DE3586993T3 - Kontinuierliche intravenöse infusion von adenosin an menschlichen patienten, einheitsdosierungsform von adenosin und dessen verwendung bei der herstellung von arzneimitteln. - Google Patents
Kontinuierliche intravenöse infusion von adenosin an menschlichen patienten, einheitsdosierungsform von adenosin und dessen verwendung bei der herstellung von arzneimitteln.Info
- Publication number
- DE3586993T3 DE3586993T3 DE3586993T DE3586993T DE3586993T3 DE 3586993 T3 DE3586993 T3 DE 3586993T3 DE 3586993 T DE3586993 T DE 3586993T DE 3586993 T DE3586993 T DE 3586993T DE 3586993 T3 DE3586993 T3 DE 3586993T3
- Authority
- DE
- Germany
- Prior art keywords
- adenosine
- solution
- cardioplegia
- potassium
- during
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title claims abstract description 178
- 239000002126 C01EB10 - Adenosine Substances 0.000 title claims abstract description 87
- 229960005305 adenosine Drugs 0.000 title claims abstract description 87
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 238000001802 infusion Methods 0.000 title abstract description 19
- 238000001990 intravenous administration Methods 0.000 title abstract description 6
- 239000002552 dosage form Substances 0.000 title description 3
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000000243 solution Substances 0.000 claims description 25
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 12
- 239000011591 potassium Substances 0.000 claims description 12
- 229910052700 potassium Inorganic materials 0.000 claims description 12
- 238000001356 surgical procedure Methods 0.000 claims description 11
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- 238000000034 method Methods 0.000 claims description 6
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- 239000008148 cardioplegic solution Substances 0.000 claims 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 1
- 230000024883 vasodilation Effects 0.000 abstract description 10
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- XEYBHCRIKKKOSS-UHFFFAOYSA-N disodium;azanylidyneoxidanium;iron(2+);pentacyanide Chemical compound [Na+].[Na+].[Fe+2].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].[O+]#N XEYBHCRIKKKOSS-UHFFFAOYSA-N 0.000 description 5
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77951685A | 1985-09-24 | 1985-09-24 | |
| PCT/SE1985/000423 WO1987001593A1 (en) | 1985-09-24 | 1985-10-29 | Continuous intravenous infusion of adenosine to human patients, a unit dosage form of adenosine and use of adenosine for the manufacture of medicaments |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE3586993D1 DE3586993D1 (de) | 1993-02-25 |
| DE3586993T2 DE3586993T2 (de) | 1993-04-29 |
| DE3586993T3 true DE3586993T3 (de) | 1998-03-19 |
Family
ID=25116698
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3586993T Expired - Fee Related DE3586993T3 (de) | 1985-09-24 | 1985-10-29 | Kontinuierliche intravenöse infusion von adenosin an menschlichen patienten, einheitsdosierungsform von adenosin und dessen verwendung bei der herstellung von arzneimitteln. |
| DE19853590855 Withdrawn DE3590855T1 (enExample) | 1985-09-24 | 1985-10-29 | |
| DE1999175044 Active DE19975044I2 (de) | 1985-09-24 | 1985-10-29 | Verwendung von Adenosin zur Herstellung eines Arzneimittels f}r kontinuierliche Intraven¦se Infusionan menschlichen Patienten |
| DE3588205T Expired - Lifetime DE3588205T2 (de) | 1985-09-24 | 1985-10-29 | Verwendung von Adenosin zur Herstellung eines Arzneimittels für kontinuierliche Intravenöse Infusion an menschlichen Patienten |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19853590855 Withdrawn DE3590855T1 (enExample) | 1985-09-24 | 1985-10-29 | |
| DE1999175044 Active DE19975044I2 (de) | 1985-09-24 | 1985-10-29 | Verwendung von Adenosin zur Herstellung eines Arzneimittels f}r kontinuierliche Intraven¦se Infusionan menschlichen Patienten |
| DE3588205T Expired - Lifetime DE3588205T2 (de) | 1985-09-24 | 1985-10-29 | Verwendung von Adenosin zur Herstellung eines Arzneimittels für kontinuierliche Intravenöse Infusion an menschlichen Patienten |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP0506205B1 (enExample) |
| JP (1) | JP2535504B2 (enExample) |
| AT (2) | ATE176154T1 (enExample) |
| AU (1) | AU613304B2 (enExample) |
| CA (1) | CA1301652C (enExample) |
| DE (4) | DE3586993T3 (enExample) |
| DK (1) | DK253187A (enExample) |
| NZ (1) | NZ217592A (enExample) |
| WO (1) | WO1987001593A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0290496B2 (en) * | 1986-10-06 | 1995-12-20 | The University Of Virginia Alumni Patents Foundation | Use of an adenosine, hypoxanthine and ribose-containing solution for improved protection of the heart during surgery |
| US5070877A (en) * | 1988-08-11 | 1991-12-10 | Medco Research, Inc. | Novel method of myocardial imaging |
| US5677290A (en) * | 1990-05-10 | 1997-10-14 | Fukunaga; Atsuo F. | Therapeutic use of adenosine compounds as surgical anesthetics |
| US6004945A (en) | 1990-05-10 | 1999-12-21 | Fukunaga; Atsuo F. | Use of adenosine compounds to relieve pain |
| US5256398A (en) * | 1990-11-08 | 1993-10-26 | Whitby Research, Inc. | Composition for determining viability of tissue |
| US5681278A (en) * | 1994-06-23 | 1997-10-28 | Cormedics Corp. | Coronary vasculature treatment method |
| CA2814586C (en) | 2010-10-15 | 2024-01-30 | Cytopherx, Inc. | Cytopheretic cartridge and use thereof |
| JP5729660B2 (ja) * | 2011-11-21 | 2015-06-03 | 株式会社ディナーヴ | 腎動脈アブレーション用のカテーテルおよびシステム |
| AU2012364760B2 (en) | 2012-01-09 | 2018-05-31 | Seastar Medical Inc. | Cartridge and method for increasing myocardial function |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3845205A (en) * | 1970-06-04 | 1974-10-29 | Univ Sydney | 2-loweralkylthioadenosines |
| FR2129833B1 (enExample) * | 1971-03-16 | 1974-08-02 | Cerm Cent Europ Rech Mauvernay | |
| ZA7467B (en) * | 1973-01-16 | 1974-11-27 | J Voorhees | Compositions and treatment of proliferative skin diseases with b2 agonists |
| DE3133925A1 (de) * | 1981-08-27 | 1983-03-17 | A. Nattermann & Cie GmbH, 5000 Köln | Arzneimittel zur behandlung von hypertonie |
| DE3406533A1 (de) * | 1984-02-23 | 1985-08-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten |
-
1985
- 1985-10-29 JP JP60504950A patent/JP2535504B2/ja not_active Expired - Lifetime
- 1985-10-29 DE DE3586993T patent/DE3586993T3/de not_active Expired - Fee Related
- 1985-10-29 DE DE19853590855 patent/DE3590855T1/de not_active Withdrawn
- 1985-10-29 WO PCT/SE1985/000423 patent/WO1987001593A1/en not_active Ceased
- 1985-10-29 AU AU50655/85A patent/AU613304B2/en not_active Expired
- 1985-10-29 DE DE1999175044 patent/DE19975044I2/de active Active
- 1985-10-29 DE DE3588205T patent/DE3588205T2/de not_active Expired - Lifetime
- 1985-10-29 EP EP92201323A patent/EP0506205B1/en not_active Expired - Lifetime
- 1985-10-29 AT AT92201323T patent/ATE176154T1/de not_active IP Right Cessation
- 1985-10-29 AT AT85905544T patent/ATE84419T1/de not_active IP Right Cessation
- 1985-10-29 EP EP85905544A patent/EP0275249B2/en not_active Expired - Lifetime
-
1986
- 1986-09-16 NZ NZ217592A patent/NZ217592A/xx unknown
- 1986-09-23 CA CA000518809A patent/CA1301652C/en not_active Expired - Lifetime
-
1987
- 1987-05-19 DK DK253187A patent/DK253187A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU5065585A (en) | 1987-04-07 |
| DE3590855T1 (enExample) | 1988-08-25 |
| EP0275249B1 (en) | 1993-01-13 |
| DK253187D0 (da) | 1987-05-19 |
| EP0275249B2 (en) | 1997-12-17 |
| DE19975044I2 (de) | 2006-02-02 |
| NZ217592A (en) | 1990-10-26 |
| ATE176154T1 (de) | 1999-02-15 |
| WO1987001593A1 (en) | 1987-03-26 |
| CA1301652C (en) | 1992-05-26 |
| EP0506205A1 (en) | 1992-09-30 |
| DE3586993D1 (de) | 1993-02-25 |
| JPS63501497A (ja) | 1988-06-09 |
| EP0275249A1 (en) | 1988-07-27 |
| ATE84419T1 (de) | 1993-01-15 |
| JP2535504B2 (ja) | 1996-09-18 |
| AU613304B2 (en) | 1991-08-01 |
| DE3586993T2 (de) | 1993-04-29 |
| DK253187A (da) | 1987-05-19 |
| DE3588205D1 (de) | 1999-03-11 |
| EP0506205B1 (en) | 1999-01-27 |
| DE3588205T2 (de) | 1999-06-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8363 | Opposition against the patent | ||
| 8366 | Restricted maintained after opposition proceedings | ||
| 8339 | Ceased/non-payment of the annual fee |