Universite de Caen Normandie
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioprojet SC, Universite de Caen Normandie, Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Bioprojet SC
Application granted granted Critical
Publication of DE3673047D1 publication Critical patent/DE3673047D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE8686400639T 1985-03-26 1986-03-25 (imidazolyl-4)-piperidine, ihre herstellung und anwendung als heilmittel. Expired - Lifetime DE3673047D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8504496A FR2579596B1 (fr) 1985-03-26 1985-03-26 (imidazolyl-4) piperidines, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
DE3673047D1 true DE3673047D1 (de) 1990-09-06

Family

ID=9317596

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686400639T Expired - Lifetime DE3673047D1 (de) 1985-03-26 1986-03-25 (imidazolyl-4)-piperidine, ihre herstellung und anwendung als heilmittel.

Country Status (6)

Country Link
US (1) US4707487A (de)
EP (1) EP0197840B1 (de)
JP (1) JPH0768239B2 (de)
DE (1) DE3673047D1 (de)
ES (1) ES8703867A1 (de)
FR (1) FR2579596B1 (de)

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FR2671083B1 (fr) * 1990-12-31 1994-12-23 Inst Nat Sante Rech Med Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques.
FR2674855B1 (fr) * 1991-04-03 1994-01-14 Synthelabo Derives de piperidine, leur preparation et leur application en therapeutique.
GB9115740D0 (en) * 1991-07-20 1991-09-04 Smithkline Beecham Plc Medicaments
KR0142801B1 (en) * 1991-12-18 1998-07-15 Schering Corp Imidazoylalkyl substituted with a six membered nitrogen containing heterocyclic ring t
DK0618905T3 (da) * 1991-12-18 1995-12-04 Schering Corp Imidazolyl-alkyl-piperazin- og -diazepinderivater som histamin H3-agonister/antagonister
US5932596A (en) * 1991-12-18 1999-08-03 Schering Corporation Imidazoylalkyl substituted with a six membered nitrogen containing nitrogen containing heterocyclic ring
JPH07121939B2 (ja) * 1991-12-18 1995-12-25 シェリング・コーポレーション 窒素含有４または５員複素環で置換されたイミダゾリルまたはイミダゾイルアルキル化合物
US5807872A (en) * 1992-12-16 1998-09-15 Schering Corporation Imidazoylalkyl substituted with a six membered nitrogen containing heterocyclic ring
US5380858A (en) * 1992-04-01 1995-01-10 The University Of Toledo Process for the preparation of intermediates useful for the synthesis of histamine receptor antagonists
US5486526A (en) * 1992-04-01 1996-01-23 The University Of Toledo Histamine H3 -receptor antagonists and therapeutic uses thereof
JPH07509219A (ja) * 1992-04-01 1995-10-12 ザ　ユニバーシティー　オブ　トレド Ｈ↓３受容体アンタゴニストとしての４−［４’−ピペリジニルまたは３’−ピロリジニル］置換イミダゾールおよび治療上のその使用方法
US5639775A (en) * 1992-04-01 1997-06-17 The University Of Toledo 4-[4'-piperodinyl or 3'-pirrolidinyl] substituted imidazoles as H3 -receptor antagonists and therapeutic uses thereof
FR2696177B1 (fr) * 1992-09-28 1995-05-12 Synthelabo Dérivés de pipéridine, leur préparation et leur application en thérapeutique.
FR2696176B1 (fr) * 1992-09-28 1994-11-10 Synthelabo Dérivés de pipéridine, leur préparation et leur application en thérapeutique.
KR960701858A (ko) * 1993-01-25 1996-03-28 가와노 다케히코 이미다졸계 화합물(Imidazole-series compound)
US5741800A (en) * 1993-06-22 1998-04-21 Knoll Aktiengesellachaft Azolyl-cyclic amine derivates with immunomodulatory activity
WO1995006037A1 (en) * 1993-08-27 1995-03-02 Vrije Universiteit New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor
NL9302045A (nl) * 1993-08-27 1995-03-16 Vrije Universiteit Nieuwe imidazoolafgeleide met agonistische of antagonistische activiteit op de histamine H3-receptor.
DE69530988T2 (de) * 1994-08-05 2003-12-04 Pfizer Benzimidazolderivate mit dopaminerger wirkung
US5889010A (en) * 1995-05-18 1999-03-30 Pfizer Inc. Benzimidazole derivatives having dopaminergic activity
ATE213412T1 (de) * 1995-05-30 2002-03-15 Gliatech Inc 1h-4(5)substituierte imidazolderivate
US5652258A (en) * 1995-05-30 1997-07-29 Gliatech, Inc. 2-(4-imidazoyl) cyclopropyl derivatives
US6448282B1 (en) 1995-05-30 2002-09-10 Gliatech, Inc. 1H-4(5)-substituted imidazole derivatives
AU704139B2 (en) * 1995-11-22 1999-04-15 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
FR2765221B1 (fr) * 1997-06-25 1999-07-30 Synthelabo Derives de 4-[(1h-imidazol-4-yl)piperidin-1-yl]anilide, leur preparation et leur application en therapeutique
US6407132B1 (en) 1997-07-25 2002-06-18 James Black Foundation Limited Substituted imidazole derivatives and their use as histamine H3 receptor ligands
US6034251A (en) * 1997-11-07 2000-03-07 Schering Corporation Phenyl-alkyl-imidazoles
FR2772377B1 (fr) * 1997-12-12 2000-01-07 Synthelabo Derives de 1-(1-h-imidazol-2-yl)pyrrolidines et 1-(1-h-imidazol-2-ylpiperidines), leur preparation et leur application en therapeutique
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
US6908926B1 (en) 1999-04-16 2005-06-21 Novo Nordisk A/S Substituted imidazoles, their preparation and use
AU3957600A (en) * 1999-04-26 2000-11-10 Boehringer Ingelheim International Gmbh Piperidyl-imidazole derivatives, their preparations and therapeutic uses
US6887870B1 (en) * 1999-10-12 2005-05-03 Bristol-Myers Squibb Company Heterocyclic sodium/proton exchange inhibitors and method
US6437147B1 (en) 2000-03-17 2002-08-20 Novo Nordisk Imidazole compounds
US6610721B2 (en) 2000-03-17 2003-08-26 Novo Nordisk A/S Imidazo heterocyclic compounds
US7332508B2 (en) * 2002-12-18 2008-02-19 Novo Nordisk A/S Substituted homopiperidine, piperidine or pyrrolidine derivatives
US20050009841A1 (en) * 2003-07-11 2005-01-13 Zheng Guo Zhu Novel amides useful for treating pain
WO2005082893A2 (en) 2004-02-25 2005-09-09 Eli Lilly And Company Histamine h3 receptor antagonists, preparation and therapeutic uses
PT1735278E (pt) 2004-04-01 2010-03-09 Lilly Co Eli Agentes receptores h3 de histamina, sua preparação e utilizações terapêuticas
CN1956952B (zh) * 2004-06-02 2013-12-11 伊莱利利公司 组胺h3受体药剂、制备和治疗学用途
BRPI0514553A (pt) 2004-08-23 2008-06-17 Lilly Co Eli composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos para inibir o receptor de histamina h3 em um mamìfero, para o tratamento de um distúrbio do sistema nervoso, para o tratamento de obesidade e para o tratamento de um distúrbio ou doença, e, uso de um composto ou um sal do mesmo
US20100113544A1 (en) * 2004-09-03 2010-05-06 Ehime University Suppressant for cerebral infarction attributed to long-time ischemia
JP5011496B2 (ja) * 2004-10-15 2012-08-29 国立大学法人愛媛大学 脳梗塞抑制剤
DK1805169T3 (da) 2004-10-18 2009-03-16 Lilly Co Eli Histamin H3-receptorinhibitorer, deres fremstilling og terapeutiske anvendelser
US7563248B2 (en) * 2005-03-17 2009-07-21 Smisson-Cartledge Biomedical Llc Infusion fluid heat exchanger and cartridge
EP1707203A1 (de) 2005-04-01 2006-10-04 Bioprojet Verwendung von Alkylaminen, die kein Imidazole enthalten, als Histamin H3 Rezeptor Liganden, zur Behandlung von Morbus Parkinson, obstruktiver Schlafapnoe, vaskularer Demenz, Demenz mit Lewy Korpen
EP1717233A1 (de) * 2005-04-29 2006-11-02 Bioprojet Liganden für den Histamin H3-Rezeptor und ihre therapeutische Anwendung
EP1717235A3 (de) 2005-04-29 2007-02-28 Bioprojet Phenoxypropylpiperidine und -pyrrolidine und ihre Verwendung als Liganden für den Histamin H3-Rezeptor
WO2009011872A1 (en) * 2007-07-17 2009-01-22 Merck & Co., Inc. Soluble epoxide hydrolase inhibitors, compositions containing such compounds and methods of treatment
WO2010074588A2 (en) 2008-12-24 2010-07-01 BIAL - PORTELA & Cª, S.A. Pharmaceutical compounds
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
DK2435432T6 (da) * 2009-05-26 2023-12-18 Abbvie Ireland Unlimited Co Apoptose-inducerende midler til behandling af cancer og immune og autoimmune sygdomme
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
EP3378477A1 (de) * 2017-03-21 2018-09-26 BIOPROJET Pharma Neue therapeutische verwendungen von h3-liganden

Family Cites Families (3)

* Cited by examiner, † Cited by third party
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US4087531A (en) * 1974-05-16 1978-05-02 Boehringer Ingelheim Gmbh N-(3-(p-Fluoro-benzoyl)-n-propyl)-4-(imidazolidin-2-one-1-yl)-piperidines and salts thereof
US4217350A (en) * 1976-01-21 1980-08-12 Ciba-Geigy Corporation Oxygenated N-aryl-diazacyclic compounds
US4329348A (en) * 1979-02-26 1982-05-11 Ciba-Geigy Corporation N-Oxacyclic-alkylpiperidines as psychostimulants

Also Published As

Publication number Publication date
JPH0768239B2 (ja) 1995-07-26
US4707487A (en) 1987-11-17
ES553351A0 (es) 1987-03-16
ES8703867A1 (es) 1987-03-16
JPS61267574A (ja) 1986-11-27
FR2579596B1 (fr) 1987-11-20
FR2579596A1 (fr) 1986-10-03
EP0197840A1 (de) 1986-10-15
EP0197840B1 (de) 1990-08-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee