DE3611227A1 - Verfahren und reagenz zur bestimmung von substraten oder enzymaktivitaeten - Google Patents

Verfahren und reagenz zur bestimmung von substraten oder enzymaktivitaeten

Info

Publication number
DE3611227A1
DE3611227A1 DE19863611227 DE3611227A DE3611227A1 DE 3611227 A1 DE3611227 A1 DE 3611227A1 DE 19863611227 DE19863611227 DE 19863611227 DE 3611227 A DE3611227 A DE 3611227A DE 3611227 A1 DE3611227 A1 DE 3611227A1
Authority
DE
Germany
Prior art keywords
radical
phenyl
carboxyl
substituted
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19863611227
Other languages
German (de)
English (en)
Inventor
Michael-Harold Dr Rer Nat Town
Joachim Dr Rer Nat Siedel
Joachim Dr Rer Nat Ziegenhorn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE19863611227 priority Critical patent/DE3611227A1/de
Priority to AT87104466T priority patent/ATE73782T1/de
Priority to DE8787104466T priority patent/DE3777429D1/de
Priority to EP87104466A priority patent/EP0239931B1/de
Priority to JP62081357A priority patent/JPS62249979A/ja
Priority to US07/035,617 priority patent/US5013647A/en
Publication of DE3611227A1 publication Critical patent/DE3611227A1/de
Priority to US07/661,271 priority patent/US5196314A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
    • C12Q2326/90—Developer
    • C12Q2326/92—Nitro blue tetrazolium chloride, i.e. NBT
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/805—Test papers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE19863611227 1986-04-04 1986-04-04 Verfahren und reagenz zur bestimmung von substraten oder enzymaktivitaeten Withdrawn DE3611227A1 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE19863611227 DE3611227A1 (de) 1986-04-04 1986-04-04 Verfahren und reagenz zur bestimmung von substraten oder enzymaktivitaeten
AT87104466T ATE73782T1 (de) 1986-04-04 1987-03-26 Verfahren und reagenz zur bestimmung von substraten oder enzymaktivitaeten.
DE8787104466T DE3777429D1 (de) 1986-04-04 1987-03-26 Verfahren und reagenz zur bestimmung von substraten oder enzymaktivitaeten.
EP87104466A EP0239931B1 (de) 1986-04-04 1987-03-26 Verfahren und Reagenz zur Bestimmung von Substraten oder Enzymaktivitäten
JP62081357A JPS62249979A (ja) 1986-04-04 1987-04-03 基質又は酵素活性を測定するための方法及び試薬
US07/035,617 US5013647A (en) 1986-04-04 1987-04-03 Removal of interfering reducing substances with tetrazolium salts in redox measurement reactions
US07/661,271 US5196314A (en) 1986-04-04 1991-02-26 Process and reagent for the determination of substrates or enzyme activities

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863611227 DE3611227A1 (de) 1986-04-04 1986-04-04 Verfahren und reagenz zur bestimmung von substraten oder enzymaktivitaeten

Publications (1)

Publication Number Publication Date
DE3611227A1 true DE3611227A1 (de) 1987-10-08

Family

ID=6297866

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19863611227 Withdrawn DE3611227A1 (de) 1986-04-04 1986-04-04 Verfahren und reagenz zur bestimmung von substraten oder enzymaktivitaeten
DE8787104466T Expired - Lifetime DE3777429D1 (de) 1986-04-04 1987-03-26 Verfahren und reagenz zur bestimmung von substraten oder enzymaktivitaeten.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8787104466T Expired - Lifetime DE3777429D1 (de) 1986-04-04 1987-03-26 Verfahren und reagenz zur bestimmung von substraten oder enzymaktivitaeten.

Country Status (5)

Country Link
US (1) US5013647A (OSRAM)
EP (1) EP0239931B1 (OSRAM)
JP (1) JPS62249979A (OSRAM)
AT (1) ATE73782T1 (OSRAM)
DE (2) DE3611227A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5126275A (en) * 1990-09-19 1992-06-30 Miles Inc. Analytical method using tetrazolium salt indicators having a reflectance plateau

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196314A (en) * 1986-04-04 1993-03-23 Boehringer Mannheim Gmbh Process and reagent for the determination of substrates or enzyme activities
JPS6348457A (ja) * 1986-08-19 1988-03-01 Fuji Photo Film Co Ltd 乾式多層分析要素
US5312759A (en) * 1989-12-20 1994-05-17 Iatron Laboratories, Inc. Method for measurement of fructosamines using 1,2-quinones
CA2049237C (en) * 1990-09-19 1999-10-19 Gunther Beck 2-thiazolyl tetrazolium salt indicators
US5290536A (en) * 1990-09-19 1994-03-01 Miles Inc. Phenyl substituted 2-thiazolyl tetrazolium salt indicators
CA2049209C (en) * 1990-09-19 1992-03-20 Jurgen Kocher Phenyl-substituted 2-thiazolyl tetrazolium salt indicators
US5250695A (en) * 1992-06-15 1993-10-05 Miles Inc. Use of specific counteranions to modify the solubility of tetrazolium salts
US6352835B1 (en) 1998-11-17 2002-03-05 Kyoto Daiichi Kagaku Co. Ltd. Method of measuring substance in sample using a redox reaction
DE60325727D1 (de) * 2002-06-07 2009-02-26 Arkray Inc Testverfahren mit einer oxidations-/reduktionsreaktion mit formazan
US7153666B2 (en) 2003-07-17 2006-12-26 General Atomics Methods and compositions for determination of glycated proteins
EP2044444B1 (en) 2006-07-25 2013-03-20 General Atomics Methods for assaying percentage of glycated hemoglobin
US7943385B2 (en) 2006-07-25 2011-05-17 General Atomics Methods for assaying percentage of glycated hemoglobin
EP2278318B1 (en) * 2008-05-09 2018-11-28 Panasonic Intellectual Property Management Co., Ltd. Method for measuring creatinine concentration
WO2009140343A1 (en) 2008-05-13 2009-11-19 General Atomics Electrochemical biosensor for direct determination of percentage of glycated hemoglobin
US9044018B2 (en) 2009-12-28 2015-06-02 The Regents Of The University Of California Mitigation of alternate bearing

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2713581A (en) * 1949-02-23 1955-07-19 Montclair Res Corp Certain tetrazolium salts and process for preparing them
GB738585A (en) * 1952-07-17 1955-10-19 May & Baker Ltd Improvements in or relating to tetrazolium compounds
BE615097A (OSRAM) * 1961-03-14
DE2147466C3 (de) * 1971-09-23 1980-06-26 Boehringer Mannheim Gmbh, 6800 Mannheim 5- (4-N-trimethyl-ammonium-phenyl) tetrazoliumsalze
DE2625834B2 (de) * 1976-06-09 1978-10-12 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur Bestimmung von Substraten oder Enzymaktivitäten
GB1513488A (en) * 1976-11-11 1978-06-07 Lushina O Method of preparing 2h-tetrazolium chlorides and 2h-tetrazolium chlorides hydrochlorides
JPS5524103A (en) * 1978-08-08 1980-02-21 Doujin Yatsukagaku Kenkyusho:Goushi Tetrazolium salt compound and absorption photometry of dehydrogenase using the same
DE3012368C2 (de) * 1980-03-29 1982-04-15 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und diagnostische Mittel zum Nachweis von Redox-Reaktionen
DE3013371A1 (de) * 1980-04-05 1981-10-15 Gerd Schulz Fahrzeug- und Container-Technik, 2100 Hamburg Verriegelung fuer container
DE3048662A1 (de) * 1980-12-23 1982-07-22 Boehringer Mannheim Gmbh, 6800 Mannheim Stabilisierte zubereitung von tetrazoliumsalzen
US4444880A (en) * 1982-07-27 1984-04-24 Syva Company Periodate removal of ascorbate interference in dipsticks for immunoassays
JPS59106476A (ja) * 1982-12-11 1984-06-20 Wako Pure Chem Ind Ltd 水溶性テトラゾリウム化合物、およびその化合物を用いて還元性物質を測定する方法
JPS59219270A (ja) * 1983-05-30 1984-12-10 Wako Pure Chem Ind Ltd テトラゾリウム塩を含有する溶液の安定化方法
DE3425118A1 (de) * 1984-07-07 1986-01-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue redox-indikatoren
US4683035A (en) * 1986-02-03 1987-07-28 Nalco Chemical Company Method for in situ corrosion detection using electrochemically active compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5126275A (en) * 1990-09-19 1992-06-30 Miles Inc. Analytical method using tetrazolium salt indicators having a reflectance plateau

Also Published As

Publication number Publication date
EP0239931A3 (en) 1988-05-18
EP0239931A2 (de) 1987-10-07
JPS62249979A (ja) 1987-10-30
JPH0445510B2 (OSRAM) 1992-07-27
US5013647A (en) 1991-05-07
EP0239931B1 (de) 1992-03-18
ATE73782T1 (de) 1992-04-15
DE3777429D1 (de) 1992-04-23

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Legal Events

Date Code Title Description
8141 Disposal/no request for examination