DE3564268D1 - 5,6-dihydro-4h-cyclopenta(b)thiophene-6-carboxylic acids, processes for their preparation and therapeutical agents containing them - Google Patents

5,6-dihydro-4h-cyclopenta(b)thiophene-6-carboxylic acids, processes for their preparation and therapeutical agents containing them

Info

Publication number
DE3564268D1
DE3564268D1 DE8585401139T DE3564268T DE3564268D1 DE 3564268 D1 DE3564268 D1 DE 3564268D1 DE 8585401139 T DE8585401139 T DE 8585401139T DE 3564268 T DE3564268 T DE 3564268T DE 3564268 D1 DE3564268 D1 DE 3564268D1
Authority
DE
Germany
Prior art keywords
cyclopenta
thiophene
dihydro
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8585401139T
Other languages
English (en)
Inventor
Gerard Ferrand
Jacques Barbanton
Jean-Claude Depin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA SAS
LIPHA Liyonnaise Industrielle Pharmaceutique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LIPHA SAS, LIPHA Liyonnaise Industrielle Pharmaceutique filed Critical LIPHA SAS
Application granted granted Critical
Publication of DE3564268D1 publication Critical patent/DE3564268D1/de
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE8585401139T 1984-07-09 1985-06-11 5,6-dihydro-4h-cyclopenta(b)thiophene-6-carboxylic acids, processes for their preparation and therapeutical agents containing them Expired DE3564268D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8410861A FR2567125B1 (fr) 1984-07-09 1984-07-09 Acides dihydro-5,6-4h-cyclopenta (b) thiophenecarboxylique-6, procedes de preparation et medicaments les contenant

Publications (1)

Publication Number Publication Date
DE3564268D1 true DE3564268D1 (en) 1988-09-15

Family

ID=9305925

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585401139T Expired DE3564268D1 (en) 1984-07-09 1985-06-11 5,6-dihydro-4h-cyclopenta(b)thiophene-6-carboxylic acids, processes for their preparation and therapeutical agents containing them

Country Status (26)

Country Link
US (1) US4649153A (de)
EP (1) EP0172041B1 (de)
JP (1) JPH072733B2 (de)
AR (1) AR242381A1 (de)
AT (1) ATE36329T1 (de)
AU (1) AU573147B2 (de)
CA (1) CA1249834A (de)
CS (1) CS255887B2 (de)
DD (1) DD235454A5 (de)
DE (1) DE3564268D1 (de)
DK (1) DK161321C (de)
ES (1) ES8604550A1 (de)
FR (1) FR2567125B1 (de)
GR (1) GR851609B (de)
HU (1) HU202519B (de)
IE (1) IE58362B1 (de)
IL (1) IL75527A (de)
IN (1) IN166471B (de)
MA (1) MA20481A1 (de)
MX (1) MX162258A (de)
NO (1) NO171499C (de)
NZ (1) NZ212619A (de)
OA (1) OA08076A (de)
SU (1) SU1402261A3 (de)
YU (1) YU113885A (de)
ZA (1) ZA854519B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692460A (en) * 1986-12-24 1987-09-08 Mcneilab, Inc. Cyclopenta[b]thiophenes having anti-inflammatory activity similar to steroids
IL103106A (en) * 1991-09-25 1998-06-15 Sanofi Elf Sites of tynocyclopentanone oximes, their preparation and pharmaceutical preparations containing them
JP2011525537A (ja) * 2008-06-24 2011-09-22 ブリストル−マイヤーズ スクイブ カンパニー グルココルチコイド受容体、AP−1、および/またはNF−κB活性のシクロペンタチオフェン調節剤およびその使用
RU2661151C1 (ru) * 2017-12-14 2018-07-12 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Селективные ингибиторы глицеральдегид-3-фосфатдегидрогеназы микобактерий

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2167334A1 (en) * 1972-01-13 1973-08-24 Roussel Uclaf 4-aroyl-5-alkylthiophene-2-acetic acids - with analgesic and antiinflammatory activity
DK464274A (de) * 1973-09-11 1975-05-12 Sandoz Ag

Also Published As

Publication number Publication date
HUT38331A (en) 1986-05-28
IE58362B1 (en) 1993-09-08
JPS6140280A (ja) 1986-02-26
FR2567125A1 (fr) 1986-01-10
IN166471B (de) 1990-05-19
DK161321B (da) 1991-06-24
HU202519B (en) 1991-03-28
AR242381A1 (es) 1993-03-31
GR851609B (de) 1985-11-26
NO852741L (no) 1986-01-10
NO171499C (no) 1993-03-24
IE851486L (en) 1986-01-09
NZ212619A (en) 1988-02-12
CA1249834A (fr) 1989-02-07
IL75527A (en) 1988-11-30
MX162258A (es) 1991-04-18
DK310685D0 (da) 1985-07-08
CS510785A2 (en) 1987-07-16
MA20481A1 (fr) 1986-04-01
ES8604550A1 (es) 1986-02-01
DK310685A (da) 1986-01-10
ATE36329T1 (de) 1988-08-15
EP0172041A1 (de) 1986-02-19
NO171499B (no) 1992-12-14
FR2567125B1 (fr) 1986-12-05
DD235454A5 (de) 1986-05-07
SU1402261A3 (ru) 1988-06-07
US4649153A (en) 1987-03-10
DK161321C (da) 1992-01-06
EP0172041B1 (de) 1988-08-10
IL75527A0 (en) 1985-10-31
ES544961A0 (es) 1986-02-01
ZA854519B (en) 1986-02-26
CS255887B2 (en) 1988-03-15
JPH072733B2 (ja) 1995-01-18
YU113885A (en) 1987-10-31
OA08076A (fr) 1987-03-31
AU4362585A (en) 1986-01-16
AU573147B2 (en) 1988-05-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee