DE3662194D1 - Lipoxygenase inhibitors - Google Patents

Lipoxygenase inhibitors

Info

Publication number
DE3662194D1
DE3662194D1 DE8686302952T DE3662194T DE3662194D1 DE 3662194 D1 DE3662194 D1 DE 3662194D1 DE 8686302952 T DE8686302952 T DE 8686302952T DE 3662194 T DE3662194 T DE 3662194T DE 3662194 D1 DE3662194 D1 DE 3662194D1
Authority
DE
Germany
Prior art keywords
lipoxygenase inhibitors
lipoxygenase
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8686302952T
Other languages
English (en)
Inventor
Joseph G Atkinson
Yvan Guindon
Cheuk K Lau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Application granted granted Critical
Publication of DE3662194D1 publication Critical patent/DE3662194D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
DE8686302952T 1985-04-19 1986-04-18 Lipoxygenase inhibitors Expired DE3662194D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/725,265 US4663347A (en) 1983-10-31 1985-04-19 Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis

Publications (1)

Publication Number Publication Date
DE3662194D1 true DE3662194D1 (en) 1989-04-06

Family

ID=24913823

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686302952T Expired DE3662194D1 (en) 1985-04-19 1986-04-18 Lipoxygenase inhibitors

Country Status (4)

Country Link
US (1) US4663347A (de)
EP (1) EP0200443B1 (de)
JP (1) JPS6253980A (de)
DE (1) DE3662194D1 (de)

Families Citing this family (27)

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EP0270690B1 (de) * 1986-06-21 1991-05-15 Dainippon Ink And Chemicals, Inc. Arzneimittel zur behandlung und prophylaxe von leber- und nierenkrankheiten
FR2611713B1 (fr) * 1987-02-27 1990-11-30 Adir Nouveaux derives de l'acide (dihydro-2,3 oxo-2 benzofurannyl-3)-2 acetique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US4912131A (en) * 1987-06-18 1990-03-27 Merck Frosst Canada, Inc. 4,7-diacyloxybenzofuran derivatives
US4778805A (en) * 1987-06-18 1988-10-18 Merck Frosst Canada 4,7-benzofurandione derivatives useful as inhibitors of leukotriene synthesis
US4800228A (en) * 1987-06-18 1989-01-24 Merck Frosst Canada, Inc. 4,7-diacetoxy-2-(4-methoxybenzyl)-3,5,6-trimethylbenzofuran
US4968821A (en) * 1987-06-18 1990-11-06 Merck Frosst Canada, Inc. 4,7-benzofurandione derivatives
US4910317A (en) * 1987-07-14 1990-03-20 Warner-Lambert Company Benzofurans and benzothiophenes having antiallergic activity and method of use thereof
JPH01100164A (ja) * 1987-10-12 1989-04-18 Shionogi & Co Ltd スルファモイル−２−ベンゾフランカルボン酸誘導体
US5047555A (en) * 1988-12-13 1991-09-10 Tanabe Seiyaku Co., Ltd. 4-aminophenol derivatives and processes for preparing the same
US5093351A (en) * 1989-01-05 1992-03-03 Du Pont Merck Pharmaceutical Company Substituted indole, benzofuran and benzothiophene derivatives as 5-lipoxygenase inhibitors
US4975457A (en) * 1989-09-25 1990-12-04 Merck & Co., Inc. Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis
DE4115184A1 (de) * 1991-05-09 1992-11-12 Bayer Ag Benzothiophen-2-carboxamid-s,s-dioxide
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
GB9309324D0 (en) * 1993-05-06 1993-06-16 Bayer Ag Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives
DE4328074A1 (de) * 1993-08-20 1995-02-23 Bayer Ag Schimmelfeste Dispersionsfarbenanstriche
US5541181A (en) * 1994-05-26 1996-07-30 Bristol-Myers Squibb Company Compound produced by a strain of micromonospora
GB9504460D0 (en) 1995-03-06 1995-04-26 Bayer Ag N-(3-Benzofuranyl)urea-derivatives
US5514704A (en) * 1995-03-13 1996-05-07 Eli Lilly And Company Benzothiophenes to inhibit leukotrienes
GB9614718D0 (en) 1996-07-12 1996-09-04 Bayer Ag 3-ureido-pyridofurans and -pyridothiophenes
US5908859A (en) * 1997-08-11 1999-06-01 Eli Lilly And Company Benzothiophenes for inhibiting hyperlipidemia
FR2778662B1 (fr) * 1998-05-12 2000-06-16 Adir Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6569879B2 (en) * 2000-02-18 2003-05-27 Merck & Co., Inc. Aryloxyacetic acids for diabetes and lipid disorders
ES2225641T3 (es) 2000-12-05 2005-03-16 F. Hoffmann-La Roche Ag Derivados de benzofurano y benzotiofeno como inhibidores de cox-2 selectivos.
NZ789295A (en) 2009-04-29 2024-02-23 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
AU2011202542A1 (en) 2010-07-14 2012-02-02 Indian Institute Of Science Benzothiophene carboxamide compounds, composition and applications thereof
RU2455299C2 (ru) * 2010-10-07 2012-07-10 Учреждение Российской Академии Наук Институт Нефтехимии И Катализа Ран СПОСОБ ПОЛУЧЕНИЯ МЕТИЛОВОГО ЭФИРА 2-БЕНЗО[b]ФУРАНКАРБОНОВОЙ КИСЛОТЫ
RU2467004C2 (ru) * 2010-10-07 2012-11-20 Учреждение Российской Академии Наук Институт Нефтехимии И Катализа Ран СПОСОБ ПОЛУЧЕНИЯ МЕТИЛОВОГО ЭФИРА 2-БЕНЗО[b]ФУРАНКАРБОНОВОЙ КИСЛОТЫ

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL277744A (de) * 1961-05-19
YU178168A (en) * 1967-07-28 1974-02-28 Geigy Ag J R Postopek za pripravo novih heterociklicnih amino-karboksilnih kislin
CH484092A (de) * 1967-07-28 1970-01-15 Geigy Ag J R Verfahren zur Herstellung von neuen heterocyclischen Carbonsäuren
US3665074A (en) * 1968-04-10 1972-05-23 Haessle Ab Certain benzofuran derivatives useful for relief of pain,inflammation,pyresis and tussive irritation
GB1233268A (de) * 1968-07-01 1971-05-26
CH500966A (de) * 1968-07-17 1970-12-31 Ciba Geigy Ag Verfahren zur Herstellung von neuen heterocyclischen Carbonsäuren
CH540900A (de) * 1968-07-17 1973-10-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen heterocyclischen Carbonsäuren
US3574208A (en) * 1968-07-22 1971-04-06 Geigy Chem Corp 3-tertiaryamino propionyl-benzo furan-2-carboxylic acid
US3627785A (en) * 1968-07-22 1971-12-14 Geigy Chem Corp Benzofuran-2-carboxylic acids
SU399106A3 (de) * 1968-07-26 1973-09-27
US3674810A (en) * 1970-08-19 1972-07-04 Geigy Chem Corp 4-chloro-5-(2-methylene-butyryl)-benzo(6)thiophene-2-carboxylic acids
US3830929A (en) * 1973-04-11 1974-08-20 Ugine Kuhlmann Process for the treatment of hyperuricemia
FR2231372A1 (en) * 1973-05-29 1974-12-27 Ugine Kuhlmann 2-(3-Aminopropionyl)-benzofuran compns. - for treating spasm and as inhibitors of biosynthesis of uric acid
JPS528312B2 (de) * 1973-08-31 1977-03-08
US3915687A (en) * 1973-11-12 1975-10-28 Consortium Elektrochem Ind Herbicide
GB1464242A (en) * 1974-04-18 1977-02-09 Smithkline Corp Benzoyl benzofurans and compositions comprising them
GB1509213A (en) * 1975-07-02 1978-05-04 Int Computers Ltd Printing methods and apparatus
US4085117A (en) * 1976-10-18 1978-04-18 Merck & Co., Inc. 6,7-Disubstituted-5-(acyl)benzofuran-2-carboxylic acids
US4100294A (en) * 1976-12-06 1978-07-11 Merck & Co., Inc. 5-(Hydroxy (substituted) methyl)-2,3-dihydrobenzo furan-2-carboxylic acid and its derivatives
US4325961A (en) 1977-06-01 1982-04-20 Merck & Co., Inc. Fluorinated amino acids
DK292678A (da) * 1977-06-30 1978-12-31 Shell Int Research Benzofuranderivater
PT68303A (en) 1977-07-26 1978-08-01 Merck & Co Inc Process for the preparation of dibenzo/b,f/thiepin
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6056143B2 (ja) 1979-08-02 1985-12-09 山之内製薬株式会社 アミジン誘導体ならびにその製造法
PH16099A (en) 1979-03-06 1983-06-24 Yamanouchi Pharma Co Ltd Guanidinothiazole compounds,process for preparing them and medical composition containing them
DE2909754A1 (de) * 1979-03-13 1980-09-18 Thomae Gmbh Dr K Neue benzofuran- und benzothiophenderivate, deren herstellung und deren verwendung als arzneimittel
EP0019955A1 (de) * 1979-05-16 1980-12-10 Shell Internationale Researchmaatschappij B.V. Benzofurancarbonsäure-Derivate, ihre Herstellung und ihre Verwendung in Lipogenese inhibierenden Zusammensetzungen
US4213998A (en) * 1979-06-07 1980-07-22 Shell Oil Company Inhibition of lipogenesis
US4229467A (en) * 1979-08-16 1980-10-21 Richardson-Merrell Inc. Alkoxy benzofuran carboxylic acids and salts and esters thereof as hypolipidemic agents
JPS5639015A (en) * 1979-09-06 1981-04-14 Kaken Pharmaceut Co Ltd Ophthalmic solution for regulating intraocular tension
US4237160A (en) 1979-11-27 1980-12-02 Merck Sharp & Dohme (I.A.) Corp. 3-Hydroxymethyldibenzo[b,f]thiepins as prostaglandin antagonists
DE3175201D1 (en) 1980-04-30 1986-10-02 Merck & Co Inc Aminothiadiazoles as gastric secretion inhibitors
US4394508A (en) 1980-06-07 1983-07-19 Bristol-Myers Company Chemical compounds
JPS5731616A (en) * 1980-08-01 1982-02-20 Kyowa Hakko Kogyo Co Ltd Relaxing agent for muscle comprising benzofurancarboxylic acid amide
JPS5740479A (en) * 1980-08-21 1982-03-06 Kaken Pharmaceut Co Ltd Preparation of benzofuran derivative and its acid addition salt
EP0061800B1 (de) * 1981-03-24 1985-08-28 FISONS plc Anti-SRS-A-Carbonsäurederivate, Verfahren zu deren Herstellung und pharmazeutische Formulierungen, die jene enthalten
ZA824343B (en) * 1981-07-01 1983-04-27 Upjohn Co Pyridinyl- and imidazolyl-benzofurane and benzothiophenes
ZA825413B (en) * 1981-08-26 1983-06-29 Pfizer Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them
DE3469169D1 (en) * 1983-04-21 1988-03-10 Merck Frosst Canada Inc Leukotriene antagonists, their production and use and compositions containing them
EP0146243A1 (de) 1983-10-31 1985-06-26 Merck Frosst Canada Inc. Lipoxygenase-Inhibitoren

Also Published As

Publication number Publication date
US4663347A (en) 1987-05-05
JPS6253980A (ja) 1987-03-09
EP0200443A1 (de) 1986-11-05
EP0200443B1 (de) 1989-03-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee