DE3580526D1 - Sorbentmittel fuer protease und verfaren zum reinigen von gewebeplasminogenaktivator mit demselben. - Google Patents

Sorbentmittel fuer protease und verfaren zum reinigen von gewebeplasminogenaktivator mit demselben.

Info

Publication number
DE3580526D1
DE3580526D1 DE8585108201T DE3580526T DE3580526D1 DE 3580526 D1 DE3580526 D1 DE 3580526D1 DE 8585108201 T DE8585108201 T DE 8585108201T DE 3580526 T DE3580526 T DE 3580526T DE 3580526 D1 DE3580526 D1 DE 3580526D1
Authority
DE
Germany
Prior art keywords
protease
same
plasminogen activator
processing agent
tissue plasminogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585108201T
Other languages
English (en)
Inventor
Tetsuya Someno
Kazuo Kato
Yasushi Takahashi
Shinichi Ishii
Tomio Takeuchi
Hamao Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Application granted granted Critical
Publication of DE3580526D1 publication Critical patent/DE3580526D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3251—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulphur
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
DE8585108201T 1984-07-06 1985-07-02 Sorbentmittel fuer protease und verfaren zum reinigen von gewebeplasminogenaktivator mit demselben. Expired - Lifetime DE3580526D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59138924A JPS6119485A (ja) 1984-07-06 1984-07-06 プロテア−ゼ吸着体

Publications (1)

Publication Number Publication Date
DE3580526D1 true DE3580526D1 (de) 1990-12-20

Family

ID=15233313

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585108201T Expired - Lifetime DE3580526D1 (de) 1984-07-06 1985-07-02 Sorbentmittel fuer protease und verfaren zum reinigen von gewebeplasminogenaktivator mit demselben.

Country Status (4)

Country Link
US (1) US4708944A (de)
EP (1) EP0167152B1 (de)
JP (1) JPS6119485A (de)
DE (1) DE3580526D1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3827415A1 (de) * 1988-08-12 1990-02-15 Behringwerke Ag Peptidderivate, verfahren zu ihrer herstellung und ihre verwendung
US5676947A (en) * 1989-02-07 1997-10-14 Boehringer Manneheim Gmbh Method for treating thromboembolic conditions using thrombolytically active proteins
US5227297A (en) * 1990-04-17 1993-07-13 Smithkline Beecham Corporation Affinity purification ligands
US5141862A (en) * 1990-04-17 1992-08-25 Smithkline Beecham Corporation Method of purifying tpa or plasminogen activator using a tripeptide of the formula: -X-Y-argininal wherein X and Y are selected from the group consisting of pro,phe,trp and tyr
JPH0628601U (ja) * 1992-09-02 1994-04-15 京都度器株式会社 巻 尺
AU715608B2 (en) * 1996-03-20 2000-02-03 Morphosys Ag Purification of tissue plasminogen activator (tPA)
US20090123109A1 (en) 2007-11-09 2009-05-14 Lxdata Inc Temperature sensor using an optical fiber
BR112021023457A2 (pt) * 2019-07-01 2022-01-25 Basf Se Composto, uso do composto, composição, e, métodos para preparar a composição e um composto

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947352A (en) * 1974-05-31 1976-03-30 Pedro Cuatrecasas Polysaccharide matrices for use as adsorbents in affinity chromatography techniques
CH627783A5 (en) * 1978-01-01 1982-01-29 Fabre Sa Pierre Process for the production of a plasminogen activator
SU1028679A1 (ru) * 1981-06-17 1983-07-15 Ордена Ленина институт элементоорганических соединений им.А.Н.Несмеянова Нитрофенилдисульфидное производное сшитой агарозы в качестве хемосорбента дл изучени белок-белкового взаимодействи и способ его получени
US4525465A (en) * 1983-10-07 1985-06-25 Nippon Kayaku Kabushiki Kaisha Water-insoluble biospecific absorbent containing argininal derivative

Also Published As

Publication number Publication date
EP0167152A3 (en) 1986-12-30
JPH0362389B2 (de) 1991-09-25
EP0167152B1 (de) 1990-11-14
US4708944A (en) 1987-11-24
EP0167152A2 (de) 1986-01-08
JPS6119485A (ja) 1986-01-28

Similar Documents

Publication Publication Date Title
BR8901723A (pt) Composicao de limpeza liquida,aquosa,homogenea e limpida
DE69012888D1 (de) Plasminogenaktivator.
FR2556222B1 (fr) Agent de pansement proteolytique
NO885367D0 (no) Hudrense- og -kondisjoneringsmiddel.
DE69023520D1 (de) Flüssiges, enzymhaltiges Reinigungsmittel.
DE68924477D1 (de) Gleitkommaeinheit mit gleichzeitiger Multiplikation und Addition.
DE69717133D1 (de) Flüssige reinigungsmittel, die proteolytisches enzyme, peptidaldehyd und kalziumionen enthalten
DE3485552D1 (de) Einrichtung zum aufnehmen und behandeln von blut.
DE3586834D1 (de) Vorrichtung und medium zum reinigen von koerperfluessigkeiten.
DE3482028D1 (de) Ddavp-antidiuretisches mittel und dessen verwendung.
DK96787D0 (da) Human vaevs-plasminogenaktivator
DK219289A (da) Tekstilkonditionerende middel og dets anvendelse
DE68916363D1 (de) Verfahren zum Reinigen und/oder Entkeimen und Sterilisieren von Hämodyalisevorrichtungen.
DE3580526D1 (de) Sorbentmittel fuer protease und verfaren zum reinigen von gewebeplasminogenaktivator mit demselben.
DE3780506D1 (de) Reinigung des einkettigen und zweikettigen gewebeplasminogenaktivators.
DK50987A (da) Polypeptid med plasminogenaktivatorvirkning
FI883943A (fi) Modifierade plasminogen-aktivatorer.
NL191755C (nl) Plasminogeenactivator en trombolytisch middel.
DE3783693D1 (de) Verfahren zur reinigung des gewebeplasminogenaktivators.
DE69007121D1 (de) Enzymhaltige flüssige waschmittelzusammensetzungen und deren verwendung.
DE3577985D1 (de) Organotitan-verbindungen und oberflaechenbehandlungsmittel.
DE3878465D1 (de) Methode zum reinigen von alkylseleniden und alkyltelluriden.
DK96888D0 (da) Rekombinant humant vaevsplasminogen aktivatormateriale
DE68915230D1 (de) Verfahren zum Reinigen von Gewebe-Plasminogenaktivator.
DE3582793D1 (de) Desinfizierendes und reinigendes mittel.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee